Abstract：
PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 13 patients had ependymomas, 6 had myxopapillary ependymomas, and 1 had anaplastic ependymoma. All patients received radical surgery for tumor removal with 13 patients achieving complete resection and 7 incomplete resection due to technical difficulty. Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone. The total tumor dose ranged from 50 to 60 Gy. RESULTS:Among the 20 patients, 19 patients were alive and showed local control. The median survival time of all patients was 109 months, with 104 months in the complete resection alone group and 135 months in the incomplete resection with postoperative radiotherapy group. One patient with anaplastic ependymoma and no postoperative radiotherapy developed leptomeningeal seeding 9 months after surgery. Salvage therapy of radiotherapy and chemotherapy maintained normal neurological functions. The patient expired 34 months from the initial diagnosis due to progression of leptomeningeal seeding. CONCLUSION:Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival. Patients should receive complete resection if technically possible. Postoperative radiotherapy is not recommended for complete resection. For incomplete resection, postoperative local radiotherapy is recommended and it can also achieve excellent local control and survival. Local radiotherapy with 50-60 Gy is effective and safe. Salvage radiotherapy improves quality of life for local recurrence or leptomeningeal seeding patients.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SHdoi
10.1007/s11060-004-1386-ysubject
Has Abstractpub_date
2005-01-01 00:00:00pages
205-10issue
2eissn
0167-594Xissn
1573-7373journal_volume
71pub_type
杂志文章abstract：:The records of thirty-four patients with meningeal carcinomatosis treated at our hospital between 1984 and 1990 were reviewed. The sources, histologies, metastatic lesions outside the central nervous system, the history of the treatment of primary lesions and intraparenchymal of metastatic brain tumors and the period ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00172949
更新日期：1992-05-01 00:00:00
abstract：:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1...
journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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doi：10.1023/a:1016342013616
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journal_title：Journal of neuro-oncology
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doi：10.1023/a:1005771717409
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-012-0951-z
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doi：10.1007/s11060-012-0896-2
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01324597
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-007-9493-1
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journal_title：Journal of neuro-oncology
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pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01058354
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01063775
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1023/b:neon.0000014549.77646.f6
更新日期：2004-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01052924
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01059959
更新日期：1995-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00177430
更新日期：1988-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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journal_title：Journal of neuro-oncology
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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更新日期：2014-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/BF01059949
更新日期：1995-01-01 00:00:00
abstract：:We report one year follow up of a case of extramedullary hematopoiesis within the clivus. The imaging findings, brief clinical course, and endoscopic transphenoidal approach are described. A 29-year-old female with thalassemia developed worsening cranial nerve signs. After imaging studies discovered a large clival mas...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0208-7
更新日期：2010-12-01 00:00:00
