Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients.


BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall with superparamagnetic iron oxide nanoparticles ("NanoPaste" technique). Patients underwent six 1-h hyperthermia sessions in an alternating magnetic field and, if possible, received concurrent fractionated radiotherapy at a dose of 39.6 Gy. RESULTS:There were no major side effects during active treatment. However, after 2-5 months, patients developed increasing clinical symptoms. CT scans showed tumor flare reactions with prominent edema around nanoparticle deposits. Patients were treated with dexamethasone and, if necessary, underwent re-surgery to remove nanoparticles. Histopathology revealed sustained necrosis directly adjacent to aggregated nanoparticles without evidence for tumor activity. Immunohistochemistry showed upregulation of Caspase-3 and heat shock protein 70, prominent infiltration of macrophages with ingested nanoparticles and CD3+ T-cells. Flow cytometric analysis of freshly prepared tumor cell suspensions revealed increased intracellular ratios of IFN-γ to IL-4 in CD4+ and CD8+ memory T cells, and activation of tumor-associated myeloid cells and microglia with upregulation of HLA-DR and PD-L1. Two patients had long-lasting treatment responses > 23 months without receiving any further therapy. CONCLUSION:Intracavitary thermotherapy combined with radiotherapy can induce a prominent inflammatory reaction around the resection cavity which might trigger potent antitumor immune responses possibly leading to long-term stabilization of recurrent GBM patients. These results warrant further investigations in a prospective phase-I trial.


J Neurooncol


Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W




Has Abstract


2019-01-01 00:00:00














  • High-dose cytarabine salvage therapy for recurrent primary CNS lymphoma.

    abstract::Treatment of recurrent primary CNS lymphoma (PCNSL) though not standardized most often utilizes whole brain radiotherapy, re-challenge with high-dose methotrexate, or administration of an alkylating chemotherapy. High-dose cytarabine (HD-araC) has been advocated as an active agent in PCNSL but limited information exis...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Chamberlain MC

    更新日期:2016-02-01 00:00:00

  • Molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss: gain of chromosome 19p and histological grade III negatively correlate with patient's prognosis.

    abstract::Although 1p19q codeleted gliomas are the most favorable molecular subgroup of lower-grade gliomas, there are cases with early recurrence or short survival. The objective of this study was to elucidate molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss. The st...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Hayashi S,Kitamura Y,Hirose Y,Yoshida K,Sasaki H

    更新日期:2017-03-01 00:00:00

  • Pituitary metastasis: is there still a place for neurosurgical treatment?

    abstract::Pituitary metastases are uncommon, ranging from 1 to 5 % of all metastases. Between 10 and 30 % of pituitary lesions are symptomatic responsible for diabetes insipidus, visual field defect or cranial nerve palsy. Primary sites are lung or breast in two-thirds of cases. There is no current reference concerning treatmen...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Gilard V,Alexandru C,Proust F,Derrey S,Hannequin P,Langlois O

    更新日期:2016-01-01 00:00:00

  • Carboplatin and etoposide (CE) chemotherapy in patients with recurrent or progressive oligodendroglial tumors.

    abstract:BACKGROUND:Oligodendroglial tumors are rare and chemosensitive diseases; but the overall results with current chemotherapy regimens cannot be considered satisfactory and other active treatments are necessary. We decided to determine the efficacy and toxicity profile of the carboplatin and etoposide (CE) regimen in this...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Scopece L,Franceschi E,Cavallo G,Paioli A,Paioli G,Conforti R,Palmerini E,Berzioli C,Spagnolli F,Esposti RD,Crinò L

    更新日期:2006-09-01 00:00:00

  • Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m-labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptor.

    abstract::The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII), using athymic nude mi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Takasu S,Takahashi T,Okamoto S,Oriuchi N,Nakayashiki N,Okamoto K,Muramatsu H,Hayashi T,Nakahara N,Mizuno M,Wakabayashi T,Higuchi T,Endo K,Kozaki K,Miyaishi O,Saga S,Ueda R,Yoshida J,Yoshikawa K

