当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > The contribution of magnetic resonance spectroscopy and echoplanar perfusion-weighted MRI in the initial assessment of brain tumours.

The contribution of magnetic resonance spectroscopy and echoplanar perfusion-weighted MRI in the initial assessment of brain tumours.

Abstract：

:Conventional Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the cornerstone in the initial evaluation of brain tumours. The purpose of this study is to evaluate the contribution of Magnetic Resonance Spectroscopy (MRS) and Perfusion-weighted MRI to distinguish malignant from benign tumours. We included 55 patients diagnosed with single brain tumour by CT and MRI, and final histopathological verification of the tumour type: 25 were low-grade gliomas, 8 anaplastic gliomas, 11 glioblastomas, and 11 solitary metastases. We carried out brain MRS and dynamic perfusion-weighted echoplanar MRI in all cases. Perfusion was assessed in the centre of the lesion and in the area of maximum contrast-enhancement. In MRS, we found significant differences in Choline/Creatine ratios in relation to the tumour type with the highest values in high-grade gliomas and metastases. A Ch/Cr ratio equal or higher than 1.78 predicted malignancy at 80% sensitivity and 73% specificity. We found no significant differences in the relative cerebral blood volume (rCBV) for every type of tumour. The mean rCBV was 1.24 for benign tumours and 1.5 for the malignant ones(1.24 for low-grade gliomas, 1.91 for anaplastic gliomas, 1.03 for glioblastomas, and 1.57 for metastases). We conclude that, individually considered, MRS is superior to Perfusion-weighted MRI in the initial assessment of brain tumours. Perfusion MRI has not demonstrated predictive power to distinguish malignant from benign tumours.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Fayed N,Modrego PJ

doi

10.1007/s11060-004-2180-6

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

261-5

issue

3

eissn

0167-594X

issn

1573-7373

journal_volume

72

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • MIP-1alpha antagonizes the effect of a GM-CSF-enhanced subcutaneous vaccine in a mouse glioma model.

    abstract：:Subcutaneous vaccination using granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced glioma cells substantially prolongs survival in the mouse GL261 glioma model. To potentiate the efficacy of GM-CSF-based vaccination, syngeneic C57BL/6 mice bearing pre-implanted intracerebral GL261 gliomas were vaccina...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000013497.04322.fc

    authors： Herrlinger U,Aulwurm S,Strik H,Weit S,Naumann U,Weller M

    更新日期：2004-01-01 00:00:00

  • Management of cerebral metastases from malignant melanoma: results of a combined, simultaneous treatment with fotemustine and irradiation.

    abstract：:We report results of a conservative treatment for brain metastases from malignant melanoma with a combination of irradiation and chemotherapy (fotemustine and/or DTIC). To date, 12 patients have been treated. There was a complete remission of the brain metastases in four patients. In two patients a partial remission w...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006280304912

    authors： Ulrich J,Gademann G,Gollnick H

    更新日期：1999-06-01 00:00:00

  • Intramedullary non-Hodgkin's lymphoma of the spinal cord: a case report and literature review.

    abstract：:We describe the case of a young man presenting with an extra-nodal, intramedullary non-Hodgkin's lymphoma of the cervical spinal cord. This is a very uncommon presentation of this neoplasm. The patient was treated with craniospinal radiotherapy, with survival for two and a half years before death from recurrent diseas...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF01059959

    authors： McDonald AC,Nicoll JA,Rampling R

    更新日期：1995-01-01 00:00:00

  • Clusters of histologic characteristics in children with infratentorial neuroglial tumors. The Childhood Brain Tumor Consortium.

    abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1023/a:1005984531474

    authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

    更新日期：1998-08-01 00:00:00

  • Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors.

    abstract：:The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern of serum NCAM bands in patients with gliomas (n = 34), wit...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-006-9312-0

    authors： Todaro L,Christiansen S,Varela M,Campodónico P,Pallotta MG,Lastiri J,Sacerdote de Lustig E,Bal de Kier Joffé E,Puricelli L

