Contrast encoding in retinal bipolar cells: current vs. voltage.

Abstract:

:To investigate the influence of voltage-sensitive conductances in shaping light-evoked responses of retinal bipolar cells, whole-cell recordings were made in the slice preparation of the tiger salamander, Ambystoma tigrinum. To study contrast encoding, the retina was stimulated with 0.5-s steps of negative and positive contrasts of variable magnitude. In the main, responses recorded under voltage- and current-clamp modes were remarkably similar. In general agreement with past results in the intact retina, the contrast/response curves were relatively steep for small contrasts, thus showing high contrast gain; the dynamic range was narrow, and responses tended to saturate at relatively small contrasts. For ON and OFF cells, linear regression analysis showed that the current response accounted for 83-93% of the variance of the voltage response. Analysis of specific parameters of the contrast/response curve showed that contrast gain was marginally higher for voltage than current in three of four cases, while no significant differences were found for half-maximal contrast (C50), dynamic range, or contrast dominance. In sum, the overall similarity between current and voltage responses indicates that voltage-sensitive conductances do not play a major role in determining the shape of the bipolar cell's contrast response in the light-adapted retina. The salient characteristics of the contrast response of bipolars apparently arise between the level of the cone voltage response and the postsynaptic current of bipolar cells, via the transformation between cone voltage and transmitter release and/or via the interaction between the neurotransmitter glutamate and its postsynaptic receptors on bipolar cells.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Thoreson WB,Burkhardt DA

doi

10.1017/s0952523803201036

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

19-28

issue

1

eissn

0952-5238

issn

1469-8714

pii

S0952523803201036

journal_volume

20

pub_type

杂志文章
  • Striate cortex increases contrast gain of macaque LGN neurons.

    abstract::Recurrent projections comprise a universal feature of cerebral organization. Here, we show that the corticofugal projections from the striate cortex (VI) to the lateral geniculate nucleus (LGN) robustly and multiplicatively enhance the responses of parvocellular neurons, stimulated by gratings restricted to the classi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800174012

    authors: Przybyszewski AW,Gaska JP,Foote W,Pollen DA

    更新日期:2000-07-01 00:00:00

  • Development of the primate area of high acuity, 3: temporal relationships between pit formation, retinal elongation and cone packing.

    abstract::By establishing an avascular, highly elastic, region within the fetal area of high acuity (AHA), the developing primate eye has created a unique substrate on which the mechanical forces of intraocular pressure (IOP) and growth-induced retinal stretch (stretch) can act. We proposed (Springer & Hendrickson, 2004b) that ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S095252380522206X

    authors: Springer AD,Hendrickson AE

    更新日期:2005-03-01 00:00:00

  • Color space distortions in patients with type 2 diabetes mellitus.

    abstract::Color vision impairment was examined in patients with type 2 diabetes mellitus (DM2) without retinopathy. We assessed the type and degree of distortions of individual color spaces. DM2 patients (n = 32), and age-matched controls (n = 20) were tested using the Farnsworth D-15 and the Lanthony D-15d tests. In addition, ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806233546

    authors: Feitosa-Santana C,Oiwa NN,Paramei GV,Bimler D,Costa MF,Lago M,Nishi M,Ventura DF

    更新日期:2006-05-01 00:00:00

  • Morphology of retinogeniculate axons in the macaque.

    abstract::The size, pattern of terminal arborizations, and laminar specificity of individual retinogeniculate axons were studied in the macaque following injections of HRP into the optic tract. Axons that terminated in the magnocellular layers had significantly larger fiber diameters and wider terminal fields than those that te...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800001206

    authors: Conley M,Fitzpatrick D

    更新日期:1989-01-01 00:00:00

  • Bipolar or rectified chromatic detection mechanisms?

    abstract::It is widely accepted that human color vision is based on two types of cone-opponent mechanism, one differencing L and M cone types (loosely termed "red-green"), and the other differencing S with the L and M cones (loosely termed "blue-yellow"). The traditional view of the early processing of human color vision sugges...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523801181125

    authors: Sankeralli MJ,Mullen KT

    更新日期:2001-01-01 00:00:00

  • Distribution of the alpha1 subunit of the GABA(A) receptor on midget and parasol ganglion cells in the retina of the common marmoset Callithrix jacchus.

