High dose chemotherapy with autologous bone marrow rescue for children with diffuse pontine brain stem tumors. Children's Cancer Group.

abstract：:In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (F...

journal_title：Journal of neuro-oncology

authors： Czarnek N,Clark K,Peters KB,Mazurowski MA

更新日期：2017-03-01 00:00:00

abstract：OBJECT:There is little population-based data available on primary spinal cord tumors. Many of the existing statistics are not current or were obtained from surgical series. Historically, population-based data were collected only for malignant tumors, and only recently have data begun to be collected on non-malignant tu...

journal_title：Journal of neuro-oncology

authors： Schellinger KA,Propp JM,Villano JL,McCarthy BJ

更新日期：2008-04-01 00:00:00

abstract：:Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the ava...

journal_title：Journal of neuro-oncology

authors： Park HK,Steven D C

更新日期：2012-05-01 00:00:00

abstract：:The growth pattern of pilocytic astrocytoma (PAs) is unpredictable. Gene expression profiling has recently demonstrated an inverse relationship between myelin basic protein (MBP) expression and progression free survival (PFS) in PAs. We present here the pattern of expression of oligodendroglial differentiation markers...

journal_title：Journal of neuro-oncology

authors： Takei H,Yogeswaren ST,Wong KK,Mehta V,Chintagumpala M,Dauser RC,Lau CC,Adesina AM

更新日期：2008-01-01 00:00:00

abstract：:After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year. The patient reported subjective relief of symptoms after 1 month. Magnetic resonance imaging (MRI) contro...

journal_title：Journal of neuro-oncology

authors： Piribauer M,Czech T,Dieckmann K,Birner P,Hainfellner JA,Prayer D,Fazeny-Dörner B,Weinländer G,Marosi C

更新日期：2004-02-01 00:00:00

abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

journal_title：Journal of neuro-oncology

authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

更新日期：2001-12-01 00:00:00

abstract：:The completion of the Human Genome Project resulted in discovery of many unknown novel genes. This feat paved the way for the future development of novel therapeutics for the treatment of human disease based on novel biological functions and pathways. Towards this aim, we undertook a bioinformatics analysis of in-hous...

journal_title：Journal of neuro-oncology

authors： Junes-Gill KS,Gallaher TK,Gluzman-Poltorak Z,Miller JD,Wheeler CJ,Fan X,Basile LA

更新日期：2011-04-01 00:00:00

abstract：:p53 mutations are the most frequently detected genetic alterations of gliomas, appearing in a similar proportion of low and high grade astrocytomas, while the amplification of epidermal growth factor receptor (EGFR) gene appears mainly in glioblastomas. Thus, these changes seem to delineate two subgroups of high grade...

journal_title：Journal of neuro-oncology

authors： Kordek R,Biernat W,Alwasiak J,Maculewicz R,Yanagihara R,Liberski PP

更新日期：1995-10-01 00:00:00

abstract：:The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic cleavage. ETs exert their biological effects through the activation of two receptors sub...

journal_title：Journal of neuro-oncology

authors： Paolillo M,Barbieri A,Zanassi P,Schinelli S

更新日期：2006-08-01 00:00:00

abstract：:Children with recurrent high grade gliomas (HGG) have a dismal outcome with a median progression free survival (PFS) of 12 weeks. Adults with recurrent HGG treated with irinotecan and bevacizumab reportedly have a 63% response rate and a median PFS of 23 weeks. There is a paucity of corresponding published pediatric d...

journal_title：Journal of neuro-oncology

authors： Parekh C,Jubran R,Erdreich-Epstein A,Panigrahy A,Bluml S,Finlay J,Dhall G

更新日期：2011-07-01 00:00:00

abstract：:Global and gene-specific changes to the epigenome are hallmarks of most tumours including those of pituitary origin, and this fact might offer important clues about diagnostic and therapeutic applications. We performed global DNA methylation screening with 6 invasive and 6 noninvasive nonfunctioning pituitary adenomas...

journal_title：Journal of neuro-oncology

authors： Gu Y,Zhou X,Hu F,Yu Y,Xie T,Huang Y,Zhao X,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:An anti-epithelial membrane antigen monoclonal (Clone E29) was used as part of a panel of antisera in the investigation of primary CNS and metastatic tumours. In contrast to others, definite and often strongly positive cross-reactivity has been demonstrated on glial cells. The material consisted of fourteen astrocytom...

journal_title：Journal of neuro-oncology

authors： Hitchcock E,Morris CS

更新日期：1987-01-01 00:00:00

abstract：:Malignant rhabdoid tumors (MRT) are aggressive neoplasms generally of the infant kidney, although a few extrarenal, central nervous system-located, were reported. We describe two cases of such tumors arising intracerebrally in patients aged 16 and 31 years, hence older than the usually reported, with survival times of...

journal_title：Journal of neuro-oncology

authors： Pimentel J,Silva R,Pimentel T

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall wi...

journal_title：Journal of neuro-oncology

authors： Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Elevated serum alkaline phosphatase has been previously studied as a biomarker for progression of metastatic disease and implicated in adverse skeletal events and worsened survival. The purpose of this study was to determine if serum alkaline phosphatase was a predictor of short-term mortality of patients un...

journal_title：Journal of neuro-oncology

authors： Karhade AV,Thio QCBS,Ogink PT,Schwab JH

更新日期：2018-10-01 00:00:00

abstract：:NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...