    更新日期：2007-06-01 00:00:00

  • Pencil beam scanning proton therapy for pediatric intracranial ependymoma.

    abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2090-4

    authors： Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

    更新日期：2016-05-01 00:00:00

  • Shortened ex vivo manufacturing time of EGFRvIII-specific chimeric antigen receptor (CAR) T cells reduces immune exhaustion and enhances antiglioma therapeutic function.

    abstract：BACKGROUND:Non-viral manufacturing of CAR T cells via the Sleeping Beauty transposon is cost effective and reduces the risk of insertional mutagenesis from viral transduction. However, the current gold standard methodology requires ex vivo numerical expansion of these cells on artificial antigen-presenting cells (AaPCs...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03311-y

    authors： Caruso HG,Tanaka R,Liang J,Ling X,Sabbagh A,Henry VK,Collier TL,Heimberger AB

    更新日期：2019-12-01 00:00:00

  • TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas.

    abstract：:TERT promoter (TERTp) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations,...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1999-3

    authors： Nencha U,Rahimian A,Giry M,Sechi A,Mokhtari K,Polivka M,Schmitt Y,Di Stefano AL,Alentorn A,Labussière M,Sanson M

    更新日期：2016-02-01 00:00:00

  • T cell response to Hu-D peptides in patients with anti-Hu syndrome.

    abstract：:The anti-Hu syndrome is the most common paraneoplastic neurologic syndrome but the exact mechanism of immune mediated neuronal injury remains unknown. Anti-Hu antibodies do not appear to play a pivotal role in the pathogenesis of the disease. To assess cell-mediated immunity, we selected 51 peptides from the Hu-D sequ...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-004-1723-1

    authors： Rousseau A,Benyahia B,Dalmau J,Connan F,Guillet JG,Delattre JY,Choppin J

    更新日期：2005-02-01 00:00:00

  • Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome.

    abstract：:We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-9181-3

    authors： Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PP

    更新日期：2005-01-01 00:00:00

  • Gene expression profiling analysis reveals that DLG3 is down-regulated in glioblastoma.

    abstract：:Glioblastoma multiforme (GBM) is the most malignant glioma. In the current study, 149 astrocytoma gene expression datasets were classified by prediction analysis of microarray. Strikingly, disks large homolog 3 (DLG3), a membrane-associated guanylate kinase-family gene, had the highest score in the GBM subset. DLG3 mR...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1325-x

    authors： Liu Z,Niu Y,Xie M,Bu Y,Yao Z,Gao C

    更新日期：2014-02-01 00:00:00

  • Indications for salvage surgery during treatment for intracranial germ cell tumors.

    abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2827-3

    authors： Kanamori M,Kumabe T,Watanabe M,Chonan M,Saito R,Yamashita Y,Ogawa Y,Sonoda Y,Tominaga T

    更新日期：2018-07-01 00:00:00

  • A complex mechanism for HDGF-mediated cell growth, migration, invasion, and TMZ chemosensitivity in glioma.

    abstract：:HDGF is overexpressed in gliomas as compared to normal brain. We therefore analyzed the molecular mechanisms of HDGF action in gliomas. HDGF was downregulated in normal brain tissue as compared to glioma specimens at both the mRNA and the protein levels. In glioma samples, increased HDGF expression was associated with...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1512-4

    authors： Song Y,Hu Z,Long H,Peng Y,Zhang X,Que T,Zheng S,Li Z,Wang G,Yi L,Liu Z,Fang W,Qi S

    更新日期：2014-09-01 00:00:00

  • Metastatic choroid plexus papilloma: a case report.

    abstract：:Choroid plexus papillomas (CPPs) are generally regarded as benign tumours, with a favourable long-term prognosis. Complete resection should result in cure. We present a case of diffuse craniospinal seeding from an apparently completely resected fourth ventricular primary tumour. A 51-year-old male is discussed, who pr...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1015044012574

    authors： McEvoy AW,Galloway M,Revesz T,Kitchen ND

    更新日期：2002-02-01 00:00:00

  • UKT-04 trial of continuous metronomic low-dose chemotherapy with methotrexate and cyclophosphamide for recurrent glioblastoma.

