Agnosias: recognition disorders in patients with brain tumors.

abstract：:Convection-enhanced delivery (CED) of highly stable PEGylated liposomes encapsulating chemotherapeutic drugs has previously been effective against malignant glioma xenografts. We have developed a novel, convectable non-PEGylated liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor t...

journal_title：Journal of neuro-oncology

authors： Grahn AY,Bankiewicz KS,Dugich-Djordjevic M,Bringas JR,Hadaczek P,Johnson GA,Eastman S,Luz M

更新日期：2009-11-01 00:00:00

abstract：:Despite total macroscopic resection of meningiomas relapses do occur in these tumours, possibly because of microscopic clusters of neoplastic cells left in the dura mater or in the arachnoid membrane. The invasiveness of the neoplastic cells of human meningiomas has been related to expression of matrix-metalloproteina...

journal_title：Journal of neuro-oncology

authors： Barresi V,Vitarelli E,Tuccari G,Barresi G

更新日期：2011-04-01 00:00:00

abstract：:The aim of this work was to determine the accuracy and precision of stereotactic localization and treatment delivery using a helical tomotherapy based stereotactic radiosurgery (SRS) system. A tomotherapy specific radiosurgery workflow was designed that exploits the system's on board megavotage CT (MVCT) imaging syste...

journal_title：Journal of neuro-oncology

authors： Soisson ET,Hardcastle N,Tomé WA

更新日期：2010-06-01 00:00:00

abstract：:This paper describes the pathobiology of some of the more common skull base tumors. In addition to clinicopathologic features, emphasis is placed upon methods of diagnosis utilizing immunoperoxidase stains and molecular markers that may or may not impact upon prognosis. ...

journal_title：Journal of neuro-oncology

authors： Barnes L,Kapadia SB

更新日期：1994-01-01 00:00:00

abstract：:Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...

journal_title：Journal of neuro-oncology

authors： Fillmore HL,VanMeter TE,Broaddus WC

更新日期：2001-06-01 00:00:00

abstract：:Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) have been identified in approximately 70-80 % of astrocytomas and oligodendrogliomas of WHO grades II and III, and in secondary glioblastomas. In addition, a low incidence of IDH2 mutations has been detected in these tumors, and the occurence of IDH1 and...

journal_title：Journal of neuro-oncology

authors： Ahmadi R,Stockhammer F,Becker N,Hohlen K,Misch M,Christians A,Dictus C,Herold-Mende C,Capper D,Unterberg A,von Deimling A,Wick W,Hartmann C

更新日期：2012-08-01 00:00:00

abstract：:In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (F...

journal_title：Journal of neuro-oncology

authors： Czarnek N,Clark K,Peters KB,Mazurowski MA

更新日期：2017-03-01 00:00:00

abstract：:Conventional Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the cornerstone in the initial evaluation of brain tumours. The purpose of this study is to evaluate the contribution of Magnetic Resonance Spectroscopy (MRS) and Perfusion-weighted MRI to distinguish malignant from benign tumours. We inclu...

journal_title：Journal of neuro-oncology

authors： Fayed N,Modrego PJ

更新日期：2005-05-01 00:00:00

abstract：:Peripheral neuropathies occur in 5% of patients with Non-Hodgkin Lymphoma and represent the effects of therapy, direct compression or nerve infiltration by tumor, or paraneoplastic effects. Multifocal motor neuropathy with conduction block (MMNCB) is a rare demyelinating disorder of unknown etiology characterized by p...

journal_title：Journal of neuro-oncology

authors： Stern BV,Baehring JM,Kleopa KA,Hochberg FH

更新日期：2006-05-01 00:00:00

abstract：:Increasing interest has developed in the use of the photodynamic agent, Hematoporphyrin derivative (HpD) for photoradiation therapy (PRT) as adjunctive therapy of malignant glial tumors of the brain. HpD, injected systemically, is preferentially taken up and retained by neoplastic tissue. Early studies of such uptake ...

