A phase II trial of PTK787/ZK 222584 in recurrent or progressive radiation and surgery refractory meningiomas.

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...

journal_title：Journal of neuro-oncology

authors： Kanamori M,Kumabe T,Watanabe M,Chonan M,Saito R,Yamashita Y,Ogawa Y,Sonoda Y,Tominaga T

更新日期：2018-07-01 00:00:00

abstract：:From 1974 to 1992, 63 patients diagnosed with low-grade pure or mixed oligo-astrocytoma were seen and treated at our institution. All patients underwent CT scan pre-operatively. There were 20 female and 43 males ranging in age from 12 to 73 years (median age of 33 years). 15 patients had a stereotactic biopsy as the o...

journal_title：Journal of neuro-oncology

authors： Bahary JP,Villemure JG,Choi S,Leblanc R,Olivier A,Bertrand G,Souhami L,Tampieri D,Hazel J

更新日期：1996-02-01 00:00:00

abstract：:Degradation and remodelling of the extracellular matrix has been investigated, with the main focus on the balance between matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases (TIMP). Recent reports disclose the presence of a novel MMP-inhibiting cell membrane-anchored glycoprotein designated 'rev...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Nomura R,Teramoto A

更新日期：2008-09-01 00:00:00

abstract：:When SK-N-BE(2) human neuroblastoma cells were exposed for 1h to growth medium supplemented with [14C]arachidonic acid (AA) at final concentrations ranging from 1 microM to 100 microM, an amount of this fatty acid was uptaken ranging form a 2% to a 120% of that present in cells at steady state. As more [14C]AA was upt...

journal_title：Journal of neuro-oncology

authors： Spinedi A

更新日期：1997-01-01 00:00:00

abstract：:A list of active investigative brain tumor protocols in North America is presented. The fact that there are 138 protocols (and certainly some have been missed) indicates the diversity and intensity of research into this difficult problem. The geographic diversity of institutions involved in brain tumor clinical trials...

journal_title：Journal of neuro-oncology

authors： Bernstein M,Rutka J

更新日期：1993-09-01 00:00:00

abstract：:Successful management of a heavily pretreated 58-year-old woman with metastatic esthesioneuoblastoma using temozolomide is reported. There is no standard treatment of this tumors with extra- and intracranial manifestations. The response, long term stability and high quality of life using temozolomide for this tumor en...

journal_title：Journal of neuro-oncology

authors： Wick W,Wick A,Küker W,Dichgans J,Weller M

更新日期：2004-10-01 00:00:00

abstract：:Hypermethylation of the MGMT gene promoter and mutation of the TP53 tumor-suppressor gene are frequently present in diffuse astrocytomas. However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplastic astrocytoma (AI...

journal_title：Journal of neuro-oncology

authors： Groenendijk FH,Taal W,Dubbink HJ,Haarloo CR,Kouwenhoven MC,van den Bent MJ,Kros JM,Dinjens WN

更新日期：2011-02-01 00:00:00

abstract：:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1...

journal_title：Journal of neuro-oncology

authors： Purdy E,Johnston DL,Bartels U,Fryer C,Carret AS,Crooks B,Eisenstat DD,Lafay-Cousin L,Larouche V,Wilson B,Zelcer S,Silva M,Bouffet E,Keene D,Strother DR

更新日期：2014-04-01 00:00:00

abstract：:Proliferative activities were determined in 72 human brain tumors, including 20 metastatic carcinomas, 41 gliomas, 8 meningiomas and 3 hematological tumors. Immunocytochemical techniques included labeling with monoclonal antibody (mAb) to bromodeoxyuridine (BrdU) which identifies S phase cells after previous in vitro ...

