Chronic lymphocytic leukemia with central nervous system involvement: report of two cases with a comprehensive literature review.

abstract：OBJECT:Etoposide, a topoisomerase-II inhibitor promotes DNA damage and apoptosis of cancer cells. In this study, we have examined the ability of the histone deacetylase inhibitor, valproic acid (VPA) to modulate gene expression and sensitize glioblastoma cell lines to the cytotoxic effects of etoposide in vitro. METHO...

journal_title：Journal of neuro-oncology

authors： Das CM,Aguilera D,Vasquez H,Prasad P,Zhang M,Wolff JE,Gopalakrishnan V

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Recent studies suggest a relatively high prevalence of autoimmune disorders (AD) among primary CNS lymphoma (PCNSL) patients, however, the literature is limited to case reports. To gain a better understanding of AD-PCNSL we reviewed and analyzed all cases described in the literature. METHODS:We searched the...

journal_title：Journal of neuro-oncology

authors： Kaulen LD,Karschnia P,Dietrich J,Baehring JM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall wi...

journal_title：Journal of neuro-oncology

authors： Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W

更新日期：2019-01-01 00:00:00

abstract：:Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. The aim of this study is to ...

journal_title：Journal of neuro-oncology

authors： Minniti G,Salvati M,Arcella A,Buttarelli F,D'Elia A,Lanzetta G,Esposito V,Scarpino S,Maurizi Enrici R,Giangaspero F

更新日期：2011-04-01 00:00:00

abstract：:We have developed an in vitro assay for Natural Killer (NK) cell cytolysis of and binding to substrate attached human glioma and fetal brain cells. The monolayer cells were labeled with [51Cr] and the effectors were directly sedimented onto these substrate attached target cells. Using this method we screened several g...

journal_title：Journal of neuro-oncology

authors： Kazimer RM,Whisler RL,Stephens RE,Pearl DK,Yates AJ

更新日期：1989-07-01 00:00:00

abstract：INTRODUCTION:Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions. METHODS:A total of 75 pediatric patients with spinal tumor...

journal_title：Journal of neuro-oncology

authors： Chou SC,Kuo MF,Lai DM,Chen CM,Xiao F,Tsuang FY,Yang SH

更新日期：2020-02-01 00:00:00

abstract：:Sacral chordoma is a vessel-rich and infiltrative tumor, but the fundamental knowledge of its biological behavior remains unknown. This study was designed to investigate the expression levels and contributions of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in the angiogenesis and r...

journal_title：Journal of neuro-oncology

authors： Chen KW,Yang HL,Lu J,Wang GL,Ji YM,Wu GZ,Zhu LF,Liu JY,Chen XQ,Gu YP

更新日期：2011-02-01 00:00:00

abstract：:Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-p...

journal_title：Journal of neuro-oncology

authors： Mahato D,Vivas-Buitrago T,Gassie K,Jentoft M,Tavanaiepour D,Quiñones-Hinojosa A

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:There has been a resurgence of interest in brachytherapy as a treatment for glioblastoma, with several currently ongoing clinical trials. To provide a foundation for the analysis of these trials, we analyze the Surveillance, Epidemiology, and End Results (SEER) database to determine whether receipt of brac...

journal_title：Journal of neuro-oncology

authors： Bartek J Jr,Alattar AA,Dhawan S,Ma J,Koga T,Nakaji P,Dusenbery KE,Chen CC

更新日期：2019-10-01 00:00:00

abstract：:Craniopharyngiomas and pituitary adenomas are both tumors of the hypothalamic and pituitary region, respectively that are frequently associated with endocrine defects either because of direct involvement of hormone producing cells (most pituitary tumors) or because of secondary defects due to disturbance of hypothalam...

journal_title：Journal of neuro-oncology

authors： Oikonomou E,Barreto DC,Soares B,De Marco L,Buchfelder M,Adams EF

更新日期：2005-07-01 00:00:00

abstract：:The Hedgehog (Hh) signaling pathway has been implicated in the most common childhood brain tumor, medulloblastoma (MB). Given the toxicity of post-surgical treatments for MB, continued need exists for new, targeted therapies. Based upon our finding that Neuropilin (Nrp) transmembrane proteins are required for Hh signa...

journal_title：Journal of neuro-oncology

authors： Hayden Gephart MG,Su YS,Bandara S,Tsai FC,Hong J,Conley N,Rayburn H,Milenkovic L,Meyer T,Scott MP

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Patterns of failure in patients with olfactory neuroblastoma (ONB) according to two surgical approaches, craniofacial resection (CFR) and endoscopic surgery (ENDO), have yet to be analyzed. METHODS:We retrospectively reviewed 28 patients with surgically treated ONB between January 1995 and October 2017. F...

journal_title：Journal of neuro-oncology

authors： Kim N,Lee CG,Kim EH,Kim CH,Keum KC,Lee KS,Chang JH,Suh CO

更新日期：2019-01-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degree...

journal_title：Journal of neuro-oncology

authors： McAbee JH,Degorre-Kerbaul C,Valdez K,Wendler A,Shankavaram UT,Watts C,Camphausen K,Tofilon PJ

更新日期：2020-09-01 00:00:00

abstract：:Choroid plexus papillomas (CPPs) are generally regarded as benign tumours, with a favourable long-term prognosis. Complete resection should result in cure. We present a case of diffuse craniospinal seeding from an apparently completely resected fourth ventricular primary tumour. A 51-year-old male is discussed, who pr...

