Abstract：
:Research that uses a psychoneuroimmunology (PNI) framework seeks to determine whether valid associations exist among stress, immune function, and health. These associations are difficult to conclusively determine due to the fact that PNI research is fraught with methodological difficulties. These difficulties arise from the multifaceted and complex nature of the neuro-endocrine-immune network that is the phenomenon of interest in PNI. This article discusses multiple issues of which investigators should be aware when designing and implementing PNI research including (1) the control of potentially immunomodulating variables related to demographics, behavior, and lifestyle; (2) the manner in which stress, endocrine function, immunity, and health outcomes are measured in consideration of the theoretical relevance to the research question, population, or disease entity understudy; (3) the way physiological specimens are procured and stored; and (4) the methods by which assays are performed.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Robinson FP,Mathews HL,Witek-Janusek Ldoi
10.1177/10900402003004002subject
Has Abstractpub_date
2002-04-01 00:00:00pages
165-75issue
4eissn
1099-8004issn
1552-4175journal_volume
3pub_type
杂志文章abstract：:The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable t...
journal_title：Biological research for nursing
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