Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures.

abstract：:Cancer related stroke may have different phenotypes from non-cancer stroke, especially in terms of stroke progression and recurrence. We performed a case-control study to identify their incidences and risk factors in cancer related stroke. Between January 2001 and December 2009, we conducted a retrospective review of ...

journal_title：Journal of neuro-oncology

authors： Kim JM,Jung KH,Park KH,Lee ST,Chu K,Roh JK

更新日期：2013-02-01 00:00:00

abstract：:Brain tumors and anti-cancer treatments can cause a wide range of cognitive deficits that in turn, being a major cause of disability, significantly affect patients' independence and quality of life. To evaluate the neurocognitive status of a non selected population of brain tumors outpatients, investigating the correl...

journal_title：Journal of neuro-oncology

authors： Zucchella C,Bartolo M,Di Lorenzo C,Villani V,Pace A

更新日期：2013-05-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

journal_title：Journal of neuro-oncology

authors： Raychaudhuri B,Vogelbaum MA

更新日期：2011-01-01 00:00:00

abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

journal_title：Journal of neuro-oncology

authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:White matter changes (WMCs) can develop following systemic chemotherapy in patients with primary central nervous system lymphomas (PCNSLs), but the frequency and extent of these changes is not well characterized. This single center retrospective semi-quantitative study was performed to determine the rate, timin...

journal_title：Journal of neuro-oncology

authors： Estephan F,Ye X,Dzaye O,Wagner-Johnston N,Swinnen L,Gladstone DE,Ambinder R,Kamson DO,Lambrecht S,Grossman SA,Lin DDM,Holdhoff M

更新日期：2019-12-01 00:00:00

abstract：:Glioblastoma (GBM) is among the most aggressive primary brain tumors, with a median survival rate of 12-15 months. MicroRNAs have been implicated in GBM development as oncogenes or tumor suppressors. In this study, we demonstrated that miR-519a expression was frequently downregulated in GBM specimens and cell lines, a...

journal_title：Journal of neuro-oncology

authors： Hong L,Ya-Wei L,Hai W,Qiang Z,Jun-Jie L,Huang A,Song-Tao Q,Yun-Tao L

更新日期：2016-05-01 00:00:00

abstract：:Primary intramedullary spinal cord tumors are a rare entity, comprising 4–10 %of all spinal cord tumors. The current report presents data on intramedullary spinal cord anaplastic astrocytomas and glioblastomas in adults using the national surveillance, epidemiology, and end results database (1973–2008), and evaluates ...

journal_title：Journal of neuro-oncology

authors： Wong AP,Dahdaleh NS,Fessler RG,Melkonian SC,Lin Y,Smith ZA,Lam SK

更新日期：2013-12-01 00:00:00

abstract：:This paper reviews the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT). A major advantage of an ABNS for BNCT over reactor-based neutron sources is the potential for siting withi...

journal_title：Journal of neuro-oncology

authors： Blue TE,Yanch JC

更新日期：2003-03-01 00:00:00

abstract：OBJECT:Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported. METHODS:Eighty-three cases of subependymoma were retrieved from the files of the Armed Forces Institute of Pathology. Clinicopatholo...

journal_title：Journal of neuro-oncology

authors： Rushing EJ,Cooper PB,Quezado M,Begnami M,Crespo A,Smirniotopoulos JG,Ecklund J,Olsen C,Santi M

更新日期：2007-12-01 00:00:00

abstract：:Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data fro...

journal_title：Journal of neuro-oncology

authors： Shabihkhani M,Telesca D,Movassaghi M,Naeini YB,Naeini KM,Hojat SA,Gupta D,Lucey GM,Ontiveros M,Wang MW,Hanna LS,Sanchez DE,Mareninov S,Khanlou N,Vinters HV,Bergsneider M,Nghiemphu PL,Lai A,Liau LM,Cloughesy TF,Yon

更新日期：2017-04-01 00:00:00

abstract：:Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes, as the yolk sac circulation. Angiogenesis is responsible for the rem...

journal_title：Journal of neuro-oncology

authors： Patan S

更新日期：2000-10-01 00:00:00

abstract：INTRODUCTION:Informal family caregivers (FCG) are an integral and crucial human component in the cancer care continuum. However, research and interventions to help alleviate documented anxiety and burden on this group is lacking. To address the absence of effective interventions, we developed the electronic Support Net...

journal_title：Journal of neuro-oncology

authors： Reblin M,Ketcher D,Forsyth P,Mendivil E,Kane L,Pok J,Meyer M,Wu YP,Agutter J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...

journal_title：Journal of neuro-oncology

authors： Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SH

更新日期：2005-01-01 00:00:00

abstract：:Extracranial metastases from glioblastoma (GBM) are uncommon with an estimated incidence of less than 2%. We report two cases of metastatic GBM seen within an 8-week period followed by a literature review. We attempted to identify common factors or a causative mechanism. Factors that predominated among the reviewed ca...

journal_title：Journal of neuro-oncology

authors： Kalokhe G,Grimm SA,Chandler JP,Helenowski I,Rademaker A,Raizer JJ

更新日期：2012-03-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：:Among diffuse gliomas, oligodendrogliomas may account for 25% of cases. They have a better prognosis and chemosensitivity as compared to astrocytomas. Genetic studies have shown a correlation between oligodendrocyte phenotype and presence of 1p/19q deletions. In addition, these deletions are of prognostic value. The a...

journal_title：Journal of neuro-oncology

authors： Bouvier C,Roll P,Quilichini B,Metellus P,Calisti A,Gilles S,Chinot O,Fina F,Martin PM,Figarella-Branger D

