Type beta transforming growth factor and epidermal growth factor suppress the plasminogen activator activity in a human glioblastoma cell line.

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:The purpose of our study was to determine the statistical significance of thresholds of relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC) and ADC ratios in grading cerebral gliomas. MATERIALS AND METHODS:In this retrospective study, 51 patients with histopathologically confirmed prima...

journal_title：Journal of neuro-oncology

authors： Arvinda HR,Kesavadas C,Sarma PS,Thomas B,Radhakrishnan VV,Gupta AK,Kapilamoorthy TR,Nair S

更新日期：2009-08-01 00:00:00

abstract：:Pediatric glial tumors differ from adult gliomas in several ways that are of major therapeutic importance. First, the value of extensive tumor resection, which is controversial for malignant intrinsic brain tumors in adults, has been confirmed for a variety of childhood brain tumors, such as supratentorial high-grade ...

journal_title：Journal of neuro-oncology

authors： Pollack IF

更新日期：1999-05-01 00:00:00

abstract：:Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial malignant gliomas received a combination of nimustine hydrochloride; 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), cisplatin and etoposide (ACE ...

journal_title：Journal of neuro-oncology

authors： Beppu T,Yoshida Y,Arai H,Wada T,Suzuki M,Ogawa A,Hakozaki S,Kubo N

更新日期：2000-09-01 00:00:00

abstract：:To determine binding and distribution of Na2B12H11SH (BSH) in glioma tissue in case of boron neutron capture therapy, an antibody to this compound was produced and used in immunohistochemical investigations. It is possible to trace BSH in immunohistochemistry, because BSH is firmly bound to the glioma tissue. The anti...

journal_title：Journal of neuro-oncology

authors： Otersen B,Haritz D,Grochulla F,Bergmann M,Sierralta W,Gabel D

更新日期：1997-05-01 00:00:00

abstract：:The diagnosis of brain metastases is associated with a poor prognosis reflecting uncontrolled primary disease that has spread to the relative sanctuary of the central nervous system. 20 % of brain metastases occur in the posterior fossa and are associated with significant morbidity. The risk of acute hydrocephalus and...

journal_title：Journal of neuro-oncology

authors： Sunderland GJ,Jenkinson MD,Zakaria R

更新日期：2016-12-01 00:00:00

abstract：:Proneural and mesenchymal are two subtypes of glioblastoma identified by gene expression profiling. In this study, the primary aim was to detect markers to develop a clinically applicable method for distinguishing proneural and mesenchymal glioblastoma. The secondary aims were to investigate the temporospatial dynamic...

journal_title：Journal of neuro-oncology

authors： Murata H,Yoshimoto K,Hatae R,Akagi Y,Mizoguchi M,Hata N,Kuga D,Nakamizo A,Amano T,Sayama T,Iihara K

更新日期：2015-10-01 00:00:00

abstract：:The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth of or development of new enhanci...

journal_title：Journal of neuro-oncology

authors： Kazda T,Hardie JG,Pafundi DH,Kaufmann TJ,Brinkmann DH,Laack NN

更新日期：2015-03-01 00:00:00

abstract：:A 65 year old woman presented with a recurrent locally advanced esthesioneuroblastoma. She had earlier been treated with radiation followed by surgery. The recurrence was located in earlier radiated tissues with intracranial infiltration. She underwent treatment with combined intra-arterial chemotherapy (BCNU) i.a., v...

journal_title：Journal of neuro-oncology

authors： Watne K,Hager B

更新日期：1987-01-01 00:00:00

abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

journal_title：Journal of neuro-oncology

authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

更新日期：2001-12-01 00:00:00

abstract：:Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in tumors of neuroectodermal origin such as melanoma and glioma. Many of these tumors are of neuroectodermal or ectomesenchymal origin which is suggestive of TERT promoter mutations playing a role i...

journal_title：Journal of neuro-oncology

authors： Dubbink HJ,Bakels H,Post E,Zwarthoff EC,Verdijk RM

更新日期：2014-11-01 00:00:00

abstract：:Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS)...

journal_title：Journal of neuro-oncology

authors： Imber BS,Braunstein SE,Wu FY,Nabavizadeh N,Boehling N,Weinberg VK,Tihan T,Barnes M,Mueller S,Butowski NA,Clarke JL,Chang SM,McDermott MM,Prados MD,Berger MS,Haas-Kogan DA

更新日期：2016-01-01 00:00:00

abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

journal_title：Journal of neuro-oncology

authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Recent advances in targeted therapy have prolonged overall survival (OS) for patients with lung cancer. The impact of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) on brain metastases (BM) treated with stereotactic radiosurgery (SRS) has not, however, been fully elucidated. We investiga...

