Visual function in regenerating teleost retina following surgical lesioning.

Abstract:

:Regeneration of the teleost retina following surgical extirpation of 25% to 100% of the neural retina was investigated in goldfish (Carrasius auratus) and sunfish (Lepomis cyanellus). The retina will regenerate following removal of up to 95% of the neural retina, however complete extirpation prevented regeneration. Visual sensitivity was assessed by examining components of the electroretinogram (ERG) and the dorsal light reflex (DLR) during regeneration. B-wave amplitudes in the experimental eyes increased throughout the study and central connections were reestablished as indicated by the progressive improvement in the dorsal light reflex. The recovery of visual function was closely correlated with retinal regeneration. Visual recovery progressed more slowly than following complete cytotoxic destruction of the mature retina (Mensinger & Powers, 1999) because the surgery removed a large number of the pluripotent cell population and restricted the number and distribution of regenerating foci.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Mensinger AF,Powers MK

doi

10.1017/S0952523807070265

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

299-307

issue

3

eissn

0952-5238

issn

1469-8714

pii

S0952523807070265

journal_volume

24

pub_type

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