Effect of irradiation on transforming growth factor-beta secretion by malignant glioma cells.

abstract：INTRODUCTION:Low-grade glioma (LGG) represent the most common pediatric central nervous system tumor. When total surgical resection is not feasible, chemotherapy is first-line therapy in children. Multiple pediatric LGG chemotherapy regimens have been investigated with variable 2-year event free survival (EFS) rates of...

journal_title：Journal of neuro-oncology

authors： Nellan A,Wright E,Campbell K,Davies KD,Donson AM,Amani V,Judd A,Hemenway MS,Raybin J,Foreman NK,Rush S,Dorris K

更新日期：2020-07-01 00:00:00

abstract：:Disparities in American health care based on socially-defined patient characteristics such as race, ethnicity, and socioeconomic position are well-documented. We review differences and disparities in incidence, pathobiology, processes and outcomes of care, and survival based on social factors for brain tumors of all h...

journal_title：Journal of neuro-oncology

authors： Curry WT Jr,Barker FG 2nd

更新日期：2009-05-01 00:00:00

abstract：:A case of a functioning invasive pituitary oncocytoma in a 50-year-old man is reported. The serum prolactin was increased and immunocytochemical staining was positive for prolactin. In addition to numerous mitochondria within the neoplastic cells, structurally abnormal mitochondria with crystalline inclusions were als...

journal_title：Journal of neuro-oncology

authors： Chowdhury C,Roy S,Gupta N,Kochupillai N,Banerji AK

更新日期：1986-01-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：INTRODUCTION:Glioblastoma (GBM) is the most common primary brain cancer. The average survival time for the majority of patients is approximately 15 months after diagnosis. A major feature of GBM that contributes to its poor prognosis is its high invasiveness. Caveolae are plasma membrane subdomains that participate in ...

journal_title：Journal of neuro-oncology

authors： Pu W,Nassar ZD,Khabbazi S,Xie N,McMahon KA,Parton RG,Riggins GJ,Harris JM,Parat MO

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To evaluate perioperative management, early outcomes and hemocoagulative disorders in infants up to 1 year old, undergoing neurosurgery for brain tumors removal. DESIGN:Retrospective evaluation of prospectively collected data regarding all infants aged <1 year admitted to PICU from 1994 to 2004, following in...

journal_title：Journal of neuro-oncology

authors： Piastra M,Di Rocco C,Caresta E,Zorzi G,De Luca D,Caldarelli M,La Torre G,Conti G,Antonelli M,Eaton S,Pietrini D

更新日期：2008-11-01 00:00:00

abstract：:Gemistocytic astrocytoma still continues to be enigmatic; both in terms of definition and prognostic implications. The major issue of contention has been the clinical relevance of this pathological entity. The currently accepted definition of gemistocytic astrocytoma requires 20% or more gemistocytes, and considers th...

journal_title：Journal of neuro-oncology

authors： Tihan T,Vohra P,Berger MS,Keles GE

更新日期：2006-01-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1) or its ligand (PD-L1) have been shown to be effective in treating patients with a variety of cancers. Biomarker studies have found positive associations between clinical response rates and PD-L1 expression on tumor cells, as well as the presence of ...

journal_title：Journal of neuro-oncology

authors： Wang S,Liechty B,Patel S,Weber JS,Hollmann TJ,Snuderl M,Karajannis MA

更新日期：2018-05-01 00:00:00

abstract：:To evaluate the safety and efficacy of hypofractionated radiotherapy (RT) with a standard temozolomide (TMZ) regimen for adults with newly diagnosed glioblastoma multiforme (GBM), twenty-six consecutive adults (range 39-79 years) who met our enrollment criteria received short courses of hypofractionated RT (45 Gy in 1...

journal_title：Journal of neuro-oncology

authors： Terasaki M,Eto T,Nakashima S,Okada Y,Ogo E,Sugita Y,Tokutomi T,Shigemori M

更新日期：2011-04-01 00:00:00

abstract：:A pilot study was performed combining cis-diamminedichloroplatinum (CDDP) and radiation therapy to treat patients with high-grade astrocytomas. CDDP at a dose of 40 mg/m2/week intravenously was given during the course of cranial irradiation. Following irradiation, CDDP was given every three weeks on a schedule of 35-4...

