Effect of lonidamine on human malignant gliomas: biochemical studies.

abstract：:Diffuse invasion of the brain by tumor cells is a hallmark of human glioblastomas and a major cause for the poor prognosis of these tumors. This phenomenon is only partially reproduced by rodent models of gliomas that display a very high rate of proliferation and limited cell migration. We have analyzed the developmen...

journal_title：Journal of neuro-oncology

authors： Guillamo JS,Lisovoski F,Christov C,Le Guérinel C,Defer GL,Peschanski M,Lefrançois T

更新日期：2001-05-01 00:00:00

abstract：:We examined the mechanism of action of nitrosoureas as represented by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) with respect to p53 and the G2M cell cycle checkpoint using two glioblastoma cell lines: U251MG and U373MG, with mutated p53. At log-phase cell growth, fresh medium con...

journal_title：Journal of neuro-oncology

authors： Nakamizo A,Inamura T,Inoha S,Amano T,Ochi H,Ikezaki K,Fukui M

更新日期：2002-08-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

journal_title：Journal of neuro-oncology

authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...

journal_title：Journal of neuro-oncology

authors： van den Bent MJ,Pronk L,Sillevis Smitt PA,Vecht CJ,Eskens FA,Verweij J

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:Feasibility, antitumor activity and toxicity of accelerated hyperfractionated radiation therapy (Acc Hfx RT) and concurrent carboplatin/etoposide (CBDCA/VP 16) chemotherapy were investigated in patients with malignant glioma. MATERIAL AND METHODS:Seventy-nine patients with either glioblastoma multiforme (GBM) ...

journal_title：Journal of neuro-oncology

authors： Jeremic B,Shibamoto Y,Grujicic D,Stojanovic M,Milicic B,Nikolic N,Dagovic A,Aleksandrovic J

更新日期：2001-01-01 00:00:00

abstract：:Cancer is a leading cause of death in the United States. Despite the development of advanced treatment for many malignancies, a large number of patients will require evaluation and possible surgical intervention for lesions which have metastasized to or directly invaded the spinal column. The recommendations for opera...

journal_title：Journal of neuro-oncology

authors： Welch WC,Jacobs GB

更新日期：1995-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and devastating form of primary central nervous system malignancy. The prognosis for patients diagnosed with GBM is poor, having a median survival rate of 12-15 months. Despite modern advances in the development of antineoplastic agents, the efficacy of newer anti-cance...

journal_title：Journal of neuro-oncology

authors： Gurley SN,Abidi AH,Allison P,Guan P,Duntsch C,Robertson JH,Kosanke SD,Keir ST,Bigner DD,Elberger AJ,Moore BM 2nd

更新日期：2012-11-01 00:00:00

abstract：:Neuron-specific enolase (NSE) is one of the iso-forms of enolase, a glycolytic enzyme found in the neuroendocrine system. NSE is one of the most widely used tumor markers in small-cell lung carcinoma (SCLC). To assess the value of NSE in discriminating between the sites of metastases in SCLC-patients with and without ...

journal_title：Journal of neuro-oncology

authors： van de Pol M,Twijnstra A,ten Velde GP,Menheere PP

更新日期：1994-01-01 00:00:00

abstract：:Comparison between myelography (MY) and magnetic resonance imaging (MRI) was carried out in 36 patients with clinical suspicion of spinal cord or root compression due to metastatic disease in the spinal canal. In 3 patients metastatic lesions were visualized on MY but not on MRI, while there were no cases with a negat...

journal_title：Journal of neuro-oncology

authors： Helweg-Larsen S,Wagner A,Kjaer L,Johnsen A,Boesen J,Palner T,Sørensen PS

更新日期：1992-07-01 00:00:00

abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

journal_title：Journal of neuro-oncology

authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

更新日期：1992-06-01 00:00:00

abstract：:TERT promoter (TERTp) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations,...

journal_title：Journal of neuro-oncology

authors： Nencha U,Rahimian A,Giry M,Sechi A,Mokhtari K,Polivka M,Schmitt Y,Di Stefano AL,Alentorn A,Labussière M,Sanson M

