Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity.

abstract：:Anaplastic ganglioglioma (AGG) are rare central nervous system tumours. Patient and treatment factors associated with outcome are poorly defined and limited to small retrospective case series and single case reports. Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated potentia...

journal_title：Journal of neuro-oncology

authors： Selvanathan SK,Hammouche S,Salminen HJ,Jenkinson MD

更新日期：2011-12-01 00:00:00

abstract：:During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous do...

journal_title：Journal of neuro-oncology

authors： Yano H,Nakayama N,Ohe N,Miwa K,Shinoda J,Iwama T

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The purpose of our study was to determine the statistical significance of thresholds of relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC) and ADC ratios in grading cerebral gliomas. MATERIALS AND METHODS:In this retrospective study, 51 patients with histopathologically confirmed prima...

journal_title：Journal of neuro-oncology

authors： Arvinda HR,Kesavadas C,Sarma PS,Thomas B,Radhakrishnan VV,Gupta AK,Kapilamoorthy TR,Nair S

更新日期：2009-08-01 00:00:00

abstract：:There are two errors and one omission in the original article. Author Gottardo's correct name is Nicholas G. Gottardo, author Hulleman's correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements should include the following sentence: "We would like to thank Dr Angel Montero Carcaboso (Hospital Sant Joan...

journal_title：Journal of neuro-oncology

authors： Tsoli M,Shen H,Mayoh C,Franshaw L,Ehteda A,Upton D,Carvalho D,Vinci M,Meel MH,van Vuurden D,Plessier A,Castel D,Drissi R,Farrell M,Cryan J,Crimmins D,Caird J,Pears J,Francis S,Ludlow LEA,Carai A,Mastronuzzi A,

更新日期：2019-01-01 00:00:00

abstract：:A phase I study was conducted to evaluate the dose-limiting toxicities (DLTs) and to determine the maximum tolerated dose (MTD)/recommended phase II dose of bendamustine with concurrent whole brain radiation (WBR) in patients with brain metastases (BM) from solid tumors. Four doses of intravenous weekly bendamustine w...

journal_title：Journal of neuro-oncology

authors： Pan E,Yu D,Zhao X,Neuger A,Smith P,Chinnaiyan P,Yu HH

更新日期：2014-09-01 00:00:00

abstract：:We describe a 61-year-old man with a multiple neurologic complication of Merkel cell carcinoma, a rare skin cancer. An enhancing brain mass, and cytologically proven leptomeningeal disease produced a succession of symptoms including seizures, bilateral radiculopathies, myoclonus, a cauda equina syndrome and altered me...

journal_title：Journal of neuro-oncology

authors： Snodgrass SM,Landy H,Markoe AM,Feun L

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Under-enrollment in clinical trials significantly limits valid analyses of clinical interventions and generalizability of findings. Often it results in premature study termination, with estimates of 22% to 50% of clinical trials terminated due to poor accrual. Currently, there are limited reports addressing the...

journal_title：Journal of neuro-oncology

authors： Morshed RA,Reihl SJ,Molinaro AM,Kakaizada S,Young JS,Schulte JD,Butowski N,Taylor J,Bush NA,Aghi MK,Berger MS,Chang S,Clarke J,Hervey-Jumper SL

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:To evaluate the prognostic value of the Glasgow Prognostic Score (GPS), the combination of C-reactive protein (CRP) and albumin, in glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (GPS). METHODS:Data of newly diagnosed GBM patients treated wi...

journal_title：Journal of neuro-oncology

authors： Topkan E,Selek U,Ozdemir Y,Yildirim BA,Guler OC,Ciner F,Mertsoylu H,Tufan K

更新日期：2018-09-01 00:00:00

abstract：:Patients with brain metastasis (BM) from renal cell carcinoma (RCC) are associated with poor prognosis. Between 1990 and 2015, data of consecutive RCC patients with BM were retrospectively analyzed from a urologic oncologic database. The treatment outcome was evaluated by overall survival (OS), which was defined as in...

journal_title：Journal of neuro-oncology

authors： Du Y,Pahernik S,Hadaschik B,Teber D,Duensing S,Jäger D,Hohenfellner M,Grüllich C

更新日期：2016-10-01 00:00:00

abstract：:To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution fr...

journal_title：Journal of neuro-oncology

authors： Kim JM,Miller JA,Kotecha R,Xiao R,Juloori A,Ward MC,Ahluwalia MS,Mohammadi AM,Peereboom DM,Murphy ES,Suh JH,Barnett GH,Vogelbaum MA,Angelov L,Stevens GH,Chao ST

