Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma?

abstract：:Diffuse invasion of the brain by tumor cells is a hallmark of human glioblastomas and a major cause for the poor prognosis of these tumors. This phenomenon is only partially reproduced by rodent models of gliomas that display a very high rate of proliferation and limited cell migration. We have analyzed the developmen...

journal_title：Journal of neuro-oncology

authors： Guillamo JS,Lisovoski F,Christov C,Le Guérinel C,Defer GL,Peschanski M,Lefrançois T

更新日期：2001-05-01 00:00:00

abstract：:To cast light on the mechanisms of drug-resistance, experimental brain tumors were immunohistochemically evaluated for expression of glutathione S-transferase (GST)-alpha, mu, pi, p-glycoprotein and apoptosis-related factors, such as bcl-2 and p53, as well as by the terminal deoxynucleotidyl transferase-mediated dUTP-...

journal_title：Journal of neuro-oncology

authors： Yabuno T,Konishi N,Nakamura M,Tsuzuki T,Tsunoda S,Sakaki T,Hiasa Y

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:A prospective study of patients with glioma was carried out. Special attention was paid to the first seizure, to the histology, and to the efficacy and prophylactic role of antiepileptic drugs (AEDs). Prognostic factors were analyzed. METHODS:Between February 1st 2004 and April 1st 2006 patients who underwent ...

journal_title：Journal of neuro-oncology

authors： Rosati A,Tomassini A,Pollo B,Ambrosi C,Schwarz A,Padovani A,Bonetti B

更新日期：2009-07-01 00:00:00

abstract：:The abilities of growth factors to cause normal cells to express the properties associated with transformed cells is discussed in specific reference to the oligodendrocyte-type-2 astrocyte (O-2A) progenitor cell. In the O-2A lineage, it has been possible to use growth factors and other defined molecules to induce or p...

journal_title：Journal of neuro-oncology

authors： Noble M,Mayer-Pröschel M

更新日期：1997-12-01 00:00:00

abstract：:To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All received systemic or intrathecal chemotherapy and six received additional cranial or spinal radiotherapy. Six patient...

journal_title：Journal of neuro-oncology

authors： Pradat PF,Hoang-Xuan K,Cornu P,Mokhtari K,Martin-Duverneuil N,Poisson M,Delattre JY

更新日期：1999-09-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is down-regulated during periods of embryological cell migration and may be important in local tumor migration or metastases. Conflicting information exists in the literature about NCAM expression in human glial tumors and little is known about its expression in human brain metasta...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Orr EA,Savelieva E,Owens GC,Kruse CA

更新日期：1999-01-01 00:00:00

abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals receiving a single injection of either 6 x 10(4) U rTNF-alpha or an equivalent volume of excipient (vehicle) in their right parietal lobe. In order to demonstrate ...

journal_title：Journal of neuro-oncology

authors： Wright JL,Merchant RE

更新日期：1994-01-01 00:00:00

abstract：:Radiation necrosis is a devastating complication following radiation to the central nervous system. The purpose of this study was to perform a comprehensive analysis of cases in the literature using bevacizumab, a monoclonal antibody against vascular endothelial growth factor, as treatment for radiation necrosis. A ME...

journal_title：Journal of neuro-oncology

authors： Tye K,Engelhard HH,Slavin KV,Nicholas MK,Chmura SJ,Kwok Y,Ho DS,Weichselbaum RR,Koshy M

更新日期：2014-04-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

journal_title：Journal of neuro-oncology

authors： Raychaudhuri B,Vogelbaum MA

更新日期：2011-01-01 00:00:00

abstract：:Antisense bcl-2 therapy combined with chemotherapy has been proved to be effective in various tumors. However, the role played by antisense bcl-2 therapy alone is not clear. In this study, we compared the apoptosis and the protein profiles of antisense bcl-2 transfected human neuroblastoma SK-N-MC cells to the control...

journal_title：Journal of neuro-oncology

authors： Li Y,Lu Z,Chen F,Guan J,Hu L,Xu Y,Chen J

更新日期：2005-03-01 00:00:00

abstract：:In a cohort of 25 patients with supratentorial low grade glioma, the timing of radiotherapy made no significance difference for 10 year survival. Patients who received early radiotherapy had a 55% 10 year survival and those receiving delayed radiotherapy had a 53% 10 year survival. Radiotherapy was delayed a median of...

