The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities.

abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang LD,Tao L,Li YT,Wu ZY,Yan CW

更新日期：2015-02-01 00:00:00

abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...

journal_title：Journal of biochemical and molecular toxicology

authors： Yadavilli S,Chen Z,Albrecht T,Muganda PM

更新日期：2009-11-01 00:00:00

abstract：:The quantitative influence of copper on the interaction between cytochrome c and sulfite, which is a derivate of sulfur dioxide in the human body, has been studied by fluorescence spectrometry and ultraviolet absorption spectrometry in vitro. The results indicate that copper may intensely combine with protein componen...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang J,Guo D,Yuan X

更新日期：2006-01-01 00:00:00

abstract：:Carbonic anhydrase (CA) was purified from Ağrı Balık Lake trout gill (fCA) by affinity chromatography on a sepharose 4B-tyrosine-sulfanilamide column. The fCA enzyme was purified with about a 303.9 purification factor, a specific activity 4130.4 EU (mg-protein)(-1), and a yield of 79.3 by using sepharose-4B-L tyrosine...

journal_title：Journal of biochemical and molecular toxicology

authors： Demirdag R,Comakli V,Kuzu M,Yerlikaya E,Şentürk M

更新日期：2015-03-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:Troxerutin, a natural flavonoid guards against oxidative stress and apoptosis with a high capability of passing through the blood-brain barrier. Our aim was to investigate the role of troxerutin in experimentally induced retinal neurodegeneration by modulating the interferon-gamma (IFNγ)-extracellular signal-regulated...

journal_title：Journal of biochemical and molecular toxicology

authors： Ibrahim RR,El-Esawy RO,El-Sakaa MH

更新日期：2020-06-01 00:00:00

abstract：:Effects of Cd2+ and two complexes of bivalent cadmium with 1,3-bis(4-chlorbenzylidenamino)-guanidine and anabasine on ion permeability of the inner membrane and respiration of isolated rat liver mitochondria were studied. Starting from 5 microM, Cd2+ decreased state 3 and DNP-stimulated respiration of mitochondria and...

journal_title：Journal of biochemical and molecular toxicology

authors： Korotkov SM,Glazunov VV,Rozengart EV,Suvorov AA,Nikitina ER

更新日期：1999-01-01 00:00:00

abstract：:Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity w...

journal_title：Journal of biochemical and molecular toxicology

authors： Keshk WA,Soliman NA,Abo El-Noor MM,Wahdan AA,Shareef MM

更新日期：2014-08-01 00:00:00

abstract：:The main topic of this study was to investigate the effect of benzo[a]pyrene (BP) on microRNAs and their target genes expression levels in primary cell cultures from normal and malignant endometrial tissue. MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment. The treatment of both cultures with BP ...

journal_title：Journal of biochemical and molecular toxicology

authors： Chanyshev MD,Koval OA,Nushtaeva AA,Gulyaeva LF

更新日期：2019-06-01 00:00:00

abstract：:Copper toxicity is associated with formation of reactive oxygen species, which are capable to oxidize proteins. The selective removal of the latter by the 20S proteasome is considered an essential part of the cell antioxidant defense system. The aim of the present study was to investigate whether peptidase activities ...

journal_title：Journal of biochemical and molecular toxicology

authors： Alexandrova A,Petrov L,Georgieva A,Kessiova M,Tzvetanova E,Kirkova M,Kukan M

更新日期：2008-09-01 00:00:00

abstract：:Changes in the chemical or physical conditions of the cell that impose a negative effect on growth demand rapid cellular responses, which are essential for survival. Molecular mechanisms induced upon exposure of cells to such adverse conditions are commonly designated as stress responses. Herein, different methods whi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamnik P,Raspor P

更新日期：2005-01-01 00:00:00

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:We studied action of inorganic phosphate (P(i)) on toxic effects of Tl+ in isolated rat liver mitochondria. This is a convenient model to study the toxicity of heavy metals. P(i) markedly retarded contraction of energized mitochondria swollen in the TlNO3 medium and even stronger stimulated swelling and state 4 of suc...

journal_title：Journal of biochemical and molecular toxicology

authors： Korotkov SM,Emel'yanova LV,Yagodina OV

更新日期：2008-05-01 00:00:00

abstract：:To date, microRNA-4709 (miR-4709) has not been studied in colon adenocarcinoma (COAD) on the basis of experiments. In our study, we aimed to investigate the biological roles and clinical significance of miR-4709 in COAD. The expression difference between miR-4709 and NR3C2 was measured based on The Cancer Genome Atlas...

journal_title：Journal of biochemical and molecular toxicology

authors： Yu M,Yu HL,Li QH,Zhang L,Chen YX

更新日期：2019-12-01 00:00:00

abstract：:The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, re...

journal_title：Journal of biochemical and molecular toxicology

authors： Ajiboye TO,Alabi KA,Ariyo FA,Adeleye AO,Ojewuyi OB,Balogun A,Sunmonu TO

更新日期：2015-03-01 00:00:00

abstract：:Recent studies have established the importance of estrogen-related receptor γ (ERRγ) as a required participant for insulin secretion in pancreatic β cells. Key downstream genes of ERRγ remain unclear in the pancreatic β cell. To understand the molecular role of ERRγ and elucidate potential key candidate genes involved...

