Abstract:
:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and metastatic NB and, in particular, NB metastatic stage IVS. We have assayed 36 localized and 117 metastatic neuroblastomas for evidence of internucleosomal DNA degradation and confirmed DNA fragmentation by the flow cytometric Terminal deoxynucleotidyl Transferase method, which also allowed us to measure DNA content and cell cycle phases. These techniques provided evidence of apoptosis in 18 out of 153 samples (11.8%), that were equally distributed among all stages except IVS, i.e. 11.1% in stage I (2/18), 11.1% in stage II (2/18), 13.2% in stage III (5/38), 13.4% in stage IV (9/67), and 0% in stage IVS (0/12). Tumor tissue samples collected at onset and also at relapse for the same patients showed that apoptosis may occur at relapse. In addition, cells appear to undergo apoptosis independently from N-myc amplification, cell cycle phase and DNA ploidy. In conclusion, apoptosis seems to take place with about an equal frequency for both favourable and unfavourable stages with an exception for IVS. Since DNA fragmentation remained undetected in stage IVS, we suggest that apoptosis is not a mechanism of spontaneous regression for these patients. A better basic understanding of the complex molecular mechanisms and biochemical pathways that control apoptosis in neuroblastoma appears to be necessary.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti Wdoi
10.1023/a:1005738926317subject
Has Abstractpub_date
1997-01-01 00:00:00pages
209-15issue
1-2eissn
0167-594Xissn
1573-7373journal_volume
31pub_type
杂志文章abstract::Brain tumor patients undergo various combinations therapies, leading to very complex and confusing imaging appearances on follow up MR imaging and hence, differentiating recurrent or progressing tumors from treatment induced necrosis or effects has always been a challenge in neuro-oncologic imaging. This particular to...
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更新日期:2015-05-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:1984-01-01 00:00:00
abstract::The actual role of 18F-FDG PET/CT in evaluating primary brain lymphoma is still an open issue. Brain lymphoma usually show elevated 18F-FDG uptake, often higher than other brain tumors or inflammatory processes, but the metabolic behavior of this lymphoma is not still understood. Our aim was to investigate the particu...
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-013-1194-3
更新日期:2013-10-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1010620420241
更新日期:2001-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of neuro-oncology
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doi:10.1023/a:1023393532546
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journal_title:Journal of neuro-oncology
pub_type:
doi:10.1007/BF01049979
更新日期:1993-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-009-0040-0
更新日期:2010-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-014-1614-z
更新日期:2015-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/BF02341156
更新日期:1990-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1007/s11060-012-0919-z
更新日期:2012-09-01 00:00:00
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更新日期:2004-01-01 00:00:00
abstract::Transfection of primary cultures of human cells with origin of replication deficient SV40 DNA has been carried out by others to generate in vitro models of malignant transformation in vivo. The present work describes progressive alterations in karyotype and phenotype in one such transfected (neuroglial) cell line (SVG...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/BF00182082
更新日期:1990-02-01 00:00:00
abstract::Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. We examined patients with low grade supratentorial brain tumors to determine characteristics of pa...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-011-0779-y
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB. METHODS:Clin...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-018-2935-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:White matter changes (WMCs) can develop following systemic chemotherapy in patients with primary central nervous system lymphomas (PCNSLs), but the frequency and extent of these changes is not well characterized. This single center retrospective semi-quantitative study was performed to determine the rate, timin...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-019-03279-9
更新日期:2019-12-01 00:00:00
abstract::Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults. Vestibular schwannomas are the most common, followed by meningiomas. Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors. We describe a pilocyti...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-014-1630-z
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The diagnosis of sarcomatous transformation of plexiform neurofibromas in Neurofibromatosis-1 (NF 1) is a clinical and radiological challenge. Considerable overlap exists in the clinical and the radiological characteristics between the benign enlarging neurofibromas and their counterparts undergoing malignan...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-006-9161-x
更新日期:2006-10-01 00:00:00
abstract::Malignant primary spinal cord gliomas (PSCGs) are rare, and the optimal treatment for these lesions remains controversial. We report herein treatment outcomes of six malignant PSCGs managed with temozolomide (TMZ)-based multidisciplinary treatment. TMZ was administered concomitantly with fractionated radiotherapy for ...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1007/s11060-010-0249-y
更新日期:2011-01-01 00:00:00