当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Ependymoma in children under the age of 3 years: a report from the Canadian Pediatric Brain Tumour Consortium.

Ependymoma in children under the age of 3 years: a report from the Canadian Pediatric Brain Tumour Consortium.

Abstract：

:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1990 to 2005, inclusive, 75 (13 %) were EP. These cases were analyzed. A mean annual age-adjusted incidence rate of 4.6 per 100,000 children years was calculated. The male:female ratio was 1.77. Of the tumors, 80 % were infratentorial in location, 67 % were WHO grade II histology, and 29 % were metastatic at diagnosis. All patients underwent a surgical procedure. A complete resection of the tumor was achieved in 56 % of the cases; 43 % of these patients survive while 36 % of the patients with tumors less than completely resected survive. Initial therapy consisted of surgery alone in 23 % of patients, or surgery plus chemotherapy (37 %), radiation therapy (RT; 19 %), or both (21 %). Any use of RT increased with patient age. The 5-year EFS rates for patients in each of the four treatment groups was 22, 11.5, 46.2 and 64.8 %, respectively. For all patients the median survival was 63 ± 6 months and 5-year overall survival was 55 ± 6 %. Patients treated with surgery and chemotherapy alone were younger and had a lower rate of survival than older patients who were more often treated with radiation therapy containing regimens. Further study is needed to determine which patients are optimally served with these treatment modalities.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Purdy E,Johnston DL,Bartels U,Fryer C,Carret AS,Crooks B,Eisenstat DD,Lafay-Cousin L,Larouche V,Wilson B,Zelcer S,Silva M,Bouffet E,Keene D,Strother DR

doi

10.1007/s11060-014-1396-3

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

359-64

issue

2

eissn

0167-594X

issn

1573-7373

journal_volume

117

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival.

    abstract：:The growth pattern of pilocytic astrocytoma (PAs) is unpredictable. Gene expression profiling has recently demonstrated an inverse relationship between myelin basic protein (MBP) expression and progression free survival (PFS) in PAs. We present here the pattern of expression of oligodendroglial differentiation markers...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-007-9455-7

    authors： Takei H,Yogeswaren ST,Wong KK,Mehta V,Chintagumpala M,Dauser RC,Lau CC,Adesina AM

    更新日期：2008-01-01 00:00:00

  • Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression.

    abstract：:The leucine-rich repeats and immunoglobulin-like domains (LRIG) protein family is comprised of three integral membrane proteins: LRIG1, LRIG2, and LRIG3. LRIG1 is a negative regulator of growth factor signaling. The expression and subcellular localization of LRIG proteins have prognostic implications in primary brain ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0856-x

    authors： Ghasimi S,Haapasalo H,Eray M,Korhonen K,Brännström T,Hedman H,Andersson U

    更新日期：2012-07-01 00:00:00

  • Surgery, tamoxifen, carboplatin, and radiotherapy in the treatment of newly diagnosed glioblastoma patients.

    abstract：:A historically controlled phase II study was undertaken to investigate the efficacy and toxicity of a postoperative treatment consisting of high-dose continuous tamoxifen, carboplatin and radiotherapy in patients with newly diagnosed glioblastoma. Between 1995 and 1998, 50 patients with newly diagnosed glioblastomas u...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1026533016912

    authors： Puchner MJ,Herrmann HD,Berger J,Cristante L

    更新日期：2000-09-01 00:00:00

  • Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines.

    abstract：:In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation. Cepharanthine (CEP), a biscoclaurine-derived alkaloid, reportedly potentiates the effects of antitumor agents and induces apoptosis in some cancer cells. Here, we examined the effects of CEP, alone and in...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1014548618440

    authors： Kono K,Takahashi JA,Ueba T,Mori H,Hashimoto N,Fukumoto M

    更新日期：2002-01-01 00:00:00

  • Favorable long-term outcome of low-grade oligodendrogliomas irrespective of 1p/19q status when treated without radiotherapy.

