当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment.

The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment.

Abstract：

PURPOSE:Under-enrollment in clinical trials significantly limits valid analyses of clinical interventions and generalizability of findings. Often it results in premature study termination, with estimates of 22% to 50% of clinical trials terminated due to poor accrual. Currently, there are limited reports addressing the influence of race/ethnicity and socioeconomic status on clinical trial enrollment in adult glioma patients. The goal of this study was to test the hypothesis that race and socioeconomic status negatively impact therapeutic clinical trial enrollment. METHODS:988 adult patients were identified from the UCSF Tumor Board Registry and analyzed to determine the rate of therapeutic clinical trial screening and study enrollment. RESULTS:At initial diagnosis, 43.6% and 17.5% of glioma patients were screened and enrolled in a therapeutic clinical trial, respectively. At recurrence, 49.8% and 26.3% of patients were screened and enrolled in a clinical trial, respectively. Thirty-three percent of the study population belonged to a NIH-designated underrepresented minority group; Asian/Pacific-Islander comprised 19.6% of the overall cohort. On univariate analysis, only in-state location, distance to the hospital, and WHO grade were associated with enrollment at initial diagnosis and recurrence. Minority status, insurance type, median household income, and percent below poverty were not associated with clinical trial enrollment. CONCLUSION:Minority and socioeconomic status did not impact adult glioma clinical trial enrollment. Proximity to the tertiary care cancer center may be an important consideration for minority patients. Patient screening should be carefully considered in order to avoid bias based on minority and socioeconomic status.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Morshed RA,Reihl SJ,Molinaro AM,Kakaizada S,Young JS,Schulte JD,Butowski N,Taylor J,Bush NA,Aghi MK,Berger MS,Chang S,Clarke J,Hervey-Jumper SL

doi

10.1007/s11060-020-03503-x

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

131-139

issue

1

eissn

0167-594X

issn

1573-7373

pii

10.1007/s11060-020-03503-x

journal_volume

148

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Detection of p21WAF1/Cip1 in brain metastases.

    abstract：:The p21WAF1/Cip1 (p21) protein, a negative regulator of G1 checkpoint control, was overexpressed in the majority of human gliomas. To investigate whether p21 expression in brain metastases from various systemic origins is similar to that in gliomas and whether p21 expression is regulated differently in brain metastase...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005972808311

    authors： Ruan S,Fuller G,Levin V,Bruner JM,Zhang W

    更新日期：1998-05-01 00:00:00

  • Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy?

    abstract：:The classification of cartilaginous tumors of the skull base, including chondroid chordoma and chondrosarcoma remains the subject of controversy. Critical review of the literature and our own experience of chordomas and cartilaginous tumors of the skull base led to the following conclusions: 1) Chondrosarcoma of the s...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01328954

    authors： Ishida T,Dorfman HD

    更新日期：1994-01-01 00:00:00

  • MR-spectroscopic imaging of glial tumors in the spotlight of the 2016 WHO classification.

    abstract：BACKGROUND:The purpose of this study is to map spatial metabolite differences across three molecular subgroups of glial tumors, defined by the IDH1/2 mutation and 1p19q-co-deletion, using magnetic resonance spectroscopy. This work reports a new MR spectroscopy based classification algorithm by applying a radiomics anal...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2881-x

    authors： Diamandis E,Gabriel CPS,Würtemberger U,Guggenberger K,Urbach H,Staszewski O,Lassmann S,Schnell O,Grauvogel J,Mader I,Heiland DH

    更新日期：2018-09-01 00:00:00

  • Bevacizumab for radiation necrosis following treatment of high grade glioma: a systematic review of the literature.

    abstract：:This review identifies the current literature on the use of bevacizumab for cerebral radiation necrosis in patients with high-grade gliomas, summarizes the clinical course and complications following bevacizumab, and discusses the relative costs and benefits of this therapeutic option. A Medline search was conducted o...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-013-1233-0

    authors： Lubelski D,Abdullah KG,Weil RJ,Marko NF

    更新日期：2013-12-01 00:00:00

  • Agnosias: recognition disorders in patients with brain tumors.

    abstract：:Two main varieties of recognition disorders are distinguished in neuropsychology: agnosias and semantic disorders. The term agnosias is generally used to denote recognition defects limited to a single perceptual modality (which is itself apparently intact), whereas the term semantic disorders is used to denote recogni...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0823-6

    authors： Gainotti G

    更新日期：2012-06-01 00:00:00

  • Medulloblastoma with melanotic differentiation: case report and review of the literature.

    abstract：:Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in t...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-010-0436-x

    authors： Phillips CL,Miles L,Jones BV,Sutton M,Crone K,Fouladi M

    更新日期：2011-07-01 00:00:00

  • A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas.

    abstract：:Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse intrinsic pontine gliomas (DIPG) or HGG has not been reported in a prospective study. In a safety and feasibility study, children and young adults with newly diagn...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-2008-6

    authors： Hummel TR,Salloum R,Drissi R,Kumar S,Sobo M,Goldman S,Pai A,Leach J,Lane A,Pruitt D,Sutton M,Chow LM,Grimme L,Doughman R,Backus L,Miles L,Stevenson C,Fouladi M,DeWire M

