Abstract：
:Once considered a "no man's land" especially when invaded by a diffuse low grade glioma (DLGG), the insula remains to this day a surgical challenge. Surgery for insular DLGG involves consideration of its hidden location under the potentially eloquent operculae, the proximity to vascular tree and high density of functions not only in the insular cortex but also in the white fiber pathways passing under the insular lobe. The natural history of DLGG and the potential benefits and consequences of the surgical approach also need a close look. In the last decade, a better knowledge of the functional anatomy and connectivity of this region, as well as an improvement in surgical techniques as direct stimulation mapping, combined with an increasing literature showing a favorable impact of maximal resection for DLGG, were deciding factors in the paradigmatic shift from expectative treatment to early surgical management. Here, our goal is to discuss the structural and functional aspects of the insula, the specificities of insular and paralimbic DLGG by emphasizing the technical considerations of surgery in this region, as well as its oncological and functional outcomes. In summary, this new strategy based upon early maximal safe surgical resection showed both oncological benefit and preservation of quality of life-or even an improvement thanks to epilepsy relief.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Michaud K,Duffau Hdoi
10.1007/s11060-016-2120-2subject
Has Abstractpub_date
2016-11-01 00:00:00pages
289-298issue
2eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-016-2120-2journal_volume
130pub_type
杂志文章,评审abstract：:A 65 year old woman presented with a recurrent locally advanced esthesioneuroblastoma. She had earlier been treated with radiation followed by surgery. The recurrence was located in earlier radiated tissues with intracranial infiltration. She underwent treatment with combined intra-arterial chemotherapy (BCNU) i.a., v...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00162764
更新日期：1987-01-01 00:00:00
abstract：:Malignant gliomas are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatment. Recent progress on enhanced studies of ion channels involved in glioma cells shed new light on the investigation of glioma cell growth and proliferation. H...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-004-4205-6
更新日期：2005-05-01 00:00:00
abstract：:Recent developments in the treatment of hematological malignancies, especially with the advent of proteasome inhibitors and immunomodulatory drugs in plasma cell dyscrasias, call for an increased collaboration between hematologists and neurologists. This collaboration involves differentiating chemotherapy-induced peri...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-014-1632-x
更新日期：2015-01-01 00:00:00
abstract：:Type 2 diabetes mellitus (DM) and obesity are known risk factors for poor outcomes in patients with systemic malignancies but are not well-studied in the brain tumor population. In this study we asked if type 2 DM and elevated body mass index (BMI) are independent risk factors for poor prognosis in patients with high-...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0676-4
更新日期：2012-01-01 00:00:00
abstract：:Sixteen immunocompetent patients, 10 of whom were previously reported, with primary non-Hodgkins lymphoma of the central nervous system (PCNSL) were treated and followed longitudinally by the Neuro-oncology Service at the University of California, San Francisco (UCSF) and the University of California, San Diego (UCSD)...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00172603
更新日期：1992-11-01 00:00:00
abstract：:The aim of this work was to determine the accuracy and precision of stereotactic localization and treatment delivery using a helical tomotherapy based stereotactic radiosurgery (SRS) system. A tomotherapy specific radiosurgery workflow was designed that exploits the system's on board megavotage CT (MVCT) imaging syste...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0227-4
更新日期：2010-06-01 00:00:00
abstract：:We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of generalized convulsion. Head- and spinal magnetic resonance imaging (MRI) showed widespread gadolinium (Gd)-enhanced lesions extending to the bilate...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-009-9876-6
更新日期：2009-09-01 00:00:00
abstract：:Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors a...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/a:1012721723387
更新日期：2001-09-01 00:00:00
abstract：:The aim of this study is to investigate the anti-cancer effect of the bispecific diphtheria toxin (DT) based immunotoxin DTATEGF, which targets both the epidermal growth factor (EGF) receptor (EGFR) and the urokinase-type plasminogen activator (uPA) receptor (uPAR) in vitro and in vivo when delivered by convection-enh...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0904-6
更新日期：2012-09-01 00:00:00
abstract：:Soon after the initial description of acromegaly in the late 19th century, neurosurgeons performed the first operative procedures for the disease. Transcranial procedures eventually yielded to the transsphenoidal approach. Reasonably effective medical therapy was introduced in the 1970s and pharmacological progress co...