journal_title：Journal of neuro-oncology

authors： Morimura T,Kitz K,Stein H,Budka H

更新日期：1991-02-01 00:00:00

abstract：:Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

journal_title：Journal of neuro-oncology

authors： Nahreini P,Andreatta C,Hanson A,Prasad KN

更新日期：2003-05-01 00:00:00

abstract：:Glioblastoma cells secrete transforming growth factor-beta (TGF-beta), which has a variety of immunosuppressive properties. We investigated the effect of irradiation TGF-beta secretion by malignant glioma cells. Three malignant glioma cell lines (T98G, A172, KG-1-C) were cultured and irradiated using 10 and 50 Gy Lina...

journal_title：Journal of neuro-oncology

authors： Satoh E,Naganuma H,Sasaki A,Nagasaka M,Ogata H,Nukui H

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall wi...

journal_title：Journal of neuro-oncology

authors： Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W

更新日期：2019-01-01 00:00:00

abstract：:Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL). The Primary and Recurrent Glioma registry at Duke's The Pres...

journal_title：Journal of neuro-oncology

authors： Randazzo DM,McSherry F,Herndon JE 2nd,Affronti ML,Lipp ES,Flahiff C,Miller E,Woodring S,Freeman M,Healy P,Minchew J,Boulton S,Desjardins A,Vlahovic G,Friedman HS,Keir S,Peters KB

更新日期：2017-09-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

journal_title：Journal of neuro-oncology

authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Prediction of clinical outcomes in patients with primary central nervous system lymphoma (PCNSL) is important for optimization of treatment planning. Quantitative imaging biomarkers for PCNSL have not yet been established. This study evaluated the prognostic value of pretreatment dynamic contrast-enhanced MRI a...

journal_title：Journal of neuro-oncology

authors： Hatzoglou V,Oh JH,Buck O,Lin X,Lee M,Shukla-Dave A,Young RJ,Peck KK,Vachha B,Holodny AI,Grommes C

更新日期：2018-11-01 00:00:00

abstract：:Despite similar morphological aspects, anaplastic oligodendroglial tumors (AOTs) form a heterogeneous clinical subgroup of gliomas. The chromosome arms 1p/19q codeletion has been shown to be a relevant biomarker in AOTs and to be perfectly exclusive from EGFR amplification in gliomas. To identify new genomic regions a...

journal_title：Journal of neuro-oncology

authors： Idbaih A,Dalmasso C,Kouwenhoven M,Jeuken J,Carpentier C,Gorlia T,Kros JM,French P,Teepen J,Broët P,Delattre O,Mokhtari K,Sanson M,Delattre JY,van den Bent M,Hoang-Xuan K

更新日期：2011-06-01 00:00:00

abstract：:We observed a stripe-like pattern of regional cerebral blood volume (rCBV) increase in a defined region adjacent to the contrast enhancement (CE) on MRI of glioblastomas (GBM) that we defined as the "striate sign" (SS). We hypothesized that the SS marks infiltration of GBM outside the CE volume transforming into futur...

journal_title：Journal of neuro-oncology

authors： Blasel S,Franz K,Ackermann H,Weidauer S,Zanella F,Hattingen E

更新日期：2011-07-01 00:00:00

abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

journal_title：Journal of neuro-oncology

authors： Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development ...

journal_title：Journal of neuro-oncology

authors： Olsson A,Bouaoun L,Auvinen A,Feychting M,Johansen C,Mathiesen T,Melin B,Lahkola A,Larjavaara S,Villegier AS,Byrnes G,Deltour I,Schüz J

更新日期：2019-01-01 00:00:00

abstract：:We report a case of association of a brain tumor with multiple colorectal polyposis and offer an analysis of the relevant literature with a view to revising the classification of the syndrome in relation to familial multiple polyposis and Gardner's syndrome. Differences emerged, depending on the brain tumor type, whic...

journal_title：Journal of neuro-oncology

authors： Cervoni L,Celli P,Tarantino R,Fortuna A

更新日期：1995-01-01 00:00:00

abstract：:There is a need for better predictors for short survival in patients with brain metastases undergoing open surgery. The graded prognostic assessment (GPA) has recently been developed to predict survival in patients with brain metastases. We explored the prognostic capabilities of GPA in a consecutive neurosurgical pop...