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To evaluate perioperative management, early outcomes and hemocoagulative disorders in infants up to 1 year old, undergoing neurosurgery for brain tumors removal. DESIGN:Retrospective evaluation of prospectively collected data regarding all infants aged <1 year admitted to PICU from 1994 to 2004, following in...

journal_title：Journal of neuro-oncology

authors： Piastra M,Di Rocco C,Caresta E,Zorzi G,De Luca D,Caldarelli M,La Torre G,Conti G,Antonelli M,Eaton S,Pietrini D

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Diffuse pontine tumors are highly lethal, and there are few long-term survivors with the standard treatment of external beam irradiation. We investigated the effectiveness of high-dose thiotepa and etoposide-based chemotherapy regimens with autologous bone marrow rescue (ABMR) in children with pontine tumors. ...

journal_title：Journal of neuro-oncology

authors： Dunkel IJ,Garvin JH Jr,Goldman S,Ettinger LJ,Kaplan AM,Cairo M,Li H,Boyett JM,Finlay JL

更新日期：1998-03-01 00:00:00

abstract：:Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...

journal_title：Journal of neuro-oncology

authors： De Braganca KC,Janjigian YY,Azzoli CG,Kris MG,Pietanza MC,Nolan CP,Omuro AM,Holodny AI,Lassman AB

更新日期：2010-12-01 00:00:00

abstract：:Sixteen immunocompetent patients, 10 of whom were previously reported, with primary non-Hodgkins lymphoma of the central nervous system (PCNSL) were treated and followed longitudinally by the Neuro-oncology Service at the University of California, San Francisco (UCSF) and the University of California, San Diego (UCSD)...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Levin VA

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:This study was undertaken to evaluate the radiographic response to two cycles of chemotherapy prior to irradiation in newly diagnosed children with high-grade astrocytomas. PATIENTS AND METHODS:One hundred and thirty children less than 21 years of age with newly-diagnosed high-grade astrocytoma were treated wi...

journal_title：Journal of neuro-oncology

authors： Finlay JL,Geyer JR,Turski PA,Yates AJ,Boyett JM,Allen JC,Packer RJ

更新日期：1994-01-01 00:00:00

abstract：:Patients with unresectable glioblastoma or anaplastic astrocytoma have a dismal prognosis. The role of neoadjuvant chemotherapy prior to irradiation in these patients has been studied primarily in non-randomized studies. We have compared the effect of neoadjuvant chemotherapy plus radiotherapy versus concomitant radio...

journal_title：Journal of neuro-oncology

authors： Capdevila L,Cros S,Ramirez JL,Sanz C,Carrato C,Romeo M,Etxaniz O,Hostalot C,Massuet A,Cuadra JL,Villà S,Balañà C

更新日期：2014-03-01 00:00:00

abstract：:To date, no histopathological vascular investigation focusing on peritumoral brain zone (PBZ) has been reported for glioblastoma. We analyzed 10 newly diagnosed cases of glioblastomas. For these PBZs, histopathological investigation was performed by hematoxylin-eosin (H&E) staining and immunohistochemistry was analyze...

journal_title：Journal of neuro-oncology

authors： Tamura R,Ohara K,Sasaki H,Morimoto Y,Yoshida K,Toda M

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：:We characterized health-related quality of life (HRQoL), cognitive, and functional status in newly diagnosed glioblastoma (GBM) patients receiving Tumor treating fields (TTFields) with temozolomide (TMZ) versus TMZ alone in a planned interim analysis of a randomized phase III trial [NCT00916409], which showed signific...

journal_title：Journal of neuro-oncology

authors： Zhu JJ,Demireva P,Kanner AA,Pannullo S,Mehdorn M,Avgeropoulos N,Salmaggi A,Silvani A,Goldlust S,David C,Benouaich-Amiel A,Zvi Ram on behalf of the EF-14 Trial Investigators.

