TERT promoter mutations and BRAF mutations are rare in sporadic, and TERT promoter mutations are absent in NF1-related malignant peripheral nerve sheath tumors.

abstract：:Aneurysmal bone cysts (ABCs) are benign bone lesions with annual incidences ranging from 1.4 to 3.2 cases per million people. Approximately, 10-30% of ABCs are found in the spine. Such lesions are traditionally treated with curettage or other intralesional techniques. Because ABCs can be locally aggressive, intralesio...

journal_title：Journal of neuro-oncology

authors： Boriani S,Lo SF,Puvanesarajah V,Fisher CG,Varga PP,Rhines LD,Germscheid NM,Luzzati A,Chou D,Reynolds JJ,Williams RP,Zadnik P,Groves M,Sciubba DM,Bettegowda C,Gokaslan ZL,AOSpine Knowledge Forum Tumor.

更新日期：2014-10-01 00:00:00

abstract：:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI...

journal_title：Journal of neuro-oncology

authors： Korshunov A,Savostikova M,Ozerov S

更新日期：2002-07-01 00:00:00

abstract：:Global and gene-specific changes to the epigenome are hallmarks of most tumours including those of pituitary origin, and this fact might offer important clues about diagnostic and therapeutic applications. We performed global DNA methylation screening with 6 invasive and 6 noninvasive nonfunctioning pituitary adenomas...

journal_title：Journal of neuro-oncology

authors： Gu Y,Zhou X,Hu F,Yu Y,Xie T,Huang Y,Zhao X,Zhang X

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degree...

journal_title：Journal of neuro-oncology

authors： McAbee JH,Degorre-Kerbaul C,Valdez K,Wendler A,Shankavaram UT,Watts C,Camphausen K,Tofilon PJ

更新日期：2020-09-01 00:00:00

abstract：:To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All received systemic or intrathecal chemotherapy and six received additional cranial or spinal radiotherapy. Six patient...

journal_title：Journal of neuro-oncology

authors： Pradat PF,Hoang-Xuan K,Cornu P,Mokhtari K,Martin-Duverneuil N,Poisson M,Delattre JY

更新日期：1999-09-01 00:00:00

abstract：:Cyclin-dependent kinase 4 inhibitor (CDKN2/p16) is a cell cycle regulatory protein that has been demonstrated to be inactivated by mutations, deletions or transcriptional silencing during pathogenesis of a variety of human malignancies. We studied the correlation of CDKN2/p16 expression with cell proliferation activit...

journal_title：Journal of neuro-oncology

authors： Miettinen H,Kononen J,Sallinen P,Alho H,Helen P,Helin H,Kalimo H,Paljärvi L,Isola J,Haapasalo H

更新日期：1999-02-01 00:00:00

abstract：:Elevated neutrophil-lymphocyte ratio (NLR) may predict worse outcomes in cancer, including glioblastoma (GBM). This study assessed whether change in NLR during focal radiotherapy and concomitant temozolomide (RT-TMZ) provides further prognostic information. This was a retrospective review of patients treated with RT-T...

journal_title：Journal of neuro-oncology

authors： Mason M,Maurice C,McNamara MG,Tieu MT,Lwin Z,Millar BA,Menard C,Laperriere N,Milosevic M,Atenafu EG,Mason W,Chung C

更新日期：2017-05-01 00:00:00

abstract：:Cancer is a leading cause of death in the United States. Despite the development of advanced treatment for many malignancies, a large number of patients will require evaluation and possible surgical intervention for lesions which have metastasized to or directly invaded the spinal column. The recommendations for opera...

journal_title：Journal of neuro-oncology

authors： Welch WC,Jacobs GB

更新日期：1995-01-01 00:00:00

abstract：:We prospectively addressed whether EGFR and KRAS mutations, EML4-ALK, ROS1 and RET rearrangements, or wild-type (WT), affects radiosurgery outcomes and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastases (BM). Of 326 patients with BM treated in 2012-2014 with Gamma Knife radiosur...

