Phenotypic change of human cultured meningioma cells.

abstract：:The purpose of this study is to characterize the time course of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) uptake of primary central nervous system lymphomas (PCNSL) comparing with those of other common brain tumors such as malignant gliomas and meningioma. Ten patients with PCNSL, 14 with malignant gliomas and 7...

journal_title：Journal of neuro-oncology

authors： Shinoda J,Yano H,Murase S,Yoshimura S,Sakai N,Asano T

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Molecular data has become an essential part of the updated World Health Organization (WHO) grading of central nervous system tumors. However, stereotactic needle biopsies provide only small volume specimens and limit the extent of histologic and molecular testing that can be performed. We assessed the use of a ...

journal_title：Journal of neuro-oncology

authors： Bander ED,Jones SH,Pisapia D,Magge R,Fine H,Schwartz TH,Ramakrishna R

更新日期：2019-01-01 00:00:00

abstract：:The actual role of 18F-FDG PET/CT in evaluating primary brain lymphoma is still an open issue. Brain lymphoma usually show elevated 18F-FDG uptake, often higher than other brain tumors or inflammatory processes, but the metabolic behavior of this lymphoma is not still understood. Our aim was to investigate the particu...

journal_title：Journal of neuro-oncology

authors： Albano D,Bosio G,Bertoli M,Giubbini R,Bertagna F

更新日期：2018-02-01 00:00:00

abstract：:Glioblastoma cells secrete transforming growth factor-beta (TGF-beta), which has a variety of immunosuppressive properties. We investigated the effect of irradiation TGF-beta secretion by malignant glioma cells. Three malignant glioma cell lines (T98G, A172, KG-1-C) were cultured and irradiated using 10 and 50 Gy Lina...

journal_title：Journal of neuro-oncology

authors： Satoh E,Naganuma H,Sasaki A,Nagasaka M,Ogata H,Nukui H

更新日期：1997-07-01 00:00:00

abstract：:Some unresectable and symptomatic meningiomas recur after conventional radiation therapy or stereotactic radiosurgery and are a therapeutic challenge. Evidence-based data from medical therapy for patients with recurrent meningioma can be deemed insufficient. Because of the prevalent expression of PDGF receptors in men...

journal_title：Journal of neuro-oncology

authors： Horak P,Wöhrer A,Hassler M,Hainfellner J,Preusser M,Marosi C

更新日期：2012-09-01 00:00:00

abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

journal_title：Journal of neuro-oncology

authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

更新日期：2018-05-01 00:00:00

abstract：:Despite advances in surgery, chemotherapy and radiotherapy, the outcomes of patients with GBM have not significantly improved. Tumor recurrence in the resection margins occurs in more than 80% of cases indicating aggressive treatment modalities, such as gene therapy are warranted. We have examined photochemical intern...

journal_title：Journal of neuro-oncology

authors： Wang F,Zamora G,Sun CH,Trinidad A,Chun C,Kwon YJ,Berg K,Madsen SJ,Hirschberg H

更新日期：2014-05-01 00:00:00

abstract：:Thermal stability signatures of complex molecule interaction in biological fluids can be measured using a new approach called differential scanning calorimetry (DSC). The thermal stability of plasma proteome has been described previously as a method of producing a disease-specific "signature," termed thermogram, in se...

journal_title：Journal of neuro-oncology

authors： Chagovetz AA,Jensen RL,Recht L,Glantz M,Chagovetz AM

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Malignant gliomas have a dismal prognosis and significant efforts are being made to develop more effective treatments. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. The aim of this study is to d...

journal_title：Journal of neuro-oncology

authors： Prada F,Sheybani N,Franzini A,Moore D,Cordeiro D,Sheehan J,Timbie K,Xu Z

更新日期：2020-07-01 00:00:00

abstract：:Patients with metastatic well-differentiated thyroid cancer have a generally favorable long-term outcome although multi-organ involvement is a known marker of poor prognosis. Brain metastases are rare, occurring in less than 1% of patients with thyroid cancer. Few patients have been managed with stereotactic radiosurg...

journal_title：Journal of neuro-oncology

authors： Bernad DM,Sperduto PW,Souhami L,Jensen AW,Roberge D

更新日期：2010-06-01 00:00:00

abstract：:Leptomeningeal carcinomatosis is a painful and debilitating complication of cancer. Indwelling reservoirs provide continuous assess to the subarachnoid space, making leptomeningeal cancer potentially amenable to gene therapy. Adeno-associated virus (AAV) is a defective virus not associated with any human disease. We u...

journal_title：Journal of neuro-oncology

authors： Rosenfeld MR,Bergman I,Schramm L,Griffin JA,Kaplitt MG,Meneses PI

更新日期：1997-09-01 00:00:00

abstract：:Neurocytomas gained importance since 1995, which is reflected by the increasing number of reports on this entity. This study was performed to determine the best available treatment for typical and atypical neurocytomas (MIB-1 labeling index >3%, atypical histology) in various age groups ( 18 years). The...

journal_title：Journal of neuro-oncology

authors： Rades D,Schild SE

更新日期：2006-05-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of p...

journal_title：Journal of neuro-oncology

authors： Tichy J,Spechtmeyer S,Mittelbronn M,Hattingen E,Rieger J,Senft C,Foerch C

更新日期：2016-01-01 00:00:00

abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...

journal_title：Journal of neuro-oncology

authors： Benke T,Wagner M,Pallua AK,Muigg A,Stockhammer G

更新日期：2004-01-01 00:00:00

abstract：:Pilocytic astrocytomas are rare intracranial gliomas that are typically treated with surgical extirpation. Our aim was to report the radiologic and clinical outcomes of patients treated with stereotactic radiosurgery (SRS) for pilocytic astrocytoma in the primary and salvage setting. Patients with pilocytic astrocytom...

