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Structural determinants of integrin recognition by talin.

Abstract：

:The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.

journal_name

Mol Cell

journal_title

Molecular cell

authors

García-Alvarez B,de Pereda JM,Calderwood DA,Ulmer TS,Critchley D,Campbell ID,Ginsberg MH,Liddington RC

doi

10.1016/s1097-2765(02)00823-7

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

49-58

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(02)00823-7

journal_volume

11

pub_type

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