Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma.


:There are two errors and one omission in the original article. Author Gottardo's correct name is Nicholas G. Gottardo, author Hulleman's correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements should include the following sentence: "We would like to thank Dr Angel Montero Carcaboso (Hospital Sant Joan de Deu, Barcelona, Spain) for generously supplying the HSJD-DIPG007 cells."


J Neurooncol


Tsoli M,Shen H,Mayoh C,Franshaw L,Ehteda A,Upton D,Carvalho D,Vinci M,Meel MH,van Vuurden D,Plessier A,Castel D,Drissi R,Farrell M,Cryan J,Crimmins D,Caird J,Pears J,Francis S,Ludlow LEA,Carai A,Mastronuzzi A,




Has Abstract


2019-01-01 00:00:00














  • Signal transduction molecules in gliomas of all grades.

    abstract:PURPOSE:To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV g...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Ermoian RP,Kaprealian T,Lamborn KR,Yang X,Jelluma N,Arvold ND,Zeidman R,Berger MS,Stokoe D,Haas-Kogan DA

    更新日期:2009-01-01 00:00:00

  • Pediatric neuro-oncology survival disparities in California.

    abstract::The objective of this study was to investigate racial/ethnic differences in survival for pediatric high-grade glioma (HGG) and medulloblastoma in the state of California. We obtained data from the California Cancer Registry on 552 high-grade glioma patients (110 brainstem, 442 non-brainstem) and 648 medulloblastoma pa...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Cooney T,Fisher PG,Tao L,Clarke CA,Partap S

    更新日期:2018-05-01 00:00:00

  • Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. II. Cytokine production and in vivo efficacy of glioma-sensitized lymphocytes.

    abstract::We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cells into each hind foot pad. After 10 days, the tumor-draining lymph n...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rice CD,Baldwin NG,Biron RT,Bear HD,Merchant RE

    更新日期:1997-03-01 00:00:00

  • Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children.

    abstract::Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Allen J,Wisoff J,Helson L,Pearce J,Arenson E

    更新日期:1992-01-01 00:00:00

  • Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.

    abstract::Glioblastoma multiforme (GBM) is the most common and devastating form of primary central nervous system malignancy. The prognosis for patients diagnosed with GBM is poor, having a median survival rate of 12-15 months. Despite modern advances in the development of antineoplastic agents, the efficacy of newer anti-cance...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Gurley SN,Abidi AH,Allison P,Guan P,Duntsch C,Robertson JH,Kosanke SD,Keir ST,Bigner DD,Elberger AJ,Moore BM 2nd

    更新日期:2012-11-01 00:00:00

  • Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma.

    abstract:PURPOSE:Prediction of clinical outcomes in patients with primary central nervous system lymphoma (PCNSL) is important for optimization of treatment planning. Quantitative imaging biomarkers for PCNSL have not yet been established. This study evaluated the prognostic value of pretreatment dynamic contrast-enhanced MRI a...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Hatzoglou V,Oh JH,Buck O,Lin X,Lee M,Shukla-Dave A,Young RJ,Peck KK,Vachha B,Holodny AI,Grommes C

    更新日期:2018-11-01 00:00:00

  • Adenoviral (full-length) Apo2L/TRAIL gene transfer is an ineffective treatment strategy for malignant glioma.

    abstract::Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Naumann U,Waltereit R,Schulz JB,Weller M

    更新日期:2003-01-01 00:00:00

  • Efficacy and safety of bevacizumab in active brain metastases from non-small cell lung cancer.

    abstract::Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: De Braganca KC,Janjigian YY,Azzoli CG,Kris MG,Pietanza MC,Nolan CP,Omuro AM,Holodny AI,Lassman AB

    更新日期:2010-12-01 00:00:00

  • Gliomatosis cerebri: clinical characteristics, management, and outcomes.

    abstract::Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

    更新日期:2013-04-01 00:00:00

  • A phase II study of nimustine hydrochloride, cisplatin, and etoposide combination chemotherapy for supratentorial malignant gliomas.

    abstract::Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial malignant gliomas received a combination of nimustine hydrochloride; 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), cisplatin and etoposide (ACE ...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Beppu T,Yoshida Y,Arai H,Wada T,Suzuki M,Ogawa A,Hakozaki S,Kubo N