    更新日期：2016-03-01 00:00:00

  • Opportunities for clinical research in meningioma.

    abstract：:Meningiomas, when benign, are commonly treated with surgical resection alone. However, the optimal treatment for patients with subtotally resected or recurrent World Health Organization (WHO) grade I tumors, or WHO grade II and III tumors, regardless of the extent of resection, is not well defined, with both a paucity...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-010-0375-6

    authors： Vogelbaum MA,Leland Rogers C,Linskey MA,Mehta MP

    更新日期：2010-09-01 00:00:00

  • Is mortality due to primary malignant brain and other central nervous system tumors decreasing?

    abstract：:Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates f...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2449-1

    authors： Gittleman H,Kromer C,Ostrom QT,Blanda R,Russell J,Kruchko C,Barnholtz-Sloan JS

    更新日期：2017-06-01 00:00:00

  • Outcomes of postoperative stereotactic radiosurgery to the resection cavity versus stereotactic radiosurgery alone for melanoma brain metastases.

    abstract：:To investigate local control and radiation-induced brain necrosis in patients with melanoma brain metastases who received complete resection plus fractionated stereotactic radiosurgery (fSRS, 3 × 9 Gy) or fSRS alone. Factors associated with the clinical outcomes and the development of brain necrosis have been assessed...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2394-z

    authors： Minniti G,Paolini S,D'Andrea G,Lanzetta G,Cicone F,Confaloni V,Bozzao A,Esposito V,Osti M

    更新日期：2017-05-01 00:00:00

  • STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma.

    abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1843-9

    authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

    更新日期：2015-09-01 00:00:00

  • Predictors of survival in metastatic melanoma patients with leptomeningeal disease (LMD).

    abstract：PURPOSE:Although the survival of most melanoma patients diagnosed with leptomeningeal disease (LMD) is short, some patients can have better outcomes and prolonged survival. A large retrospective cohort of patients was analyzed to identify features associated with survival with LMD from melanoma. METHODS:Clinical chara...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03121-2

    authors： Ferguson SD,Bindal S,Bassett RL Jr,Haydu LE,McCutcheon IE,Heimberger AB,Li J,O'Brien BJ,Guha-Thakurta N,Tetzlaff MT,Tawbi H,Davies MA,Glitza IC

    更新日期：2019-05-01 00:00:00

  • Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas.

    abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000033383.84900.c1

    authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

    更新日期：2004-07-01 00:00:00

  • Ethynyldeoxyuridine (EdU) suppresses in vitro population expansion and in vivo tumor progression of human glioblastoma cells.

    abstract：:Thymidine analogs (TAs) are synthetic nucleosides that incorporate into newly synthesized DNA. Halogenated pyrimidines (HPs), such as bromodeoxyuridine (BrdU), are a class of TAs that can be detected with antibodies and are commonly used for birthdating individual cells and for assessing the proliferative index of cel...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-011-0621-6

    authors： Ross HH,Rahman M,Levkoff LH,Millette S,Martin-Carreras T,Dunbar EM,Reynolds BA,Laywell ED

    更新日期：2011-12-01 00:00:00

  • Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis.

    abstract：:To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. P...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0939-8

    authors： Perkins SM,Mitra N,Fei W,Shinohara ET

    更新日期：2012-10-01 00:00:00

  • Will high dose chemotherapy followed by autologous bone marrow transplantation supplant cranio-spinal irradiation in young children treated for medulloblastoma?

    abstract：UNLABELLED:Cranio-spinal irradiation is the gold standard treatment used in non metastatic medulloblastoma as prophylaxis against central nervous system (CNS) metastases. However, given the severe late effects caused by this procedure in children under 3 years of age, most pediatric oncologists are currently treating t...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00146088

    authors： Dupuis-Girod S,Hartmann O,Benhamou E,Doz F,Mechinaud F,Bouffet E,Coze C,Kalifa C

    更新日期：1996-01-01 00:00:00

  • Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy.

    abstract：:High-dose (1-3.5 g/m2) methotrexate (MTX) followed by whole-brain radiation therapy (WBRT) has consistently improved length of survival in primary central nervous system lymphoma (PCNSL), but the prognosis remains dismal. To optimize and enhance the dose intensity of MTX, we applied MTX at 8 g/m2 to 20 patients with P...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1023760824739

    authors： Watanabe T,Katayama Y,Yoshino A,Komine C,Yokoyama T,Fukushima T

    更新日期：2003-05-01 00:00:00

  • Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center.

    abstract：PURPOSE:Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB. METHODS:Clin...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2935-0

    authors： Jia Q,Liu C,Yang J,Ji Y,Wei H,Liu T,Yang X,Yang C,Xiao J

    更新日期：2018-10-01 00:00:00

  • Prediction of lower-grade glioma molecular subtypes using deep learning.