journal_title：Journal of neuro-oncology

authors： Little FM,Gomer CJ,Hyman S,Apuzzo ML

更新日期：1984-01-01 00:00:00

abstract：:During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investigate the anti-tumor effects of concurrent 5-aminolevulinic acid (ALA)-mediated PDT and hyperthermia (HT) in huma...

journal_title：Journal of neuro-oncology

authors： Hirschberg H,Sun CH,Tromberg BJ,Yeh AT,Madsen SJ

更新日期：2004-12-01 00:00:00

abstract：:To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. P...

journal_title：Journal of neuro-oncology

authors： Perkins SM,Mitra N,Fei W,Shinohara ET

更新日期：2012-10-01 00:00:00

abstract：:We describe the case of a young man presenting with an extra-nodal, intramedullary non-Hodgkin's lymphoma of the cervical spinal cord. This is a very uncommon presentation of this neoplasm. The patient was treated with craniospinal radiotherapy, with survival for two and a half years before death from recurrent diseas...

journal_title：Journal of neuro-oncology

authors： McDonald AC,Nicoll JA,Rampling R

更新日期：1995-01-01 00:00:00

abstract：:This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

journal_title：Journal of neuro-oncology

authors： Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Comparison of the influence of two different brain tumors (C6 and CNS1 glioma) on methotrexate (MTX) disposition in plasma, brain, and tumor tissue extracellular fluid (ECF). METHODS:Serial collection of plasma samples and brain ECF dialysates after i.v. bolus administration of MTX (50 mg kg(-1)) for 4 h. Quan...

journal_title：Journal of neuro-oncology

authors： Dukic SF,Kaltenbach ML,Heurtaux T,Hoizey G,Lallemand A,Vistelle R

更新日期：2004-03-01 00:00:00

abstract：:Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary gliobla...

journal_title：Journal of neuro-oncology

authors： Hamisch C,Ruge M,Kellermann S,Kohl AC,Duval I,Goldbrunner R,Grau SJ

更新日期：2017-06-01 00:00:00

abstract：:Intravascular lymphomatosis (IL) is a rare entity only recently included in lymphoma classification, whose main feature is the exclusive or predominant growth of neoplastic cells within blood vessels. The vast majority of the patients affected by IL belong to the 7th or 8th decade of life and present with skin rash or...

journal_title：Journal of neuro-oncology

authors： Massimino M,Giardini R,Cefalo G,Simonetti F,Pollo B,Giombini S,Tesoro-Tess JD,Ponzoni M,Patriarca C

更新日期：2001-01-01 00:00:00

abstract：:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1...

journal_title：Journal of neuro-oncology

authors： Purdy E,Johnston DL,Bartels U,Fryer C,Carret AS,Crooks B,Eisenstat DD,Lafay-Cousin L,Larouche V,Wilson B,Zelcer S,Silva M,Bouffet E,Keene D,Strother DR

更新日期：2014-04-01 00:00:00

abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

journal_title：Journal of neuro-oncology

authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

更新日期：2001-12-01 00:00:00

abstract：:Compared to classical oncological outcome measures such as time to progression and survival, the importance of cognitive functioning in patients with diffuse infiltrative brain tumors has only recently been recognized. Apart from the relatively low incidence and the invariably fatal outcome of gliomas, the general ass...

journal_title：Journal of neuro-oncology

authors： Klein M,Duffau H,De Witt Hamer PC

更新日期：2012-06-01 00:00:00

abstract：:We conducted a phase II study to test methotrexate (5 g/m(2)), as a single agent prior to radiochemotherapy for pediatric high-grade glioma and diffuse intrinsic pontine glioma. Thirty patients (19 male, median age 10.8) were enrolled. Tumors were located as follows: cortex 10, pons 7, other 13. Tumor resection was cl...

journal_title：Journal of neuro-oncology

authors： Wolff JE,Kortmann RD,Wolff B,Pietsch T,Peters O,Schmid HJ,Rutkowski S,Warmuth-Metz M,Kramm C

