当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Particular features of cell-mediated immunity in patients with anaplastic gliomas. A comparison with kidney and bladder cancer patients.

Particular features of cell-mediated immunity in patients with anaplastic gliomas. A comparison with kidney and bladder cancer patients.

Abstract：

:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These parameters were also evaluated in 24 healthy donors as control, in 24 patients affected by bladder cancer and in nine cases of kidney cancer. Our data show, pre-operatively, a statistically significant impairment of ADCC and SLMC activity in glioma patients as compared both with controls, bladder and kidney cancer patients. The particular impairment of K and NK functions in gliomas is discussed with regard to the specific features of Central Nervous System malignancies. An improvement of ADCC activity was also found in the post-operative samples. This finding confirms other reports about partial restoring of altered immunocompetence after surgery, suggesting a link between extention of tumor mass and impaired immunological reactions.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

doi

10.1007/BF00165716

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

327-32

issue

4

eissn

0167-594X

issn

1573-7373

journal_volume

1

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas.

    abstract：:The cell-penetrating trans-activator of transcription (TAT) is a cationic peptide derived from human immunodeficiency virus-1. It has been used to facilitate macromolecule delivery to various cell types. This cationic peptide is capable of crossing the blood-brain barrier and therefore might be useful for enhancing th...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2429-5

    authors： Nguyen J,Hossain SS,Cooke JRN,Ellis JA,Deci MB,Emala CW,Bruce JN,Bigio IJ,Straubinger RM,Joshi S

    更新日期：2017-05-01 00:00:00

  • Reproductive factors and risk of primary brain tumors in women.

    abstract：:Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the onset of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1427-0

    authors： Anic GM,Madden MH,Nabors LB,Olson JJ,LaRocca RV,Thompson ZJ,Pamnani SJ,Forsyth PA,Thompson RC,Egan KM

    更新日期：2014-06-01 00:00:00

  • Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children.

    abstract：:Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00172458

    authors： Allen J,Wisoff J,Helson L,Pearce J,Arenson E

    更新日期：1992-01-01 00:00:00

  • Spinal cord compression in prostate cancer.

    abstract：:Approximately 200,000 men will be diagnosed with prostate cancer in 1994. While localized disease is potentially curable with surgery or radiation therapy, metastatic disease is incurable. The most frequent site of metastasis is bone. Spinal cord compression occurs in approximately 7% of men with prostate cancer. Back...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01053418

    authors： Osborn JL,Getzenberg RH,Trump DL

    更新日期：1995-01-01 00:00:00

  • Analysis of p53 tumor suppressor gene in families with multiple glioma patients.

    abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1013890022041

    authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

    更新日期：2001-12-01 00:00:00

  • White matter changes in primary central nervous system lymphoma patients treated with high-dose methotrexate with or without rituximab.

    abstract：PURPOSE:White matter changes (WMCs) can develop following systemic chemotherapy in patients with primary central nervous system lymphomas (PCNSLs), but the frequency and extent of these changes is not well characterized. This single center retrospective semi-quantitative study was performed to determine the rate, timin...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03279-9

    authors： Estephan F,Ye X,Dzaye O,Wagner-Johnston N,Swinnen L,Gladstone DE,Ambinder R,Kamson DO,Lambrecht S,Grossman SA,Lin DDM,Holdhoff M

    更新日期：2019-12-01 00:00:00

  • Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-alpha in the rat.

    abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals receiving a single injection of either 6 x 10(4) U rTNF-alpha or an equivalent volume of excipient (vehicle) in their right parietal lobe. In order to demonstrate ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF01057957

    authors： Wright JL,Merchant RE

    更新日期：1994-01-01 00:00:00

  • Relapse patterns in pediatric embryonal central nervous system tumors.

    abstract：:Embryonal tumors of the central nervous system (CNS) share histological features and were therefore initially grouped as primitive neuroectodermal tumors (PNET) and treated similarly. We sought to determine the relapse patterns of specific embryonal CNS tumors. We conducted a historical cohort study of children diagno...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-013-1213-4

    authors： Perreault S,Lober RM,Carret AS,Zhang G,Hershon L,Décarie JC,Yeom K,Vogel H,Fisher PG,Partap S

    更新日期：2013-11-01 00:00:00

  • Favorable long-term outcome of low-grade oligodendrogliomas irrespective of 1p/19q status when treated without radiotherapy.