journal_title：Journal of biochemical and molecular toxicology

authors： Lei Z,JunHui L,PeiFeng L

更新日期：2019-10-01 00:00:00

abstract：:We investigated the effects of the herbicide thiobencarb on the growth, photosynthetic activity, and expression profile of photosynthesis-related proteins in the marine diatom Thalassiosira pseudonana. Growth rate was suppressed by 50% at a thiobencarb concentration of 1.26 mg/L. Growth and photosystem II activity (Fv...

journal_title：Journal of biochemical and molecular toxicology

authors： Shimasaki Y,Tsuyama M,Tasmin R,Qiu X,Shimizu M,Sato Y,Yamasaki Y,Kato-Unoki Y,Nukata A,Nakashima T,Ichinose H,Wariishi H,Honjo T,Oshima Y

更新日期：2013-09-01 00:00:00

abstract：:The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For this purpose, two different groups each of which contains eight rats (n = 8) were formed as being ...

journal_title：Journal of biochemical and molecular toxicology

authors： Kocyigit UM,Taslimi P,Gurses F,Soylu S,Durna Dastan S,Gulcin İ

更新日期：2018-03-01 00:00:00

abstract：:Allyl alcohol hepatotoxicity is mediated by an alcohol dehydrogenase-derived biotranformation product, acrolein. This highly reactive alpha,beta-unsaturated aldehyde readily alkylates model proteins in vitro, forming, among other products, Michael addition adducts that possess a free carbonyl group. Whether such damag...

journal_title：Journal of biochemical and molecular toxicology

authors： Burcham PC,Fontaine F

更新日期：2001-01-01 00:00:00

abstract：:The present study aims to investigate the protective effect of quercetin against Aroclor-1254-induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor-1254 (2 mg/kg bwt/day intraper...

journal_title：Journal of biochemical and molecular toxicology

authors： Sekaran S,Kandaswamy S,Gunasekaran K,Perumal E,Afsar Basha FY,Madhan Mohan BJ,Jagadeesan A

更新日期：2012-12-01 00:00:00

abstract：:Ochratoxin A (OTA) is nephrotoxic, immunosuppressive, and teratogenic in many species and is a possible human carcinogen. In this study, we investigated the OTA pollution situations of grains in northern China and the signaling pathway that mediated OTA-induced apoptosis in human tubular kidney cells (HKCs). Samples o...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhang X,Cui J,Kang W

更新日期：2012-03-01 00:00:00

abstract：:This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl2 ) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against CdCl2 (50 μM) as was observed by MTT assay. Precondi...

journal_title：Journal of biochemical and molecular toxicology

authors： Rathi VK,Das S,Parampalli Raghavendra A,Rao BSS

更新日期：2017-08-01 00:00:00

abstract：:c-Myc and vascular endothelial growth factor (VEGF) genes are frequently deregulated and overexpressed in this malignancy, and strategies designed to inhibit c-Myc and VEGF expression in cancer cells may have considerable therapeutic value. In the present study, we design and use short interfering RNA (siRNA) to inhib...

journal_title：Journal of biochemical and molecular toxicology

authors： Tai J,Wang G,Liu T,Wang L,Lin C,Li F

更新日期：2012-12-01 00:00:00

abstract：:The effects of Echis pyramidum venom (EPV) (0.25, 0.50, and 1.00 mg/kg) on activities of superoxide dismutase (SOD) and catalase (CAT) and levels of thiobarbituric acid reactive substances (TBARS) and total thiols (T-SH) in liver and kidneys of rats were investigated. EPV significantly and dose dependently decreased t...

journal_title：Journal of biochemical and molecular toxicology

authors： Al Asmari AK,Khan HA,Manthiri RA,Al Yahya KM,Al Otaibi KE

更新日期：2014-09-01 00:00:00

abstract：:Schisandrin A (SchA) has been reported as a multidrug resistance-reversing agent; however, its antitumor effects have been rarely reported. Consequently, we attempted to explore whether SchA per se possesses an antitumor property in choriocarcinoma JEG-3 and BeWo cells and its potential mechanisms. JEG-3, BeWo, and HT...

journal_title：Journal of biochemical and molecular toxicology

authors： Ji L,Ma L

更新日期：2020-04-01 00:00:00

abstract：:The oxysterol 7beta-hydroxycholesterol (7beta-OH) has been shown to induce apoptosis in a number of cell lines. Though not fully elucidated, the mechanism through which this oxysterol induces cell death is thought to involve the generation of an oxidative stress leading to perturbation of the mitochondrion and release...

journal_title：Journal of biochemical and molecular toxicology

authors： Ryan L,O'Callaghan YC,O'Brien NM

更新日期：2004-01-01 00:00:00

abstract：:The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/...

journal_title：Journal of biochemical and molecular toxicology

authors： Apopa PL,He X,Ma Q

更新日期：2008-02-01 00:00:00

abstract：:The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are al...

journal_title：Journal of biochemical and molecular toxicology

authors： Saravia J,Lee GI,Lomnicki S,Dellinger B,Cormier SA

更新日期：2013-01-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00