Pathological laughter and behavioural change in childhood pontine glioma.


:Children with pontine glioma usually present classically with ataxia, motor deficits and cranial nerve palsies. The pons has generally not been regarded as a structure that mediates complex affective behaviour. However, we report nine children who either at the time of presentation or progression demonstrated marked behavioural changes manifesting as either "pathological laughter" or separation anxiety in the form of school refusal. A mechanism of how pontine lesions can cause such complex affective and cognitive behaviour has been suggested to consist of the disruption of a network of cerebro-ponto-cerebellar pathways and the evidence for this mechanism is discussed.


J Neurooncol


Hargrave DR,Mabbott DJ,Bouffet E




Has Abstract


2006-05-01 00:00:00












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    abstract::Cell differentiation agent-2 (CDA-2) is an extraction from healthy human urine consisting of primary organic acids and peptides, and it has been demonstrated to inhibit growth and induce differentiation in glioma and other cell lines. But the mechanism of CDA-2 remains unclear. In this study, we demonstrated that CDA-...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Xie YK,Huo SF,Zhang G,Zhang F,Lian ZP,Tang XL,Jin C

    更新日期:2012-11-01 00:00:00

  • Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.

    abstract::Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. The aim of this study is to ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Minniti G,Salvati M,Arcella A,Buttarelli F,D'Elia A,Lanzetta G,Esposito V,Scarpino S,Maurizi Enrici R,Giangaspero F

    更新日期:2011-04-01 00:00:00

  • In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma.

    abstract::Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

    更新日期:2003-06-01 00:00:00

  • Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report.

    abstract::We report a 13-month-old boy with diencephalic syndrome (DS) due to an optico-hypothalamic juvenile pilocytic astrocytoma (JPA). Massive neuroaxis dissemination was identified at diagnosis. He received 6 courses of combined conventional-dose chemotherapy consisting of carboplatin (CBDCA), etoposide (VP-16), and cyclop...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Kageji T,Nagahiro S,Horiguchi H,Watanabe T,Suzuya H,Okamoto Y,Kuroda Y

    更新日期:2003-05-01 00:00:00

  • The relaxation response resiliency program (3RP) in patients with neurofibromatosis 1, neurofibromatosis 2, and schwannomatosis: results from a pilot study.

    abstract::NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Vranceanu AM,Merker VL,Plotkin SR,Park ER

    更新日期:2014-10-01 00:00:00

  • Prospective assessment of quality of life in adult patients with primary brain tumors in routine neurooncology practice.

    abstract::The aim of this article is to evaluate and assess the impact of various factors on quality of life (QOL) in adult patients with primary brain tumors seen consecutively in routine neurooncology practice. Two hundred and fifty-seven adult patients, after undergoing surgical intervention and histologically proven primary...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Budrukkar A,Jalali R,Dutta D,Sarin R,Devlekar R,Parab S,Kakde A

    更新日期:2009-12-01 00:00:00

  • Phenotypic and functional characterization of Glioblastoma cancer stem cells identified through 5-aminolevulinic acid-assisted surgery [corrected].

    abstract::5-aminolevulinic acid (5-ALA) introduction in the surgical management of Glioblastoma (GBM) enables the intra-operatively identification of cancer cells in the mass by means of fluorescence. Here, we analyzed the phenotype of GBM cells isolated from distinct tumour areas determined by 5-ALA (tumour core, 5-ALA intense...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rampazzo E,Della Puppa A,Frasson C,Battilana G,Bianco S,Scienza R,Basso G,Persano L

    更新日期:2014-02-01 00:00:00

  • Neurocognitive training in patients with high-grade glioma: a pilot study.

    abstract::Although their neurocognitive performance is one of the major concerns of patients with high-grade gliomas (HGG) and although neurocognitive deficits have been described to be associated with negative outcome, neurocognitive rehabilitation is usually not integrated into the routine care of patients with malignant glio...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Hassler MR,Elandt K,Preusser M,Lehrner J,Binder P,Dieckmann K,Rottenfusser A,Marosi C

    更新日期:2010-03-01 00:00:00

  • Steroid psychosis: a review for neurosurgeons.

    abstract::Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Ross DA,Cetas JS

    更新日期:2012-09-01 00:00:00

  • Functioning oncocytic adenoma of the pituitary.

