Abstract：
INTRODUCTION:Central nervous system (CNS) involvement, especially involvement of the cerebrospinal fluid (CSF), is common in several haematological malignancies. Intrathecal (IT) chemotherapy can be used to manage CSF involvement. METHODS:Here we evaluated the effectiveness of IT chemotherapy among 80 patients with haematological malignancies and CSF localization who were treated with IT chemotherapy from 2001 to 2012. RESULTS:The majority of patients was diagnosed with diffuse large B-cell lymphoma (26%) or acute lymphoblastic leukaemia/lymphoblastic lymphoma (19%). After first-line IT chemotherapy, which mainly consisted of methotrexate (MTX) and corticosteroids, CSF complete response (CSF CR) was achieved in 76% of patients. 91% reached CSF CR when including second-line IT-chemotherapy. Clinical response was documented in 75%. Although most patients were additionally treated with systemic chemotherapy, response rate did not differ between patients treated with CNS-penetrating and CNS-non-penetrating drugs. CNS progression/relapse occurred in 40% of patients with median progression-free survival of 12.2 months. The median overall survival was 18.3 months; 55% of the patients died during follow-up. CONCLUSIONS:Our analysis shows a high response rate after first-line IT chemotherapy, but also a relatively high progression/relapse percentage.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Dara A,Mook BB,Doorduijn JK,van den Bent MJ,Dinmohamed AG,Bromberg JECdoi
10.1007/s11060-018-2849-xsubject
Has Abstractpub_date
2018-08-01 00:00:00pages
117-123issue
1eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-018-2849-xjournal_volume
139pub_type
杂志文章abstract：:There is general agreement that most chemotherapy agents achieve only relatively low concentrations in the normal central nervous system, that the blood-brain barrier is variably disrupted in malignant brain tumors, and that the concentration of chemotherapy drugs in the brain adjacent to tumor is intermediate between...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF01052723
更新日期：1994-01-01 00:00:00
abstract：INTRODUCTION:To evaluate the prognostic value of the Glasgow Prognostic Score (GPS), the combination of C-reactive protein (CRP) and albumin, in glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (GPS). METHODS:Data of newly diagnosed GBM patients treated wi...
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,多中心研究
doi：10.1007/s11060-011-0574-9
更新日期：2011-11-01 00:00:00
abstract：:Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-p...
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abstract：:The treatment of childhood low grade glioma (LGG), if not amenable to complete resection, quite often is a relevant clinical challenge. LGG in many instances are indeed slow growing tumors, which, if not controlled, can cause severe morbidity and ultimately jeopardize life. Most of the time children bearing an unresec...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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doi：10.1007/s11060-017-2445-5
更新日期：2017-06-01 00:00:00
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doi：10.1007/s11060-009-9861-0
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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abstract：:Elevated neutrophil-lymphocyte ratio (NLR) may predict worse outcomes in cancer, including glioblastoma (GBM). This study assessed whether change in NLR during focal radiotherapy and concomitant temozolomide (RT-TMZ) provides further prognostic information. This was a retrospective review of patients treated with RT-T...
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF01054272
更新日期：1993-07-01 00:00:00
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doi：10.1007/BF00178119
更新日期：1984-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006353322307
更新日期：1999-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2819-3
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:A prospective Phase II study of CPT-11 in adult patients with recurrent supratentorial glioblastoma multiforme (GBM). METHODS:Forty patients (25 men, 15 women) ages 32-71 years (median 59), with recurrent GBM were treated. All patients had previously been treated with surgery and involved field radiotherapy...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
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更新日期：2002-01-01 00:00:00
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doi：10.1007/BF00195605
更新日期：1987-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11060-016-2068-2
更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11060-019-03330-9
更新日期：2019-12-01 00:00:00
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更新日期：2012-03-01 00:00:00
abstract：:Measurement of oxygen pressure (pO2) in tumor tissue is important, because pO2 is a major factor for radiosensitivity in malignant glioma treatment. We attempted to elucidate the changes in pO2 level in glioblastoma tissue of patients under various conditions. Eighteen patients with newly diagnosed glioblastoma were r...
journal_title：Journal of neuro-oncology
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doi：10.1023/a:1015832726054
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11060-006-9304-0
更新日期：2007-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1023/b:neon.0000013483.50955.2f
更新日期：2004-01-01 00:00:00
abstract：:A case of multiple brain metastases from breast carcinoma treated with tamoxifen is described. She remained in remission for 58 months and is still alive after 82+ months of hormone therapy. The case indicates that hormonal treatment may be very effective in the management of brain metastases from breast carcinoma. ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00146879
更新日期：1991-04-01 00:00:00
abstract：:A positron emission tomography study using [18F]-fluorodeoxyglucose was undertaken to identify and quantitate whether diaschisis occurred in cerebral cortex, basal ganglia, or thalamus, as well as in cerebellar cortex and dentate nuclei in patients with malignant glioma. The relationship between diaschisis in these ce...
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pub_type： 杂志文章
doi：10.1007/BF00177839
更新日期：1990-04-01 00:00:00