    更新日期:2003-07-01 00:00:00

  • Primary or salvage stereotactic radiosurgery for brain metastatic small cell lung cancer.

    abstract:PURPOSE:We evaluated the outcomes after stereotactic radiosurgery (SRS) for patients who developed new or progressive brain disease regardless of whether they had no prior radiation, PCI, or WBRT. METHODS:We retrospectively identified 90 SCLC patients who had SRS between 1991 and 2018. Thirty-one patients had no evide...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Faramand A,Niranjan A,Kano H,Flickinger J,Lunsford LD

    更新日期:2019-08-01 00:00:00

  • MIP-1alpha antagonizes the effect of a GM-CSF-enhanced subcutaneous vaccine in a mouse glioma model.

    abstract::Subcutaneous vaccination using granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced glioma cells substantially prolongs survival in the mouse GL261 glioma model. To potentiate the efficacy of GM-CSF-based vaccination, syngeneic C57BL/6 mice bearing pre-implanted intracerebral GL261 gliomas were vaccina...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Herrlinger U,Aulwurm S,Strik H,Weit S,Naumann U,Weller M

    更新日期:2004-01-01 00:00:00

  • Phase I study of bendamustine with concurrent whole brain radiation therapy in patients with brain metastases from solid tumors.

    abstract::A phase I study was conducted to evaluate the dose-limiting toxicities (DLTs) and to determine the maximum tolerated dose (MTD)/recommended phase II dose of bendamustine with concurrent whole brain radiation (WBR) in patients with brain metastases (BM) from solid tumors. Four doses of intravenous weekly bendamustine w...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Pan E,Yu D,Zhao X,Neuger A,Smith P,Chinnaiyan P,Yu HH

    更新日期:2014-09-01 00:00:00

  • Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation.

    abstract::Patients with unresectable glioblastoma or anaplastic astrocytoma have a dismal prognosis. The role of neoadjuvant chemotherapy prior to irradiation in these patients has been studied primarily in non-randomized studies. We have compared the effect of neoadjuvant chemotherapy plus radiotherapy versus concomitant radio...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Capdevila L,Cros S,Ramirez JL,Sanz C,Carrato C,Romeo M,Etxaniz O,Hostalot C,Massuet A,Cuadra JL,Villà S,Balañà C

    更新日期:2014-03-01 00:00:00

  • Stereotactic radiosurgery as a therapeutic strategy for intracranial metastatic prostate carcinoma.

    abstract::Intracranial metastatic prostate carcinoma is rare. We sought to determine the clinical outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) for patients with intracranial prostate carcinoma metastases. We studied data from 10 patients who underwent radiosurgery for 15 intracranial metastases (9 dural-based an...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Flannery T,Kano H,Niranjan A,Monaco EA 3rd,Flickinger JC,Lunsford LD,Kondziolka D

    更新日期:2010-02-01 00:00:00

  • An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas.

    abstract::The human glioma cell lines, U87 and T98G, were evaluated for their ability to survive and form colonies in an acidic environment of pH(ext) 6.0. In contrast to U87, which showed an 80-90% survival rate, only 40% of T98G cells survived 6 days at pH(ext) 6.0 and lost their colony forming ability when returned to a norm...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Schnier JB,Nishi K,Harley WR,Gorin FA

    更新日期:2008-08-01 00:00:00

  • Characterization of intracranial space-occupying lesions by ⁹⁹(m)Tc-Tetrofosmin SPECT.

    abstract::Differentiating neoplastic from non-neoplastic intracranial lesions is of paramount importance for patient management. Benign lesions can have many of the features of malignant brain tumors on both computed tomography (CT) and conventional magnetic resonance imaging (MRI). Herewith, we set out to investigate the role ...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Fotopoulos AD,Kyritsis AP,Tsiouris S,Al-Boucharali J,Papadopoulos A,Voulgaris S,Alexiou GA