    abstract::A case of a functioning invasive pituitary oncocytoma in a 50-year-old man is reported. The serum prolactin was increased and immunocytochemical staining was positive for prolactin. In addition to numerous mitochondria within the neoplastic cells, structurally abnormal mitochondria with crystalline inclusions were als...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Chowdhury C,Roy S,Gupta N,Kochupillai N,Banerji AK

    更新日期:1986-01-01 00:00:00

  • Correction to: Which elderly newly diagnosed glioblastoma patients can benefit from radiotherapy and temozolomide? A PERNO prospective study.

    abstract::The members of the PERNO Study Group were not individually captured in the metadata of the original publication. They are included in the metadata of this publication. ...

    journal_title:Journal of neuro-oncology

    pub_type: 已发布勘误


    authors: Franceschi E,Depenni R,Paccapelo A,Ermani M,Faedi M,Sturiale C,Michiara M,Servadei F,Pavesi G,Urbini B,Pisanello A,Crisi G,Cavallo MA,Dazzi C,Biasini C,Bertolini F,Mucciarini C,Pasini G,Baruzzi A,Brandes AA,PERNO

    更新日期:2018-01-01 00:00:00

  • Epigenetic preconditioning with decitabine sensitizes glioblastoma to temozolomide via induction of MLH1.

    abstract:INTRODUCTION:To improve the standard treatment paradigm for glioblastoma (GBM), efforts have been made to explore the efficacy of epigenetic agents as chemosensitizers. Recent data suggest possible synergy between decitabine (DAC), a DNA hypomethylating agent, and temozolomide (TMZ) in GBM, but the mechanism remains un...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Gallitto M,Cheng He R,Inocencio JF,Wang H,Zhang Y,Deikus G,Wasserman I,Strahl M,Smith M,Sebra R,Yong RL

    更新日期:2020-05-01 00:00:00

  • Inhibition of the glioblastoma cell cycle by type I IFNs occurs at both the G1 and S phases and correlates with the upregulation of p21(WAF1/CIP1).

    abstract::The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

    更新日期:2000-07-01 00:00:00

  • Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.

    abstract::Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

    更新日期:1998-12-01 00:00:00

  • Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.

    abstract::The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated. In this study, the details of the cell death mechanism induced by ALA-PDT were investigated in three human glioma cell lines (U251MG, U87MG, and U118MG...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Inoue H,Kajimoto Y,Shibata MA,Miyoshi N,Ogawa N,Miyatake S,Otsuki Y,Kuroiwa T

    更新日期:2007-07-01 00:00:00

  • Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma?

    abstract::Systemic high-dose methotrexate (HD-MTX) is the most effective chemotherapeutic agent in the treatment of primary central nervous system lymphoma (PCNSL). Leptomeningeal involvement is common and intrathecal methotrexate (IT-MTX) is frequently used in combination with HD-MTX, but its benefits are not established. Usin...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Khan RB,Shi W,Thaler HT,DeAngelis LM,Abrey LE

    更新日期:2002-06-01 00:00:00

  • Pre- and post-operative assessment of visuo-spatial functions in right hemisphere tumour patients: a pilot study.

    abstract::Patients with neglect fail to report, respond to, or orient to stimuli presented on the opposite side of the brain lesion. Spatial neglect is a multi-componential syndrome and many of its symptoms and signs need specific testing to detect their different clinical manifestations. Given that neglect has a dramatic effec...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Emanuele B,Santini B,Talacchi A,Gerosa M,Savazzi S

    更新日期:2012-06-01 00:00:00

  • Surgical treatment of anterior basal meningiomas.

    abstract::Meningiomas of the anterior skull base account for 40% of all intracranial meningiomas. Of these, almost half are sphenoid wing meningiomas; the other half are tuberculum sella tumors or olfactory groove tumors. Anterior clinoidal (medial sphenoid wing) meningiomas are a subcategory of the sphenoid wing meningiomas; t...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: DeMonte F

    更新日期:1996-09-01 00:00:00

  • Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor.

    abstract::Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults. Vestibular schwannomas are the most common, followed by meningiomas. Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors. We describe a pilocyti...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Francesco F,Maurizio I,Stefano C,Marina S,Ugo S,Massimo S

    更新日期:2010-04-01 00:00:00

  • Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma.

