Induction of apoptosis in glioma cells by molecules released from activated macrophages.

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：:Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

journal_title：Journal of neuro-oncology

authors： Aguilar LK,Aguilar-Cordova E

更新日期：2003-12-01 00:00:00

abstract：:The aim of this study was to assess the effectiveness of adding viral vector-mediated gene therapy with herpes simplex virus thymidine kinase (HSV-tk) to standard treatment, in comparison with standard treatment alone to treat patients with high-grade gliomas (HGGs). A literature search of the databases PubMed, Embase...

journal_title：Journal of neuro-oncology

authors： Zhao F,Tian J,An L,Yang K

更新日期：2014-06-01 00:00:00

abstract：:During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous do...

journal_title：Journal of neuro-oncology

authors： Yano H,Nakayama N,Ohe N,Miwa K,Shinoda J,Iwama T

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:While hypofractionated stereotactic radiotherapy (HFSRT) is being increasingly used for treating brain metastases, clinical data concerning the incidence and risk factors of its main side-effect, namely radiation necrosis (RN), remain limited. In this context, we assessed risk factors of RN in a single cen...

journal_title：Journal of neuro-oncology

authors： Di Perri D,Tanguy R,Malet C,Robert A,Sunyach MP

更新日期：2020-09-01 00:00:00

abstract：:Brain metastasis often has a poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Therefore, it is urgent to identify factors associated with lung cancer brain metastasis. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) also known as noncoding nuclear-enriched abundant transcrip...

journal_title：Journal of neuro-oncology

authors： Shen L,Chen L,Wang Y,Jiang X,Xia H,Zhuang Z

更新日期：2015-01-01 00:00:00

abstract：:The most common medical problems in brain tumor patients include the management of seizures, peritumoral edema, medication side effects, venous thromboembolism (VTE), fatigue and cognitive dysfunction. Despite their importance, there are relatively few studies specifically addressing these issues. There is increasing ...

journal_title：Journal of neuro-oncology

authors： Wen PY,Schiff D,Kesari S,Drappatz J,Gigas DC,Doherty L

更新日期：2006-12-01 00:00:00

abstract：:The use of radiotherapy alone to treat primary central nervous system lymphoma (PCNSL) does not produce the high local control and survival rates that it does in limited extranodal non-Hodgkin's lymphoma outside the central nervous system (CNS). Even with doses of whole brain radiation therapy (WBRT) to 40+20 Gy boost...

journal_title：Journal of neuro-oncology

authors： Nelson DF

更新日期：1999-07-01 00:00:00

abstract：:The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44-67% at first lumbar puncture which increases...

journal_title：Journal of neuro-oncology

authors： van Bussel MTJ,Pluim D,Bol M,Beijnen JH,Schellens JHM,Brandsma D

更新日期：2018-03-01 00:00:00

abstract：:In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (F...

journal_title：Journal of neuro-oncology

authors： Czarnek N,Clark K,Peters KB,Mazurowski MA

更新日期：2017-03-01 00:00:00

abstract：:There is considerable interest in the role of the TRK family of neurotrophin receptors in regulating the survival, growth and differentiation of normal and neoplastic nerve cells. Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors o...

journal_title：Journal of neuro-oncology

authors： Brodeur GM,Nakagawara A,Yamashiro DJ,Ikegaki N,Liu XG,Azar CG,Lee CP,Evans AE

更新日期：1997-01-01 00:00:00

abstract：:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI...

journal_title：Journal of neuro-oncology

authors： Korshunov A,Savostikova M,Ozerov S

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Central neurocytoma is recognized as a indolent intraventricular tumor arising from the ependyma around the foramen of Monro and anterior part of the lateral ventricles, and well demarcated from the brain parenchyma. Surgical removal can be curative without postoperative therapy. However, malig...

journal_title：Journal of neuro-oncology

authors： Ogawa Y,Sugawara T,Seki H,Sakuma T

更新日期：2006-09-01 00:00:00

abstract：OBJECT:Although atypical teratoid/rhabdoid tumor (AT/RT) is known to generate through inactivation of the hSNF5/INI1 gene on chromosome 22q, the downstream molecular mechanism remains unclear. We histologically and molecularly reviewed our pediatric brain tumors for unrecognized AT/RTs and evaluated the role of cyclin ...

journal_title：Journal of neuro-oncology

authors： Fujisawa H,Misaki K,Takabatake Y,Hasegawa M,Yamashita J

更新日期：2005-06-01 00:00:00

abstract：:A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice develop choroid ple...

