Histopathological and cytogenetic findings in benign, atypical and anaplastic human meningiomas: a study of 60 tumors.

abstract：INTRODUCTION:Brain tumors make up over a quarter of pediatric malignancies. Depending on the age of presentation and treatment, pediatric brain tumor survivors experience varying degrees of treatment induced morbidity and sequelae. Epigenetic mechanisms play a critical role in silencing of tumor suppressor genes and ac...

journal_title：Journal of neuro-oncology

authors： Bhattacharya D,Pomeroy SL,Pomeranz Krummel DA,Sengupta S

更新日期：2020-10-01 00:00:00

abstract：:Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridizati...

journal_title：Journal of neuro-oncology

authors： Min HS,Kim B,Park SH

更新日期：2008-12-01 00:00:00

abstract：OBJECT:Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported. METHODS:Eighty-three cases of subependymoma were retrieved from the files of the Armed Forces Institute of Pathology. Clinicopatholo...

journal_title：Journal of neuro-oncology

authors： Rushing EJ,Cooper PB,Quezado M,Begnami M,Crespo A,Smirniotopoulos JG,Ecklund J,Olsen C,Santi M

更新日期：2007-12-01 00:00:00

abstract：:Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

journal_title：Journal of neuro-oncology

authors： Nahreini P,Andreatta C,Hanson A,Prasad KN

更新日期：2003-05-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：:Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...

journal_title：Journal of neuro-oncology

authors： Fillmore HL,VanMeter TE,Broaddus WC

更新日期：2001-06-01 00:00:00

abstract：:Extensive surgical resection of centrally localized, newly diagnosed glioblastoma can lead to opening ventricles and therefore carries a potential risk of spreading tumor cells into the cebrospinal fluid. However, whether ventricle opening consequently implies a greater frequency of distant tumor recurrence after radi...

journal_title：Journal of neuro-oncology

authors： Adeberg S,Diehl C,Jung CS,Rieken S,Combs SE,Unterberg A,Debus J

更新日期：2016-05-01 00:00:00

abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：:Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

journal_title：Journal of neuro-oncology

authors： Allen J,Wisoff J,Helson L,Pearce J,Arenson E

更新日期：1992-01-01 00:00:00

abstract：:Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in t...

journal_title：Journal of neuro-oncology

authors： Phillips CL,Miles L,Jones BV,Sutton M,Crone K,Fouladi M

更新日期：2011-07-01 00:00:00

abstract：:This paper reviews the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT). A major advantage of an ABNS for BNCT over reactor-based neutron sources is the potential for siting withi...

journal_title：Journal of neuro-oncology

authors： Blue TE,Yanch JC

更新日期：2003-03-01 00:00:00

abstract：:After chromosome 22 and NF2 inactivation, the loss of chromosome 1p is one of the most frequent abnormalities encountered in meningiomas. However the putative tumor suppressor gene located on 1p inactivated in meningiomas has still to be identified. We screened 68 meningiomas for LOH on chromosome 22 and 1. We found 3...

journal_title：Journal of neuro-oncology

authors： Leuraud P,Marie Y,Robin E,Huguet S,He J,Mokhtari K,Cornu P,Hoang-Xuan K,Sanson M

更新日期：2000-12-01 00:00:00

abstract：:The current study reports longitudinal coping responses among parents of children diagnosed with an embryonal brain tumor. Patients (n = 219) were enrolled on a treatment protocol for a pediatric embryonal brain tumor. Their parents (n = 251) completed the Coping Response Inventory at time of their child's diagnosis a...

journal_title：Journal of neuro-oncology

authors： Palmer SL,Lesh S,Wallace D,Bonner MJ,Swain M,Chapieski L,Janzen L,Mabbott D,Knight S,Boyle R,Armstrong CL,Gajjar A

更新日期：2011-11-01 00:00:00

abstract：:A case of a functioning invasive pituitary oncocytoma in a 50-year-old man is reported. The serum prolactin was increased and immunocytochemical staining was positive for prolactin. In addition to numerous mitochondria within the neoplastic cells, structurally abnormal mitochondria with crystalline inclusions were als...

journal_title：Journal of neuro-oncology

authors： Chowdhury C,Roy S,Gupta N,Kochupillai N,Banerji AK

更新日期：1986-01-01 00:00:00

abstract：:Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...

journal_title：Journal of neuro-oncology

authors： Bleeker FE,Molenaar RJ,Leenstra S

更新日期：2012-05-01 00:00:00

abstract：:From 1974 to 1992, 63 patients diagnosed with low-grade pure or mixed oligo-astrocytoma were seen and treated at our institution. All patients underwent CT scan pre-operatively. There were 20 female and 43 males ranging in age from 12 to 73 years (median age of 33 years). 15 patients had a stereotactic biopsy as the o...

journal_title：Journal of neuro-oncology

authors： Bahary JP,Villemure JG,Choi S,Leblanc R,Olivier A,Bertrand G,Souhami L,Tampieri D,Hazel J

更新日期：1996-02-01 00:00:00

abstract：:Boron neutron capture therapy (BNCT) is an experimental form of radiation therapy for malignant brain tumors and peripheral melanoma. The micro-distribution of the boron compound is critical to determine the radiation effects for both tumors and normal tissue. In the current dose calculation of BNCT, normal brain tiss...