    abstract：:Despite the accumulating evidences of high chemosensitivity especially in anaplastic oligodendrogliomas with loss of chromosomes 1p and 19q, the optimal management strategy for low-grade tumors using the 1p/19q information remains controversial. We have treated all low-grade oligodendrogliomas by a chemotherapy-preced...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0340-4

    authors： Iwadate Y,Matsutani T,Hasegawa Y,Shinozaki N,Higuchi Y,Saeki N

    更新日期：2011-05-01 00:00:00

  • Primary cerebral lymphomatoid granulomatosis: report of four cases and literature review.

    abstract：BACKGROUND:Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS). Unique involvement of the CNS has been reported rarely. We report our experience with LYG confined to the brain and...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-009-9834-3

    authors： Lucantoni C,De Bonis P,Doglietto F,Esposito G,Larocca LM,Mangiola A,Martini M,Papacci F,Teofili L,Pompucci A

    更新日期：2009-09-01 00:00:00

  • Early perfusion MRI predicts survival outcome in patients with recurrent glioblastoma treated with bevacizumab and carboplatin.

    abstract：:Bevacizumab, an anti-angiogenic agent, is FDA-approved for use in patients with recurrent glioblastoma multiforme (rGBM). The radiologic evaluation of tumor response to bevacizumab is complex and there is no validated method of monitoring tumor vascularity during therapy. We evaluated perfusion-weighted MR imaging (PW...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2300-0

    authors： Bennett IE,Field KM,Hovens CM,Moffat BA,Rosenthal MA,Drummond K,Kaye AH,Morokoff AP

    更新日期：2017-01-01 00:00:00

  • Chemotherapy as prophylaxis and treatment of meningosis in children less than 3 years of age with medulloblastoma.

    abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1005924017460

    authors： Schmandt S,Kühl J

    更新日期：1998-06-01 00:00:00

  • Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas.

    abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2753-4

    authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

    更新日期：2018-05-01 00:00:00

  • Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement.

    abstract：INTRODUCTION:There is growing evidence that the subventricular zone (SVZ) plays a key role in glioblastoma (GBM) tumorigenesis. However, little is known regarding how the SVZ, which is a harbor for adult neural stem cells, may be influenced by chemoradiation. The current diffusion-weighted imaging (DWI) study explored ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03460-5

    authors： Cho N,Wang C,Raymond C,Kaprealian T,Ji M,Salamon N,Pope WB,Nghiemphu PL,Lai A,Cloughesy TF,Ellingson BM

    更新日期：2020-05-01 00:00:00

  • Chronic lymphocytic leukemia with central nervous system involvement: report of two cases with a comprehensive literature review.

    abstract：:Central nervous system (CNS) involvement is a rare complication of chronic lymphocytic leukemia (CLL) with varied outcomes. We contribute two additional cases of CLL with CNS involvement. The clinical course and response to treatment are described. All 78 previously reported cases of CLL with CNS involvement are prese...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-011-0636-z

    authors： Moazzam AA,Drappatz J,Kim RY,Kesari S

    更新日期：2012-01-01 00:00:00

  • Efficacy of intrathecal chemotherapy in patients with central nervous system involvement of hematological malignancies: a retrospective analysis.

    abstract：INTRODUCTION:Central nervous system (CNS) involvement, especially involvement of the cerebrospinal fluid (CSF), is common in several haematological malignancies. Intrathecal (IT) chemotherapy can be used to manage CSF involvement. METHODS:Here we evaluated the effectiveness of IT chemotherapy among 80 patients with ha...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2849-x

    authors： Dara A,Mook BB,Doorduijn JK,van den Bent MJ,Dinmohamed AG,Bromberg JEC

    更新日期：2018-08-01 00:00:00

  • Gamma knife surgery for 1-10 brain metastases without prophylactic whole-brain radiation therapy: analysis of cases meeting the Japanese prospective multi-institute study (JLGK0901) inclusion criteria.