journal_title：Journal of neuro-oncology

authors： Knisely JP,Haffty BG,Christopher SR

更新日期：1997-08-01 00:00:00

abstract：:Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-p...

journal_title：Journal of neuro-oncology

authors： Mahato D,Vivas-Buitrago T,Gassie K,Jentoft M,Tavanaiepour D,Quiñones-Hinojosa A

更新日期：2018-01-01 00:00:00

abstract：:Transfection of primary cultures of human cells with origin of replication deficient SV40 DNA has been carried out by others to generate in vitro models of malignant transformation in vivo. The present work describes progressive alterations in karyotype and phenotype in one such transfected (neuroglial) cell line (SVG...

journal_title：Journal of neuro-oncology

authors： Davey P,Rauth AM,Mason L,Addy L

更新日期：1990-02-01 00:00:00

abstract：:Majority of the cerebellopontine angle (CPA) tumors are acoustic neuromas, while bulk of the non-acoustic tumors are formed by meningiomas and epidermoid cysts. Primary paraganglioma is a rare tumor in this location, with only two such cases having been reported in the literature, till date. Recently, a case has been ...

journal_title：Journal of neuro-oncology

authors： Deb P,Sharma MC,Gaikwad S,Gupta A,Mehta VS,Sarkar C

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:A retrospective comparison evaluating survival in two well-matched cohorts of patients with cytologically positive neoplastic meningitis (NM) presenting with or without encephalopathy. METHODS:Two cohorts were studied: 20 with and 20 without of NM-related encephalopathy defined as a confusional syndrome. Co...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Tsao-Wei D,Groshen S

更新日期：2005-04-01 00:00:00

abstract：:We report one year follow up of a case of extramedullary hematopoiesis within the clivus. The imaging findings, brief clinical course, and endoscopic transphenoidal approach are described. A 29-year-old female with thalassemia developed worsening cranial nerve signs. After imaging studies discovered a large clival mas...

journal_title：Journal of neuro-oncology

authors： Reames DL,Lindstrom K,Raghavan P,Jane J Jr

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To assess the neurocognitive function and neurological toxicity of frameless linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) in patients with 10 or more brain metastases (BM). PATIENTS AND METHODS:Forty consecutive adult patients who received SRS for ten or more 10 BM < 3 cm in maximum size we...

journal_title：Journal of neuro-oncology

authors： Minniti G,Capone L,Nardiello B,El Gawhary R,Raza G,Scaringi C,Bianciardi F,Gentile P,Paolini S

更新日期：2020-05-01 00:00:00

abstract：:The aim of the present study is to evaluate the impact of extent of resection at initial and repeat craniotomy on overall survival of patients with recurrent glioblastoma. The authors retrospectively reviewed the records of all adults patients who underwent repeat resection of recurrent glioblastoma following radiatio...

journal_title：Journal of neuro-oncology

authors： Perrini P,Gambacciani C,Weiss A,Pasqualetti F,Delishaj D,Paiar F,Morganti R,Vannozzi R,Lutzemberger L

更新日期：2017-02-01 00:00:00

abstract：:Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS)...

journal_title：Journal of neuro-oncology

authors： Imber BS,Braunstein SE,Wu FY,Nabavizadeh N,Boehling N,Weinberg VK,Tihan T,Barnes M,Mueller S,Butowski NA,Clarke JL,Chang SM,McDermott MM,Prados MD,Berger MS,Haas-Kogan DA

更新日期：2016-01-01 00:00:00

abstract：:When a malignant tumor invades the child's cerebellum, the cost of successful treatment is often significant cognitive morbidity. A review of neuropsychological outcome revealed that survivors of childhood medulloblastoma (MB) have long-term deficits in intelligence, memory, language, attention, academic skills, psych...

journal_title：Journal of neuro-oncology

authors： Dennis M,Spiegler BJ,Hetherington CR,Greenberg ML

更新日期：1996-07-01 00:00:00

abstract：:In earlier studies, we demonstrated that intratumoral infusions of alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the major histocompatibility complex (MHC) antigens of the host, effectively retarded the intracranial growth of Fischer 9L gliosarcoma. We further demonstrated that continuous in vitro exposur...

journal_title：Journal of neuro-oncology

authors： Paul DB,Read SB,Kulprathipanja NV,Gomez GG,Kleinschmidt-DeMasters BK,Schiltz PM,Kruse CA

