Endocrine and metabolic regulation of renal drug transporters.

abstract：:Previously reported results showed that the BmKK2's intron could be recognized and spliced in cultured HEK 293T cells. At the same time, a cryptic splicing site of BmKK2 gene was found in the second exon. Moreover, replacing BmKK2's intron with BmP03's intron (an artificial BmKK2-BmP03 mosaic gene) did not affect the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhijian C,Chao D,Dahe J,Wenxin L

更新日期：2006-01-01 00:00:00

abstract：:Carbohydrate-derived aldehydes cause irreversible loss of protein function via glycation. We previously observed that glyceraldehyde 3-phosphate (Glyc3P) abolishes the enzyme activity of cardiac aspartate aminotransferase (cAAT). We also examined the protective effects of carnosine against Glyc3P-induced loss of enzym...

journal_title：Journal of biochemical and molecular toxicology

authors： Seidler NW

更新日期：2000-01-01 00:00:00

abstract：:The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/...

journal_title：Journal of biochemical and molecular toxicology

authors： Apopa PL,He X,Ma Q

更新日期：2008-02-01 00:00:00

abstract：:The cytochrome P450 (CYP) isoform CYP2C11 is specifically expressed in the liver of adult male rats, and 5alpha-reductase is specifically expressed in the liver of the adult female rats. The sexually dimorphic expressions of these hepatic enzymes are regulated by the sex-dependent profiles of the circulating growth ho...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishizuka M,Yonemoto J,Zaha H,Tohyama C,Sone H

更新日期：2003-01-01 00:00:00

abstract：:The expression of glutathione S-transferase (GST) is a crucial factor in determining the sensitivity of cells and organs in response to a variety of toxicants. In this study, we cloned the core nucleotide of alpha, kappa, mu, mGST, pi, rho, and theta-like GST genes from bighead carp (Aristichthys nobilis). Their deriv...

journal_title：Journal of biochemical and molecular toxicology

authors： Li G,Xie P,Li H,Chen J,Hao L,Xiong Q

更新日期：2010-07-01 00:00:00

abstract：:The action of carbenoxolone on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In perfused livers, carbenoxolone (200-300 microM) increased oxygen consumption, glucose production and glycolysis from endogenous glycogen. Gluconeogenesis from lactate or fructose, an energy...

journal_title：Journal of biochemical and molecular toxicology

authors： Pivato LS,Constantin RP,Ishii-Iwamoto EL,Kelmer-Bracht AM,Yamamoto NS,Constantin J,Bracht A

更新日期：2006-01-01 00:00:00

abstract：:Our earlier investigation demonstrated that methoxychlor treatment induced hepatic cytochrome P450 2B1/2B2 and 3A proteins in rats and enhanced their respective enzymatic activities. To determine the mechanism of the methoxychlor-mediated induction and whether methoxychlor acts as a frank inducer and not merely by cau...

journal_title：Journal of biochemical and molecular toxicology

authors： Li HC,Kupfer D

更新日期：1998-01-01 00:00:00

abstract：:β-Lactam antibiotics such as ceftriaxone, are potent stimulators of the expression of l-glutamate transporter GLT-1 and may exert neuroprotective effects when chronically used in rats and mice. In this study, we used two animal models to test the neurological effect of subchronic treatment with ceftriaxone: experiment...

journal_title：Journal of biochemical and molecular toxicology

authors： Fachim HA,Guizzo R,Cunha AOS,Pereira AC,Dos Anjos LC,Mortari MR,Dos Santos WF

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, ...

journal_title：Journal of biochemical and molecular toxicology

authors： Li B,Suemaru K,Kitamura Y,Gomita Y,Araki H,Cui R

更新日期：2013-11-01 00:00:00

abstract：:This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl2 ) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against CdCl2 (50 μM) as was observed by MTT assay. Precondi...

journal_title：Journal of biochemical and molecular toxicology

authors： Rathi VK,Das S,Parampalli Raghavendra A,Rao BSS

更新日期：2017-08-01 00:00:00

abstract：:We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid-reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additionally, we investigated the anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Eger GA,Ferreira VV,Batista CR,Bonde HL,de Lima DD,Rodrigues AF,da Cruz JG,Magro DD

更新日期：2016-10-01 00:00:00

abstract：:The quantitative influence of copper on the interaction between cytochrome c and sulfite, which is a derivate of sulfur dioxide in the human body, has been studied by fluorescence spectrometry and ultraviolet absorption spectrometry in vitro. The results indicate that copper may intensely combine with protein componen...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang J,Guo D,Yuan X

更新日期：2006-01-01 00:00:00

abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang LD,Tao L,Li YT,Wu ZY,Yan CW

更新日期：2015-02-01 00:00:00

abstract：:The full-length sequence of the protein phosphatase 2A subunit A (PP2A-A) cDNA from silver carp was cloned and sequenced. Additionally, the transcription of PP2A-A in the liver, kidney, and spleen of fish after microcystin (MC)-exposure were also determined in this study. The results reveal that PP2A-A cDNA is 2833 ba...

