The effects of saccadic eye movements on the activity of geniculate relay neurons in the monkey.

Abstract:

:Saccadic suppression is the reduced visibility that occurs during saccadic eye movements. Recent psychophysical studies have suggested that this is due to a reduction in responsiveness of magnocellular (M), but not parvocellular (P), cells of the lateral geniculate nucleus. To address this and other phenomena of responsiveness during saccades, we recorded from geniculate neurons in the behaving monkey before, during, and after saccades. Specifically, we measured neuronal responses to a flashing, whole-field illumination. Contrary to the prediction, most M neurons showed pronounced enhancement of visual activity during saccades, whereas such responsiveness of parvocellular (P) neurons was not significantly affected by saccades. We also analyzed the extent to which saccades affected burst firing, which results from activation of a voltage-dependent Ca2+ conductance. We found that both M and P cells displayed a significant suppression of burst firing during saccades. These results do not support the idea that saccadic suppression has an obvious substrate in reduced responsiveness of geniculate cells, but this suppression may be related to an increased visual threshold for detection associated with reduced burst firing.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Ramcharan EJ,Gnadt JW,Sherman SM

doi

10.1017/s0952523801182106

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

253-8

issue

2

eissn

0952-5238

issn

1469-8714

pii

S0952523801182106

journal_volume

18

pub_type

杂志文章
  • Relationship between numbers of retinal ganglion cells and lateral geniculate neurons in the rhesus monkey.

    abstract::Studies of the numbers of retinal ganglion cells and lateral geniculate nucleus (LGN) neurons in primates suggest that the numbers of both types of neurons may vary over a two-fold range from one individual to another. This raises the question of whether the numbers of ganglion cells and LGN neurons are related or var...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800007239

    authors: Spear PD,Kim CB,Ahmad A,Tom BW

    更新日期:1996-01-01 00:00:00

  • Calcium-permeable glutamate receptors in horizontal cells of the mammalian retina.

    abstract::Mechanisms that mediate the calcium influx in mammalian horizontal cells were studied. Horizontal cells (HCs) enzymatically dissociated from the rabbit retina were recorded by the whole-cell configuration of the patch-clamp technique and by calcium image ratioespectrophotometry of Fura-2 loaded cells. AMPA-preferring ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:

    authors: Rivera L,Blanco R,de la Villa P

    更新日期:2001-11-01 00:00:00

  • Light-sensitive melatonin synthesis by Xenopus photoreceptors after destruction of the inner retina.

    abstract::Several lines of evidence indicate that retinal photoreceptors produce melatonin. However, there are other potential melatonin sources in the retina, and melatonin synthesis can be regulated by feedback from the inner retina. To analyze cellular mechanisms of melatonin regulation in retinal photoreceptors, we have dev...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800005009

    authors: Cahill GM,Besharse JC

    更新日期:1992-05-01 00:00:00

  • A novel system for the classification of diseased retinal ganglion cells.

    abstract::Retinal ganglion cell (RGC) dendritic atrophy is an early feature of many forms of retinal degeneration, providing a challenge to RGC classification. The characterization of these changes is complicated by the possibility that selective labeling of any particular class can confound the estimation of dendritic remodeli...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523814000248

    authors: Tribble JR,Cross SD,Samsel PA,Sengpiel F,Morgan JE

    更新日期:2014-11-01 00:00:00

  • Controversies about the visual areas located at the anterior border of area V2 in primates.

    abstract::Anatomical and electrophysiological studies have provided us with detailed information regarding the extent and topography of the primary (V1) and secondary (V2) visual areas in primates. The consensus about the V1 and V2 maps, however, is in sharp contrast with controversies regarding the organization of the cortical...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/S0952523815000188

    authors: Gattass R,Lima B,Soares JG,Ungerleider LG

    更新日期:2015-01-01 00:00:00

  • Distribution of the alpha1 subunit of the GABA(A) receptor on midget and parasol ganglion cells in the retina of the common marmoset Callithrix jacchus.