    abstract：:Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Continuous oral low-dose chemotherapy with methotrexate (MTX) and cyclophosphamide (CPM) has modest activity in heavily pretreated patients with breast cancer. We explored the efficacy of 100 mg CPM daily and 5 mg MTX twice weekly in relapsed glioblast...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-004-1726-y

    authors： Herrlinger U,Rieger J,Steinbach JP,Nägele T,Dichgans J,Weller M

    更新日期：2005-02-01 00:00:00

  • Frequency and clinical significance of chromosome 7 and 10 aneuploidies, amplification of the EGFR gene, deletion of PTEN and TP53 genes, and 1p/19q deficiency in a sample of adult patients diagnosed with glioblastoma from Southern Brazil.

    abstract：:Glioblastoma stands out as the most frequent central nervous system neoplasia, presenting a poor prognosis. The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnose...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2606-6

    authors： Koshiyama DB,Trevisan P,Graziadio C,Rosa RFM,Cunegatto B,Scholl J,Provenzi VO,de Sá AP,Soares FP,Velho MC,de A P Filho N,Oliveira CA,Zen PRG

    更新日期：2017-12-01 00:00:00

  • Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI.

    abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-03036-4

    authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

    更新日期：2019-01-01 00:00:00

  • Meningioma of the cerebellopontine angle in identical twins: a case report.

    abstract：:Meningiomas in identical twins are extremely rare. To our knowledge, only one previous report of meningiomas in identical twins has been published. We present identical twin sisters with meningiomas. The tumors were located at a similar, but not a common, position (the cerebellopontine angle) in both twins. Histologic...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-0083-2

    authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

    更新日期：2010-07-01 00:00:00

  • Suppression of Cdc2 dephosphorylation at the tyrosine 15 residue during nitrosourea-induced G2M phase arrest in glioblastoma cell lines.

    abstract：:We examined the mechanism of action of nitrosoureas as represented by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) with respect to p53 and the G2M cell cycle checkpoint using two glioblastoma cell lines: U251MG and U373MG, with mutated p53. At log-phase cell growth, fresh medium con...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1016342013616

    authors： Nakamizo A,Inamura T,Inoha S,Amano T,Ochi H,Ikezaki K,Fukui M

    更新日期：2002-08-01 00:00:00

  • Calcification in high grade gliomas treated with bevacizumab.

    abstract：:Calcification is a rare phenomenon in high grade glioma (HGG). CT scans are sensitive to mineralization but used infrequently for tumor assessment in the MRI era. The presence of calcification can be overlooked on routine MRI. Calcification may reflect chronicity and natural changes in the tumor or its milieu over tim...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1796-z

    authors： Blumenthal DT,Aisenstein O,Ben-Horin I,Ben Bashat D,Artzi M,Corn BW,Kanner AA,Ram Z,Bokstein F

    更新日期：2015-06-01 00:00:00

  • Growth inhibition of human glioma cells modulated by retrovirus gene transfection with antisense IL-8.

    abstract：:The human glioma cell line, NP-1, expresses IL-8 mRNA and constitutively secretes IL-8 protein. Administration of recombinant IL-8 increased the proliferation of NP-1 cells in a dose-dependent manner. In the presence of anti-IL-8 antiserum, the IL-8 mediated proliferation of NP-1 cell growth was inhibited. Further, NP...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF01054723

    authors： Yamanaka R,Tanaka R,Yoshida S,Saitoh T,Fujita K

    更新日期：1995-01-01 00:00:00

  • Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death.

    abstract：:The microvasculature of brain tumors has been proposed as the primary target for ionizing radiation (IR)-induced apoptosis. However, the contribution of low dose IR-induced non-apoptotic cell death pathways has not been investigated. This study aimed to characterize the effect of IR on human brain microvascular endoth...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-006-9171-8

    authors： McLaughlin N,Annabi B,Lachambre MP,Kim KS,Bahary JP,Moumdjian R,Béliveau R

