High expression of a novel splicing variant of VEGF, L-VEGF144 in glioblastoma multiforme is associated with a poorer prognosis in bevacizumab treatment.

abstract：:We describe a 61-year-old man with a multiple neurologic complication of Merkel cell carcinoma, a rare skin cancer. An enhancing brain mass, and cytologically proven leptomeningeal disease produced a succession of symptoms including seizures, bilateral radiculopathies, myoclonus, a cauda equina syndrome and altered me...

journal_title：Journal of neuro-oncology

authors： Snodgrass SM,Landy H,Markoe AM,Feun L

更新日期：1994-01-01 00:00:00

abstract：OBJECT:There is little population-based data available on primary spinal cord tumors. Many of the existing statistics are not current or were obtained from surgical series. Historically, population-based data were collected only for malignant tumors, and only recently have data begun to be collected on non-malignant tu...

journal_title：Journal of neuro-oncology

authors： Schellinger KA,Propp JM,Villano JL,McCarthy BJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:We evaluated the outcomes after stereotactic radiosurgery (SRS) for patients who developed new or progressive brain disease regardless of whether they had no prior radiation, PCI, or WBRT. METHODS:We retrospectively identified 90 SCLC patients who had SRS between 1991 and 2018. Thirty-one patients had no evide...

journal_title：Journal of neuro-oncology

authors： Faramand A,Niranjan A,Kano H,Flickinger J,Lunsford LD

更新日期：2019-08-01 00:00:00

abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

journal_title：Journal of neuro-oncology

authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

更新日期：2018-05-01 00:00:00

abstract：:Meningiomas may display benign (Grade I), atypical (Grade II) and anaplastic (Grade III) histopathological findings. The cytogenetic studies strongly suggest that secondary changes (moreover loss of chromosome 22) appear to be associated with more atypical features and with greater clinical aggressivity. We studied 60...

journal_title：Journal of neuro-oncology

authors： Cerdá-Nicolás M,López-Gineś C,Pérez-Bacete M,Barcia-Salorio JL,Llombart-Bosch A

更新日期：2000-04-01 00:00:00

abstract：:To increase awareness about lymphomatosis cerebri by describing a patient with a unique presentation Case report a 58 year old woman presented with progressive lower extremity weakness, postural hypotension, and 90 pound weight loss over 3 months a brain magnetic resonance image revealed multiple non-enhancing foci of...

journal_title：Journal of neuro-oncology

authors： Keswani A,Bigio E,Grimm S

更新日期：2012-09-01 00:00:00

abstract：:HDGF is overexpressed in gliomas as compared to normal brain. We therefore analyzed the molecular mechanisms of HDGF action in gliomas. HDGF was downregulated in normal brain tissue as compared to glioma specimens at both the mRNA and the protein levels. In glioma samples, increased HDGF expression was associated with...

journal_title：Journal of neuro-oncology

authors： Song Y,Hu Z,Long H,Peng Y,Zhang X,Que T,Zheng S,Li Z,Wang G,Yi L,Liu Z,Fang W,Qi S

更新日期：2014-09-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：:Malignancy involving the skull base remains a formidable management challenge. Advances and refinements in diagnostic imaging, instrumentation, microvascular reconstruction, and an improved overall appreciation of the anatomy of the skullbase have extended the boundaries of tumor resectability and in some cases, obvia...

journal_title：Journal of neuro-oncology

authors： DeMonte F

更新日期：2004-08-01 00:00:00

abstract：:We conducted a phase II study to test methotrexate (5 g/m(2)), as a single agent prior to radiochemotherapy for pediatric high-grade glioma and diffuse intrinsic pontine glioma. Thirty patients (19 male, median age 10.8) were enrolled. Tumors were located as follows: cortex 10, pons 7, other 13. Tumor resection was cl...

journal_title：Journal of neuro-oncology

authors： Wolff JE,Kortmann RD,Wolff B,Pietsch T,Peters O,Schmid HJ,Rutkowski S,Warmuth-Metz M,Kramm C

更新日期：2011-05-01 00:00:00

abstract：:Since its description in 1982, central neurocytoma (CN) has been a relatively innocuous rare tumor of the central nervous system. Comprising of less than 0.5% of all intracranial tumors, most are reported to be slow growing, with low recurrence rates, and a favorable prognosis. Because of its rarity, its cellular biol...