journal_title：Journal of neuro-oncology

authors： Feun LG,Stewart DJ,Maor M,Leavens M,Savaraj N,Burgess MA,Yung WK,Benjamin RS

更新日期：1983-01-01 00:00:00

abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...

journal_title：Journal of neuro-oncology

authors： Benke T,Wagner M,Pallua AK,Muigg A,Stockhammer G

更新日期：2004-01-01 00:00:00

abstract：:The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic cleavage. ETs exert their biological effects through the activation of two receptors sub...

journal_title：Journal of neuro-oncology

authors： Paolillo M,Barbieri A,Zanassi P,Schinelli S

更新日期：2006-08-01 00:00:00

abstract：:Primary brain tumors cumulatively represent the most common solid tumors of childhood and are the leading cause of cancer related death in this age group. Traditionally, molecular findings and histological analyses from biopsies of resected tumor tissue have been used for diagnosis and classification of these diseases...

journal_title：Journal of neuro-oncology

authors： Samuel N,Remke M,Rutka JT,Raught B,Malkin D

更新日期：2014-06-01 00:00:00

abstract：:A rat glioma model was employed to estimate the Ca2+ kinetics in the tumor arteriolar smooth muscle cells. Electron microcytochemistry revealed that the density of intracellular Ca2+ deposits in the intra-tumor arteriolar smooth muscle cells was significantly greater, with slightly higher membrane Ca(2+)-adenosine tri...

journal_title：Journal of neuro-oncology

authors： Zenke K,Nakagawa K,Kumon Y,Ohta S,Hatakeyama T,Sakaki S

更新日期：1996-10-01 00:00:00

abstract：:Anguidine pretreatment was previously shown to potentiate cis-platinum in Chinese hamster ovary cells by 100-fold, probably by enhancing cellular cis-platinum uptake. Since both cis-platinum and anguidine have been reported to have clinical efficacy in human brain tumors, the present study was initiated to investigate...

journal_title：Journal of neuro-oncology

authors： Hromas RA,Yung WK

更新日期：1986-01-01 00:00:00

abstract：:Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the e...

journal_title：Journal of neuro-oncology

authors： Di K,Keir ST,Alexandru-Abrams D,Gong X,Nguyen H,Friedman HS,Bota DA

更新日期：2014-12-01 00:00:00

abstract：:The activation of autocrine loops involving proto-oncogene related receptor tyrosine kinases has led to the analysis of a large number of growth factor systems in human glioma specimens and cell lines. The ErbB-2 system, also called HER-2 or neu, is analogous to the epidermal growth factor receptor system (EGF-R, ErbB...

journal_title：Journal of neuro-oncology

authors： Westphal M,Meima L,Szonyi E,Lofgren J,Meissner H,Hamel W,Nikolics K,Sliwkowski MX

更新日期：1997-12-01 00:00:00

abstract：:Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...

journal_title：Journal of neuro-oncology

authors： Jennings MT,Asadourian LL,Jennings VD,Shapiro JR,Thaler HT

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

journal_title：Journal of neuro-oncology

authors： Endo T,Su CC,Numagami Y,Shirane R

更新日期：2004-05-01 00:00:00

abstract：:5-aminolevulinic acid (5-ALA) introduction in the surgical management of Glioblastoma (GBM) enables the intra-operatively identification of cancer cells in the mass by means of fluorescence. Here, we analyzed the phenotype of GBM cells isolated from distinct tumour areas determined by 5-ALA (tumour core, 5-ALA intense...

journal_title：Journal of neuro-oncology

authors： Rampazzo E,Della Puppa A,Frasson C,Battilana G,Bianco S,Scienza R,Basso G,Persano L

更新日期：2014-02-01 00:00:00

abstract：:HDGF is overexpressed in gliomas as compared to normal brain. We therefore analyzed the molecular mechanisms of HDGF action in gliomas. HDGF was downregulated in normal brain tissue as compared to glioma specimens at both the mRNA and the protein levels. In glioma samples, increased HDGF expression was associated with...