    更新日期:2011-01-01 00:00:00

  • Concomitant differentiation and partial proteasome inhibition trigger apoptosis in neuroblastoma cells.

    abstract::Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Nahreini P,Andreatta C,Hanson A,Prasad KN

    更新日期:2003-05-01 00:00:00

  • Differential effects of methionine enkephalin on the growth of brain tumor cells.

    abstract::The effect of methionine enkephalin on the growth of human brain tumor cells was investigated. The results show that this endogenous opioid has dual effects on tumor cell growth. This peptide exerted an inhibitory effect in SK-N-MC human neuroblastoma cell line; in contrast, in U-373 MG human astrocytoma cell line, th...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Lee YS,Wurster RD

    更新日期:1994-01-01 00:00:00

  • Prognostic utility of gene therapy with herpes simplex virus thymidine kinase for patients with high-grade malignant gliomas: a systematic review and meta analysis.

    abstract::The aim of this study was to assess the effectiveness of adding viral vector-mediated gene therapy with herpes simplex virus thymidine kinase (HSV-tk) to standard treatment, in comparison with standard treatment alone to treat patients with high-grade gliomas (HGGs). A literature search of the databases PubMed, Embase...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Zhao F,Tian J,An L,Yang K

    更新日期:2014-06-01 00:00:00

  • Fluorescein-mediated sonodynamic therapy in a rat glioma model.

    abstract:INTRODUCTION:Malignant gliomas have a dismal prognosis and significant efforts are being made to develop more effective treatments. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. The aim of this study is to d...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Prada F,Sheybani N,Franzini A,Moore D,Cordeiro D,Sheehan J,Timbie K,Xu Z

    更新日期:2020-07-01 00:00:00

  • Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors.

    abstract::Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1) or its ligand (PD-L1) have been shown to be effective in treating patients with a variety of cancers. Biomarker studies have found positive associations between clinical response rates and PD-L1 expression on tumor cells, as well as the presence of ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Wang S,Liechty B,Patel S,Weber JS,Hollmann TJ,Snuderl M,Karajannis MA

    更新日期:2018-05-01 00:00:00

  • Are preoperative sex-related differences of affective symptoms in primary brain tumor patients associated with postoperative histopathological grading?

    abstract::Our objective was to explore the impact of the histopathological tumor type on affective symptoms before surgery among male and female patients with supratentorial primary brain tumors. A total of 44 adult patients were included in the study. Depression and anxiety were measured using the Beck Depression Inventory (BD...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Richter A,Jenewein J,Krayenbühl N,Woernle C,Bellut D

    更新日期:2016-01-01 00:00:00

  • Results of contemporary surgical management of radiation necrosis using frameless stereotaxis and intraoperative magnetic resonance imaging.

    abstract:OBJECTIVE:Radiation necrosis is a well-known complication of radiotherapy for malignant brain tumors. Although surgery was once considered the mainstay of treatment, no recent reports have evaluated the use of intraoperative magnetic resonance imaging (IOMRI) and frameless stereotaxis during surgical resection of radia...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: McPherson CM,Warnick RE

    更新日期:2004-05-01 00:00:00

  • Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas.

    abstract::Meningioma is a common intracranial tumor, originating from the meninges of the skull or spinal canal. Most meningiomas are benign tumors, however atypical or anaplastic tumors can be found in 6% of cases. Patients with asymptomatic small benign meningiomas can be followed without therapy, but in symptomatic patients ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Sioka C,Kyritsis AP

    更新日期:2009-03-01 00:00:00

  • Radiation necrosis with stereotactic radiosurgery combined with CTLA-4 blockade and PD-1 inhibition for treatment of intracranial disease in metastatic melanoma.