journal_title：Journal of neuro-oncology

authors： Tran H,Medina-Flores R,Cerilli LA,Phelps J,Lee FC,Wong G,Turner P

更新日期：2010-11-01 00:00:00

abstract：:Proliferative activities were determined in 72 human brain tumors, including 20 metastatic carcinomas, 41 gliomas, 8 meningiomas and 3 hematological tumors. Immunocytochemical techniques included labeling with monoclonal antibody (mAb) to bromodeoxyuridine (BrdU) which identifies S phase cells after previous in vitro ...

journal_title：Journal of neuro-oncology

authors： Morimura T,Kitz K,Stein H,Budka H

更新日期：1991-02-01 00:00:00

abstract：:Leptomeningeal disease (LMD) is a highly aggressive and usually rapidly fatal condition. The purpose of this study is to identify clinical factors that can serve to predict for LMD at the time of stereotactic radiosurgery (SRS) for brain metastases from breast carcinoma. We conducted a retrospective review of patients...

journal_title：Journal of neuro-oncology

authors： Trifiletti DM,Romano KD,Xu Z,Reardon KA,Sheehan J

更新日期：2015-09-01 00:00:00

abstract：:Anti-Hu paraneoplastic syndromes are usually associated with an underlying neoplasia, although a few patients who are anti-Hu-positive never develop cancer after long-term follow-up. Tumour therapy remains the mainstay of therapeutic options, and early immune therapy in parallel is advisable. When no tumour is found, ...

journal_title：Journal of neuro-oncology

authors： Coret F,Bosca I,Fratalia L,Perez-Griera J,Pascual A,Casanova B

更新日期：2009-07-01 00:00:00

abstract：:NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...

journal_title：Journal of neuro-oncology

authors： Vranceanu AM,Merker VL,Plotkin SR,Park ER

更新日期：2014-10-01 00:00:00

abstract：:Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...

journal_title：Journal of neuro-oncology

authors： De Braganca KC,Janjigian YY,Azzoli CG,Kris MG,Pietanza MC,Nolan CP,Omuro AM,Holodny AI,Lassman AB

更新日期：2010-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and devastating form of primary central nervous system malignancy. The prognosis for patients diagnosed with GBM is poor, having a median survival rate of 12-15 months. Despite modern advances in the development of antineoplastic agents, the efficacy of newer anti-cance...

journal_title：Journal of neuro-oncology

authors： Gurley SN,Abidi AH,Allison P,Guan P,Duntsch C,Robertson JH,Kosanke SD,Keir ST,Bigner DD,Elberger AJ,Moore BM 2nd

更新日期：2012-11-01 00:00:00

abstract：:The purpose of our study was to explore the difference between isocitrate dehydrogenase (IDH)-1/2 gene mutation-positive and -negative high-grade gliomas (HGGs) using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. We enrolled 52 patients with histopathologi...

journal_title：Journal of neuro-oncology

authors： Lee S,Choi SH,Ryoo I,Yoon TJ,Kim TM,Lee SH,Park CK,Kim JH,Sohn CH,Park SH,Kim IH

更新日期：2015-01-01 00:00:00

abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

journal_title：Journal of neuro-oncology

authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:Recent advances in targeted therapy have prolonged overall survival (OS) for patients with lung cancer. The impact of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) on brain metastases (BM) treated with stereotactic radiosurgery (SRS) has not, however, been fully elucidated. We investiga...

journal_title：Journal of neuro-oncology

authors： Yomo S,Serizawa T,Yamamoto M,Higuchi Y,Sato Y,Shuto T,Akabane A,Jokura H,Kawagishi J,Aoyama H

更新日期：2019-10-01 00:00:00

abstract：:Intravascular lymphomatosis (IL) is a rare entity only recently included in lymphoma classification, whose main feature is the exclusive or predominant growth of neoplastic cells within blood vessels. The vast majority of the patients affected by IL belong to the 7th or 8th decade of life and present with skin rash or...

journal_title：Journal of neuro-oncology

authors： Massimino M,Giardini R,Cefalo G,Simonetti F,Pollo B,Giombini S,Tesoro-Tess JD,Ponzoni M,Patriarca C