    abstract::The inhibitory neurotransmitter gamma aminobutyric acid (GABA) has been shown to influence the responses of ganglion cells in the mammalian retina. Consistently, GABA(A) receptor subunits have been localized to different ganglion cell types. In this study, the distribution of the alpha1 subunit of the GABA(A) receptor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800173109

    authors: Macri J,Martin PR,Grünert U

    更新日期:2000-05-01 00:00:00

  • Computation of motion direction by quail retinal ganglion cells that have a nonconcentric receptive field.

    abstract::One type of retinal ganglion cells prefers object motion in a particular direction. Neuronal mechanisms for the computation of motion direction are still unknown. We quantitatively mapped excitatory and inhibitory regions of receptive fields for directionally selective retinal ganglion cells in the Japanese quail, and...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800172086

    authors: Uchiyama H,Kanaya T,Sonohata S

    更新日期:2000-03-01 00:00:00

  • Recoverin immunoreactivity in mammalian cone bipolar cells.

    abstract::Human, macaque monkey, and rat retinas were immunostained with a polyclonal antibody preparation against purified recoverin, a 23-kD calcium-binding protein isolated from bovine retina that localizes to rods and cones (Dizhoor et al., 1991). In addition to immunoreactive photoreceptors, we have identified subpopulatio...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800003175

    authors: Milam AH,Dacey DM,Dizhoor AM

    更新日期:1993-01-01 00:00:00

  • Characteristics of period doubling in the human cone flicker electroretinogram.

    abstract::Electroretinogram (ERG) responses of the cone system to a flickering stimulus can exhibit a cyclic variation in amplitude. This phenomenon of synchronous period doubling has been attributed to a nonlinear feedback mechanism within the retina that alters response gain. The aim of the present study was to investigate in...

    journal_title:Visual neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1017/S0952523805226111

    authors: Alexander KR,Levine MW,Super BJ

    更新日期:2005-11-01 00:00:00

  • Interlaminar connections of the superior colliculus in the tree shrew. II: Projections from the superficial gray to the optic layer.

    abstract::This study of the tree shrew, Tupaia belangeri, provides evidence for an intracollicular pathway that arises in the superficial gray layer and terminates in the optic layer. As a first step, Nissl, myelin, and cytochrome oxidase stains were used to identify the layers of the superior colliculus in the tree shrew. Seco...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008464

    authors: Lee P,Hall WC

    更新日期:1995-05-01 00:00:00

  • Development of the rabbit retina, III: Differential retinal growth, and density of projection neurons and interneurons.

    abstract::To provide a quantitative description of postnatal retinal expansion in rabbits, a new procedure was developed to map the retinae, which cover the inner surface of hemispheres or parts of rotation ellipsoids, in situ, onto a single plane. This method, as well as the known distribution of Müller cells per unit retinal ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004703

    authors: Reichenbach A,Schnitzer J,Reichelt E,Osborne NN,Fritzsche B,Puls A,Richter U,Friedrich A,Knothe AK,Schober W

    更新日期:1993-05-01 00:00:00

  • Toward a unified model of vertebrate rod phototransduction.

    abstract::Recently, we introduced a phototransduction model that was able to account for the reproducibility of vertebrate rod single-photon responses (SPRs) (Hamer et al., 2003). The model was able to reproduce SPR statistics by means of stochastic activation and inactivation of rhodopsin (R*), transducin (G alpha ), and phosp...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523805224045

    authors: Hamer RD,Nicholas SC,Tranchina D,Lamb TD,Jarvinen JL

    更新日期:2005-07-01 00:00:00

  • Selective labeling of visual corpus callosum connections with aspartate in cat and rat.

    abstract::Tritiated neurotransmitter candidates were unilaterally injected in visual cortical regions with abundant corpus callosum connections. D-aspartate (Asp) or gamma-aminobutyric acid (GABA) was injected along the area 17/18 border in cat, and the area 17/18a and 17/18b borders in rat. Retrograde Asp label was found contr...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004351

    authors: Elberger AJ

    更新日期:1989-01-01 00:00:00

  • Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.