    abstract::The inhibitory neurotransmitter gamma aminobutyric acid (GABA) has been shown to influence the responses of ganglion cells in the mammalian retina. Consistently, GABA(A) receptor subunits have been localized to different ganglion cell types. In this study, the distribution of the alpha1 subunit of the GABA(A) receptor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800173109

    authors: Macri J,Martin PR,Grünert U

    更新日期:2000-05-01 00:00:00

  • Multi-nucleate retinal pigment epithelium cells of the human macula exhibit a characteristic and highly specific distribution.

    abstract:BACKGROUND:The human retinal pigment epithelium (RPE) is reportedly 3% bi-nucleated. The importance to human vision of multi-nucleated (MN)-RPE cells could be clarified with more data about their distribution in central retina. METHODS:Nineteen human RPE-flatmounts (9 ≤ 51 years, 10 > 80 years) were imaged at 12 locat...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523815000310

    authors: Starnes AC,Huisingh C,McGwin G Jr,Sloan KR,Ablonczy Z,Smith RT,Curcio CA,Ach T

    更新日期:2016-01-01 00:00:00

  • The fate of the oculomotor system in clinical bilateral anophthalmia.

    abstract::The interdependence of the development of the eye and oculomotor system during embryogenesis is currently unclear. The occurrence of clinical anophthalmia, where the globe fails to develop, permits us to study the effects this has on the development of the complex neuromuscular system controlling eye movements. In thi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523812000119

    authors: Bridge H,Ragge N,Jenkinson N,Cowey A,Watkins KE

    更新日期:2012-05-01 00:00:00

  • Comparison of the responses to light and to GABA of cells postsynaptic to barnacle photoreceptors (I-cells).

    abstract::We tested the hypothesis that gamma-aminobutyric acid (GABA) is the transmitter released by barnacle photoreceptors onto postsynaptic cells (I-cells). GABA was applied to I-cells either by superfusion or by ejecting it with pressure from a pipette positioned close to the I-cell's soma. The I-cell's response to GABA wa...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800005496

    authors: Callaway JC,Stuart AE

    更新日期:1989-10-01 00:00:00

  • Center/surround organization of retinal bipolar cells: High correlation of fundamental responses of center and surround to sinusoidal contrasts.

    abstract::Receptive field organization of cone-driven bipolar cells was investigated by intracellular recording in the intact light-adapted retina of the tiger salamander (Ambystoma tigrinum). Centered spots and concentric annuli of optimum dimensions were used to selectively stimulate the receptive field center and surround wi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523811000071

    authors: Burkhardt DA,Bartoletti TM,Thoreson WB

    更新日期:2011-05-01 00:00:00

  • Development of the primate area of high acuity, 3: temporal relationships between pit formation, retinal elongation and cone packing.

    abstract::By establishing an avascular, highly elastic, region within the fetal area of high acuity (AHA), the developing primate eye has created a unique substrate on which the mechanical forces of intraocular pressure (IOP) and growth-induced retinal stretch (stretch) can act. We proposed (Springer & Hendrickson, 2004b) that ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S095252380522206X

    authors: Springer AD,Hendrickson AE

    更新日期:2005-03-01 00:00:00

  • Two opposite effects of ATP on the apparent sensitivity of the cGMP-gated channel of the carp retinal cone.

    abstract::Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in 33%. ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed si...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800012578

    authors: Watanabe S,Shen J

    更新日期:1997-07-01 00:00:00

  • Changing distribution of GABA-like immunoreactivity in pigeon visual areas during the early posthatching period and effects of retinal removal on tectal GABAergic systems.

    abstract::The distribution of GABA-like immunoreactivity in the pigeon visual system was studied during the first 9 days after hatching using a mouse monoclonal antibody, mAb 3A12, to glutaraldehyde linked GABA (Matute & Streit, 1986). GABA-like immunoreactivity was seen in cell bodies as well as in neuropil at the level of bot...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800009846

    authors: Bagnoli P,Fontanesi G,Streit P,Domenici L,Alesci R

    更新日期:1989-12-01 00:00:00

  • A neural and computational model for the chromatic control of accommodation.