journal_title：Journal of neuro-oncology

authors： Jakola AS,Gulati S,Nerland US,Solheim O

更新日期：2011-12-01 00:00:00

abstract：:Systemic high-dose methotrexate (HD-MTX) is the most effective chemotherapeutic agent in the treatment of primary central nervous system lymphoma (PCNSL). Leptomeningeal involvement is common and intrathecal methotrexate (IT-MTX) is frequently used in combination with HD-MTX, but its benefits are not established. Usin...

journal_title：Journal of neuro-oncology

authors： Khan RB,Shi W,Thaler HT,DeAngelis LM,Abrey LE

更新日期：2002-06-01 00:00:00

abstract：:The use of radiation therapy in the management of intramedullary spinal cord tumors remains controversial. Several studies indicate that the use of postoperative radiation therapy modestly improves both local control and survival in spinal cord ependymomas and astrocytomas. Modern treatment planning and imaging allow ...

journal_title：Journal of neuro-oncology

authors： Isaacson SR

更新日期：2000-05-01 00:00:00

abstract：:Antisense bcl-2 therapy combined with chemotherapy has been proved to be effective in various tumors. However, the role played by antisense bcl-2 therapy alone is not clear. In this study, we compared the apoptosis and the protein profiles of antisense bcl-2 transfected human neuroblastoma SK-N-MC cells to the control...

journal_title：Journal of neuro-oncology

authors： Li Y,Lu Z,Chen F,Guan J,Hu L,Xu Y,Chen J

更新日期：2005-03-01 00:00:00

abstract：:Invasion of the meninges is a relatively common complication of head and neck rhabdomyosarcoma (RMS), while RMS arising primarily within the brain or meninges is rare. We report the case of an 11-year old child with a primary "primitive" frontal lobe tumor, subsequent leptomeningeal spread and fatal intratumoral hemor...

journal_title：Journal of neuro-oncology

authors： Dropcho EJ,Allen JC

更新日期：1987-01-01 00:00:00

abstract：:Meningiomas, when benign, are commonly treated with surgical resection alone. However, the optimal treatment for patients with subtotally resected or recurrent World Health Organization (WHO) grade I tumors, or WHO grade II and III tumors, regardless of the extent of resection, is not well defined, with both a paucity...

journal_title：Journal of neuro-oncology

authors： Vogelbaum MA,Leland Rogers C,Linskey MA,Mehta MP

更新日期：2010-09-01 00:00:00

abstract：:This paper describes the pathobiology of some of the more common skull base tumors. In addition to clinicopathologic features, emphasis is placed upon methods of diagnosis utilizing immunoperoxidase stains and molecular markers that may or may not impact upon prognosis. ...

journal_title：Journal of neuro-oncology

authors： Barnes L,Kapadia SB

更新日期：1994-01-01 00:00:00

abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals receiving a single injection of either 6 x 10(4) U rTNF-alpha or an equivalent volume of excipient (vehicle) in their right parietal lobe. In order to demonstrate ...

journal_title：Journal of neuro-oncology

authors： Wright JL,Merchant RE

更新日期：1994-01-01 00:00:00

abstract：:Cyclin-dependent kinase 4 inhibitor (CDKN2/p16) is a cell cycle regulatory protein that has been demonstrated to be inactivated by mutations, deletions or transcriptional silencing during pathogenesis of a variety of human malignancies. We studied the correlation of CDKN2/p16 expression with cell proliferation activit...

journal_title：Journal of neuro-oncology

authors： Miettinen H,Kononen J,Sallinen P,Alho H,Helen P,Helin H,Kalimo H,Paljärvi L,Isola J,Haapasalo H

更新日期：1999-02-01 00:00:00