    abstract::During adaptation to an increase in environmental luminance, retinal signaling adjustments are mediated by the neuromodulator dopamine. Retinal dopamine is released with light and can affect center-surround receptive fields, the coupling state between neurons, and inhibitory pathways through inhibitory receptors and n...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523819000129

    authors: Mazade RE,Eggers ED

    更新日期:2020-02-12 00:00:00

  • Evoked potential and psychophysical analysis of Fourier and non-Fourier motion mechanisms.

    abstract::Some visual stimuli produce a strong percept of motion, even though they fail to excite motion detectors based on Fourier energy or cross correlation. Models which suffice to explain the motion percept in these non-Fourier motion (NFM) stimuli include linear spatiotemporal filtering, followed by rectification, followe...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800009573

    authors: Victor JD,Conte MM

    更新日期:1992-08-01 00:00:00

  • Simulation of an anatomically defined local circuit: the cone-horizontal cell network in cat retina.

    abstract::The outer plexiform layer of the retina contains a neural circuit in which cone synaptic terminals are electrically coupled and release glutamate onto wide-field and narrow-field horizontal cells. These are also electrically coupled and feed back through a GABAergic synapse to cones. In cat this circuit's structure is...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008440

    authors: Smith RG

    更新日期:1995-05-01 00:00:00

  • The effects of saccadic eye movements on the activity of geniculate relay neurons in the monkey.

    abstract::Saccadic suppression is the reduced visibility that occurs during saccadic eye movements. Recent psychophysical studies have suggested that this is due to a reduction in responsiveness of magnocellular (M), but not parvocellular (P), cells of the lateral geniculate nucleus. To address this and other phenomena of respo...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523801182106

    authors: Ramcharan EJ,Gnadt JW,Sherman SM

    更新日期:2001-03-01 00:00:00

  • Chromatic adaptation, perceived location, and color tuning properties.

    abstract::We have studied the influence of chromatic adaptation upon the perceived visual position of a test stimulus using a Vernier alignment task. Maximum and minimum offsets in spatial position are generated when the adapting and test stimuli lie on the same and orthogonal axes in MBDKL color space, respectively. When the t...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523804213426

    authors: McKeefry DJ,McGraw PV,Vakrou C,Whitaker D

    更新日期:2004-05-01 00:00:00

  • Decorrelation of neural activity during fixational instability: possible implications for the refinement of V1 receptive fields.

    abstract::Early in life, visual experience appears to influence the refinement and maintenance of the orientation-selective responses of neurons in the primary visual cortex. After eye opening, the statistical structure of visually driven neural responses depends not only on the stimulus, but also on how the stimulus is scanned...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523804215073

    authors: Rucci M,Casile A

    更新日期:2004-09-01 00:00:00

  • Pharmacological inactivation of pretectal nuclei reveals different modulatory effects on retino-geniculate transmission by X and Y cells in the cat.

    abstract::The modulatory influence of pretectal neurons on retino-geniculate transmission in the cat was studied by cross-correlation analysis of single-unit activity simultaneously recorded from the dorsal lateral geniculate nucleus (dLGN) and the pretectum (PT) and with reversible inactivation of the PT by GABA microiontophor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800007288

    authors: Funke K,Eysel UT

    更新日期:1995-01-01 00:00:00

  • Central factors contributing to para-contrast modulation of contour and brightness perception.

    abstract::Following up on a prior study of contour and brightness processing in visual masking (Breitmeyer et al., 2006), we investigated the effects of a binocular and dichoptic para-contrast masking on the visibility of the contour and brightness of a target presented to the other eye. Combined, the results support the contri...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070393

    authors: Breitmeyer BG,Ziegler R,Hauske G

    更新日期:2007-03-01 00:00:00

  • Multi-microelectrode investigation of monkey striate cortex: link between correlational and neuronal properties in the infragranular layers.

