Abstract:
:To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All received systemic or intrathecal chemotherapy and six received additional cranial or spinal radiotherapy. Six patients (30%) achieved a partial response (one low-grade astrocytoma, two anaplastic astrocytomas, one anaplastic oligodendroglioma and two glioblastomas). In these cases, clinical improvement was associated with radiological improvement on CT scan or MRI in five and with a major cerebrospinal fluid improvement in three. Three patients (15%) were stable for 3 months or more and 11 (55%) had progressive disease. Median survival was longer for the responding patients (10 months) than for the other patients (2 months). This study suggests that some patients with MG may benefit from a treatment combining radiotherapy to symptomatic areas and chemotherapy with agents that cross the blood-brain barrier or are delivered directly into the CSF.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Pradat PF,Hoang-Xuan K,Cornu P,Mokhtari K,Martin-Duverneuil N,Poisson M,Delattre JYdoi
10.1023/a:1006399804896subject
Has Abstractpub_date
1999-09-01 00:00:00pages
163-8issue
2eissn
0167-594Xissn
1573-7373journal_volume
44pub_type
杂志文章abstract::The records of thirty-four patients with meningeal carcinomatosis treated at our hospital between 1984 and 1990 were reviewed. The sources, histologies, metastatic lesions outside the central nervous system, the history of the treatment of primary lesions and intraparenchymal of metastatic brain tumors and the period ...
journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-06-01 00:00:00
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更新日期:1991-02-01 00:00:00
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
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更新日期:2011-01-01 00:00:00
abstract::During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous do...
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pub_type: 杂志文章
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