journal_title：Journal of neuro-oncology

authors： Trifiletti DM,Peach MS,Xu Z,Kersh R,Showalter TN,Sheehan JP

更新日期：2017-09-01 00:00:00

abstract：:Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process whereby capillary sprouts are formed in response to externally supplied chemical stimuli. The sprouts then grow and develop, driven initially by endothelial cell migration, and organize themselves into a branched, connected netw...

journal_title：Journal of neuro-oncology

authors： Chaplain MA

更新日期：2000-10-01 00:00:00

abstract：:A greater understanding of brain metastases is imperative for developing novel therapeutic strategies. Our previous study showed that insulin-like growth factor (IGF) signaling pathway was activated in brain-tropic cancer cells. In this study, we investigated the clinical relevance of activated (phosphorylated) IGF-1 ...

journal_title：Journal of neuro-oncology

authors： Wu PF,Huang WC,Yang JC,Lu YS,Shih JY,Wu SG,Lin CH,Cheng AL

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Herein, we describe a single institutio...

journal_title：Journal of neuro-oncology

authors： Goyal A,Yolcu Y,Kerezoudis P,Alvi MA,Krauss WE,Bydon M

更新日期：2019-04-01 00:00:00

abstract：:In addition to its powerful vasoconstrictive activity, endothelin-1 (ET-1) has been recognized to stimulate DNA synthesis in some cell lines. In this study, we confirmed the existence of ET-1 receptor in YKG-1 human glioma cells, and investigated its effect on DNA synthesis in YKG-1 for 6 consecutive days, comparing i...

journal_title：Journal of neuro-oncology

authors： Asano T,Aoyagi M,Hirakawa K,Ikawa Y

更新日期：1994-01-01 00:00:00

abstract：:Medulloblastomas are the most common malignant brain tumors in childhood. Emerging evidence suggests that medulloblastoma comprises at least four distinct diseases (WNT, SHH, Group 3 and 4) with different biology, clinical presentation, and outcome, with especially poor prognosis in Group 3. The tight connection of bi...

journal_title：Journal of neuro-oncology

authors： Milde T,Lodrini M,Savelyeva L,Korshunov A,Kool M,Brueckner LM,Antunes AS,Oehme I,Pekrun A,Pfister SM,Kulozik AE,Witt O,Deubzer HE

更新日期：2012-12-01 00:00:00

abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

journal_title：Journal of neuro-oncology

authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

更新日期：2004-07-01 00:00:00

abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：:Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL). The Primary and Recurrent Glioma registry at Duke's The Pres...

journal_title：Journal of neuro-oncology

authors： Randazzo DM,McSherry F,Herndon JE 2nd,Affronti ML,Lipp ES,Flahiff C,Miller E,Woodring S,Freeman M,Healy P,Minchew J,Boulton S,Desjardins A,Vlahovic G,Friedman HS,Keir S,Peters KB

更新日期：2017-09-01 00:00:00

abstract：:Computational modeling shows that intra-arterial delivery is most efficient when the delivered drugs rapidly and avidly bind to the target site. The cell-penetrating peptide trans-activator of transcription (TAT) is a candidate carrier molecule that could mediate such specificity for brain tumor chemotherapeutics. To ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Cooke JRN,Ellis JA,Emala CW,Bruce JN

更新日期：2017-12-01 00:00:00

abstract：OBJECT:There is little population-based data available on primary spinal cord tumors. Many of the existing statistics are not current or were obtained from surgical series. Historically, population-based data were collected only for malignant tumors, and only recently have data begun to be collected on non-malignant tu...

journal_title：Journal of neuro-oncology

authors： Schellinger KA,Propp JM,Villano JL,McCarthy BJ

更新日期：2008-04-01 00:00:00

abstract：:One hundred-twenty seven human brain tumors were examined by an immunoperoxidase technique for the expression of collagen Type IV, a major constituent of basement membrane. The parenchymal components were negative for the marker protein in all tumors except for neurilemmomas which were positively stained. In every cas...

journal_title：Journal of neuro-oncology

authors： Ogawa K,Oguchi M,Nakashima Y,Yamabe H

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:To study the inhibitory effects of plasmid-based siRNA targeting human epidermal growth factor receptor (EGFR) on tumor proliferation and invasion of TJ905 glioblastoma cells. METHODS:Two siRNA expression constructs targeting human EGFR extracellular domain (516-536) and catalytic domain (2400-2420) were tr...

journal_title：Journal of neuro-oncology

authors： Kang CS,Pu PY,Li YH,Zhang ZY,Qiu MZ,Huang Q,Wang GX

更新日期：2005-09-01 00:00:00

abstract：:Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates f...

journal_title：Journal of neuro-oncology

authors： Gittleman H,Kromer C,Ostrom QT,Blanda R,Russell J,Kruchko C,Barnholtz-Sloan JS

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:We sought to evaluate the effectiveness of definitive or adjuvant external-beam proton therapy on local control and survival in patients with skull-base chondrosarcoma. METHODS:We reviewed the medical records of 43 patients with a median age of 49 years (range, 23-80 years) treated with double-scattered 3D ...

journal_title：Journal of neuro-oncology

authors： Holtzman AL,Rotondo RL,Rutenberg MS,Indelicato DJ,Mercado CE,Rao D,Tavanaiepour D,Morris CG,Louis D,Flampouri S,Mendenhall WM

更新日期：2019-05-01 00:00:00