journal_title：Journal of neuro-oncology

authors： McEvoy AW,Galloway M,Revesz T,Kitchen ND

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:To analyze the surgical outcome of a consecutive and single center series of medulla oblongata (MO) and spinal cord hemangioblastomas (HB). PATIENT AND METHODS:We retrospectively reviewed the medical charts of all MO and spinal HB patients operated on in our institution between 1985 and 2002. All patients had ...

journal_title：Journal of neuro-oncology

authors： Parker F,Aghakhani N,Ducati LG,Yacubian-Fernandes A,Silva MV,David P,Richard S,Tadie M

更新日期：2009-05-01 00:00:00

abstract：:Glioblastoma (GBM) is the most malignant primary brain tumor and contains tumorigenic cancer stem cells (CSCs), which support the progression of tumor growth. The selection of CSCs and facilitation of the brain tumor niches may assist the development of novel therapeutics for GBM. Herein, hydrogel materials composed o...

journal_title：Journal of neuro-oncology

authors： Liu YC,Lee IC,Chen PY

更新日期：2018-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and ...

journal_title：Journal of neuro-oncology

authors： Sjöström S,Wibom C,Andersson U,Brännström T,Broholm H,Johansen C,Collatz-Laier H,Liu Y,Bondy M,Henriksson R,Melin B

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To assess the neurocognitive function and neurological toxicity of frameless linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) in patients with 10 or more brain metastases (BM). PATIENTS AND METHODS:Forty consecutive adult patients who received SRS for ten or more 10 BM < 3 cm in maximum size we...

journal_title：Journal of neuro-oncology

authors： Minniti G,Capone L,Nardiello B,El Gawhary R,Raza G,Scaringi C,Bianciardi F,Gentile P,Paolini S

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:Diffuse pontine tumors are highly lethal, and there are few long-term survivors with the standard treatment of external beam irradiation. We investigated the effectiveness of high-dose thiotepa and etoposide-based chemotherapy regimens with autologous bone marrow rescue (ABMR) in children with pontine tumors. ...

journal_title：Journal of neuro-oncology

authors： Dunkel IJ,Garvin JH Jr,Goldman S,Ettinger LJ,Kaplan AM,Cairo M,Li H,Boyett JM,Finlay JL

更新日期：1998-03-01 00:00:00

abstract：:Increasing interest has developed in the use of the photodynamic agent, Hematoporphyrin derivative (HpD) for photoradiation therapy (PRT) as adjunctive therapy of malignant glial tumors of the brain. HpD, injected systemically, is preferentially taken up and retained by neoplastic tissue. Early studies of such uptake ...

journal_title：Journal of neuro-oncology

authors： Little FM,Gomer CJ,Hyman S,Apuzzo ML

更新日期：1984-01-01 00:00:00

abstract：:While the 5-year overall survival is better in pediatric than in adult patients diagnosed with glioblastoma (GBM), outcomes in children remain very poor. Understanding the mechanisms of tumorigenesis and tumor propagation can identify therapeutic targets to improve these outcomes. Human cytomegalovirus (CMV) proteins ...

journal_title：Journal of neuro-oncology

authors： Wakefield A,Pignata A,Ghazi A,Ashoori A,Hegde M,Landi D,Gray T,Scheurer ME,Chintagumpala M,Adesina A,Gottschalk S,Hicks J,Powell SZ,Ahmed N

更新日期：2015-11-01 00:00:00

abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

journal_title：Journal of neuro-oncology

authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

更新日期：1983-01-01 00:00:00

abstract：:The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincrist...

journal_title：Journal of neuro-oncology

authors： Kinsella P,Clynes M,Amberger-Murphy V

更新日期：2011-01-01 00:00:00

abstract：:Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

journal_title：Journal of neuro-oncology

authors： Nahreini P,Andreatta C,Hanson A,Prasad KN

更新日期：2003-05-01 00:00:00

abstract：:Neurocytomas gained importance since 1995, which is reflected by the increasing number of reports on this entity. This study was performed to determine the best available treatment for typical and atypical neurocytomas (MIB-1 labeling index >3%, atypical histology) in various age groups ( 18 years). The...

journal_title：Journal of neuro-oncology

authors： Rades D,Schild SE

更新日期：2006-05-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:The role of immunotherapy for metastatic melanoma has expanded over the past decade triggering questions regarding the combination and timing of immunotherapy and radiation for brain metastases. We used the National Cancer Database (NCDB) to see if the time from radiation to immunotherapy in patients with me...

journal_title：Journal of neuro-oncology

authors： Wegner RE,Abel S,D'Amico RS,Mehta GU,Sheehan J

更新日期：2021-01-11 00:00:00

abstract：INTRODUCTION:Carmustine (BCNU)-impregnated biodegradable polymer wafers have been shown to prolong survival in patients with recurrent malignant glioma. Interferon alfa-2b (IFNalpha(2b)) has demonstrated antitumor activity against a number of cancers, but its use in glioma has been limited. The use of these agents in c...

journal_title：Journal of neuro-oncology

authors： Olson JJ,McKenzie E,Skurski-Martin M,Zhang Z,Brat D,Phuphanich S

更新日期：2008-12-01 00:00:00