更新日期：2011-05-01 00:00:00

abstract：:Following surgical resection for brain metastases, fractionated stereotactic radiotherapy (FSRT) has been used as an alternative to single dose treatment for large cavities and to reduce risks of late toxicity. The purpose of this study was to evaluate the outcomes of patients treated with FSRT to the post-operative b...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Freilich JM,Abuodeh Y,Figura N,Patel N,Sarangkasiri S,Chinnaiyan P,Yu HH,Etame AB,Rao NG

更新日期：2014-05-01 00:00:00

abstract：:To evaluate diagnostic accuracy of perfusion weighted imaging (PWI) and positron emission tomography (PET) using an integrated PET/MR system in tumor grading as well as in differentiating recurrent tumor from treatment-induced effects (TIE) in brain tumor patients. Twenty patients (Group A: treatment naïve, 9 patients...

journal_title：Journal of neuro-oncology

authors： Sacconi B,Raad RA,Lee J,Fine H,Kondziolka D,Golfinos JG,Babb JS,Jain R

更新日期：2016-04-01 00:00:00

abstract：:Leptomeningeal spread of childhood primary central nervous system (CNS) neoplasms, also known as leptomeningeal disease (LMD), significantly affects prognosis and treatment. Lumbar cerebrospinal fluid (CSF) cytology and spinal magnetic resonance imaging (MRI) are considered critical for diagnosis of LMD. It has been s...

journal_title：Journal of neuro-oncology

authors： Pang J,Banerjee A,Tihan T

更新日期：2008-03-01 00:00:00

abstract：:Children with a brain tumor (BT) are at risk for a number of physical and cognitive problems that may lower their health-related quality of life (HRQoL). Executive functioning (EF) and intellectual ability are hypothesized to associate with HRQoL and deficits in these areas may be amenable to interventions. This study...

journal_title：Journal of neuro-oncology

authors： Netson KL,Ashford JM,Skinner T,Carty L,Wu S,Merchant TE,Conklin HM

更新日期：2016-06-01 00:00:00

abstract：:Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...

journal_title：Journal of neuro-oncology

authors： Jennings MT,Asadourian LL,Jennings VD,Shapiro JR,Thaler HT

更新日期：1990-12-01 00:00:00

abstract：:High-grade gliomas release excitotoxic concentrations of glutamate which contributes to their malignant phenotype. To improve our understanding of the mechanisms by which glutamate enhances tumor growth and invasion, we examined alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated signaling in glio...

journal_title：Journal of neuro-oncology

authors： de Groot JF,Piao Y,Lu L,Fuller GN,Yung WK

更新日期：2008-06-01 00:00:00

abstract：:Angiogenesis is one of the key features of glioblastoma (GB). However, the use of anti-angiogenic therapies directed against vascular endothelial growth factor (VEGF) is limited by primary or acquired resistance. MET/HGF and PlGF signaling are involved in potential alternative escape mechanisms to VEGF pathway. Our ob...

journal_title：Journal of neuro-oncology

authors： Tabouret E,Denicolai E,Delfino C,Graillon T,Boucard C,Nanni I,Padovani L,Figarella-Branger D,Chinot O

更新日期：2016-12-01 00:00:00

abstract：:To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria. Sixty-three children diagnosed with HGA were treated at the Johns Hopkins Hospital...

journal_title：Journal of neuro-oncology

authors： Hales RK,Shokek O,Burger PC,Paynter NP,Chaichana KL,Quiñones-Hinojosa A,Jallo GI,Cohen KJ,Song DY,Carson BS,Wharam MD

更新日期：2010-08-01 00:00:00

abstract：:A prospective pilot study was performed in order to assess the safety of treating recurrent malignant gliomas (MGs) with locally infused autologous tumor infiltrating lymphocytes (TILs) and recombinant interleukin-2 (rIL-2). Six patients were entered between June 27, 1994 and June 2, 1995 and followed until July 1, 19...

journal_title：Journal of neuro-oncology

authors： Quattrocchi KB,Miller CH,Cush S,Bernard SA,Dull ST,Smith M,Gudeman S,Varia MA

更新日期：1999-01-01 00:00:00