更新日期：2017-12-01 00:00:00

abstract：:After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year. The patient reported subjective relief of symptoms after 1 month. Magnetic resonance imaging (MRI) contro...

journal_title：Journal of neuro-oncology

authors： Piribauer M,Czech T,Dieckmann K,Birner P,Hainfellner JA,Prayer D,Fazeny-Dörner B,Weinländer G,Marosi C

更新日期：2004-02-01 00:00:00

abstract：:We report the case of a 58 year old woman with an epidermoid cyst of the right cerebello-pontine angle that was subtotally excised. She recurred 2 years later and received radiotherapy with resolution of symptoms and shrinkage of the cyst. The natural history of epidermoid cysts and the role of radiotherapy in their m...

journal_title：Journal of neuro-oncology

authors： Parikh S,Milosevic M,Wong CS,Laperriere N

更新日期：1995-01-01 00:00:00

abstract：:Intravascular lymphomatosis (IL) is a rare entity only recently included in lymphoma classification, whose main feature is the exclusive or predominant growth of neoplastic cells within blood vessels. The vast majority of the patients affected by IL belong to the 7th or 8th decade of life and present with skin rash or...

journal_title：Journal of neuro-oncology

authors： Massimino M,Giardini R,Cefalo G,Simonetti F,Pollo B,Giombini S,Tesoro-Tess JD,Ponzoni M,Patriarca C

更新日期：2001-01-01 00:00:00

abstract：:Bevacizumab, an anti-angiogenic agent, is FDA-approved for use in patients with recurrent glioblastoma multiforme (rGBM). The radiologic evaluation of tumor response to bevacizumab is complex and there is no validated method of monitoring tumor vascularity during therapy. We evaluated perfusion-weighted MR imaging (PW...

journal_title：Journal of neuro-oncology

authors： Bennett IE,Field KM,Hovens CM,Moffat BA,Rosenthal MA,Drummond K,Kaye AH,Morokoff AP

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Molecular data has become an essential part of the updated World Health Organization (WHO) grading of central nervous system tumors. However, stereotactic needle biopsies provide only small volume specimens and limit the extent of histologic and molecular testing that can be performed. We assessed the use of a ...

journal_title：Journal of neuro-oncology

authors： Bander ED,Jones SH,Pisapia D,Magge R,Fine H,Schwartz TH,Ramakrishna R

更新日期：2019-01-01 00:00:00

abstract：:The soft agar technique for culturing human clonogenic tumor cells has been usefully applied for predicting individual clinical responses to chemotherapy, for screening of new antineoplastic drugs, and in basic biological research. The counting of colonies formed by clonogenic cells is, however, a rather time consumin...

journal_title：Journal of neuro-oncology

authors： Unsgaard G,Larsen B,Dalen A,Vik R,Ringkjøb R

更新日期：1985-01-01 00:00:00

abstract：:Peripheral neuropathies occur in 5% of patients with Non-Hodgkin Lymphoma and represent the effects of therapy, direct compression or nerve infiltration by tumor, or paraneoplastic effects. Multifocal motor neuropathy with conduction block (MMNCB) is a rare demyelinating disorder of unknown etiology characterized by p...

journal_title：Journal of neuro-oncology

authors： Stern BV,Baehring JM,Kleopa KA,Hochberg FH

更新日期：2006-05-01 00:00:00

abstract：:This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

journal_title：Journal of neuro-oncology

authors： Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

更新日期：2017-05-01 00:00:00

abstract：:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and m...

journal_title：Journal of neuro-oncology

authors： Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti W

更新日期：1997-01-01 00:00:00

abstract：:Thrombin is known to play a role as regulator in tumor spreading and tumor growth. Proteinase-activated receptor 1 (PAR 1)-type thrombin receptors were identified in different cancer cells including human glioblastoma cells. Thus a function of PAR 1 in brain tumors may be suggested. In this study, the presence of PAR ...

journal_title：Journal of neuro-oncology

authors： Kaufmann R,Patt S,Kraft R,Zieger M,Henklein P,Neupert G,Nowak G

更新日期：1999-04-01 00:00:00