Abstract:
:We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained showed an interesting molecular background of the AM and GB. AM showed TP53mutations and a 22q loss of heterozygosity (LOH). GB showed epidermal growth factor receptor (EGFR) amplification and TP53 mutations, whereas P16, PTEN, Rbwere intact in terms of LOH and/or multiplex PCR (polymerase chain reaction) analysis. Additionally, GB has a 1q LOH, which is an extremely rare alteration in glioblastomas. Identical 1q LOH was also observed in MFH.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PPdoi
10.1007/s11060-004-9181-3subject
Has Abstractpub_date
2005-01-01 00:00:00pages
27-30issue
1eissn
0167-594Xissn
1573-7373journal_volume
71pub_type
杂志文章abstract::When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibito...
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abstract::Anti-VEGF therapy with Bevacizumab (BEV) is widely used in cases of relapsed high-grade glioma (HGG). Arterial hypertension is a known side effect of anti-VEGF therapy. 42 Patients with relapsed HGG were treated with BEV 10 mg/kg on days 1 and 15 of 28-day cycles in addition to treatment with 40 mg TMZ daily until dis...
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更新日期:2011-01-01 00:00:00
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abstract:BACKGROUND:Non-viral manufacturing of CAR T cells via the Sleeping Beauty transposon is cost effective and reduces the risk of insertional mutagenesis from viral transduction. However, the current gold standard methodology requires ex vivo numerical expansion of these cells on artificial antigen-presenting cells (AaPCs...
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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doi:10.1007/BF01306456
更新日期:1994-01-01 00:00:00
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journal_title:Journal of neuro-oncology
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abstract:PURPOSE:A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in...
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更新日期:2018-12-01 00:00:00
abstract::This study concerns the use of the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] colorimetric assay to evaluate the chemosensitivity of the C6 rat glioma cell line to a panel of twelve chemotherapeutic agents. In a previous study of in vitro chemosensitivity of human glioma cell lines, the pre...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1005894723087
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Despite aspirations to achieve equality in healthcare we know that socioeconomic differences exist and may affect treatment and patient outcome, also in serious diseases such as cancer. We investigated disparities in neurosurgical care and outcome for patients with low-grade glioma (LGG). METHODS:In this na...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-019-03378-7
更新日期:2020-01-01 00:00:00
abstract::Angiogenesis is one of the key features of glioblastoma (GB). However, the use of anti-angiogenic therapies directed against vascular endothelial growth factor (VEGF) is limited by primary or acquired resistance. MET/HGF and PlGF signaling are involved in potential alternative escape mechanisms to VEGF pathway. Our ob...
journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-016-2251-5
更新日期:2016-12-01 00:00:00
abstract::Anaplastic ganglioglioma (AGG) are rare central nervous system tumours. Patient and treatment factors associated with outcome are poorly defined and limited to small retrospective case series and single case reports. Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated potentia...
journal_title:Journal of neuro-oncology
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更新日期:2011-12-01 00:00:00
abstract::Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL). The Primary and Recurrent Glioma registry at Duke's The Pres...
journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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abstract::Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective ...
journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1996-05-01 00:00:00
abstract:TARGET POPULATION:These recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM). QUESTION:What are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical fo...
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