    更新日期:2000-09-01 00:00:00

  • Gene therapeutic approach to primary and metastatic brain tumors: I. CD44 variant pre-RNA alternative splicing as a CEPT control element.

    abstract::Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant (CD44v) isoforms. Based on clear differences in the expression of these CD44v isoforms between normal and malignant tissues, we believe that eluci...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Asman DC,Dirks JF,Ge L,Resnick NM,Salvucci LA,Gau JT,Becich MJ,Cooper DL,Dougherty GJ

    更新日期:1995-12-01 00:00:00

  • Evolution of a gene therapy clinical trial. From bench to bedside and back.

    abstract::Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Aguilar LK,Aguilar-Cordova E

    更新日期:2003-12-01 00:00:00

  • Predictive model for recovery of visual field after surgery of pituitary adenoma.

    abstract::Visual field defect is a major indication for surgery of pituitary adenoma, but visual outcome after surgery is difficult to predict. We developed a nomogram that predicts postoperative restoration of visual field defects in patients with pituitary adenoma. This study was a retrospective cohort investigation of patien...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Lee J,Kim SW,Kim DW,Shin JY,Choi M,Oh MC,Kim SM,Kim EH,Kim SH,Byeon SH

    更新日期:2016-10-01 00:00:00

  • Acromegaly: historical perspectives and current therapy.

    abstract::Soon after the initial description of acromegaly in the late 19th century, neurosurgeons performed the first operative procedures for the disease. Transcranial procedures eventually yielded to the transsphenoidal approach. Reasonably effective medical therapy was introduced in the 1970s and pharmacological progress co...

    journal_title:Journal of neuro-oncology

    pub_type: 历史文章,杂志文章,评审


    authors: Jane JA Jr,Thapar K,Laws ER Jr

    更新日期:2001-09-01 00:00:00

  • Imaging techniques in neoplastic meningiosis.

    abstract::Since the introduction of CT and MRI as diagnostic aids, it has been possible to obtain direct images of neoplastic meningiosis. After more than ten years experience, the combination of MRI with the administration of a paramagnetic contrast medium is now accepted as the method of choice for the sensitive detection of ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Schumacher M,Orszagh M

    更新日期:1998-06-01 00:00:00

  • Report of GBM metastasis to the parotid gland.

    abstract::Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...

    journal_title:Journal of neuro-oncology

    pub_type: 信件


    authors: Ogungbo BI,Perry RH,Bozzino J,Mahadeva D

    更新日期:2005-09-01 00:00:00

  • Primary intracranial rhabdomyosarcoma: case report and review of the literature.

    abstract::Invasion of the meninges is a relatively common complication of head and neck rhabdomyosarcoma (RMS), while RMS arising primarily within the brain or meninges is rare. We report the case of an 11-year old child with a primary "primitive" frontal lobe tumor, subsequent leptomeningeal spread and fatal intratumoral hemor...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Dropcho EJ,Allen JC

    更新日期:1987-01-01 00:00:00

  • Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.

    abstract::Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. The aim of this study is to ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Minniti G,Salvati M,Arcella A,Buttarelli F,D'Elia A,Lanzetta G,Esposito V,Scarpino S,Maurizi Enrici R,Giangaspero F

    更新日期:2011-04-01 00:00:00

  • Intradural clival chordoma: a rare pathological entity.

    abstract::Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

    更新日期:2010-01-01 00:00:00

  • Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma.

    abstract::Optimal treatment of anaplastic oligodendroglial tumors (AOT) in elderly patients is debatable. We report a retrospective study of 44 consecutive patients aged 70 years or older [median age: 74 years; median Karnofsky performance status (KPS): 70] treated with up-front chemotherapy using temozolomide (TMZ) at conventi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Ducray F,del Rio MS,Carpentier C,Psimaras D,Idbaih A,Dehais C,Kaloshi G,Mokhtari K,Taillibert S,Laigle-Donadey F,Omuro A,Sanson M,Delattre JY,Hoang-Xuan K

    更新日期:2011-02-01 00:00:00

  • Pencil beam scanning proton therapy for pediatric intracranial ependymoma.

    abstract::To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

    更新日期:2016-05-01 00:00:00

  • Histologic evidence of a radiosensitizing effect of Taxol in patients with astrocytomas.