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK) is expressed in ~ 60% of glioblastomas and conveys tumorigenic functions. Therefore, ALK inhibitory strategies with alectinib are conceivable for patients with glioblastoma. The aims of this preclinical study were to investigate efficacy as well as to understand and potential...

journal_title：Journal of neuro-oncology

authors： Berberich A,Schmitt LM,Pusch S,Hielscher T,Rübmann P,Hucke N,Latzer P,Heßling B,Lemke D,Kessler T,Platten M,Wick W

更新日期：2020-01-01 00:00:00

abstract：:The actual role of 18F-FDG PET/CT in evaluating primary brain lymphoma is still an open issue. Brain lymphoma usually show elevated 18F-FDG uptake, often higher than other brain tumors or inflammatory processes, but the metabolic behavior of this lymphoma is not still understood. Our aim was to investigate the particu...

journal_title：Journal of neuro-oncology

authors： Albano D,Bosio G,Bertoli M,Giubbini R,Bertagna F

更新日期：2018-02-01 00:00:00

abstract：:We have established a new xenogeneic animal model of leptomeningeal metastasis (LM) by intracisternal inoculation of human CEM T-cell lymphoma into nude rats, and used it to evaluate the anti-lymphoma efficacy of an anti-CD7 ricin A chain immunotoxin (DA7). In vitro incubation with 2 microg/ml DA7 for 72 h inhibited C...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Schmidberger H,Buchholz R,Wehrmann M,Vallera DA,Schabet M

更新日期：1998-10-01 00:00:00

abstract：:Conventional Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the cornerstone in the initial evaluation of brain tumours. The purpose of this study is to evaluate the contribution of Magnetic Resonance Spectroscopy (MRS) and Perfusion-weighted MRI to distinguish malignant from benign tumours. We inclu...

journal_title：Journal of neuro-oncology

authors： Fayed N,Modrego PJ

更新日期：2005-05-01 00:00:00

abstract：:Glioblastoma cells secrete transforming growth factor-beta (TGF-beta), which has a variety of immunosuppressive properties. We investigated the effect of irradiation TGF-beta secretion by malignant glioma cells. Three malignant glioma cell lines (T98G, A172, KG-1-C) were cultured and irradiated using 10 and 50 Gy Lina...

journal_title：Journal of neuro-oncology

authors： Satoh E,Naganuma H,Sasaki A,Nagasaka M,Ogata H,Nukui H

更新日期：1997-07-01 00:00:00

abstract：:Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire wa...

journal_title：Journal of neuro-oncology

authors： Azizi AA,Schouten-van Meeteren AYN

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To analyze the surgical outcome of a consecutive and single center series of medulla oblongata (MO) and spinal cord hemangioblastomas (HB). PATIENT AND METHODS:We retrospectively reviewed the medical charts of all MO and spinal HB patients operated on in our institution between 1985 and 2002. All patients had ...

journal_title：Journal of neuro-oncology

authors： Parker F,Aghakhani N,Ducati LG,Yacubian-Fernandes A,Silva MV,David P,Richard S,Tadie M

更新日期：2009-05-01 00:00:00

abstract：:The aim of this investigation was to define characteristic properties of cellular energy metabolism in meningiomas in vitro dependent on the histological subtype. We analysed marker enzymes of representative metabolic pathways localized in the mitochondria (respiratory chain, citric acid cycle, beta-oxidation of fatty...

journal_title：Journal of neuro-oncology

authors： Herting B,Meixensberger J,Roggendorf W,Reichmann H

更新日期：2003-11-01 00:00:00

abstract：:To explore the antitumor mechanism of bacterial cytosine deaminase plus 5-fluorocytosine (CD/5-FCyt) in combination with interferons (IFNs), glioma cells were transduced with recombinant retroviruses expressing CD. The transduced glioma cells become sensitive to the nontoxic prodrug 5-FCyt. Apoptosis, DNA damage, byst...

journal_title：Journal of neuro-oncology

authors： Wang ZH,Samuels S,Gama Sosa MA,Kolodny EH

更新日期：1998-02-01 00:00:00

abstract：:Children with recurrent high grade gliomas (HGG) have a dismal outcome with a median progression free survival (PFS) of 12 weeks. Adults with recurrent HGG treated with irinotecan and bevacizumab reportedly have a 63% response rate and a median PFS of 23 weeks. There is a paucity of corresponding published pediatric d...

journal_title：Journal of neuro-oncology

authors： Parekh C,Jubran R,Erdreich-Epstein A,Panigrahy A,Bluml S,Finlay J,Dhall G

更新日期：2011-07-01 00:00:00

abstract：:Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

journal_title：Journal of neuro-oncology

authors： Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

更新日期：2013-04-01 00:00:00

abstract：:The use of radiotherapy alone to treat primary central nervous system lymphoma (PCNSL) does not produce the high local control and survival rates that it does in limited extranodal non-Hodgkin's lymphoma outside the central nervous system (CNS). Even with doses of whole brain radiation therapy (WBRT) to 40+20 Gy boost...

journal_title：Journal of neuro-oncology

authors： Nelson DF

更新日期：1999-07-01 00:00:00

abstract：:Neural stem cells (NSC) have unique differentiation-, proliferation-, and motility properties. To investigate whether they secrete factors that interfere with the proliferation of glioma cells, we grew glioma cells in conditioned medium (CM) obtained from cultures of neurospheres including neural stem / progenitor cel...

journal_title：Journal of neuro-oncology

authors： Suzuki T,Izumoto S,Wada K,Fujimoto Y,Maruno M,Yamasaki M,Kanemura Y,Shimazaki T,Okano H,Yoshimine T

更新日期：2005-09-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00