journal_title：Journal of neuro-oncology

authors： Yomo S,Serizawa T,Yamamoto M,Higuchi Y,Sato Y,Shuto T,Akabane A,Jokura H,Kawagishi J,Aoyama H

更新日期：2019-10-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

journal_title：Journal of neuro-oncology

authors： Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

更新日期：2003-06-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00

abstract：:This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

journal_title：Journal of neuro-oncology

authors： Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:High hospital case volumes are associated with improved treatment outcomes for numerous diseases. We assessed the association between academic non-profit hospital case volume and survival of adult glioblastoma patients. METHODS:From the nationwide Finnish Cancer Registry, we identified all adult (≥ 18 yea...

journal_title：Journal of neuro-oncology

authors： Raj R,Seppä K,Luostarinen T,Malila N,Seppälä M,Pitkäniemi J,Korja M

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:Feasibility, antitumor activity and toxicity of accelerated hyperfractionated radiation therapy (Acc Hfx RT) and concurrent carboplatin/etoposide (CBDCA/VP 16) chemotherapy were investigated in patients with malignant glioma. MATERIAL AND METHODS:Seventy-nine patients with either glioblastoma multiforme (GBM) ...

journal_title：Journal of neuro-oncology

authors： Jeremic B,Shibamoto Y,Grujicic D,Stojanovic M,Milicic B,Nikolic N,Dagovic A,Aleksandrovic J

更新日期：2001-01-01 00:00:00

abstract：:A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...

journal_title：Journal of neuro-oncology

authors： Qasho R,Lunardi P,Lo Bianco FM,di Stefano M

更新日期：1998-05-01 00:00:00

abstract：:When SK-N-BE(2) human neuroblastoma cells were exposed for 1h to growth medium supplemented with [14C]arachidonic acid (AA) at final concentrations ranging from 1 microM to 100 microM, an amount of this fatty acid was uptaken ranging form a 2% to a 120% of that present in cells at steady state. As more [14C]AA was upt...

journal_title：Journal of neuro-oncology

authors： Spinedi A

更新日期：1997-01-01 00:00:00

abstract：:Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. We examined patients with low grade supratentorial brain tumors to determine characteristics of pa...

journal_title：Journal of neuro-oncology

authors： Das RR,Artsy E,Hurwitz S,Wen PY,Black P,Golby A,Dworetzky B,Lee JW

更新日期：2012-05-01 00:00:00

abstract：:Levels of rhodamine 123 (Rh-123), a new antineoplastic drug, were measured using high performance liquid chromatography in normal brain, malignant glioma and brain adjacent to tumor after a single intravenous injection of drug into rats with intracerebral tumors. Consistently higher levels of Rh-123 were seen in tumor...

journal_title：Journal of neuro-oncology

authors： Powers SK,Ellington K

更新日期：1988-12-01 00:00:00

abstract：:Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...

journal_title：Journal of neuro-oncology

authors： Ross DA,Cetas JS

更新日期：2012-09-01 00:00:00

abstract：:Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping ove...

journal_title：Journal of neuro-oncology

authors： Malgulwar PB,Nambirajan A,Pathak P,Faruq M,Rajeshwari M,Singh M,Suri V,Sarkar C,Sharma MC

更新日期：2018-05-01 00:00:00

abstract：:We report a case of a 2 year-old boy who initially presented with macrocephaly and severe global developmental delay. Imaging revealed a large left temporo-parietal mass that was lobulated, calcified, focally enhancing and partially cystic. A second surgery was required for tumor recurrence approximately one year late...

journal_title：Journal of neuro-oncology

authors： Dunham C,Sugo E,Tobias V,Wills E,Perry A

更新日期：2007-08-01 00:00:00

abstract：:The basement membrane collagen IV-degrading matrix metalloproteinases -2 and -9 (MMPs) are most often linked to the malignant phenotype of tumor cells by playing a critical role in invasion, metastasis, angiogenesis, and vasculogenesis. We verified the activity of these two MMPs in the sera of patients affected by bra...

journal_title：Journal of neuro-oncology

authors： Ricci S,Guadagno E,Bruzzese D,Del Basso De Caro M,Peca C,Sgulò FG,Maiuri F,Di Carlo A

更新日期：2017-01-01 00:00:00

abstract：:Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Idbaih A,Ducray F,Crinière E,Fèvre-Montange M,Jouvet A,Delattre JY

更新日期：2010-05-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Paraneoplastic cerebellar degeneration is a rare neurological disorder that frequently precedes the detection of malignancy. Here, we report the case of a 60 year-old woman with locally advanced squamous cell carcinoma of the tongue who developed a subacute cerebellar syndrome associated with the presence of anti-CV2/...

journal_title：Journal of neuro-oncology

authors： Saloustros E,Zaganas I,Mavridis M,Vamvakas L,Plaitakis A,Georgoulias V,Mavroudis D

更新日期：2010-04-01 00:00:00