    abstract::Accommodation is more accurate with polychromatic stimuli than with narrowband or monochromatic stimuli. The aim of this paper is to develop a computational model for how the visual system uses the extra information in polychromatic stimuli to increase the accuracy of accommodation responses. The proposed model is dev...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800000705

    authors: Flitcroft DI

    更新日期:1990-12-01 00:00:00

  • Contrast encoding in retinal bipolar cells: current vs. voltage.

    abstract::To investigate the influence of voltage-sensitive conductances in shaping light-evoked responses of retinal bipolar cells, whole-cell recordings were made in the slice preparation of the tiger salamander, Ambystoma tigrinum. To study contrast encoding, the retina was stimulated with 0.5-s steps of negative and positiv...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523803201036

    authors: Thoreson WB,Burkhardt DA

    更新日期:2003-01-01 00:00:00

  • Development of the rabbit retina, III: Differential retinal growth, and density of projection neurons and interneurons.

    abstract::To provide a quantitative description of postnatal retinal expansion in rabbits, a new procedure was developed to map the retinae, which cover the inner surface of hemispheres or parts of rotation ellipsoids, in situ, onto a single plane. This method, as well as the known distribution of Müller cells per unit retinal ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004703

    authors: Reichenbach A,Schnitzer J,Reichelt E,Osborne NN,Fritzsche B,Puls A,Richter U,Friedrich A,Knothe AK,Schober W

    更新日期:1993-05-01 00:00:00

  • Eel visual pigments revisited: the fate of retinal cones during metamorphosis.

    abstract::During their complex life history, anguilliform eels go through a major metamorphosis when developing from a fresh water yellow eel into a deep-sea silver eel. In addition to major changes in body morphology, the visual system also adapts from a fresh water teleost duplex retina with rods and cones, to a specialized d...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080152

    authors: Bowmaker JK,Semo M,Hunt DM,Jeffery G

    更新日期:2008-05-01 00:00:00

  • Dissociating early and late visual processing via the Ebbinghaus illusion.

    abstract::Visual perception is not instantaneous; the perceptual representation of our environment builds up over time. This can strongly affect our responses to visual stimuli. Here, we study the temporal dynamics of visual processing by analyzing the time course of priming effects induced by the well-known Ebbinghaus illusion...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523816000134

    authors: Schmidt F,Weber A,Haberkamp A

    更新日期:2016-01-01 00:00:00

  • Is the input to a GABAergic synapse the sole asymmetry in turtle's retinal directional selectivity?

    abstract::We examined the effects of picrotoxin and pentylenetetrazol (PTZ) on the responses to motions of ON-OFF directionally selective (DS) ganglion cells of the turtle's retina. These drugs are antagonists of the inhibitory neurotransmitter GABA. For continuous motions, picrotoxin markedly reduced the overall directionality...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008105

    authors: Smith RD,Grzywacz NM,Borg-Graham LJ

    更新日期:1996-05-01 00:00:00

  • Topography of long- and middle-wavelength sensitive cone opsin gene expression in human and Old World monkey retina.

    abstract::The topographical distributions of the relative ratio of long- (L) and middle- (M) wavelength sensitive cone opsin messenger RNA (mRNA) in human and baboon retinas were mapped using real-time polymerase chain reaction. The L:M mRNA ratio increased in a central-to-peripheral gradient in both species, being quite pronou...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S095252380623325X

    authors: Neitz M,Balding SD,McMahon C,Sjoberg SA,Neitz J

    更新日期:2006-05-01 00:00:00

  • Early development of eye and retina in lanternfish larvae.

    abstract::The morphological characteristics of the eyes and the retinae of lanternfish larvae of Lampanyctus crocodilus, Benthosema glaciale, and Myctophum punctatum were analyzed in pre-flexion, flexion, and post-flexion stages. Pre-flexion larvae of L. crocodilus, the species with the shallowest depth distribution, had spheri...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070484

    authors: Bozzano A,Pankhurst PM,Sabatés A

    更新日期:2007-05-01 00:00:00

  • Visual experience promotes the isotropic representation of orientation preference.