    更新日期：2006-11-01 00:00:00

  • Stereotactic radiosurgery as a therapeutic strategy for intracranial metastatic prostate carcinoma.

    abstract：:Intracranial metastatic prostate carcinoma is rare. We sought to determine the clinical outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) for patients with intracranial prostate carcinoma metastases. We studied data from 10 patients who underwent radiosurgery for 15 intracranial metastases (9 dural-based an...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-9966-5

    authors： Flannery T,Kano H,Niranjan A,Monaco EA 3rd,Flickinger JC,Lunsford LD,Kondziolka D

    更新日期：2010-02-01 00:00:00

  • Results of microsurgical treatment of medulla oblongata and spinal cord hemangioblastomas: a comparison of two distinct clinical patient groups.

    abstract：PURPOSE:To analyze the surgical outcome of a consecutive and single center series of medulla oblongata (MO) and spinal cord hemangioblastomas (HB). PATIENT AND METHODS:We retrospectively reviewed the medical charts of all MO and spinal HB patients operated on in our institution between 1985 and 2002. All patients had ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-9861-0

    authors： Parker F,Aghakhani N,Ducati LG,Yacubian-Fernandes A,Silva MV,David P,Richard S,Tadie M

    更新日期：2009-05-01 00:00:00

  • A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature.

    abstract：:Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventric...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-007-9466-4

    authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

    更新日期：2008-01-01 00:00:00

  • Treatment recommendations for the various subgroups of neurocytomas.

    abstract：:Neurocytomas gained importance since 1995, which is reflected by the increasing number of reports on this entity. This study was performed to determine the best available treatment for typical and atypical neurocytomas (MIB-1 labeling index >3%, atypical histology) in various age groups ( 18 years). The...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-005-9047-3

    authors： Rades D,Schild SE

    更新日期：2006-05-01 00:00:00

  • A phase II trial of PTK787/ZK 222584 in recurrent or progressive radiation and surgery refractory meningiomas.

    abstract：:When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibito...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1358-9

    authors： Raizer JJ,Grimm SA,Rademaker A,Chandler JP,Muro K,Helenowski I,Rice L,McCarthy K,Johnston SK,Mrugala MM,Chamberlain M

    更新日期：2014-03-01 00:00:00

  • The relaxation response resiliency program (3RP) in patients with neurofibromatosis 1, neurofibromatosis 2, and schwannomatosis: results from a pilot study.

    abstract：:NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1522-2

    authors： Vranceanu AM,Merker VL,Plotkin SR,Park ER

    更新日期：2014-10-01 00:00:00

  • Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases.

    abstract：:Anti-PD-1/PD-L1 therapies have demonstrated activity in patients with advanced stage non-small cell lung cancer (NSCLC). However, little is known about the safety and feasibility of patients receiving anti-PD-1/PD-L1 therapy and stereotactic radiation for the treatment of brain metastases. Data were analyzed retrospec...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2437-5

    authors： Ahmed KA,Kim S,Arrington J,Naghavi AO,Dilling TJ,Creelan BC,Antonia SJ,Caudell JJ,Harrison LB,Sahebjam S,Gray JE,Etame AB,Johnstone PA,Yu M,Perez BA

    更新日期：2017-06-01 00:00:00

  • Hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with or without bevacizumab (BEV) for newly diagnosed glioblastoma multiforme (GBM): a comparison of two prospective phase II trials.

    abstract：:To compare progression-free (PFS) and overall survival (OS) in patients treated in two consecutive phase II trials of hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with or without bevacizumab (BEV). Patients with newly diagnosed glioblastoma multiforme (GBM) after biopsy or resec...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1791-4

    authors： Carlson JA,Reddy K,Gaspar LE,Ney D,Kavanagh BD,Damek D,Lillehei K,Chen C

    更新日期：2015-06-01 00:00:00