Abstract:
:A number of reduced amino Schiff base ligands and corresponding ruthenium(III) complexes were designed and prepared based on the fact that amino acids not only possess multiple coordinate atoms but also improve the solubility of drugs in the body. The interaction of the complexes with calf thymus DNA was analyzed with spectroscopic methods of ultraviolet-visible absorption spectra, DNA competitive binding with ethidium bromide, circular dichroism spectra, and DNA melting experiments, and DNA viscosity measurements, indicating that the complexes bind to DNA primarily in the grooving mode. With respect to the ligands, the cytotoxicity in vitro of the complexes against Hela, A549, and MCF-7 cells was much enhanced, with most of the IC50 values less than 50 μM or even comparable with those of cisplatin.
journal_name
J Biochem Mol Toxicoljournal_title
Journal of biochemical and molecular toxicologyauthors
Zhang Z,Yang Z,Wu Y,Yuan Z,Du J,Li Ldoi
10.1002/jbt.22510subject
Has Abstractpub_date
2020-08-01 00:00:00pages
e22510issue
8eissn
1095-6670issn
1099-0461journal_volume
34pub_type
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