    abstract：:We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1-10 brain metastases without prophylactic whole-brain radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-010-0169-x

    authors： Serizawa T,Hirai T,Nagano O,Higuchi Y,Matsuda S,Ono J,Saeki N

    更新日期：2010-06-01 00:00:00

  • Cognition and resective surgery for diffuse infiltrative glioma: an overview.

    abstract：:Compared to classical oncological outcome measures such as time to progression and survival, the importance of cognitive functioning in patients with diffuse infiltrative brain tumors has only recently been recognized. Apart from the relatively low incidence and the invariably fatal outcome of gliomas, the general ass...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-012-0811-x

    authors： Klein M,Duffau H,De Witt Hamer PC

    更新日期：2012-06-01 00:00:00

  • Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones.

    abstract：:Glioblastoma multiforme is a primary brain tumor associated with extensive invasion into surrounding brain tissue. Matrix metalloproteinases (MMPs) and urokinase plasminogen activation (uPA) system are shown to be involved in tumor invasion as they help in degradation of extracellular matrix (ECM) proteins and thus as...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-006-9126-0

    authors： Puli S,Lai JC,Bhushan A

    更新日期：2006-09-01 00:00:00

  • Atypical teratoid/rhabdoid tumor case report: treatment with surgical excision, radiation therapy, and alternative medicines.

    abstract：:Intracranial atypical teratoid/rhabdoid tumors (AT/RT) are rare with a poor prognosis. We report one case of a 7-year old girl living over 17 months after the diagnosis of AT/RT in the left frontal lobe. Treatment was partial surgical resection and post-operative radiation therapy. Radiation therapy resulted in comple...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-3120-1

    authors： Howes TL,Buatti JM,O'Dorisio MS,Kirby PA,Ryken TC

    更新日期：2005-03-01 00:00:00

  • Stereotactic radiosurgery of benign intracranial tumors.

    abstract：:Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors. Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation do...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-009-9831-6

    authors： Pollock BE

    更新日期：2009-05-01 00:00:00

  • Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis.

    abstract：:To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. P...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0939-8

    authors： Perkins SM,Mitra N,Fei W,Shinohara ET

    更新日期：2012-10-01 00:00:00

  • Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma.

    abstract：:Aberrant expression of stem cell-related genes in tumors may confer more primitive and aggressive traits affecting clinical outcome. Here, we investigated expression and prognostic value of the neural stem cell marker CD133, as well as of the pluripotency genes LIN28 and OCT4 in 37 samples of pediatric medulloblastoma...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-011-0647-9

    authors： Rodini CO,Suzuki DE,Saba-Silva N,Cappellano A,de Souza JE,Cavalheiro S,Toledo SR,Okamoto OK

    更新日期：2012-01-01 00:00:00

  • Neural differentiation arrest in embryonal carcinoma cells with forced expression of EWS-FLI1.

    abstract：:Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET. However, the specific details of EWS/PNET oncogenesis and exact role of EWS-FLI1 remain largely un...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9646-x

    authors： Yang Y,Zhang L,Wei Y,Wang H,Fukuma M,Xu H,Xiong W,Zheng J

    更新日期：2008-11-01 00:00:00

  • Brain stem gliomas in childhood. Rational approach and treatment.

    abstract：:Thirty-six infants and children with brain stem glioma diagnosed between 1967 and 1980 were reviewed. Posterior fossa craniotomy was performed in 25, with biopsy or partial resection in 18, cyst aspiration in 2, and exploration alone in 5. The 19 surgical specimens obtained revealed neoplastic cells in 15 but only gli...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00177896

    authors： Tomita T,McLone DG,Naidich TP

    更新日期：1984-01-01 00:00:00

  • Influence of C6 and CNS1 brain tumors on methotrexate pharmacokinetics in plasma and brain tissue.