journal_title：Journal of biochemical and molecular toxicology

authors： Ma J,Feng Y,Xie W,Li X

更新日期：2015-09-01 00:00:00

abstract：:Mitochondria play an important role in myocardial tissue homeostasis; therefore, deterioration in mitochondrial function will eventually lead to cardiomyocyte and endothelial cell death and consequently cardiovascular dysfunction. Lithium (Li+ ) is an effective drug for bipolar disorder with known cardiotoxic side eff...

journal_title：Journal of biochemical and molecular toxicology

authors： Salimi A,Gholamifar E,Naserzadeh P,Hosseini MJ,Pourahmad J

更新日期：2017-02-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sp...

journal_title：Journal of biochemical and molecular toxicology

authors： Prathima P,Pavani R,Sukeerthi S,Sainath SB

更新日期：2018-02-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00

abstract：:Enantiomers of cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate show stereo-specific inhibition for acetylcholinesterase and butyrylcholinesterase. For both inhibition reaction, (2S,4aR,8aS)-cis,cis-decahydro-2-naphthyl-N-n- butylcarbamate is more potent than (2R,4aS,8aR)-cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate...

journal_title：Journal of biochemical and molecular toxicology

authors： Lin MC,Yeh SJ,Chen IR,Lin G

更新日期：2011-09-01 00:00:00

abstract：:Diabetic neuropathic pain is characterized by spontaneous pain with hyperalgesia and allodynia. We investigated whether (-)-epigallocatechin-3-O-gallate could improve diabetic neuropathic pain development through hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects. Diabetes was induced in rats by s...

journal_title：Journal of biochemical and molecular toxicology

authors： Abo-Salem OM,Ali TM,Harisa GI,Mehanna OM,Younos IH,Almalki WH

更新日期：2020-08-01 00:00:00

abstract：:Schisandrin A (SchA) has been reported as a multidrug resistance-reversing agent; however, its antitumor effects have been rarely reported. Consequently, we attempted to explore whether SchA per se possesses an antitumor property in choriocarcinoma JEG-3 and BeWo cells and its potential mechanisms. JEG-3, BeWo, and HT...

journal_title：Journal of biochemical and molecular toxicology

authors： Ji L,Ma L

更新日期：2020-04-01 00:00:00

abstract：UNLABELLED:Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2-dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29 cells over time, and defined the pr...

journal_title：Journal of biochemical and molecular toxicology

authors： Erzinger MM,Bovet C,Uzozie A,Sturla SJ

更新日期：2015-01-01 00:00:00

abstract：:Here, we aimed to investigate the carcinogenic effects of apolipoprotein C1 (APOC1) in prostate cancer (PCa). APOC1 expression was evaluated in PCa and normal prostate specimens, and lentivirus-mediated RNA interference was used to knockdown APOC1 in DU145 cells. The effects of APOC1 silencing on cell proliferation, c...

journal_title：Journal of biochemical and molecular toxicology

authors： Su WP,Sun LN,Yang SL,Zhao H,Zeng TY,Wu WZ,Wang D

更新日期：2018-05-02 00:00:00

abstract：:Habitual consumption of some Melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. Areca nut (AN; Areca catechu), piper inflorescence (PBI; Piper betle), betel quid (BQ), guava buds (GB; Psidium guajava), the leaves (NL), juice (NJ), fru...

journal_title：Journal of biochemical and molecular toxicology

authors： Owen PL,Matainaho T,Sirois M,Johns T

更新日期：2007-01-01 00:00:00

abstract：:Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...

journal_title：Journal of biochemical and molecular toxicology

authors： Bozcaarmutlu A

更新日期：2007-01-01 00:00:00

abstract：:The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to evaluate its effects in the liver. Body weight and fo...

journal_title：Journal of biochemical and molecular toxicology

authors： Resende AD,Leal S,Batista-Pinto C,Garcez F,Sá SI

更新日期：2019-05-01 00:00:00

abstract：:The toxicities of 4 short-chain alcohols--namely methanol, ethanol, iso-propanol and iso-butanol--were compared in the nematode Caenorhabditis elegans using several different ecotoxicological endpoints. Range-finding tests were conducted using transgenic PC161 worms carrying a double reporter construct (GFP plus lacZ)...

journal_title：Journal of biochemical and molecular toxicology

authors： Thompson G,de Pomerai DI

更新日期：2005-01-01 00:00:00

abstract：:It is well established that crosstalk between cancer-associated fibroblasts (CAFs) and cancer cells plays a critical role in the occurrence and development of oral squamous cell carcinoma (OSCC). The molecular mechanisms underlying such interaction, however, remain far from clear. Accumulating data have indicated that...

journal_title：Journal of biochemical and molecular toxicology

authors： Min A,Zhu C,Peng S,Shuai C,Sun L,Han Y,Qian Y,Gao S,Su T

更新日期：2016-04-01 00:00:00

abstract：:Oxidative shock and production of reactive oxygen species are known to play a major role in situations leading to neuron degeneration, but the precise mechanisms responsible for cell degeneration remain uncertain. In the present article, we have studied in PC 12 cells the effect of cumene hydroxyperoxide on both cell ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vimard F,Saucet M,Nicole O,Feuilloley M,Duval D

更新日期：2011-07-01 00:00:00