Intramedullary spinal cord metastases: an institutional review of survival and outcomes.

abstract：PURPOSE:This study explored the superiority of temozolomide (TMZ) + interferonβ (IFNβ) to standard TMZ as treatment for newly diagnosed glioblastoma (GBM) via randomized phase II screening design. EXPERIMENTAL DESIGN:Eligibility criteria included histologically proven GBM, with 50% of the tumor located in supratentori...

journal_title：Journal of neuro-oncology

authors： Wakabayashi T,Natsume A,Mizusawa J,Katayama H,Fukuda H,Sumi M,Nishikawa R,Narita Y,Muragaki Y,Maruyama T,Ito T,Beppu T,Nakamura H,Kayama T,Sato S,Nagane M,Mishima K,Nakasu Y,Kurisu K,Yamasaki F,Sugiyama K,Onishi

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population. METHODS:We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed fo...

journal_title：Journal of neuro-oncology

authors： Wong J,Goddard K,Laperriere N,Dang J,Bouffet E,Bartels U,Hodgson D,Tyldesley S,Hukin J,Cheng S,Bedard PL,Lo AC

更新日期：2020-09-01 00:00:00

abstract：:Invasion of the meninges is a relatively common complication of head and neck rhabdomyosarcoma (RMS), while RMS arising primarily within the brain or meninges is rare. We report the case of an 11-year old child with a primary "primitive" frontal lobe tumor, subsequent leptomeningeal spread and fatal intratumoral hemor...

journal_title：Journal of neuro-oncology

authors： Dropcho EJ,Allen JC

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in...

journal_title：Journal of neuro-oncology

authors： Ciesielski MJ,Bu Y,Munich SA,Teegarden P,Smolinski MP,Clements JL,Lau JYN,Hangauer DG,Fenstermaker RA

更新日期：2018-12-01 00:00:00

abstract：:Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary gliobla...

journal_title：Journal of neuro-oncology

authors： Hamisch C,Ruge M,Kellermann S,Kohl AC,Duval I,Goldbrunner R,Grau SJ

更新日期：2017-06-01 00:00:00

abstract：:Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...

journal_title：Journal of neuro-oncology

authors： Ross DA,Cetas JS

更新日期：2012-09-01 00:00:00

abstract：:Children with high-grade glioma (HGG) have a poor prognosis compared to those with low-grade glioma (LGG). Adjuvant chemotherapy may be beneficial, but its optimal use remains undetermined. Histology and extent of resection are important prognostic factors. We tested the hypothesis that patients with midline HGG treat...

journal_title：Journal of neuro-oncology

authors： Eisenstat DD,Pollack IF,Demers A,Sapp MV,Lambert P,Weisfeld-Adams JD,Burger PC,Gilles F,Davis RL,Packer R,Boyett JM,Finlay JL

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:A previous study confirmed that a novel splicing variant of large vascular endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in glioblastoma cells and specimens, but the actual biological function and clinical significance of L-VEGF144 remain unclear. METHODS:In this study...

journal_title：Journal of neuro-oncology

authors： Cheng WY,Shen CC,Chiao MT,Liang YJ,Mao TF,Liu BS,Chen JP

更新日期：2018-10-01 00:00:00

abstract：:This paper reviews the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT). A major advantage of an ABNS for BNCT over reactor-based neutron sources is the potential for siting withi...

journal_title：Journal of neuro-oncology

authors： Blue TE,Yanch JC

更新日期：2003-03-01 00:00:00

abstract：:In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation. Cepharanthine (CEP), a biscoclaurine-derived alkaloid, reportedly potentiates the effects of antitumor agents and induces apoptosis in some cancer cells. Here, we examined the effects of CEP, alone and in...

journal_title：Journal of neuro-oncology

authors： Kono K,Takahashi JA,Ueba T,Mori H,Hashimoto N,Fukumoto M

更新日期：2002-01-01 00:00:00

abstract：:Measurement of oxygen pressure (pO2) in tumor tissue is important, because pO2 is a major factor for radiosensitivity in malignant glioma treatment. We attempted to elucidate the changes in pO2 level in glioblastoma tissue of patients under various conditions. Eighteen patients with newly diagnosed glioblastoma were r...