    abstract：:Despite the accumulating evidences of high chemosensitivity especially in anaplastic oligodendrogliomas with loss of chromosomes 1p and 19q, the optimal management strategy for low-grade tumors using the 1p/19q information remains controversial. We have treated all low-grade oligodendrogliomas by a chemotherapy-preced...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0340-4

    authors： Iwadate Y,Matsutani T,Hasegawa Y,Shinozaki N,Higuchi Y,Saeki N

    更新日期：2011-05-01 00:00:00

  • Phenotypic and functional characterization of Glioblastoma cancer stem cells identified through 5-aminolevulinic acid-assisted surgery [corrected].

    abstract：:5-aminolevulinic acid (5-ALA) introduction in the surgical management of Glioblastoma (GBM) enables the intra-operatively identification of cancer cells in the mass by means of fluorescence. Here, we analyzed the phenotype of GBM cells isolated from distinct tumour areas determined by 5-ALA (tumour core, 5-ALA intense...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1348-3

    authors： Rampazzo E,Della Puppa A,Frasson C,Battilana G,Bianco S,Scienza R,Basso G,Persano L

    更新日期：2014-02-01 00:00:00

  • Health-related quality of life, cognitive screening, and functional status in a randomized phase III trial (EF-14) of tumor treating fields with temozolomide compared to temozolomide alone in newly diagnosed glioblastoma.

    abstract：:We characterized health-related quality of life (HRQoL), cognitive, and functional status in newly diagnosed glioblastoma (GBM) patients receiving Tumor treating fields (TTFields) with temozolomide (TMZ) versus TMZ alone in a planned interim analysis of a randomized phase III trial [NCT00916409], which showed signific...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11060-017-2601-y

    authors： Zhu JJ,Demireva P,Kanner AA,Pannullo S,Mehdorn M,Avgeropoulos N,Salmaggi A,Silvani A,Goldlust S,David C,Benouaich-Amiel A,Zvi Ram on behalf of the EF-14 Trial Investigators.

    更新日期：2017-12-01 00:00:00

  • Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center.

    abstract：PURPOSE:Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB. METHODS:Clin...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2935-0

    authors： Jia Q,Liu C,Yang J,Ji Y,Wei H,Liu T,Yang X,Yang C,Xiao J

    更新日期：2018-10-01 00:00:00

  • Neonatal medulloblastoma.

    abstract：:A 9-day-old female presented with a large infra- and supratentorial medulloblastoma was treated by surgery, irradiation and chemotherapy. The infant suffered from vomit a few days after birth. She was hospitalized shortly thereafter, when head enlargement was noted. A CT scan taken on admission disclosed a large mass ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01053936

    authors： Kayama T,Yoshimoto T,Shimizu H,Sakurai Y

    更新日期：1993-02-01 00:00:00

  • Phase II study of thalidomide in the treatment of recurrent glioblastoma multiforme.

    abstract：:Treatment options and prognosis remains poor for patients with recurrent glioblastoma multiforme. These tumors are highly vascularised and over express angiogenic factors such as vascular endothelial growth factor and may potentially be responsive to antiangiogenic therapies. We present the results of a phase II trial...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1012554328801

    authors： Marx GM,Pavlakis N,McCowatt S,Boyle FM,Levi JA,Bell DR,Cook R,Biggs M,Little N,Wheeler HR

    更新日期：2001-08-01 00:00:00

  • Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.

    abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006125120866

    authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

    更新日期：1998-12-01 00:00:00

  • The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease.

    abstract：:Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of D...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2372-5

    authors： Baugh J,Bartels U,Leach J,Jones B,Chaney B,Warren KE,Kirkendall J,Doughman R,Hawkins C,Miles L,Fuller C,Hassall T,Bouffet E,Lane A,Hargrave D,Grill J,Hoffman LM,Jones C,Towbin A,Savage SA,Monje M,Li XN,Ziegler

    更新日期：2017-04-01 00:00:00

  • Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy.

    abstract：PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-1386-y

    authors： Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SH

    更新日期：2005-01-01 00:00:00

  • A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma.

    abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-019-03125-y

    authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

    更新日期：2019-05-01 00:00:00

  • Intracranial Hodgkin's lymphoma in an HIV positive patient.

    abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9587-4

    authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

    更新日期：2008-08-01 00:00:00

  • Impact of resection and systemic therapy on the survival of patients with brain metastasis of metastatic renal cell carcinoma.

    abstract：:Patients with brain metastasis (BM) from renal cell carcinoma (RCC) are associated with poor prognosis. Between 1990 and 2015, data of consecutive RCC patients with BM were retrospectively analyzed from a urologic oncologic database. The treatment outcome was evaluated by overall survival (OS), which was defined as in...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2238-2

    authors： Du Y,Pahernik S,Hadaschik B,Teber D,Duensing S,Jäger D,Hohenfellner M,Grüllich C