更新日期：2017-06-01 00:00:00

abstract：:Primary germinomas in the spinal cord are very rare with only 15 cases published previously. In this case a 22-year-old woman with urinary incontinence, lumbago, and bilateral leg pain and weakness was found to have a solid tumor in the conus medullaris between the L1 and L2 vertebral bodies. Serum HCG was elevated wi...

journal_title：Journal of neuro-oncology

authors： Takahashi M,Koyama H,Matsubara T,Murata H,Miura K,Nagano A

更新日期：2006-01-01 00:00:00

abstract：:Measurement of oxygen pressure (pO2) in tumor tissue is important, because pO2 is a major factor for radiosensitivity in malignant glioma treatment. We attempted to elucidate the changes in pO2 level in glioblastoma tissue of patients under various conditions. Eighteen patients with newly diagnosed glioblastoma were r...

journal_title：Journal of neuro-oncology

authors： Beppu T,Kamada K,Yoshida Y,Arai H,Ogasawara K,Ogawa A

更新日期：2002-05-01 00:00:00

abstract：INTRODUCTION:This study evaluated an association between whole brain volume loss and neurocognitive decline following prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC). METHODS:This was a secondary analysis of a prospective clinical trial that accrued patients at a single instituti...

journal_title：Journal of neuro-oncology

authors： Gui C,Chintalapati N,Hales RK,Voong KR,Sair HI,Grimm J,Duhon M,Kleinberg LR,Vannorsdall TD,Redmond KJ

更新日期：2019-09-01 00:00:00

abstract：:The records of 14 patients with a tumour in the pineal or supra-sellar region seen at The Norwegian Radium Hospital, Oslo between 1973-1980 have been studied retrospectively. The problems with a widely accepted classification are discussed, as well as the choice of treatment (surgery versus radiation) and the indicati...

journal_title：Journal of neuro-oncology

authors： Watne K

更新日期：1986-01-01 00:00:00

abstract：:In sporadic schwannomas, inactivation of both copies of the NF2 tumor suppressor gene on 22q is common. Constitutional mutations of SMARCB1 are responsible of schwannomatosis, an inherited tumor predisposition syndrome, characterized by the development of multiple schwannomas. We analysed the frequency of copy number ...

journal_title：Journal of neuro-oncology

authors： Paganini I,Capone GL,Vitte J,Sestini R,Putignano AL,Giovannini M,Papi L

更新日期：2018-03-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Therapeutic intervention at glioblastoma (GBM) progression, as defined by current assessment criteria, is arguably too late as second-line therapies fail to extend survival. Still, most GBM trials target recurrent disease. We propose integration of a novel imaging biomarker to more confidently and promptly defi...

journal_title：Journal of neuro-oncology

authors： Gatson NTN,Bross SP,Odia Y,Mongelluzzo GJ,Hu Y,Lockard L,Manikowski JJ,Mahadevan A,Kazmi SAJ,Lacroix M,Conger AR,Vadakara J,Nayak L,Chi TL,Mehta MP,Puduvalli VK

更新日期：2020-07-01 00:00:00

abstract：:A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice develop choroid ple...

journal_title：Journal of neuro-oncology

authors： Patrick TA,Kranz DM,van Dyke TA,Roy EJ

更新日期：1997-04-01 00:00:00

abstract：:Injection of dendritic cells (DC) pulsed with tumor antigens is a novel treatment strategy against malignancies, and aims to elicit anti-tumoral cell-mediated immune responses. We studied the in vitro proliferative responses and cytokine production in T cell cultures after 2 stimulations with autologous DC loaded with...

journal_title：Journal of neuro-oncology

authors： De Vleeschouwer S,Spencer Lopes I,Ceuppens JL,Van Gool SW

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:To study the metabolic effects in vivo of L-2, 4 diaminobutyric acid (DAB) administered by retrograde microdialysis in glioblastoma and to evaluate the feasibility of the technique. METHODS:In 10 patients with glioblastoma, a stereotactic biopsy was performed followed by implantation of microdialysis cathet...

journal_title：Journal of neuro-oncology

authors： Bergenheim AT,Roslin M,Ungerstedt U,Waldenström A,Henriksson R,Ronquist G

