Abstract：
:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI) and immunoexpression of TrkC, and c-myc proteins were investigated in biopsy samples from 68 MB with an average clinical risk to determine their prognostic utility in this tumor category. The number of cases with AI > 1.5% was significantly greater in the group of tumors in patients with recurrent MB and the mean AI was significantly higher in this group -4.7% vs. 1.1%. Furthermore, the number of tumors with AI > 1.5% was greater in the group of tumors in deceased patients and the mean Al was also higher in this group -4.6% vs. 1.2%. Immunoreactivity of the c-myc and TrkC did not show any differences between groups of patients with various clinical outcomes. A close association between Al as a continuous variable and the progression-free and overall survival was found. We found no any differences in survival times for c-myc and TrkC immunoreactivity. Multivariate revealed analysis that AI is a single significant prognostic factor for MB survival. Perhaps, investigations of c-myc and TrkC mRNA levels should be useful for clinical purposes, but in order to introduce these biomolecular markers in clinical protocols its distinct prognostic significance needs to be proved by prospective studies.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Korshunov A,Savostikova M,Ozerov Sdoi
10.1023/a:1016226319068subject
Has Abstractpub_date
2002-07-01 00:00:00pages
271-9issue
3eissn
0167-594Xissn
1573-7373journal_volume
58pub_type
杂志文章abstract：:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of p...
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journal_title：Journal of neuro-oncology
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pub_type： 杂志文章,随机对照试验
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006280304912
更新日期：1999-06-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-006-9161-x
更新日期：2006-10-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-019-03224-w
更新日期：2019-08-01 00:00:00