journal_title：Journal of neuro-oncology
pub_type： 历史文章,杂志文章,评审
doi：10.1023/a:1012949214960
更新日期：2001-09-01 00:00:00
abstract：:Anti-Hu paraneoplastic syndromes are usually associated with an underlying neoplasia, although a few patients who are anti-Hu-positive never develop cancer after long-term follow-up. Tumour therapy remains the mainstay of therapeutic options, and early immune therapy in parallel is advisable. When no tumour is found, ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9787-y
更新日期：2009-07-01 00:00:00
abstract：:Malignant primary spinal cord gliomas (PSCGs) are rare, and the optimal treatment for these lesions remains controversial. We report herein treatment outcomes of six malignant PSCGs managed with temozolomide (TMZ)-based multidisciplinary treatment. TMZ was administered concomitantly with fractionated radiotherapy for ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-010-0249-y
更新日期：2011-01-01 00:00:00
abstract：:This paper presents a study of the effects of scanning parameters variability when assessing glioma sizes on MRI. A database of lesions of various shapes and sizes, segmented on 3D-SPGR MRI images, was acquired on 65 patients with low-grade glioma. Simulations of large slice thickness and patient's head rotation were ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1051-4
更新日期：2013-04-01 00:00:00
abstract：:Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well a...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-017-2464-2
更新日期：2017-07-01 00:00:00
abstract：:High-grade gliomas release excitotoxic concentrations of glutamate which contributes to their malignant phenotype. To improve our understanding of the mechanisms by which glutamate enhances tumor growth and invasion, we examined alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated signaling in glio...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9552-2
更新日期：2008-06-01 00:00:00
abstract：:Successful management of a heavily pretreated 58-year-old woman with metastatic esthesioneuoblastoma using temozolomide is reported. There is no standard treatment of this tumors with extra- and intracranial manifestations. The response, long term stability and high quality of life using temozolomide for this tumor en...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/b:neon.0000040826.30636.4a
更新日期：2004-10-01 00:00:00
abstract：:In January 2003 a symposium was held to discuss the current state of progress and future challenges for the recently described technique of convection enhanced delivery (CED). The focus of the CED symposium was on the potential use of this novel drug delivery technology to enhance the delivery of chemotherapy to malig...
journal_title：Journal of neuro-oncology
pub_type：
doi：10.1007/s11060-004-2243-8
更新日期：2005-05-01 00:00:00
abstract：:The authors report an unusual case of a myxopapillary ependymoma arising from the lateral ventricle. The patient, a 37-year-old woman, developed recurrent symptoms including scotomata, disorientation, and headache during two successive pregnancies before the definitive diagnosis. The causes of this ependymoma variant ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01050071
更新日期：1993-03-01 00:00:00
abstract：:This paper reviews the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT). A major advantage of an ABNS for BNCT over reactor-based neutron sources is the potential for siting withi...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF02699931
更新日期：2003-03-01 00:00:00
abstract：:Long term survival is rare in patients with glioblastoma multiforme (GBM). To determine if the tumors of patients with long survivals constitute a subgroup of patients with identifiable molecular genetic characteristics, we studied the p53 gene and Epidermal Growth Factor Receptor (EGF-R) expression in long-term survi...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00165483
更新日期：1996-03-01 00:00:00
abstract：:High grade astrocytomas remain incurable even though these tumors often appear localized on modern imaging studies, rarely metastasize to systemic sites, and can be aggressively treated with surgery and radiation therapy. Recent data suggest that the dissemination of astrocytoma cells along white matter tracts to dist...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005761031077
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1023/a:1006201909435
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:The Brain Tumor Reporting and Data System (BT-RADS) category 3 is suitable for identifying cases with intermediate probability of tumor recurrence that do not meet the Response Assessment in Neuro-Oncology (RANO) criteria for progression. The aim of this study was to evaluate the added value of dynamic susce...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03387-6
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Central nervous system hemangioblastoma is a benign tumor associated with or without von Hippel-Lindau (VHL) disease which is an autosomal dominant hereditary disease that results from a germline mutation in the VHL gene. A main axis of signaling pathways in central nervous system hemangioblastoma is VHL-H...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-020-03506-8
更新日期：2020-05-01 00:00:00
abstract：:Astrocytic neoplasms are genetically heterogeneous; however a low frequency of genomic changes has been found in juvenile pilocytic astrocytoma (PA) in molecular studies. Concerning pleomorphic xanthoastrocytomas (PXA), recent studies have given heterogeneous results for chromosomal alterations. We studied the subtelo...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9763-6
更新日期：2009-06-01 00:00:00
abstract：:Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the ava...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-012-0803-x
更新日期：2012-05-01 00:00:00
abstract：:A major toxic effect of the chemotherapeutic agents paclitaxel and cisplatin is peripheral neuropathy. We report the use of a rat model of cytotoxic neuropathy to evaluate the role of glutamate as a possible neuroprotectant for these two drugs. Neuropathy was manifest as gait disturbance in 100% of paclitaxel treated ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006124917643
更新日期：1999-01-01 00:00:00
abstract：:Proliferative activities were determined in 72 human brain tumors, including 20 metastatic carcinomas, 41 gliomas, 8 meningiomas and 3 hematological tumors. Immunocytochemical techniques included labeling with monoclonal antibody (mAb) to bromodeoxyuridine (BrdU) which identifies S phase cells after previous in vitro ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00151242
更新日期：1991-02-01 00:00:00
abstract：:Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF02341157
更新日期：1990-12-01 00:00:00
abstract：:This study aimed to explore the safety and efficacy of multisession gamma knife surgery (GKS) for large brain metastases with a volume of 10 cm3 or larger. Fifty-six patients who had 65 brain metastases with a volume of at least 10 cm3 were treated with multisession GKS. Three-session GKS at a prescription dose of 10 ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2317-4
更新日期：2017-02-01 00:00:00