更新日期：2006-12-01 00:00:00

abstract：:The anti-Hu syndrome is the most common paraneoplastic neurologic syndrome but the exact mechanism of immune mediated neuronal injury remains unknown. Anti-Hu antibodies do not appear to play a pivotal role in the pathogenesis of the disease. To assess cell-mediated immunity, we selected 51 peptides from the Hu-D sequ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Benyahia B,Dalmau J,Connan F,Guillet JG,Delattre JY,Choppin J

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:To evaluate the hypothesis that adults with partially resected (PR<50% resection) supratentorial low-grade glioma (LGG) benefit from higher doses of radiation. METHODS:Patients receiving post-operative radiation for WHO grade I-II LGG at the University of Western Ontario between 1979 and 2001 were studied. Pat...

journal_title：Journal of neuro-oncology

authors： Leighton C,Fisher B,Macdonald D,Stitt L,Bauman G,Cairncross J

更新日期：2007-04-01 00:00:00

abstract：:Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...

journal_title：Journal of neuro-oncology

authors： Jennings MT,Asadourian LL,Jennings VD,Shapiro JR,Thaler HT

更新日期：1990-12-01 00:00:00

abstract：:We conducted a phase II study to test methotrexate (5 g/m(2)), as a single agent prior to radiochemotherapy for pediatric high-grade glioma and diffuse intrinsic pontine glioma. Thirty patients (19 male, median age 10.8) were enrolled. Tumors were located as follows: cortex 10, pons 7, other 13. Tumor resection was cl...

journal_title：Journal of neuro-oncology

authors： Wolff JE,Kortmann RD,Wolff B,Pietsch T,Peters O,Schmid HJ,Rutkowski S,Warmuth-Metz M,Kramm C

更新日期：2011-05-01 00:00:00

abstract：:Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary gliobla...

journal_title：Journal of neuro-oncology

authors： Hamisch C,Ruge M,Kellermann S,Kohl AC,Duval I,Goldbrunner R,Grau SJ

更新日期：2017-06-01 00:00:00

abstract：:We have established a new xenogeneic animal model of leptomeningeal metastasis (LM) by intracisternal inoculation of human CEM T-cell lymphoma into nude rats, and used it to evaluate the anti-lymphoma efficacy of an anti-CD7 ricin A chain immunotoxin (DA7). In vitro incubation with 2 microg/ml DA7 for 72 h inhibited C...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Schmidberger H,Buchholz R,Wehrmann M,Vallera DA,Schabet M

更新日期：1998-10-01 00:00:00

abstract：:Although stereotactic radiosurgery (SRS) is an effective treatment option for patients with brain tumors, its increased use has raised concern for increased incidence of radiation necrosis (RN). No established standard or guidelines exists regarding non-invasive techniques to diagnose or treat RN. This study was condu...

journal_title：Journal of neuro-oncology

authors： Stockham AL,Ahluwalia M,Reddy CA,Suh JH,Kumar A,Vogelbaum MA,Barnett GH,Murphy ES,Chao ST

更新日期：2013-12-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumors (AT/RTs) are rare, malignant brain tumors which occur almost exclusively in infants and young children. There have been only 17 cases of AT/RT in adults reported in the medical literature and the rarity of this tumor makes the diagnosis in adults difficult. We describe a case of an AT...

journal_title：Journal of neuro-oncology

authors： Zarovnaya EL,Pallatroni HF,Hug EB,Ball PA,Cromwell LD,Pipas JM,Fadul CE,Meyer LP,Park JP,Biegel JA,Perry A,Rhodes CH

更新日期：2007-08-01 00:00:00

abstract：:SF188/V+ is a highly vascular human glioma model that is based on transfection of vascular endothelial growth factor (VEGF) cDNA into SF188/V- cells. This study aims to assess its growth and vascularity properties in vivo in a rat model. Thirty-two adult rats were inoculated with SF188/V+ tumor cells, and, for compari...

journal_title：Journal of neuro-oncology

authors： Grossman R,Tyler B,Brem H,Eberhart CG,Wang S,Fu DX,Wen Z,Zhou J

更新日期：2012-12-01 00:00:00

abstract：:O(6)-methylguanine-DNA-methyltransferase (MGMT) is mainly regulated by cytosine-guanine island promoter methylation that is believed to occur only in neoplastic tissue. The present study was undertaken to investigate whether methylation occurs also in non-neoplastic brains by collecting 45 non-neoplastic brains from a...

journal_title：Journal of neuro-oncology

authors： Hsu CY,Ho HL,Chang-Chien YC,Chang YW,Ho DM

更新日期：2015-02-01 00:00:00