Abstract:
:B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
journal_name
Mol Celljournal_title
Molecular cellauthors
Chipuk JE,Moldoveanu T,Llambi F,Parsons MJ,Green DRdoi
10.1016/j.molcel.2010.01.025subject
Has Abstractpub_date
2010-02-12 00:00:00pages
299-310issue
3eissn
1097-2765issn
1097-4164pii
S1097-2765(10)00079-1journal_volume
37pub_type
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