Effects of Cd2+ and two cadmium organic complexes on isolated rat liver mitochondria.

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:Diabetes mellitus is a serious worldwide metabolic disease, which is accompanied by hyperglycaemia and affects all organs and body system. Zinc (Zn) is a basic cofactor for many enzymes, which also plays an important role in stabilising the structure of insulin. Liver is the most important target organ after pancreas ...

journal_title：Journal of biochemical and molecular toxicology

authors： Sacan O,Turkyilmaz IB,Bayrak BB,Mutlu O,Akev N,Yanardag R

更新日期：2021-01-01 00:00:00

abstract：:Significant changes in drug-metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and child, as well as the risk for adverse drug reactions. To gain a better understanding of DME ontogeny, enzyme contents for six key cytochromes P450 we...

journal_title：Journal of biochemical and molecular toxicology

authors： Hines RN

更新日期：2007-01-01 00:00:00

abstract：:The transient receptor potential (TRP) channels are thermo-sensors, and transient receptor potential vanilloid (TRPV)1 and V4 are widely expressed in primary afferent neurons and nonneuronal cells. Although heat acclimation is considered as changes of thermoregulatory responses by thermo-effectors to heat, functional ...

journal_title：Journal of biochemical and molecular toxicology

authors： Sugimoto N,Matsuzaki K,Katakura M,Nakamura H,Ueda Y,Yachie A,Shido O

更新日期：2019-05-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:Proximal tubule protein take-up is interceded by 2 receptors, megalin and cubilin. These receptors rescue an assortment of filtered ligands including fundamental vitamins and hormones. The objective of this study was to investigate the potential relation of megalin receptor injury with nuclear factor-kappa B (NF-κB) u...

journal_title：Journal of biochemical and molecular toxicology

authors： Elshaer SS,Anwar HM

更新日期：2018-01-01 00:00:00

abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...

journal_title：Journal of biochemical and molecular toxicology

authors： Song Y,Wu W,Sheng L,Jiang B,Li X,Cai K

更新日期：2020-07-01 00:00:00

abstract：:We have analyzed gene expression and histopathology of rat liver treated with a histamine-3 receptor inverse agonist under development for the treatment of obesity 24 h after a single acute administration. While histopathology did not identify a clear liver toxicity, analysis of gene changes strongly suggested the dev...

journal_title：Journal of biochemical and molecular toxicology

authors： Roth A,Boess F,Landes C,Steiner G,Freichel C,Plancher JM,Raab S,de Vera Mudry C,Weiser T,Suter L

更新日期：2011-05-01 00:00:00

abstract：:In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f), carbonyl sulfonamides (3h and i), and carbonyl sulfamates (4h and 4i), which were tested against two human cytosolic carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (ACh...

journal_title：Journal of biochemical and molecular toxicology

authors： Atmaca U,Yıldırım A,Taslimi P,Çelik ST,Gülçin İ,Supuran CT,Çelik M

更新日期：2018-08-01 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:The genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated on human lymphocytes cultured in vitro. Utilizing the trypan blue dye exclusion technique assay, the LC50 of LCT was found to be 28 microM. Based on the LC50 value, it is seen that LCT was highly tox...

journal_title：Journal of biochemical and molecular toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:Changes in the chemical or physical conditions of the cell that impose a negative effect on growth demand rapid cellular responses, which are essential for survival. Molecular mechanisms induced upon exposure of cells to such adverse conditions are commonly designated as stress responses. Herein, different methods whi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamnik P,Raspor P

更新日期：2005-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...

journal_title：Journal of biochemical and molecular toxicology

authors： Kaymak E,Akin AT,Tufan E,Başaran KE,Taheri S,Özdamar S,Yakan B

更新日期：2020-09-21 00:00:00

abstract：:We determined the number and the dissociation rate constants of different complexes formed from arsenite and two peptides containing either one (RVCAVGNDYASGYHYGV for peptide 20) or three cysteines (LECAWQGK CVEGTEHLYSMKCK for peptide 10) via radioactive 73As-labeled arsenite and vacuum filtration methodology. Nonline...

journal_title：Journal of biochemical and molecular toxicology

authors： Kitchin KT,Wallace K

更新日期：2006-01-01 00:00:00

abstract：:The present study is the first attempt to report the characterization of a nucleotidase from Cerastes cerastes venom. A 70 kDa 5'-nucleotidase (Cc-5'NTase) was purified to homogeneity. The amino acid sequence of Cc-5'NTase displayed high homology with many nucleotidases. Its activity was optimal at pH 7 with a specifi...