    abstract::Recordings were taken from infragranular layers of area 17 of anesthetized monkeys with an array of 30 microelectrodes matching about one hypercolumn. From intracortical spike-train correlations, the novel neuronal property "delay scale position" related to retino-cortical delays, was derived. Relationships were estab...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800000171

    authors: Krüger J

    更新日期:1990-08-01 00:00:00

  • The determination of total cGMP levels in rod outer segments from intact toad photoreceptors in response to light superimposed on background and to consecutive flashes: a second light flash accelerates the dark recovery rate of cGMP levels in control medi

    abstract::In previous experiments we established that a light flash reduced cGMP levels of toad rod outer segments within the transduction time interval, but that recovery of the dark level of cGMP occurred more slowly than reported electrophysiological recovery of membrane potential. We now report that a second light flash acc...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800003230

    authors: Cohen AI,Blazynski C

    更新日期:1993-01-01 00:00:00

  • Visual function in regenerating teleost retina following surgical lesioning.

    abstract::Regeneration of the teleost retina following surgical extirpation of 25% to 100% of the neural retina was investigated in goldfish (Carrasius auratus) and sunfish (Lepomis cyanellus). The retina will regenerate following removal of up to 95% of the neural retina, however complete extirpation prevented regeneration. Vi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070265

    authors: Mensinger AF,Powers MK

    更新日期:2007-05-01 00:00:00

  • Spatio-temporal characterization of retinal opsin gene expression during thyroid hormone-induced and natural development of rainbow trout.

    abstract::The abundance and spatial distribution of retinal cone photoreceptors change during thyroid hormone (TH)-induced and natural development of rainbow trout (Oncorhynchus mykiss). These changes are thought to allow the fish to adapt to different photic environments throughout its life history. To date, the ontogeny of ra...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806232139

    authors: Veldhoen K,Allison WT,Veldhoen N,Anholt BR,Helbing CC,Hawryshyn CW

    更新日期:2006-03-01 00:00:00

  • Changing distribution of GABA-like immunoreactivity in pigeon visual areas during the early posthatching period and effects of retinal removal on tectal GABAergic systems.

    abstract::The distribution of GABA-like immunoreactivity in the pigeon visual system was studied during the first 9 days after hatching using a mouse monoclonal antibody, mAb 3A12, to glutaraldehyde linked GABA (Matute & Streit, 1986). GABA-like immunoreactivity was seen in cell bodies as well as in neuropil at the level of bot...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800009846

    authors: Bagnoli P,Fontanesi G,Streit P,Domenici L,Alesci R

    更新日期:1989-12-01 00:00:00

  • Visual-field map in the transcallosal sending zone of area 17 in the cat.

    abstract::The representation of the visual field in the part of area 17 containing neurons that project axons across the corpus callosum to the contralateral hemisphere was defined in the cat. Of 1424 sites sampled along 77 electrode tracks, 768 proved to be in the callosal sending zone, which was identified by retrograde trans...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380000403x

    authors: Payne BR

    更新日期:1991-09-01 00:00:00

  • A comparison of the inhibitory actions of glycine and GABA on acetylcholine release from the rabbit retina.

    abstract::The inhibition of [3H]acetylcholine (ACh) release from cholinergic amacrine cells by glycine and GABA was studied using an in vivo eyecup preparation in anesthetized rabbits. Glycine (1 mM) had no effect on basal ACh release, but completely blocked the light-evoked release of ACh. Glycine also blocked the strong poten...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523898156067

    authors: Linn DM

    更新日期:1998-11-01 00:00:00

  • Receptor targets of amacrine cells.

    abstract::Amacrine cells are a morphologically and functionally diverse group of inhibitory interneurons. Morphologically, they have been divided into approximately 30 types. Although this diversity is probably important to the fine structure and function of the retinal circuit, the amacrine cells have been more generally divid...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/S0952523812000028

    authors: Zhang C,McCall MA

    更新日期:2012-01-01 00:00:00

  • Characterization of a novel large-field cone bipolar cell type in the primate retina: evidence for selective cone connections.

    abstract::Parallel processing of visual information begins at the first synapse in the retina between the photoreceptors and bipolar cells. Ten bipolar cell types have been previously described in the primate retina: one rod and nine cone bipolar types. In this paper, we describe an 11th type of bipolar cell identified in Golgi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523810000374

    authors: Joo HR,Peterson BB,Haun TJ,Dacey DM

    更新日期:2011-01-01 00:00:00