    abstract::Aberrant expression of stem cell-related genes in tumors may confer more primitive and aggressive traits affecting clinical outcome. Here, we investigated expression and prognostic value of the neural stem cell marker CD133, as well as of the pluripotency genes LIN28 and OCT4 in 37 samples of pediatric medulloblastoma...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rodini CO,Suzuki DE,Saba-Silva N,Cappellano A,de Souza JE,Cavalheiro S,Toledo SR,Okamoto OK

    更新日期:2012-01-01 00:00:00

  • Prognostic value of the Glasgow Prognostic Score for glioblastoma multiforme patients treated with radiotherapy and temozolomide.

    abstract:INTRODUCTION:To evaluate the prognostic value of the Glasgow Prognostic Score (GPS), the combination of C-reactive protein (CRP) and albumin, in glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (GPS). METHODS:Data of newly diagnosed GBM patients treated wi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Topkan E,Selek U,Ozdemir Y,Yildirim BA,Guler OC,Ciner F,Mertsoylu H,Tufan K

    更新日期:2018-09-01 00:00:00

  • A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas.

    abstract::Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse intrinsic pontine gliomas (DIPG) or HGG has not been reported in a prospective study. In a safety and feasibility study, children and young adults with newly diagn...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Hummel TR,Salloum R,Drissi R,Kumar S,Sobo M,Goldman S,Pai A,Leach J,Lane A,Pruitt D,Sutton M,Chow LM,Grimme L,Doughman R,Backus L,Miles L,Stevenson C,Fouladi M,DeWire M

    更新日期:2016-03-01 00:00:00

  • Gliomatosis cerebri: clinical characteristics, management, and outcomes.

    abstract::Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

    更新日期:2013-04-01 00:00:00

  • Genetic variations in VEGF and VEGFR2 and glioblastoma outcome.

    abstract::Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Sjöström S,Wibom C,Andersson U,Brännström T,Broholm H,Johansen C,Collatz-Laier H,Liu Y,Bondy M,Henriksson R,Melin B

    更新日期:2011-09-01 00:00:00

  • EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid.

    abstract::The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44-67% at first lumbar puncture which increases...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: van Bussel MTJ,Pluim D,Bol M,Beijnen JH,Schellens JHM,Brandsma D

    更新日期:2018-03-01 00:00:00

  • Rare combination of spinal lesions and subcutaneous meningioma in a 44 year old man.

    abstract::A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Qasho R,Lunardi P,Lo Bianco FM,di Stefano M

    更新日期:1998-05-01 00:00:00

  • Pediatric neuro-oncology survival disparities in California.

    abstract::The objective of this study was to investigate racial/ethnic differences in survival for pediatric high-grade glioma (HGG) and medulloblastoma in the state of California. We obtained data from the California Cancer Registry on 552 high-grade glioma patients (110 brainstem, 442 non-brainstem) and 648 medulloblastoma pa...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Cooney T,Fisher PG,Tao L,Clarke CA,Partap S

    更新日期:2018-05-01 00:00:00

  • Perceptions of economic hardship and emotional health in a pilot sample of family caregivers.

    abstract::Although several studies have quantified costs of cancer care; none to date have examined how cancer costs impact family caregivers' emotional health. This study was designed to evaluate how perceptions of economic hardship influence burden, depressive symptoms, and anxiety in family caregivers of persons with a prima...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Bradley SE,Sherwood PR,Kuo J,Kammerer CM,Gettig EA,Ren D,Rohrer WM,Donovan HS,Hricik A,Newberry A,Given B

    更新日期:2009-07-01 00:00:00

  • Amelioration of experimental cisplatin and paclitaxel neuropathy with glutamate.

    abstract::A major toxic effect of the chemotherapeutic agents paclitaxel and cisplatin is peripheral neuropathy. We report the use of a rat model of cytotoxic neuropathy to evaluate the role of glutamate as a possible neuroprotectant for these two drugs. Neuropathy was manifest as gait disturbance in 100% of paclitaxel treated ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Boyle FM,Wheeler HR,Shenfield GM

    更新日期:1999-01-01 00:00:00

  • A correlative study of in vivo and in vitro labeling index using bromodeoxyuridine in human brain tumors.

    abstract::The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

    更新日期:1995-01-01 00:00:00