journal_title：Journal of neuro-oncology

authors： Patrick TA,Kranz DM,van Dyke TA,Roy EJ

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：:The treatment of childhood low grade glioma (LGG), if not amenable to complete resection, quite often is a relevant clinical challenge. LGG in many instances are indeed slow growing tumors, which, if not controlled, can cause severe morbidity and ultimately jeopardize life. Most of the time children bearing an unresec...

journal_title：Journal of neuro-oncology

authors： Perilongo G

更新日期：2005-12-01 00:00:00

abstract：:The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral a...

journal_title：Journal of neuro-oncology

authors： Clavo B,Robaina F,Valcarcel B,Catala L,Perez JL,Cabezon A,Jorge IJ,Fiuza D,Hernandez MA,Jover R,Carreras JL

更新日期：2012-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the spectrum of late effects in a large cohort of pediatric patients with low-grade gliomas (WHO grade I and II) during an observation period of 20 years. Eighty-seven patients with low-grade gliomas grouped according to tumor location (cerebellum: n=28; cerebral hemisphere...

journal_title：Journal of neuro-oncology

authors： Benesch M,Lackner H,Sovinz P,Suppan E,Schwinger W,Eder HG,Dornbusch HJ,Moser A,Triebl-Roth K,Urban C

更新日期：2006-06-01 00:00:00

abstract：:Children with a brain tumor (BT) are at risk for a number of physical and cognitive problems that may lower their health-related quality of life (HRQoL). Executive functioning (EF) and intellectual ability are hypothesized to associate with HRQoL and deficits in these areas may be amenable to interventions. This study...

journal_title：Journal of neuro-oncology

authors： Netson KL,Ashford JM,Skinner T,Carty L,Wu S,Merchant TE,Conklin HM

更新日期：2016-06-01 00:00:00

abstract：:We observed a stripe-like pattern of regional cerebral blood volume (rCBV) increase in a defined region adjacent to the contrast enhancement (CE) on MRI of glioblastomas (GBM) that we defined as the "striate sign" (SS). We hypothesized that the SS marks infiltration of GBM outside the CE volume transforming into futur...

journal_title：Journal of neuro-oncology

authors： Blasel S,Franz K,Ackermann H,Weidauer S,Zanella F,Hattingen E

更新日期：2011-07-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Paclitaxel-induced peripheral neuropathy (PN) may be severe and dose-limiting at initial doses > or = 275 mg/M2, but its neurotoxicity at doses < or = 250 mg/M2 has been incompletely characterized. The purposes of this study were to characterize and quantify paclitaxel-induced PN and to determine the utility...

journal_title：Journal of neuro-oncology

authors： Forsyth PA,Balmaceda C,Peterson K,Seidman AD,Brasher P,DeAngelis LM

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:The highly vascular malignant brain tumor glioblastoma (GBM) appears to be an ideal target for anti-angiogenic therapy; however, clinical trials to date suggest the VEGF antibody bevacizumab affects only progression-free survival. Here we analyze a group of patients with GBM who received bevacizumab treatment a...

journal_title：Journal of neuro-oncology

authors： Hovinga KE,McCrea HJ,Brennan C,Huse J,Zheng J,Esquenazi Y,Panageas KS,Tabar V

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Prediction of clinical outcomes in patients with primary central nervous system lymphoma (PCNSL) is important for optimization of treatment planning. Quantitative imaging biomarkers for PCNSL have not yet been established. This study evaluated the prognostic value of pretreatment dynamic contrast-enhanced MRI a...

journal_title：Journal of neuro-oncology

authors： Hatzoglou V,Oh JH,Buck O,Lin X,Lee M,Shukla-Dave A,Young RJ,Peck KK,Vachha B,Holodny AI,Grommes C

更新日期：2018-11-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to compare three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for the treatment of glioblastoma. MATERIALS AND METHODS:Retrospective study of 220 patients with glioblastoma, treated with 3D-CRT or IMRT, with or without surgery. Dosimetric para...

journal_title：Journal of neuro-oncology

authors： Thibouw D,Truc G,Bertaut A,Chevalier C,Aubignac L,Mirjolet C

更新日期：2018-04-01 00:00:00

abstract：:Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness. ...

journal_title：Journal of neuro-oncology

authors： Litofsky NS,Pihan G,Corvi F,Smith TW

更新日期：1998-11-01 00:00:00

abstract：:Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

journal_title：Journal of neuro-oncology

authors： Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

更新日期：2013-04-01 00:00:00

abstract：:We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. Identification of in vitro PDGFR-targeting pharmacologic agents that are suitable for preclinical testing in medulloblastoma models in vivo will be critical for effici...

journal_title：Journal of neuro-oncology

authors： Abouantoun TJ,Castellino RC,MacDonald TJ

更新日期：2011-01-01 00:00:00