    abstract::Immune checkpoint inhibitors have demonstrated remarkable benefits in cancer patients. However, concern regarding toxicity in the setting of stereotactic radiosurgery (SRS) is often raised. In this study, we characterize radiation necrosis (RN) following immunotherapy and SRS. Melanoma patients treated with SRS and an...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Fang P,Jiang W,Allen P,Glitza I,Guha N,Hwu P,Ghia A,Phan J,Mahajan A,Tawbi H,Li J

    更新日期:2017-07-01 00:00:00

  • Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome.

    abstract::We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PP

    更新日期:2005-01-01 00:00:00

  • Concurrent functional and metabolic assessment of brain tumors using hybrid PET/MR imaging.

    abstract::To evaluate diagnostic accuracy of perfusion weighted imaging (PWI) and positron emission tomography (PET) using an integrated PET/MR system in tumor grading as well as in differentiating recurrent tumor from treatment-induced effects (TIE) in brain tumor patients. Twenty patients (Group A: treatment naïve, 9 patients...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Sacconi B,Raad RA,Lee J,Fine H,Kondziolka D,Golfinos JG,Babb JS,Jain R

    更新日期:2016-04-01 00:00:00

  • Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1.

    abstract:INTRODUCTION:Glioblastoma (GBM) is the most common primary brain cancer. The average survival time for the majority of patients is approximately 15 months after diagnosis. A major feature of GBM that contributes to its poor prognosis is its high invasiveness. Caveolae are plasma membrane subdomains that participate in ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Pu W,Nassar ZD,Khabbazi S,Xie N,McMahon KA,Parton RG,Riggins GJ,Harris JM,Parat MO

    更新日期:2019-06-01 00:00:00

  • Clusters of histologic characteristics in children with infratentorial neuroglial tumors. The Childhood Brain Tumor Consortium.

    abstract::Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,多中心研究


    authors: Gilles FH,Sobel EL,Leviton A,Tavaré CJ

    更新日期:1998-08-01 00:00:00

  • Surgical resection of brain metastases: the prognostic value of the graded prognostic assessment score.

    abstract::There is a need for better predictors for short survival in patients with brain metastases undergoing open surgery. The graded prognostic assessment (GPA) has recently been developed to predict survival in patients with brain metastases. We explored the prognostic capabilities of GPA in a consecutive neurosurgical pop...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Jakola AS,Gulati S,Nerland US,Solheim O

    更新日期:2011-12-01 00:00:00

  • Establishment of interleukin 2 dependent cytotoxic T lymphocyte cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor.

    abstract::Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

    更新日期:1987-01-01 00:00:00

  • Metabolic patterns in meningiomas.

    abstract::The aim of this investigation was to define characteristic properties of cellular energy metabolism in meningiomas in vitro dependent on the histological subtype. We analysed marker enzymes of representative metabolic pathways localized in the mitochondria (respiratory chain, citric acid cycle, beta-oxidation of fatty...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Herting B,Meixensberger J,Roggendorf W,Reichmann H

    更新日期:2003-11-01 00:00:00

  • Vascular malformations of the thalamus with normal angiograms.

    abstract::We describe two patients with fatal vascular malformations of the thalamus whom we thought had gliomas. They had progressive neurological impairment with subacute onset as adults. Computed tomography showed lesions of increased density with slight post-contrast enhancement; cerebral angiography was normal. Without bio...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Norcross K,Ciric IS,Mikhael MA,Vick NA

    更新日期:1985-01-01 00:00:00

  • Extent of surrounding edema does not correlate with acute complications after radiosurgery for melanoma brain metastases.

    abstract:AIM:To assess whether extent of surrounding edema correlates with acute adverse clinical outcomes within 3 months after stereotactic radiosurgery (SRS) for melanoma brain metastases (BM). METHODS:Patients with melanoma BM treated with SRS were included in a single center retrospective analysis. A contrast-enhanced mag...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Jardim A,Scott J,Drew Z,Foote MC,Sadasivan AP,Hall B,Olson SL,Shanker M,Pinkham MB

    更新日期:2019-12-01 00:00:00