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Aneurysmal bone cysts of the spine: treatment options and considerations.

Abstract：

:Aneurysmal bone cysts (ABCs) are benign bone lesions with annual incidences ranging from 1.4 to 3.2 cases per million people. Approximately, 10-30% of ABCs are found in the spine. Such lesions are traditionally treated with curettage or other intralesional techniques. Because ABCs can be locally aggressive, intralesional resection can be incomplete and result in recurrence. This has led to increased use of novel techniques, including selective arterial embolization (SAE). This study aims to: (1) compare outcomes based on extent of surgical resection, and (2) compare the efficacy of SAE versus surgical resection. Clinical data pertaining to 71 cases of spinal ABCs were ambispectively collected from nine institutions in Europe, North America, and Australia. Twenty-two spinal ABCs were treated with surgery, 32 received preoperative embolization and surgery, and 17 were treated with SAE. Most tumors were classified as Enneking stage 2 (n = 29, 41%) and stage 3 (n = 29, 41%). Local recurrence and survival were investigated and a significant difference was not observed between treatment groups. However, all three local recurrences occurred following surgical resection. Surgical resection was further categorized based on Enneking appropriateness. Recurrences only occurred following intralesional Enneking inappropriate (EI) resections (P = 0.10), a classification that characterized 47% of all surgical resections. Furthermore, 56% of intralesional resections were EI, compared to only 10% of en bloc resections (P = 0.01). Although SAE treatment did not result in any local recurrences, 35% involved more than five embolization procedures. Spinal ABCs can be effectively treated with intralesional resection, en bloc resection, or SAE. Preoperative embolization should be considered before intralesional resection to limit intraoperative bleeding. Treatment plans must be guided by lesion characteristics and clinical presentation.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Boriani S,Lo SF,Puvanesarajah V,Fisher CG,Varga PP,Rhines LD,Germscheid NM,Luzzati A,Chou D,Reynolds JJ,Williams RP,Zadnik P,Groves M,Sciubba DM,Bettegowda C,Gokaslan ZL,AOSpine Knowledge Forum Tumor.

doi

10.1007/s11060-014-1540-0

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

171-8

issue

eissn

0167-594X

issn

1573-7373

journal_volume

120

pub_type

杂志文章,多中心研究

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Aneurysmal bone cysts of the spine: treatment options and considerations.