journal_title：Journal of neuro-oncology

authors： Song Y,Hu Z,Long H,Peng Y,Zhang X,Que T,Zheng S,Li Z,Wang G,Yi L,Liu Z,Fang W,Qi S

更新日期：2014-09-01 00:00:00

abstract：:A thirty-year-old male with an intracranial malignant meningioma, first diagnosed 9 years ago, with three recurrences was admitted with a hypoglycemic shock. The blood glucose level was 17 mg/dl, requiring treatment with high doses of intravenous and oral dextrose for improvement. A large metastatic tumor in the liver...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Sugisaki Y,Tamaki T,Saitoh N,Node Y,Shimura T,Teramoto A

更新日期：2000-03-01 00:00:00

abstract：:Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in tumors of neuroectodermal origin such as melanoma and glioma. Many of these tumors are of neuroectodermal or ectomesenchymal origin which is suggestive of TERT promoter mutations playing a role i...

journal_title：Journal of neuro-oncology

authors： Dubbink HJ,Bakels H,Post E,Zwarthoff EC,Verdijk RM

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:Stereotactic radiosurgery is an established treatment option for sporadic meningiomas, though limited data exists for radiation-induced lesions. METHODS:Patients treated with cobalt-60 radiosurgery between October 2005 and December 2018 in an institutional registry were reviewed. Single fraction treatments wer...

journal_title：Journal of neuro-oncology

authors： Huo M,Laperriere N,van Prooijen M,Shultz D,Coolens C,Hodaie M,Cusimano M,Gentili F,Zadeh G,Payne D,Schwartz M,Tsang DS

更新日期：2020-06-01 00:00:00

abstract：:Angiogenesis is one of the key features of glioblastoma (GB). However, the use of anti-angiogenic therapies directed against vascular endothelial growth factor (VEGF) is limited by primary or acquired resistance. MET/HGF and PlGF signaling are involved in potential alternative escape mechanisms to VEGF pathway. Our ob...

journal_title：Journal of neuro-oncology

authors： Tabouret E,Denicolai E,Delfino C,Graillon T,Boucard C,Nanni I,Padovani L,Figarella-Branger D,Chinot O

更新日期：2016-12-01 00:00:00

abstract：:Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness. ...

journal_title：Journal of neuro-oncology

authors： Litofsky NS,Pihan G,Corvi F,Smith TW

更新日期：1998-11-01 00:00:00

abstract：:To determine the impact of delay between surgery and radiotherapy on overall survival (OS) in temozolomide treatmented patients with the incorporation of O6-methylguanine-DNA methyltransferase (MGMT). From 2000 to 2012, 345 consecutive glioblastoma patients were treated with surgery, radiotherapy, and temozolomide at ...

journal_title：Journal of neuro-oncology

authors： Spratt DE,Folkert M,Zumsteg ZS,Chan TA,Beal K,Gutin PH,Pentsova E,Yamada Y

更新日期：2014-01-01 00:00:00

abstract：:Glioblastoma stands out as the most frequent central nervous system neoplasia, presenting a poor prognosis. The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnose...

journal_title：Journal of neuro-oncology

authors： Koshiyama DB,Trevisan P,Graziadio C,Rosa RFM,Cunegatto B,Scholl J,Provenzi VO,de Sá AP,Soares FP,Velho MC,de A P Filho N,Oliveira CA,Zen PRG

更新日期：2017-12-01 00:00:00

abstract：:There is general agreement that most chemotherapy agents achieve only relatively low concentrations in the normal central nervous system, that the blood-brain barrier is variably disrupted in malignant brain tumors, and that the concentration of chemotherapy drugs in the brain adjacent to tumor is intermediate between...

journal_title：Journal of neuro-oncology

authors： Stewart DJ

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Herein, we describe a single institutio...

journal_title：Journal of neuro-oncology

authors： Goyal A,Yolcu Y,Kerezoudis P,Alvi MA,Krauss WE,Bydon M

更新日期：2019-04-01 00:00:00