journal_title：Journal of neuro-oncology

authors： Beppu T,Kamada K,Yoshida Y,Arai H,Ogasawara K,Ogawa A

更新日期：2002-05-01 00:00:00

abstract：:Systemic high-dose methotrexate (HD-MTX) is the most effective chemotherapeutic agent in the treatment of primary central nervous system lymphoma (PCNSL). Leptomeningeal involvement is common and intrathecal methotrexate (IT-MTX) is frequently used in combination with HD-MTX, but its benefits are not established. Usin...

journal_title：Journal of neuro-oncology

authors： Khan RB,Shi W,Thaler HT,DeAngelis LM,Abrey LE

更新日期：2002-06-01 00:00:00

abstract：:Activated epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target for a variety of solid tumors, particularly malignant gliomas. A recently discovered transmembrane glycoprotein, LRIG1, antagonizes the activity of epidermal growth factor receptor family receptor tyrosine kinases and acts...

journal_title：Journal of neuro-oncology

authors： Ye F,Gao Q,Xu T,Zeng L,Ou Y,Mao F,Wang H,He Y,Wang B,Yang Z,Guo D,Lei T

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

journal_title：Journal of neuro-oncology

authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:The poor results from treatment of high grade glioma prompted us to explore new protocols involving concurrent radio-chemotherapy. Our primary objective was to evaluate the feasibility of very early postoperative chemotherapy with BCNU, concurrent radio-chemotherapy with carboplatin and teniposide, and post-rad...

journal_title：Journal of neuro-oncology

authors： Brandes AA,Rigon A,Zampieri P,Scelzi E,Amistà P,Berti F,Rotilio A,Gardiman M,Fiorentino MV

更新日期：1996-12-01 00:00:00

abstract：:Macrophages play an important role in the regulation of malignant tumors. Although glioma contains abundance of macrophages, their role in apoptosis of glioma is not known. We stimulated macrophages with lipopolysaccharide and culture supernatants of activated macrophages were collected to treat glioma cells. The resu...

journal_title：Journal of neuro-oncology

authors： Chen GG,Chu YS,Chak EC,Leung BC,Poon WS

更新日期：2002-05-01 00:00:00

abstract：:There is general agreement that most chemotherapy agents achieve only relatively low concentrations in the normal central nervous system, that the blood-brain barrier is variably disrupted in malignant brain tumors, and that the concentration of chemotherapy drugs in the brain adjacent to tumor is intermediate between...

journal_title：Journal of neuro-oncology

authors： Stewart DJ

更新日期：1994-01-01 00:00:00

abstract：:The human glioma cell lines, U87 and T98G, were evaluated for their ability to survive and form colonies in an acidic environment of pH(ext) 6.0. In contrast to U87, which showed an 80-90% survival rate, only 40% of T98G cells survived 6 days at pH(ext) 6.0 and lost their colony forming ability when returned to a norm...

journal_title：Journal of neuro-oncology

authors： Schnier JB,Nishi K,Harley WR,Gorin FA

更新日期：2008-08-01 00:00:00

abstract：:Surgical resection is not the standard of care for primary central nervous system lymphoma (PCNSL), as historical studies have demonstrated unfavorable complication rates and limited benefits. Some recent studies suggest that resection may provide a therapeutic benefit, yet the safety of these procedures has not been ...

journal_title：Journal of neuro-oncology

authors： Cloney MB,Sonabend AM,Yun J,Yang J,Iwamoto F,Singh S,Bhagat G,Canoll P,Zanazzi G,Bruce JN,Sisti M,Sheth S,Connolly ES,McKhann G

更新日期：2017-03-01 00:00:00

abstract：:We report one year follow up of a case of extramedullary hematopoiesis within the clivus. The imaging findings, brief clinical course, and endoscopic transphenoidal approach are described. A 29-year-old female with thalassemia developed worsening cranial nerve signs. After imaging studies discovered a large clival mas...