更新日期：2001-01-01 00:00:00

abstract：:Proneural and mesenchymal are two subtypes of glioblastoma identified by gene expression profiling. In this study, the primary aim was to detect markers to develop a clinically applicable method for distinguishing proneural and mesenchymal glioblastoma. The secondary aims were to investigate the temporospatial dynamic...

journal_title：Journal of neuro-oncology

authors： Murata H,Yoshimoto K,Hatae R,Akagi Y,Mizoguchi M,Hata N,Kuga D,Nakamizo A,Amano T,Sayama T,Iihara K

更新日期：2015-10-01 00:00:00

abstract：:We report the case of a 58 year old woman with an epidermoid cyst of the right cerebello-pontine angle that was subtotally excised. She recurred 2 years later and received radiotherapy with resolution of symptoms and shrinkage of the cyst. The natural history of epidermoid cysts and the role of radiotherapy in their m...

journal_title：Journal of neuro-oncology

authors： Parikh S,Milosevic M,Wong CS,Laperriere N

更新日期：1995-01-01 00:00:00

abstract：:The relationship between coagulation cascade activation and glioma cell proliferation was examined. The human glioma cell lines T98G, TM-1 and normal human astrocyte cell strain (NHA) were examined. Using anti-tissue factor (TF) antibody, immunocytochemical detection of TF antigen was obtained in both cell lines and c...

journal_title：Journal of neuro-oncology

authors： Ogiichi T,Hirashima Y,Nakamura S,Endo S,Kurimoto M,Takaku A

更新日期：2000-01-01 00:00:00

abstract：:Recently, many studies have found that the miR-106b ~25 cluster plays an oncogenic role in tumor progression. However, the precise role of each microRNAs (miRNAs) in the cluster is not yet clear. In the present study, we examined the expression of miR-106b in glioma samples and a tissue microarray by real-time PCR and...

journal_title：Journal of neuro-oncology

authors： Zhang A,Hao J,Wang K,Huang Q,Yu K,Kang C,Wang G,Jia Z,Han L,Pu P

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Radiation necrosis is a well-known complication of radiotherapy for malignant brain tumors. Although surgery was once considered the mainstay of treatment, no recent reports have evaluated the use of intraoperative magnetic resonance imaging (IOMRI) and frameless stereotaxis during surgical resection of radia...

journal_title：Journal of neuro-oncology

authors： McPherson CM,Warnick RE

更新日期：2004-05-01 00:00:00

abstract：:The value of perfusion and diffusion-weighted MRI in differentiating histological subtypes according to the 2007 WHO glioma classification scheme (i.e. astrocytoma vs. oligodendroglioma) and genetic subtypes according to the 2016 WHO reclassification (e.g. 1p/19q co-deletion and IDH1 mutation status) in WHO grade II a...

journal_title：Journal of neuro-oncology

authors： Leu K,Ott GA,Lai A,Nghiemphu PL,Pope WB,Yong WH,Liau LM,Cloughesy TF,Ellingson BM

更新日期：2017-08-01 00:00:00

abstract：:The leucine-rich repeats and immunoglobulin-like domains (LRIG) protein family is comprised of three integral membrane proteins: LRIG1, LRIG2, and LRIG3. LRIG1 is a negative regulator of growth factor signaling. The expression and subcellular localization of LRIG proteins have prognostic implications in primary brain ...

journal_title：Journal of neuro-oncology

authors： Ghasimi S,Haapasalo H,Eray M,Korhonen K,Brännström T,Hedman H,Andersson U

更新日期：2012-07-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

journal_title：Journal of neuro-oncology

authors： Raychaudhuri B,Vogelbaum MA

更新日期：2011-01-01 00:00:00

abstract：:Gamma Knife surgery (GKS) has emerged as a valuable adjuvant treatment modality for recurrent or residual craniopharyngioma. However, prognostic factors pertaining to progression-free survival (PFS) remain poorly understood. A study was conducted to address this issue. A total of 37 consecutive patients undergoing 39 ...

journal_title：Journal of neuro-oncology

authors： Xu Z,Yen CP,Schlesinger D,Sheehan J

更新日期：2011-08-01 00:00:00