The effect of intron location on the splicing of BmKK2 in 293T cells.

abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...

journal_title：Journal of biochemical and molecular toxicology

authors： Yadavilli S,Chen Z,Albrecht T,Muganda PM

更新日期：2009-11-01 00:00:00

abstract：:The etiologic link between pesticide toxicity and aplastic anemia in agricultural and agro-industrial setting has been frequently reported in epidemiological studies conducted worldwide. Chronic pesticide toxicity causes long-term bone marrow injury and perturbs the normal hematopoietic physiology, including survival ...

journal_title：Journal of biochemical and molecular toxicology

authors： Chattopadhyay S,Law S

更新日期：2020-05-14 00:00:00

abstract：:Allyl alcohol hepatotoxicity is mediated by an alcohol dehydrogenase-derived biotranformation product, acrolein. This highly reactive alpha,beta-unsaturated aldehyde readily alkylates model proteins in vitro, forming, among other products, Michael addition adducts that possess a free carbonyl group. Whether such damag...

journal_title：Journal of biochemical and molecular toxicology

authors： Burcham PC,Fontaine F

更新日期：2001-01-01 00:00:00

abstract：:c-Myc and vascular endothelial growth factor (VEGF) genes are frequently deregulated and overexpressed in this malignancy, and strategies designed to inhibit c-Myc and VEGF expression in cancer cells may have considerable therapeutic value. In the present study, we design and use short interfering RNA (siRNA) to inhib...

journal_title：Journal of biochemical and molecular toxicology

authors： Tai J,Wang G,Liu T,Wang L,Lin C,Li F

更新日期：2012-12-01 00:00:00

abstract：:The present study aims to investigate the protective effect of quercetin against Aroclor-1254-induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor-1254 (2 mg/kg bwt/day intraper...

journal_title：Journal of biochemical and molecular toxicology

authors： Sekaran S,Kandaswamy S,Gunasekaran K,Perumal E,Afsar Basha FY,Madhan Mohan BJ,Jagadeesan A

更新日期：2012-12-01 00:00:00

abstract：:Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT),...

journal_title：Journal of biochemical and molecular toxicology

authors： Raudenska M,Dvorakova V,Pacal L,Chalasova K,Kratochvilova M,Gumulec J,Ruttkay-Nedecky B,Zitka O,Kankova K,Adam V,Masarik M

更新日期：2017-06-01 00:00:00

abstract：:The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are al...

journal_title：Journal of biochemical and molecular toxicology

authors： Saravia J,Lee GI,Lomnicki S,Dellinger B,Cormier SA

更新日期：2013-01-01 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00

abstract：:Recent studies have established the importance of estrogen-related receptor γ (ERRγ) as a required participant for insulin secretion in pancreatic β cells. Key downstream genes of ERRγ remain unclear in the pancreatic β cell. To understand the molecular role of ERRγ and elucidate potential key candidate genes involved...

journal_title：Journal of biochemical and molecular toxicology

authors： Lei Z,JunHui L,PeiFeng L

更新日期：2019-10-01 00:00:00

abstract：:Proximal tubule protein take-up is interceded by 2 receptors, megalin and cubilin. These receptors rescue an assortment of filtered ligands including fundamental vitamins and hormones. The objective of this study was to investigate the potential relation of megalin receptor injury with nuclear factor-kappa B (NF-κB) u...

journal_title：Journal of biochemical and molecular toxicology

authors： Elshaer SS,Anwar HM

更新日期：2018-01-01 00:00:00

abstract：:Manganese is an essential trace element found in many enzymes. As it is the case of many essential trace elements, excessive level of manganese is toxic. It has been proven that excessive manganese could cause heart problems. In order to understand the mechanism of manganese toxicity in the heart, the effects of manga...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang H,Wang T,Li J,Gu L,Zheng X

更新日期：2006-01-01 00:00:00

abstract：:The antioxidant properties of 1,2,3,4-tetra-hydrocarbazole, 6-methoxy-1,2,3,4-tetrahydrocar-bazole (MTC), 2,3-dimethylindole, 5-methoxy-2,3-dimethylindole, and indole were investigated in the case of hemolysis of human erythrocytes and oxidative damage of DNA induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAP...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhao F,Liu ZQ

更新日期：2009-07-01 00:00:00

abstract：:Retinoic acid (RA) alters the developmental fate of the axial skeletal anlagen. "Anteriorizations" or "posteriorizations," the assumption of characteristics of embryonic areas normally anterior or posterior to the affected tissues, are correlated with altered embryonal expression domains of Hox genes after in utero RA...

journal_title：Journal of biochemical and molecular toxicology

authors： Kawanishi CY,Hartig P,Bobseine KL,Schmid J,Cardon M,Massenburg G,Chernoff N

更新日期：2003-01-01 00:00:00

abstract：:Diabetic neuropathic pain is characterized by spontaneous pain with hyperalgesia and allodynia. We investigated whether (-)-epigallocatechin-3-O-gallate could improve diabetic neuropathic pain development through hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects. Diabetes was induced in rats by s...

journal_title：Journal of biochemical and molecular toxicology

authors： Abo-Salem OM,Ali TM,Harisa GI,Mehanna OM,Younos IH,Almalki WH

更新日期：2020-08-01 00:00:00

abstract：:β-Lactam antibiotics such as ceftriaxone, are potent stimulators of the expression of l-glutamate transporter GLT-1 and may exert neuroprotective effects when chronically used in rats and mice. In this study, we used two animal models to test the neurological effect of subchronic treatment with ceftriaxone: experiment...