    abstract：PURPOSE:Comparison of the influence of two different brain tumors (C6 and CNS1 glioma) on methotrexate (MTX) disposition in plasma, brain, and tumor tissue extracellular fluid (ECF). METHODS:Serial collection of plasma samples and brain ECF dialysates after i.v. bolus administration of MTX (50 mg kg(-1)) for 4 h. Quan...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000021820.12444.4c

    authors： Dukic SF,Kaltenbach ML,Heurtaux T,Hoizey G,Lallemand A,Vistelle R

    更新日期：2004-03-01 00:00:00

  • Current and emerging treatment strategies for children with progressive chiasmatic-hypothalamic glioma diagnosed as infants: a web-based survey.

    abstract：:Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire wa...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2630-6

    authors： Azizi AA,Schouten-van Meeteren AYN

    更新日期：2018-01-01 00:00:00

  • A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma.

    abstract：:In the present study we investigated the feasibility and effectiveness of a new biweekly schedule of fotemustine (FTM) in patients with recurrent glioblastoma, after at least one previous treatment. The primary endpoint was progression-free survival at 6 months; secondary objectives were clinical response, overall sur...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-010-0329-z

    authors： Addeo R,Caraglia M,De Santi MS,Montella L,Abbruzzese A,Parlato C,Vincenzi B,Carraturo M,Faiola V,Genovese M,Cennamo G,Del Prete S

    更新日期：2011-05-01 00:00:00

  • Surgical resection for patients with benign primary brain tumors and low grade gliomas.

    abstract：:'Benign' brain tumors are a heterogeneous group of primary neoplasms representing 40% of primary brain tumors. Amongst neuroepithelial tumors, astrocytic neoplasms predominate, followed by oligodendroglial and mixed glial and glial-neuronal neoplasms. Less common are tumors of the ependyma, choroid plexus and neuroepi...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/b:neon.0000041871.46785.53

    authors： Piepmeier J,Baehring JM

    更新日期：2004-08-01 00:00:00

  • 5-Fluorocytosine-mediated apoptosis and DNA damage in glioma cells engineered to express cytosine deaminase and their enhancement with interferon.

    abstract：:To explore the antitumor mechanism of bacterial cytosine deaminase plus 5-fluorocytosine (CD/5-FCyt) in combination with interferons (IFNs), glioma cells were transduced with recombinant retroviruses expressing CD. The transduced glioma cells become sensitive to the nontoxic prodrug 5-FCyt. Apoptosis, DNA damage, byst...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005883128175

    authors： Wang ZH,Samuels S,Gama Sosa MA,Kolodny EH

    更新日期：1998-02-01 00:00:00

  • Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death.

    abstract：:The microvasculature of brain tumors has been proposed as the primary target for ionizing radiation (IR)-induced apoptosis. However, the contribution of low dose IR-induced non-apoptotic cell death pathways has not been investigated. This study aimed to characterize the effect of IR on human brain microvascular endoth...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-006-9171-8

    authors： McLaughlin N,Annabi B,Lachambre MP,Kim KS,Bahary JP,Moumdjian R,Béliveau R

    更新日期：2006-11-01 00:00:00

  • Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas.

    abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000033383.84900.c1

    authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

    更新日期：2004-07-01 00:00:00

  • Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.

    abstract：:Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the e...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1579-y

    authors： Di K,Keir ST,Alexandru-Abrams D,Gong X,Nguyen H,Friedman HS,Bota DA

    更新日期：2014-12-01 00:00:00

  • Metabolic manipulation of glioblastoma in vivo by retrograde microdialysis of L-2, 4 diaminobutyric acid (DAB).

    abstract：OBJECTIVES:To study the metabolic effects in vivo of L-2, 4 diaminobutyric acid (DAB) administered by retrograde microdialysis in glioblastoma and to evaluate the feasibility of the technique. METHODS:In 10 patients with glioblastoma, a stereotactic biopsy was performed followed by implantation of microdialysis cathet...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-006-9186-1

    authors： Bergenheim AT,Roslin M,Ungerstedt U,Waldenström A,Henriksson R,Ronquist G

    更新日期：2006-12-01 00:00:00