    abstract：INTRODUCTION:It is useful to know the molecular subtype of lower-grade gliomas (LGG) when deciding on a treatment strategy. This study aims to diagnose this preoperatively. METHODS:A deep learning model was developed to predict the 3-group molecular subtype using multimodal data including magnetic resonance imaging (M...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03376-9

    authors： Matsui Y,Maruyama T,Nitta M,Saito T,Tsuzuki S,Tamura M,Kusuda K,Fukuya Y,Asano H,Kawamata T,Masamune K,Muragaki Y

    更新日期：2020-01-01 00:00:00

  • Treatment of recurrent esthesioneuroblastoma with combined intra-arterial chemotherapy. A case report.

    abstract：:A 65 year old woman presented with a recurrent locally advanced esthesioneuroblastoma. She had earlier been treated with radiation followed by surgery. The recurrence was located in earlier radiated tissues with intracranial infiltration. She underwent treatment with combined intra-arterial chemotherapy (BCNU) i.a., v...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00162764

    authors： Watne K,Hager B

    更新日期：1987-01-01 00:00:00

  • Establishment of interleukin 2 dependent cytotoxic T lymphocyte cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor.

    abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00195603

    authors： Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

    更新日期：1987-01-01 00:00:00

  • Management of cerebral metastases from malignant melanoma: results of a combined, simultaneous treatment with fotemustine and irradiation.

    abstract：:We report results of a conservative treatment for brain metastases from malignant melanoma with a combination of irradiation and chemotherapy (fotemustine and/or DTIC). To date, 12 patients have been treated. There was a complete remission of the brain metastases in four patients. In two patients a partial remission w...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006280304912

    authors： Ulrich J,Gademann G,Gollnick H

    更新日期：1999-06-01 00:00:00

  • Effects of slice thickness and head rotation when measuring glioma sizes on MRI: in support of volume segmentation versus two largest diameters methods.

    abstract：:This paper presents a study of the effects of scanning parameters variability when assessing glioma sizes on MRI. A database of lesions of various shapes and sizes, segmented on 3D-SPGR MRI images, was acquired on 65 patients with low-grade glioma. Simulations of large slice thickness and patient's head rotation were ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1051-4

    authors： Schmitt P,Mandonnet E,Perdreau A,Angelini ED

    更新日期：2013-04-01 00:00:00

  • A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma.

    abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-019-03125-y

    authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

    更新日期：2019-05-01 00:00:00

  • Histopathological and cytogenetic findings in benign, atypical and anaplastic human meningiomas: a study of 60 tumors.

    abstract：:Meningiomas may display benign (Grade I), atypical (Grade II) and anaplastic (Grade III) histopathological findings. The cytogenetic studies strongly suggest that secondary changes (moreover loss of chromosome 22) appear to be associated with more atypical features and with greater clinical aggressivity. We studied 60...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006454107467

    authors： Cerdá-Nicolás M,López-Gineś C,Pérez-Bacete M,Barcia-Salorio JL,Llombart-Bosch A

    更新日期：2000-04-01 00:00:00

  • Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome.

    abstract：:We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-9181-3

    authors： Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PP

    更新日期：2005-01-01 00:00:00

  • Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen.

    abstract：:Children with recurrent high grade gliomas (HGG) have a dismal outcome with a median progression free survival (PFS) of 12 weeks. Adults with recurrent HGG treated with irinotecan and bevacizumab reportedly have a 63% response rate and a median PFS of 23 weeks. There is a paucity of corresponding published pediatric d...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0444-x

    authors： Parekh C,Jubran R,Erdreich-Epstein A,Panigrahy A,Bluml S,Finlay J,Dhall G

    更新日期：2011-07-01 00:00:00

  • Studies on estrogen induced pituitary tumor in the rat with special reference to the relationship of the tuberoinfundibular dopamine neuron system.

    abstract：:Pituitary tumors were experimentally induced in female Wistar rats by repeated injections of estradiol dipropionate. The hypothalamus and pituitary tumors were studied simultaneously by fluorescence histochemistry and immunohistochemistry. The pituitary gland became larger with a concomitant increase of serum prolacti...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF02571303

    authors： Fujimoto M,Yoshino E,Hirakawa K,Chihara K,Ibata Y

    更新日期：1987-01-01 00:00:00

  • A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature.

    abstract：:Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventric...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-007-9466-4

    authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

    更新日期：2008-01-01 00:00:00

  • Outcomes of salvage re-irradiation in recurrent medulloblastoma correlate with age at initial diagnosis, primary risk-stratification, and molecular subgrouping.

    abstract：PURPOSE:To report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive medulloblastoma (MB). METHODS:Medical records of patients treated with curative-intent re-RT as multi-modality management for recurrent/progressive MB between 2008 and 2018 were analyzed retrospectively. RESULTS:A total of 28 patien...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03225-9

    authors： Gupta T,Maitre M,Sastri GJ,Krishnatry R,Shirsat N,Epari S,Sahay A,Chinnaswamy G,Patil V,Shetty P,Moiyadi A

    更新日期：2019-09-01 00:00:00