journal_title：Journal of biochemical and molecular toxicology

authors： Fachim HA,Guizzo R,Cunha AOS,Pereira AC,Dos Anjos LC,Mortari MR,Dos Santos WF

更新日期：2020-11-01 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:Disruption of the balance oxidants, antioxidants cause various pathophysiological conditions such as lipid peroxidation, protein degradation, or DNA damage. We have examined possible effects of kisspeptin-10 on the structural damage produced by methionine-induced lipid peroxidation in testicle tissue of young rats. Ki...

journal_title：Journal of biochemical and molecular toxicology

authors： Akkaya H,Eyuboglu S,Erkanlı Senturk G,Yilmaz B

更新日期：2017-05-01 00:00:00

abstract：:Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, ...

journal_title：Journal of biochemical and molecular toxicology

authors： Li B,Suemaru K,Kitamura Y,Gomita Y,Araki H,Cui R

更新日期：2013-11-01 00:00:00

abstract：:The full-length sequence of the protein phosphatase 2A subunit A (PP2A-A) cDNA from silver carp was cloned and sequenced. Additionally, the transcription of PP2A-A in the liver, kidney, and spleen of fish after microcystin (MC)-exposure were also determined in this study. The results reveal that PP2A-A cDNA is 2833 ba...

journal_title：Journal of biochemical and molecular toxicology

authors： Ma J,Feng Y,Xie W,Li X

更新日期：2015-09-01 00:00:00

abstract：:We reported earlier in a guinea pig model that exposure of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, causes lung injury associated with the activation of tumor necrosis factor alpha (TNF-alpha), mitogen activated protein kinases (MAPK) signaling, and activator protein-1 (AP-1) transcription factor. Our...

journal_title：Journal of biochemical and molecular toxicology

authors： Mukhopadhyay S,Mukherjee S,Ray BK,Ray A,Stone WL,Das SK

更新日期：2010-05-01 00:00:00

abstract：:The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, re...

journal_title：Journal of biochemical and molecular toxicology

authors： Ajiboye TO,Alabi KA,Ariyo FA,Adeleye AO,Ojewuyi OB,Balogun A,Sunmonu TO

更新日期：2015-03-01 00:00:00

abstract：:Netrin-1 has been found to protect kidneys from ischemia/reperfusion injury. In this study, we aimed to address whether the protective effects were mediated through suppression of oxidative stress and neuropeptide Y. Compared to sham-operated animals, animals after ischemia/reperfusion showed marked kidney damage and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu L,Xie S,Liao X,Zhang L,Zhong L

更新日期：2013-04-01 00:00:00

abstract：:Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchicine, has been tested against two types of primary cancer cells...

journal_title：Journal of biochemical and molecular toxicology

authors： Urbaniak A,Jousheghany F,Piña-Oviedo S,Yuan Y,Majcher-Uchańska U,Klejborowska G,Moorjani A,Monzavi-Karbassi B,Huczyński A,Chambers TC

更新日期：2020-06-01 00:00:00

abstract：:Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Hamadeh HK,Bushel P,Paules R,Afshari CA

更新日期：2001-01-01 00:00:00

abstract：:The effects of Echis pyramidum venom (EPV) (0.25, 0.50, and 1.00 mg/kg) on activities of superoxide dismutase (SOD) and catalase (CAT) and levels of thiobarbituric acid reactive substances (TBARS) and total thiols (T-SH) in liver and kidneys of rats were investigated. EPV significantly and dose dependently decreased t...

journal_title：Journal of biochemical and molecular toxicology

authors： Al Asmari AK,Khan HA,Manthiri RA,Al Yahya KM,Al Otaibi KE

更新日期：2014-09-01 00:00:00

abstract：:With the rapid development of nanotechnology, nanomaterials are now being used for cancer treatment. Although studies on the application of silver nanoparticles in cancer treatment are burgeoning, few studies have investigated the toxicology mechanisms of autophagy in cancer cells under exposure to sublethal silver na...

journal_title：Journal of biochemical and molecular toxicology

authors： Chen Y,Yang T,Chen S,Qi S,Zhang Z,Xu Y

更新日期：2020-05-01 00:00:00

abstract：:Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes...

journal_title：Journal of biochemical and molecular toxicology

authors： Taslimi P,Kandemir FM,Demir Y,İleritürk M,Temel Y,Caglayan C,Gulçin İ

更新日期：2019-06-01 00:00:00

abstract：:Zingerone (ZO), an active phenolic agent derived from Zingiber officinale (Ginger), has many pharmacological properties such as antioxidant, antiangiogenic, and antitumor. However, its potential value in cancer and the mechanism by which ZO wields its therapeutic effects remain obscure. Therefore, in this current stud...

journal_title：Journal of biochemical and molecular toxicology

authors： Su P,Veeraraghavan VP,Krishna Mohan S,Lu W

更新日期：2019-12-01 00:00:00

abstract：:Uroporphyrinogen decarboxylase is an essential enzyme in all organisms and functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen. This work examines whether the four sequential decarboxylations occur at the same active site,...

journal_title：Journal of biochemical and molecular toxicology

authors： Chaufan G,Corvi MM,San Martín de Viale LC,Cárdenas ML,Ríos de Molina Mdel C

更新日期：2005-01-01 00:00:00

abstract：:The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sp...

journal_title：Journal of biochemical and molecular toxicology

authors： Prathima P,Pavani R,Sukeerthi S,Sainath SB

更新日期：2018-02-01 00:00:00