Abstract：
:Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates for malignant BT were generated using the Center for Disease Control's National Vital Statistics Systems (NVSS, ~100% of US) data from 1975 to 2012. Histology-specific incidence-based mortality rates were calculated using the National Cancer Institute's Surveillance, Epidemiology, and End-Results 9 (SEER9, ~9.4% of US) data from 1975 to 2012. Joinpoint modeling was used to estimate trends. Mortality was similar in both the NVSS and SEER9 datasets. Overall, mortality from 1975 to 2012 was higher among men, higher in older individuals, and higher in Whites compared to other races. Persons age 65+ years had significant increases in mortality for all malignant tumors overall and for glioma histologies, while persons age <20 years had no significant changes in mortality. This study reports up-to-date mortality rates by histology groupings, age, race, and sex for malignant BT. There have been no significant changes in overall mortality due to these tumors from 1975 to 2012. There have been significant increases in mortality in the elderly (age 65+ years), especially those age 75-84 years, mirroring the effect of overall population aging. Examining age-, race-, sex-, and histology-specific morality at the population level can provide important information for clinicians, researchers, and public health planning.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Gittleman H,Kromer C,Ostrom QT,Blanda R,Russell J,Kruchko C,Barnholtz-Sloan JSdoi
10.1007/s11060-017-2449-1subject
Has Abstractpub_date
2017-06-01 00:00:00pages
265-275issue
2eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-017-2449-1journal_volume
133pub_type
杂志文章abstract：:Communication support tools (CST) improve patient outcomes in oncology including: knowledge, satisfaction, self-management, and adherence to planned treatment. Little is known about communication support tools use in patients with primary or secondary brain tumours. We aimed to explore cognitive function and communica...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
abstract：:Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration...
journal_title：Journal of neuro-oncology
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更新日期：2016-09-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-014-1522-2
更新日期：2014-10-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1023/b:neon.0000024744.16031.e9
更新日期：2004-05-01 00:00:00
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journal_title：Journal of neuro-oncology
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更新日期：1985-01-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
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更新日期：2010-01-01 00:00:00
abstract：:Hypermethylation of the MGMT gene promoter and mutation of the TP53 tumor-suppressor gene are frequently present in diffuse astrocytomas. However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplastic astrocytoma (AI...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0274-x
更新日期：2011-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF02341157
更新日期：1990-12-01 00:00:00
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journal_title：Journal of neuro-oncology
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更新日期：2011-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0216-7
更新日期：2011-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01057957
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9591-8
更新日期：2008-08-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11060-018-2909-2
更新日期：2018-09-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2822-8
更新日期：2018-07-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0292-8
更新日期：2011-03-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0264-z
更新日期：2011-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-015-1843-9
更新日期：2015-09-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00163702
更新日期：1988-11-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00165099
更新日期：1989-07-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11060-017-2394-z
更新日期：2017-05-01 00:00:00
abstract：:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1016226319068
更新日期：2002-07-01 00:00:00
abstract：UNLABELLED:Cranio-spinal irradiation is the gold standard treatment used in non metastatic medulloblastoma as prophylaxis against central nervous system (CNS) metastases. However, given the severe late effects caused by this procedure in children under 3 years of age, most pediatric oncologists are currently treating t...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00146088
更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11060-008-9648-8
更新日期：2008-11-01 00:00:00
abstract：:Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
abstract：:Despite total macroscopic resection of meningiomas relapses do occur in these tumours, possibly because of microscopic clusters of neoplastic cells left in the dura mater or in the arachnoid membrane. The invasiveness of the neoplastic cells of human meningiomas has been related to expression of matrix-metalloproteina...
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更新日期：2011-04-01 00:00:00