journal_title：Journal of neuro-oncology

authors： Vranceanu AM,Merker VL,Plotkin SR,Park ER

更新日期：2014-10-01 00:00:00

abstract：:We have established a new xenogeneic animal model of leptomeningeal metastasis (LM) by intracisternal inoculation of human CEM T-cell lymphoma into nude rats, and used it to evaluate the anti-lymphoma efficacy of an anti-CD7 ricin A chain immunotoxin (DA7). In vitro incubation with 2 microg/ml DA7 for 72 h inhibited C...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Schmidberger H,Buchholz R,Wehrmann M,Vallera DA,Schabet M

更新日期：1998-10-01 00:00:00

abstract：:We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cells into each hind foot pad. After 10 days, the tumor-draining lymph n...

journal_title：Journal of neuro-oncology

authors： Rice CD,Baldwin NG,Biron RT,Bear HD,Merchant RE

更新日期：1997-03-01 00:00:00

abstract：INTRODUCTION:Central nervous system (CNS) involvement, especially involvement of the cerebrospinal fluid (CSF), is common in several haematological malignancies. Intrathecal (IT) chemotherapy can be used to manage CSF involvement. METHODS:Here we evaluated the effectiveness of IT chemotherapy among 80 patients with ha...

journal_title：Journal of neuro-oncology

authors： Dara A,Mook BB,Doorduijn JK,van den Bent MJ,Dinmohamed AG,Bromberg JEC

更新日期：2018-08-01 00:00:00

abstract：:Two patients with metastasis from lung carcinoma of the midbrain are presented. The computerized tomographic (CT) findings mimicked a primary pineal tumor, but autopsy confirmed a metastatic nodule in the midbrain in both cases. The rational approach to posterior third ventricular tumors seen on CT in adulthood is dis...

journal_title：Journal of neuro-oncology

authors： Tomita T,Wetzel N

更新日期：1984-01-01 00:00:00

abstract：:Identification of cytotoxic T lymphocyte (CTL) epitopes from additional tumor antigens is essential for the development of specific immunotherapy of malignant tumors. Neuritin, a recently discovered antigen overexpressed in astrocytoma, is considered to be a promising target for biological therapy. In the present stud...

journal_title：Journal of neuro-oncology

authors： Yang Z,Zhao T,Liu Y,Gong Z,Cheng S,Yang Q

更新日期：2013-08-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

journal_title：Journal of neuro-oncology

authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

更新日期：1998-08-01 00:00:00

abstract：:Systemic high-dose methotrexate (HD-MTX) is the most effective chemotherapeutic agent in the treatment of primary central nervous system lymphoma (PCNSL). Leptomeningeal involvement is common and intrathecal methotrexate (IT-MTX) is frequently used in combination with HD-MTX, but its benefits are not established. Usin...

journal_title：Journal of neuro-oncology

authors： Khan RB,Shi W,Thaler HT,DeAngelis LM,Abrey LE

更新日期：2002-06-01 00:00:00

abstract：:The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII), using athymic nude mi...

journal_title：Journal of neuro-oncology

authors： Takasu S,Takahashi T,Okamoto S,Oriuchi N,Nakayashiki N,Okamoto K,Muramatsu H,Hayashi T,Nakahara N,Mizuno M,Wakabayashi T,Higuchi T,Endo K,Kozaki K,Miyaishi O,Saga S,Ueda R,Yoshida J,Yoshikawa K

更新日期：2003-07-01 00:00:00

abstract：:Chromatin modification through histone deacetylase inhibition has shown evidence of activity against malignancies. The mechanism of action of such agents are pleiotropic and potentially tumor specific. In this study, we studied the mechanisms of vorinostat-induced cellular effects in gliomas. The effects of vorinostat...

journal_title：Journal of neuro-oncology

authors： Xu J,Sampath D,Lang FF,Prabhu S,Rao G,Fuller GN,Liu Y,Puduvalli VK

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:While hypofractionated stereotactic radiotherapy (HFSRT) is being increasingly used for treating brain metastases, clinical data concerning the incidence and risk factors of its main side-effect, namely radiation necrosis (RN), remain limited. In this context, we assessed risk factors of RN in a single cen...

journal_title：Journal of neuro-oncology

authors： Di Perri D,Tanguy R,Malet C,Robert A,Sunyach MP

更新日期：2020-09-01 00:00:00

abstract：:Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of D...

journal_title：Journal of neuro-oncology

authors： Baugh J,Bartels U,Leach J,Jones B,Chaney B,Warren KE,Kirkendall J,Doughman R,Hawkins C,Miles L,Fuller C,Hassall T,Bouffet E,Lane A,Hargrave D,Grill J,Hoffman LM,Jones C,Towbin A,Savage SA,Monje M,Li XN,Ziegler

更新日期：2017-04-01 00:00:00

abstract：:The aim of this investigation was to define characteristic properties of cellular energy metabolism in meningiomas in vitro dependent on the histological subtype. We analysed marker enzymes of representative metabolic pathways localized in the mitochondria (respiratory chain, citric acid cycle, beta-oxidation of fatty...

journal_title：Journal of neuro-oncology

authors： Herting B,Meixensberger J,Roggendorf W,Reichmann H

更新日期：2003-11-01 00:00:00

abstract：:Recurrent gliomas are most often treated by chemotherapy. However, these tumors typically acquire resistance to most drugs administered, and patients will usually die of recurrent tumor. Factors which may play a role include overexpression of putative multidrug resistance genes, such as the multidrug resistance gene 1...

journal_title：Journal of neuro-oncology

authors： Liang BC

更新日期：1996-08-01 00:00:00