更新日期：2003-08-01 00:00:00

abstract：:Unexpected early epidural spinal metastasis in a case of osteosarcoma occurred in a patient receiving treatment with cis-diamminedichloroplatinum-II (cisplatin). The initial neurologic symptomatology manifested as paresthesias in the feet which developed 2 months after initiation of treatment (cumulative dose of cispl...

journal_title：Journal of neuro-oncology

authors： Shimizu H,Jaffe N,Kleinerman E

更新日期：1986-01-01 00:00:00

abstract：:Communication support tools (CST) improve patient outcomes in oncology including: knowledge, satisfaction, self-management, and adherence to planned treatment. Little is known about communication support tools use in patients with primary or secondary brain tumours. We aimed to explore cognitive function and communica...

journal_title：Journal of neuro-oncology

authors： Naehrig DN,Koh ES,Vogiatzis M,Yanagisawa W,Kwong C,Shepherd HL,Milross C,Dhillon HM

更新日期：2016-01-01 00:00:00

abstract：:A historically controlled phase II study was undertaken to investigate the efficacy and toxicity of a postoperative treatment consisting of high-dose continuous tamoxifen, carboplatin and radiotherapy in patients with newly diagnosed glioblastoma. Between 1995 and 1998, 50 patients with newly diagnosed glioblastomas u...

journal_title：Journal of neuro-oncology

authors： Puchner MJ,Herrmann HD,Berger J,Cristante L

更新日期：2000-09-01 00:00:00

abstract：:While stereotactic radiosurgery (SRS) has been shown effective in the management of brain metastases, small brain metastases (≤10 mm) can pose unique challenges. Our aim was to investigate the efficacy of SRS in the treatment of small brain metastases, as well as elucidate clinically relevant factors impacting local f...

journal_title：Journal of neuro-oncology

authors： Trifiletti DM,Hill C,Cohen-Inbar O,Xu Z,Sheehan JP

更新日期：2017-09-01 00:00:00

abstract：:Neural stem cells (NSC) have unique differentiation-, proliferation-, and motility properties. To investigate whether they secrete factors that interfere with the proliferation of glioma cells, we grew glioma cells in conditioned medium (CM) obtained from cultures of neurospheres including neural stem / progenitor cel...

journal_title：Journal of neuro-oncology

authors： Suzuki T,Izumoto S,Wada K,Fujimoto Y,Maruno M,Yamasaki M,Kanemura Y,Shimazaki T,Okano H,Yoshimine T

更新日期：2005-09-01 00:00:00

abstract：:Among diffuse gliomas, oligodendrogliomas may account for 25% of cases. They have a better prognosis and chemosensitivity as compared to astrocytomas. Genetic studies have shown a correlation between oligodendrocyte phenotype and presence of 1p/19q deletions. In addition, these deletions are of prognostic value. The a...

journal_title：Journal of neuro-oncology

authors： Bouvier C,Roll P,Quilichini B,Metellus P,Calisti A,Gilles S,Chinot O,Fina F,Martin PM,Figarella-Branger D

更新日期：2004-06-01 00:00:00

abstract：:Malignant gliomas are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatment. Recent progress on enhanced studies of ion channels involved in glioma cells shed new light on the investigation of glioma cell growth and proliferation. H...

journal_title：Journal of neuro-oncology

authors： Wang WX,Ji YH

更新日期：2005-05-01 00:00:00

abstract：:Invasion of the meninges is a relatively common complication of head and neck rhabdomyosarcoma (RMS), while RMS arising primarily within the brain or meninges is rare. We report the case of an 11-year old child with a primary "primitive" frontal lobe tumor, subsequent leptomeningeal spread and fatal intratumoral hemor...

journal_title：Journal of neuro-oncology

authors： Dropcho EJ,Allen JC

更新日期：1987-01-01 00:00:00

abstract：:Neuron-specific enolase (NSE) is one of the iso-forms of enolase, a glycolytic enzyme found in the neuroendocrine system. NSE is one of the most widely used tumor markers in small-cell lung carcinoma (SCLC). To assess the value of NSE in discriminating between the sites of metastases in SCLC-patients with and without ...

journal_title：Journal of neuro-oncology

authors： van de Pol M,Twijnstra A,ten Velde GP,Menheere PP

更新日期：1994-01-01 00:00:00