    abstract::The new anticancer agent Taxol appears to potentiate the effects of radiation on brain tumor cell lines in vitro and was recently evaluated by our group as a radiosensitizer in a phase I study for primary brain tumors. In that study, we administered Taxol as a three-hour IV infusion repeated every week for six weeks a...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Wehbe T,Glantz M,Choy H,Glantz L,Cortez S,Akerley W 3rd,Mills P,Cole B

    更新日期:1998-09-01 00:00:00

  • Glioblastoma stem cells and stem cell-targeting immunotherapies.

    abstract::Advancements in immunotherapeutics promise new possibilities for the creation of glioblastoma (GBM) treatment options. Ongoing work in cancer stem cell biology has progressively elucidated the role of this tumor sub-population in oncogenesis and has distinguished them as prime therapeutic targets. Current clinical tri...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Esparza R,Azad TD,Feroze AH,Mitra SS,Cheshier SH

    更新日期:2015-07-01 00:00:00

  • Shining light on neurosurgery diagnostics using Raman spectroscopy.

    abstract::Surgical excision of brain tumors provides a means of cytoreduction and diagnosis while minimizing neurologic deficit and improving overall survival. Despite advances in functional and three-dimensional stereotactic navigation and intraoperative magnetic resonance imaging, delineating tissue in real time with physiolo...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Broadbent B,Tseng J,Kast R,Noh T,Brusatori M,Kalkanis SN,Auner GW

    更新日期:2016-10-01 00:00:00

  • Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas.

    abstract::Future success using chemotherapy against human gliomas may result from exploiting unique molecular vulnerabilities of these tumors. Chemotherapy frequently results in DNA damage. When such damage is sensed by the cell, programmed cell death, or apoptosis, may be initiated. However, chemotherapy-induced DNA damage may...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Weaver KD,Yeyeodu S,Cusack JC Jr,Baldwin AS Jr,Ewend MG

    更新日期:2003-02-01 00:00:00

  • Combined surgery, radiation, and PCV chemotherapy for astrocytomas compared to oligodendrogliomas and oligoastrocytomas WHO grade III.

    abstract::The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocytomas (AIII), oligodendrogliomas (OIII) and oligoastrocytomas (OAIII) WHO grade III. The treatment was carried...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Kristof RA,Neuloh G,Hans V,Deckert M,Urbach H,Schlegel U,Simon M,Schramm J

    更新日期:2002-09-01 00:00:00

  • Interactions among mitochondrial proteins altered in glioblastoma.

    abstract::Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fractions from patients with GBM were defined with label-free liquid chr...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Deighton RF,Le Bihan T,Martin SF,Gerth AMJ,McCulloch M,Edgar JM,Kerr LE,Whittle IR,McCulloch J

    更新日期:2014-06-01 00:00:00

  • Effect of endothelin-1 as growth factor on a human glioma cell line; its characteristic promotion of DNA synthesis.

    abstract::In addition to its powerful vasoconstrictive activity, endothelin-1 (ET-1) has been recognized to stimulate DNA synthesis in some cell lines. In this study, we confirmed the existence of ET-1 receptor in YKG-1 human glioma cells, and investigated its effect on DNA synthesis in YKG-1 for 6 consecutive days, comparing i...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Asano T,Aoyagi M,Hirakawa K,Ikawa Y

    更新日期:1994-01-01 00:00:00

  • Bevacizumab for radiation necrosis following treatment of high grade glioma: a systematic review of the literature.

    abstract::This review identifies the current literature on the use of bevacizumab for cerebral radiation necrosis in patients with high-grade gliomas, summarizes the clinical course and complications following bevacizumab, and discusses the relative costs and benefits of this therapeutic option. A Medline search was conducted o...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Lubelski D,Abdullah KG,Weil RJ,Marko NF

    更新日期:2013-12-01 00:00:00

  • Central nervous system pharmacokinetics of high-dose cytosine arabinoside.

    abstract::The cerebrospinal fluid (CSF) pharmacokinetics of cytosine arabinoside (Ara-C) was determined in 8 patients with metastatic cancer in the central nervous system. High dose (3 gm/M2) one-hour intravenous infusions of Ara-C were given with serial CSF sampling obtained from indwelling Ommaya reservoirs. CSF was analyzed ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Lopez JA,Nassif E,Vannicola P,Krikorian JG,Agarwal RP

    更新日期:1985-01-01 00:00:00