Abstract:
:Angiogenesis is one of the key features of glioblastoma (GB). However, the use of anti-angiogenic therapies directed against vascular endothelial growth factor (VEGF) is limited by primary or acquired resistance. MET/HGF and PlGF signaling are involved in potential alternative escape mechanisms to VEGF pathway. Our objective was to explore the potential changes of MET/HGF and PlGF expression, comparing initial diagnosis and recurrence after radiotherapy-temozolomide (RT/TMZ). Paired frozen tumors from both initial and recurrent surgery after radio-chemotherapy were available for 28 patients. RNA expressions of PlGF, MET, and HGF genes were analyzed by RT-qPCR. PlGF expression significantly decreased at recurrence (p = 0.021), and expression of MET showed a significant increase (p = 0.011) at recurrence. RNA expressions of MET and HGF significantly correlated both at baseline and recurrence (baseline: p = 0.005; recurrence: p = 0.019). Evolutive profile (increasing versus decreasing expression at recurrence) of MET was associated with PFS (p = 0.002) and OS (p = 0.022) at recurrence, while the evolutive profile of HGF was associated with PFS at relapse (p = 0.049). Recurrence of GB after chemo-radiation could be associated with a variation in PlGF and MET expression. These results contribute to suggest a modification of the GB angiogenic process between initial diagnosis and recurrence.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Tabouret E,Denicolai E,Delfino C,Graillon T,Boucard C,Nanni I,Padovani L,Figarella-Branger D,Chinot Odoi
10.1007/s11060-016-2251-5subject
Has Abstractpub_date
2016-12-01 00:00:00pages
431-437issue
3eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-016-2251-5journal_volume
130pub_type
杂志文章abstract::Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-014-1427-0
更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2006-07-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/b:neon.0000013497.04322.fc
更新日期:2004-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-016-2367-7
更新日期:2017-04-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1021248329980
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11060-018-03043-5
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-005-9087-8
更新日期:2006-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/BF00165584
更新日期:1986-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-013-1302-4
更新日期:2014-01-01 00:00:00
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doi:10.1007/s11060-010-0165-1
更新日期:2010-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11060-013-1122-6
更新日期:2013-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-019-03311-y
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00