    更新日期：2016-10-01 00:00:00

  • Imatinib and docetaxel in combination can effectively inhibit glioma invasion in an in vitro 3D invasion assay.

    abstract：:The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincrist...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0246-1

    authors： Kinsella P,Clynes M,Amberger-Murphy V

    更新日期：2011-01-01 00:00:00

  • Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis.

    abstract：:Glioblastomas (GBM) may originate de novo (primary), or following transformation from a lower grade glioma (secondary), and it has been postulated that these tumors may have different biological behaviors. We performed a correlative analysis involving 204 patients with glioma treated prospectively on NCCTG clinical tr...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0476-2

    authors： Jaeckle KA,Decker PA,Ballman KV,Flynn PJ,Giannini C,Scheithauer BW,Jenkins RB,Buckner JC

    更新日期：2011-08-01 00:00:00

  • Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines.

    abstract：:In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation. Cepharanthine (CEP), a biscoclaurine-derived alkaloid, reportedly potentiates the effects of antitumor agents and induces apoptosis in some cancer cells. Here, we examined the effects of CEP, alone and in...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1014548618440

    authors： Kono K,Takahashi JA,Ueba T,Mori H,Hashimoto N,Fukumoto M

    更新日期：2002-01-01 00:00:00

  • The incidence and significance of multicentric noncontrast-enhancing lesions distant from a histologically-proven glioblastoma.

    abstract：:Improvements in imaging are increasing the detection of multiple lesions in the setting of glioblastoma. Occasionally distant non-enhancing lesions may be identified which have the appearances of a multicentric low-grade glioma. We aimed to determine the incidence, prognostic significance and diagnostic value of this ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-016-2193-y

    authors： Lasocki A,Gaillard F,Tacey MA,Drummond KJ,Stuckey SL

    更新日期：2016-09-01 00:00:00

  • Establishment of interleukin 2 dependent cytotoxic T lymphocyte cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor.

    abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00195603

    authors： Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

    更新日期：1987-01-01 00:00:00

  • T cell response to Hu-D peptides in patients with anti-Hu syndrome.

    abstract：:The anti-Hu syndrome is the most common paraneoplastic neurologic syndrome but the exact mechanism of immune mediated neuronal injury remains unknown. Anti-Hu antibodies do not appear to play a pivotal role in the pathogenesis of the disease. To assess cell-mediated immunity, we selected 51 peptides from the Hu-D sequ...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-004-1723-1

    authors： Rousseau A,Benyahia B,Dalmau J,Connan F,Guillet JG,Delattre JY,Choppin J

    更新日期：2005-02-01 00:00:00

  • Type beta transforming growth factor and epidermal growth factor suppress the plasminogen activator activity in a human glioblastoma cell line.

    abstract：:In the human glioblastoma cell line, T-MG1, plasminogen activator activity (PA-activity) was demonstrated by using the chromogenic substrate S-2251. Using monoclonal antibodies against human urokinase type PA (u-PA) and human tissue type PA (t-PA), only u-PA activity was found in T-MG1 cell extracts. The u-PA activity...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00163713

    authors： Helseth E,Dalen A,Unsgaard G,Vik R

    更新日期：1988-11-01 00:00:00

  • Gliomatosis cerebri: clinical characteristics, management, and outcomes.

    abstract：:Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-013-1058-x

    authors： Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

    更新日期：2013-04-01 00:00:00

  • Tumor treating fields plus temozolomide for newly diagnosed glioblastoma: a sub-group analysis of Korean patients in the EF-14 phase 3 trial.

    abstract：BACKGROUND:Tumor treating fields (TTFields) are anti-mitotic, non-invasive loco-regional cancer therapy comprising low intensity, intermediate frequency alternating electric fields. TTFields plus Temozolomide (TTFields/TMZ) extended survival versus TMZ alone in newly diagnosed glioblastoma (GBM) patients in the EF-14 t...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11060-019-03361-2

    authors： Kim CY,Paek SH,Nam DH,Chang JH,Hong YK,Kim JH,Kim OL,Kim SH

    更新日期：2020-02-01 00:00:00

  • Prediction value of unmeasurable MR enhancement at early stage after gross-total resection on the survival state of patients with high-grade glioma.

    abstract：PROPOSE:To explore the value of unmeasurable enhancement pattern of residual cavity in predicting survival at early stage after gross-total resection in high-grade glioma (HGG) patients. METHODS:This retrospective study enrolled consecutive 51 HGG patients with unmeasurable enhancement who underwent gross-total resect...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2961-y

    authors： Quan G,Zheng Y,Chen J,Hua B,Ji X,Zhang K,Gao D,Lei J,Yuan T

    更新日期：2018-11-01 00:00:00