    abstract::Within the visual cortex of several mammalian species, more circuitry is devoted to the representation of vertical and horizontal orientations than oblique orientations. The sensitivity of this representation of orientation preference to visual experience during cortical maturation and the overabundance of cardinal co...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523804041045

    authors: Coppola DM,White LE

    更新日期:2004-01-01 00:00:00

  • Functional dopamine deficits in the senile rat retina.

    abstract::The activity of the endogenous retinal dopamine (DA) pathway has been examined in the pigmented rat using retinas obtained from normal adult (approximately 3 months) and senile adults (approximately 24 months) using an in vitro electrophysiological approach. By comparing the pharmacological sensitivity of the horizont...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800176035

    authors: Hankins MW

    更新日期:2000-11-01 00:00:00

  • The interstitial nucleus of the superior fasciculus, posterior bundle (INSFp) in the guinea pig: another nucleus of the accessory optic system processing the vertical retinal slip signal.

    abstract::As in rabbit, gerbil, and rat, the guinea pig interstitial nucleus of the superior fasciculus, posterior bundle (INSFp) is a sparse assemblage of neurons scattered among the fibers forming the fasciculus bearing this name. Most of the INSFp neurons are small and are ovoid in shape. Interspersed among these, are a few ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800002182

    authors: Benassi C,Biral GP,Lui F,Porro CA,Corazza R

    更新日期:1989-01-01 00:00:00

  • Contacts of dopaminergic interplexiform cells in the outer retina of the blue acara.

    abstract::Dopaminergic interplexiform cells in the retina of the blue acara were investigated using an antiserum against tyrosine hydroxylase and PAP visualization. In whole-mount preparations, we observed a homogeneous distribution of cell bodies throughout the retina without any indication of regional specialization. At the f...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800010737

    authors: Wagner HJ,Wulle I

    更新日期:1992-09-01 00:00:00

  • Striate cortex increases contrast gain of macaque LGN neurons.

    abstract::Recurrent projections comprise a universal feature of cerebral organization. Here, we show that the corticofugal projections from the striate cortex (VI) to the lateral geniculate nucleus (LGN) robustly and multiplicatively enhance the responses of parvocellular neurons, stimulated by gratings restricted to the classi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800174012

    authors: Przybyszewski AW,Gaska JP,Foote W,Pollen DA

    更新日期:2000-07-01 00:00:00

  • Divergent feedback connections from areas V4 and TEO in the macaque.

    abstract::Extrastriate areas TEO and V4 have been associated with form and color vision. Area V4 has also been suggested to participate in processes concerned with attention, stimulus salience, and perceptual learning. In a continuing effort to elucidate the connectional interactions and microcircuitry of these areas, we descri...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800002480

    authors: Rockland KS,Saleem KS,Tanaka K

    更新日期:1994-05-01 00:00:00

  • The retinoids of seven species of mantis shrimp.

    abstract::Eyes of stomatopod crustaceans, or mantis shrimps, contain the greatest diversity of visual pigments yet described in any species, with as many as ten or more spectral classes present in a single retina. In this study, the eyes of seven species of mantis shrimp from three superfamilies of stomatopods were examined for...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380000612x

    authors: Goldsmith TH,Cronin TW

    更新日期:1993-09-01 00:00:00

  • Selective labeling of visual corpus callosum connections with aspartate in cat and rat.

    abstract::Tritiated neurotransmitter candidates were unilaterally injected in visual cortical regions with abundant corpus callosum connections. D-aspartate (Asp) or gamma-aminobutyric acid (GABA) was injected along the area 17/18 border in cat, and the area 17/18a and 17/18b borders in rat. Retrograde Asp label was found contr...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004351

    authors: Elberger AJ

    更新日期:1989-01-01 00:00:00

  • Whole-cell recording of light-evoked photoreceptor responses in a slice preparation of the cuttlefish retina.

    abstract::A new tissue slice preparation of the cuttlefish eye is described that permits patch-clamp recordings to be acquired from intact photoreceptors during stimulation of the retina with controlled light flashes. Whole-cell recordings using this preparation, from the retinas of very young Sepia officinalis demonstrated tha...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523805223106

    authors: Chrachri A,Nelson L,Williamson R

    更新日期:2005-05-01 00:00:00