journal_title：Journal of neuro-oncology

authors： Shin SM,Cooper BT,Chachoua A,Butler J,Donahue B,Silverman JS,Kondziolka D

更新日期：2016-02-01 00:00:00

abstract：:Computational modeling shows that intra-arterial delivery is most efficient when the delivered drugs rapidly and avidly bind to the target site. The cell-penetrating peptide trans-activator of transcription (TAT) is a candidate carrier molecule that could mediate such specificity for brain tumor chemotherapeutics. To ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Cooke JRN,Ellis JA,Emala CW,Bruce JN

更新日期：2017-12-01 00:00:00

abstract：:Treatment for anaplastic astrocytoma (AA) is controversial. To assess three primary treatment approaches, patients from a single institution were retrospectively evaluated. To represent modern treatment selection, patients diagnosed with AA from December 2003 to December 2009 were selected. Those with insufficient dat...

journal_title：Journal of neuro-oncology

authors： Shonka NA,Theeler B,Cahill D,Yung A,Smith L,Lei X,Gilbert MR

更新日期：2013-06-01 00:00:00

abstract：:Transient cerebral hypoperfusion (TCH) has empirically been used to assist intraarterial (IA) drug delivery to brain tumors. Transient (<3 min) reduction of cerebral blood flow (CBF) occurs during many neuro- and cardiovascular interventions and has recently been used to better target IA drugs to brain tumors. In the ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Singh-Moon RP,Wang M,Chaudhuri DB,Holcomb M,Straubinger NL,Bruce JN,Bigio IJ,Straubinger RM

更新日期：2014-05-01 00:00:00

abstract：:We report on the long-term results of a phase II study of pre-irradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (AO) and mixed anaplastic oligoastrocytoma. Pre-RT temozolomide was given for up to 6 cycles. RT with concurrent...

journal_title：Journal of neuro-oncology

authors： Vogelbaum MA,Hu C,Peereboom DM,Macdonald DR,Giannini C,Suh JH,Jenkins RB,Laack NN,Brachman DG,Shrieve DC,Souhami L,Mehta MP

更新日期：2015-09-01 00:00:00

abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

journal_title：Journal of neuro-oncology

authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To compare chemotherapy treatment monitoring in astrocytoma by 201thallium single photon emission computed tomography (SPECT) and photon magnetic resonance spectroscopy (1H-MRS) with magnetic resonance imaging (MRI), and to evaluate the influence of morphological tumor changes on cerebral 201thallium uptake and...

journal_title：Journal of neuro-oncology

authors： Kallén K,Burtscher IM,Holtås S,Ryding E,Rosén I

更新日期：2000-01-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：:p53 mutations are the most frequently detected genetic alterations of gliomas, appearing in a similar proportion of low and high grade astrocytomas, while the amplification of epidermal growth factor receptor (EGFR) gene appears mainly in glioblastomas. Thus, these changes seem to delineate two subgroups of high grade...

journal_title：Journal of neuro-oncology

authors： Kordek R,Biernat W,Alwasiak J,Maculewicz R,Yanagihara R,Liberski PP

更新日期：1995-10-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:In earlier studies, we demonstrated that intratumoral infusions of alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the major histocompatibility complex (MHC) antigens of the host, effectively retarded the intracranial growth of Fischer 9L gliosarcoma. We further demonstrated that continuous in vitro exposur...

journal_title：Journal of neuro-oncology

authors： Paul DB,Read SB,Kulprathipanja NV,Gomez GG,Kleinschmidt-DeMasters BK,Schiltz PM,Kruse CA

更新日期：2003-08-01 00:00:00

abstract：:High-dose (1-3.5 g/m2) methotrexate (MTX) followed by whole-brain radiation therapy (WBRT) has consistently improved length of survival in primary central nervous system lymphoma (PCNSL), but the prognosis remains dismal. To optimize and enhance the dose intensity of MTX, we applied MTX at 8 g/m2 to 20 patients with P...