journal_title：Journal of biochemical and molecular toxicology

authors： Saoud S,Chérifi F,Benhassine T,Laraba-Djebari F

更新日期：2017-05-01 00:00:00

abstract：:A full-length cDNA clone encoding a novel form of the cytochrome P450 3A subfamily (Cyp3a-25) has been isolated from a mouse liver cDNA library. The sequence contained 2010 base pairs and encoded a protein with 503 amino acids. The amino acid sequence shared greater identities with rat CYP3A18 (90%) and golden hamster...

journal_title：Journal of biochemical and molecular toxicology

authors： Dai D,Bai R,Hodgson E,Rose RL

更新日期：2001-01-01 00:00:00

abstract：:Some novel derivatives of thiosemicarbazide and 1,2,4-triazole-3-thiol were synthesized and evaluated for their biological activities. The title compounds were prepared starting from readily available pyridine-2,5-dicarboxylic acid. The reaction carboxylic acid with absolute ethanol afforded the corresponding dimethyl...

journal_title：Journal of biochemical and molecular toxicology

authors： Bulut N,Kocyigit UM,Gecibesler IH,Dastan T,Karci H,Taslimi P,Durna Dastan S,Gulcin I,Cetin A

更新日期：2018-01-01 00:00:00

abstract：:Mitochondria play an important role in myocardial tissue homeostasis; therefore, deterioration in mitochondrial function will eventually lead to cardiomyocyte and endothelial cell death and consequently cardiovascular dysfunction. Lithium (Li+ ) is an effective drug for bipolar disorder with known cardiotoxic side eff...

journal_title：Journal of biochemical and molecular toxicology

authors： Salimi A,Gholamifar E,Naserzadeh P,Hosseini MJ,Pourahmad J

更新日期：2017-02-01 00:00:00

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...

journal_title：Journal of biochemical and molecular toxicology

authors： Bozcaarmutlu A

更新日期：2007-01-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00

abstract：:Paroxetine, a representative of serotonin reuptake inhibitors, has recently gained attention due to its anti-inflammatory properties. However, underlying mechanisms responsible for its immunosuppressive effects remain to be unveiled. To understand the responsible signaling mechanisms, we examined paroxetine's effect o...

journal_title：Journal of biochemical and molecular toxicology

authors： Kabiri M,Hemmatpour A,Zare F,Hadinedoushan H,Karimollah A

更新日期：2020-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:Drug resistance is a large challenge for the treatment of non-small-cell lung cancer (NSCLC). Deoxyshikonin is the naphthoquinol compound with anticancer activity. However, the role and mechanism of deoxyshikonin in cisplatin resistance of NSCLC remain poorly understood. Cell viability was assessed using 3-(4,5-dimeth...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhang S,Wang Y

更新日期：2020-10-01 00:00:00

abstract：:Diabetic neuropathic pain is characterized by spontaneous pain with hyperalgesia and allodynia. We investigated whether (-)-epigallocatechin-3-O-gallate could improve diabetic neuropathic pain development through hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects. Diabetes was induced in rats by s...

journal_title：Journal of biochemical and molecular toxicology

authors： Abo-Salem OM,Ali TM,Harisa GI,Mehanna OM,Younos IH,Almalki WH

更新日期：2020-08-01 00:00:00

abstract：:The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose-dependent cardiotoxicity. The aim of this study was to evaluate the cardioprotective effect of the combination of carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR-induced cardiomyopathy in rats. The results of the present...

journal_title：Journal of biochemical and molecular toxicology

authors： Alanazi A,Fadda L,Alhusaini A,Ahmad R

更新日期：2020-07-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds and mediates responses to many halogenated aromatic compounds (HACs). Exposure to mixtures of HACs frequently results in nonadditive behavior in both in vivo and in vitro assays. One cause is antagonism, which results when two or...

journal_title：Journal of biochemical and molecular toxicology

authors： Petrulis JR,Bunce NJ

更新日期：2000-01-01 00:00:00

abstract：:Previously reported results showed that the BmKK2's intron could be recognized and spliced in cultured HEK 293T cells. At the same time, a cryptic splicing site of BmKK2 gene was found in the second exon. Moreover, replacing BmKK2's intron with BmP03's intron (an artificial BmKK2-BmP03 mosaic gene) did not affect the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhijian C,Chao D,Dahe J,Wenxin L

更新日期：2006-01-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00