journal_title：Journal of neuro-oncology

authors： Reames DL,Lindstrom K,Raghavan P,Jane J Jr

更新日期：2010-12-01 00:00:00

abstract：:Thermal stability signatures of complex molecule interaction in biological fluids can be measured using a new approach called differential scanning calorimetry (DSC). The thermal stability of plasma proteome has been described previously as a method of producing a disease-specific "signature," termed thermogram, in se...

journal_title：Journal of neuro-oncology

authors： Chagovetz AA,Jensen RL,Recht L,Glantz M,Chagovetz AM

更新日期：2011-12-01 00:00:00

abstract：:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI...

journal_title：Journal of neuro-oncology

authors： Korshunov A,Savostikova M,Ozerov S

更新日期：2002-07-01 00:00:00

abstract：:HDGF is overexpressed in gliomas as compared to normal brain. We therefore analyzed the molecular mechanisms of HDGF action in gliomas. HDGF was downregulated in normal brain tissue as compared to glioma specimens at both the mRNA and the protein levels. In glioma samples, increased HDGF expression was associated with...

journal_title：Journal of neuro-oncology

authors： Song Y,Hu Z,Long H,Peng Y,Zhang X,Que T,Zheng S,Li Z,Wang G,Yi L,Liu Z,Fang W,Qi S

更新日期：2014-09-01 00:00:00

abstract：:Glioma is the most common primary brain tumor in adults. Six3 is a human homologue of the highly conserved sine oculis gene family and essential transcription regulatory factor in process of eye and fetal forebrain development. However, little is known about the role of Six3 in human tumorigenesis. The aim of this stu...

journal_title：Journal of neuro-oncology

authors： Zhang B,Shen C,Ge F,Ma T,Zhang Z

更新日期：2017-07-01 00:00:00

abstract：:The use of radiotherapy alone to treat primary central nervous system lymphoma (PCNSL) does not produce the high local control and survival rates that it does in limited extranodal non-Hodgkin's lymphoma outside the central nervous system (CNS). Even with doses of whole brain radiation therapy (WBRT) to 40+20 Gy boost...

journal_title：Journal of neuro-oncology

authors： Nelson DF

更新日期：1999-07-01 00:00:00

abstract：:This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

journal_title：Journal of neuro-oncology

authors： Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

更新日期：2017-05-01 00:00:00

abstract：:Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration...

journal_title：Journal of neuro-oncology

authors： Nolen SC,Lee B,Shantharam S,Yu HJ,Su L,Billimek J,Bota DA

更新日期：2016-09-01 00:00:00

abstract：:To evaluate diagnostic accuracy of perfusion weighted imaging (PWI) and positron emission tomography (PET) using an integrated PET/MR system in tumor grading as well as in differentiating recurrent tumor from treatment-induced effects (TIE) in brain tumor patients. Twenty patients (Group A: treatment naïve, 9 patients...

journal_title：Journal of neuro-oncology

authors： Sacconi B,Raad RA,Lee J,Fine H,Kondziolka D,Golfinos JG,Babb JS,Jain R

更新日期：2016-04-01 00:00:00

abstract：:Proneural and mesenchymal are two subtypes of glioblastoma identified by gene expression profiling. In this study, the primary aim was to detect markers to develop a clinically applicable method for distinguishing proneural and mesenchymal glioblastoma. The secondary aims were to investigate the temporospatial dynamic...

journal_title：Journal of neuro-oncology

authors： Murata H,Yoshimoto K,Hatae R,Akagi Y,Mizoguchi M,Hata N,Kuga D,Nakamizo A,Amano T,Sayama T,Iihara K

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions. METHODS:A total of 75 pediatric patients with spinal tumor...

journal_title：Journal of neuro-oncology

authors： Chou SC,Kuo MF,Lai DM,Chen CM,Xiao F,Tsuang FY,Yang SH

更新日期：2020-02-01 00:00:00