journal_title：Journal of neuro-oncology

authors： Shibata Y

更新日期：2008-03-01 00:00:00

abstract：:To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All received systemic or intrathecal chemotherapy and six received additional cranial or spinal radiotherapy. Six patient...

journal_title：Journal of neuro-oncology

authors： Pradat PF,Hoang-Xuan K,Cornu P,Mokhtari K,Martin-Duverneuil N,Poisson M,Delattre JY

更新日期：1999-09-01 00:00:00

abstract：:The mainstays of primary treatment of ependymoma are aggressive surgery followed by radiotherapy. Although spreading occasionally occurs in the cerebrospinal pathways, chemotherapy is still not established and no ultimate drug has so far been found. Estramustine-phosphate (EMP), with a demonstrated effect on astrocyto...

journal_title：Journal of neuro-oncology

authors： Bergenheim AT,Hartman M,Bergh J,Ridderheim PA,Henriksson R

更新日期：1994-01-01 00:00:00

abstract：:We describe a 61-year-old man with a multiple neurologic complication of Merkel cell carcinoma, a rare skin cancer. An enhancing brain mass, and cytologically proven leptomeningeal disease produced a succession of symptoms including seizures, bilateral radiculopathies, myoclonus, a cauda equina syndrome and altered me...

journal_title：Journal of neuro-oncology

authors： Snodgrass SM,Landy H,Markoe AM,Feun L

更新日期：1994-01-01 00:00:00

abstract：:A 9-day-old female presented with a large infra- and supratentorial medulloblastoma was treated by surgery, irradiation and chemotherapy. The infant suffered from vomit a few days after birth. She was hospitalized shortly thereafter, when head enlargement was noted. A CT scan taken on admission disclosed a large mass ...

journal_title：Journal of neuro-oncology

authors： Kayama T,Yoshimoto T,Shimizu H,Sakurai Y

更新日期：1993-02-01 00:00:00

abstract：:We report a case of high risk medulloblastoma with leptomeningeal intracranial and spinal metastasis in a 10-year-old girl treated successfully with conventional prolonged chemotherapy without radiotherapy. This is a particular case of medulloblastoma that at onset did not receive standard therapy for medulloblastoma ...

journal_title：Journal of neuro-oncology

authors： Schiavetti A,Varrasso G,Maurizi P,Trasimeni G,Carapella C,Castello MA

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:The field of neurosurgery has witnessed a dramatic increase in the use of stereotactic radiosurgery (SRS) as a modality to treat various cranial and spinal pathologies. However, studies have consistently demonstrated disparities in SRS training. Accordingly, the present study represents a cross-sectional a...

journal_title：Journal of neuro-oncology

authors： Samuel N,Trifiletti DM,Quinones-Hinojosa A,Lunsford LD,Sheehan J

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Malignant peripheral nerve sheath tumors (MPNSTs) are rare tumors, generally high-grade, and comprise ~ 5-10% of soft tissue sarcomas. Over two-thirds of MPNSTs metastasize, and upwards of 40% clinically recur. Etiologic risk factors for MPNSTs are historically understudied. There is evidence to suggest MPNS...

journal_title：Journal of neuro-oncology

authors： Peckham-Gregory EC,Montenegro RE,Stevenson DA,Viskochil DH,Scheurer ME,Lupo PJ,Schiffman JD

更新日期：2018-08-01 00:00:00

abstract：:The microvasculature of brain tumors has been proposed as the primary target for ionizing radiation (IR)-induced apoptosis. However, the contribution of low dose IR-induced non-apoptotic cell death pathways has not been investigated. This study aimed to characterize the effect of IR on human brain microvascular endoth...

journal_title：Journal of neuro-oncology

authors： McLaughlin N,Annabi B,Lachambre MP,Kim KS,Bahary JP,Moumdjian R,Béliveau R

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Ferumoxtran-10 belongs to the Ultra Small Particles of Iron Oxide (USPIO) class of contrast agents and induces delayed tumor enhancement in brain tumors, reflecting the trapping of iron oxide particles by the macrophages and activated microglia. The aim of the study was to compare Ferumoxtran-10 contrast enhanc...

journal_title：Journal of neuro-oncology

authors： Kremer S,Pinel S,Védrine PO,Bressenot A,Robert P,Bracard S,Plénat F

更新日期：2007-06-01 00:00:00

abstract：:The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic cleavage. ETs exert their biological effects through the activation of two receptors sub...

journal_title：Journal of neuro-oncology

authors： Paolillo M,Barbieri A,Zanassi P,Schinelli S

更新日期：2006-08-01 00:00:00

abstract：:Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults. Vestibular schwannomas are the most common, followed by meningiomas. Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors. We describe a pilocyti...

journal_title：Journal of neuro-oncology

authors： Francesco F,Maurizio I,Stefano C,Marina S,Ugo S,Massimo S

更新日期：2010-04-01 00:00:00

abstract：:Using the novel tissue microarray technique, we studied immunohistochemical expression of cell cycle regulators p53, p21, pRb in 42 grade II oligodendrogliomas, 16 grade III anaplastic oligodendrogliomas, 10 primary and 4 recidive grade II oligoastrocytomas, 10 grade III oligoastrocytomas and 2 other grade II mixed gl...

journal_title：Journal of neuro-oncology

authors： Miettinen HE,Paunu N,Rantala I,Kalimo H,Paljärvi L,Helin H,Haapasalo H

更新日期：2001-10-01 00:00:00