journal_title：Journal of neuro-oncology

authors： Watanabe T,Katayama Y,Yoshino A,Komine C,Yokoyama T,Fukushima T

更新日期：2003-05-01 00:00:00

abstract：:Adrenomedullin is a vasoactive peptide that is upregulated in higher-grade gliomas and promotes tumor cell proliferation. Since reduced activity of the anti-oncogene PTEN seems to also correlate with higher tumor grade, this suggests an inverse association between PTEN activity and adrenomedullin expression. PC12 pheo...

journal_title：Journal of neuro-oncology

authors： Betchen SA,Musatov S,Roberts J,Pena J,Kaplitt MG

更新日期：2006-09-01 00:00:00

abstract：:Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...

journal_title：Journal of neuro-oncology

authors： Ogungbo BI,Perry RH,Bozzino J,Mahadeva D

更新日期：2005-09-01 00:00:00

abstract：:Anaplastic mixed gliomas are rare tumors that occur mostly in the cerebral hemispheres. They have a distinctive histological appearance characterized by the presence of two or more glial cellular constituents. The incidence of malignant mixed glioma of the brainstem and posterior fossa is extremely low. The authors re...

journal_title：Journal of neuro-oncology

authors： Lee TT,Galarza M,Petito CK,Heros RC

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:Brain tumors make up over a quarter of pediatric malignancies. Depending on the age of presentation and treatment, pediatric brain tumor survivors experience varying degrees of treatment induced morbidity and sequelae. Epigenetic mechanisms play a critical role in silencing of tumor suppressor genes and ac...

journal_title：Journal of neuro-oncology

authors： Bhattacharya D,Pomeroy SL,Pomeranz Krummel DA,Sengupta S

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:This study evaluated an association between whole brain volume loss and neurocognitive decline following prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC). METHODS:This was a secondary analysis of a prospective clinical trial that accrued patients at a single instituti...

journal_title：Journal of neuro-oncology

authors： Gui C,Chintalapati N,Hales RK,Voong KR,Sair HI,Grimm J,Duhon M,Kleinberg LR,Vannorsdall TD,Redmond KJ

更新日期：2019-09-01 00:00:00

abstract：:We proposed to identify the efficacy of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery (SRS)/surgery in brain metastases from patients with non-small cell lung cancer (NSCLC) and clarify the association between treatment outcom...

journal_title：Journal of neuro-oncology

authors： Cai L,Zhu JF,Zhang XW,Lin SX,Su XD,Lin P,Chen K,Zhang LJ

更新日期：2014-11-01 00:00:00

abstract：:During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investigate the anti-tumor effects of concurrent 5-aminolevulinic acid (ALA)-mediated PDT and hyperthermia (HT) in huma...

journal_title：Journal of neuro-oncology

authors： Hirschberg H,Sun CH,Tromberg BJ,Yeh AT,Madsen SJ

更新日期：2004-12-01 00:00:00

abstract：:Although 1p19q codeleted gliomas are the most favorable molecular subgroup of lower-grade gliomas, there are cases with early recurrence or short survival. The objective of this study was to elucidate molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss. The st...

journal_title：Journal of neuro-oncology

authors： Hayashi S,Kitamura Y,Hirose Y,Yoshida K,Sasaki H

更新日期：2017-03-01 00:00:00

abstract：:We report a case of a 2 year-old boy who initially presented with macrocephaly and severe global developmental delay. Imaging revealed a large left temporo-parietal mass that was lobulated, calcified, focally enhancing and partially cystic. A second surgery was required for tumor recurrence approximately one year late...

journal_title：Journal of neuro-oncology

authors： Dunham C,Sugo E,Tobias V,Wills E,Perry A

更新日期：2007-08-01 00:00:00

abstract：:Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridizati...

journal_title：Journal of neuro-oncology

authors： Min HS,Kim B,Park SH

更新日期：2008-12-01 00:00:00