Stereotactic radiosurgery in the management of brain metastases from primary thyroid cancers.

abstract：:The aim of the present study was to evaluate the spectrum of late effects in a large cohort of pediatric patients with low-grade gliomas (WHO grade I and II) during an observation period of 20 years. Eighty-seven patients with low-grade gliomas grouped according to tumor location (cerebellum: n=28; cerebral hemisphere...

journal_title：Journal of neuro-oncology

authors： Benesch M,Lackner H,Sovinz P,Suppan E,Schwinger W,Eder HG,Dornbusch HJ,Moser A,Triebl-Roth K,Urban C

更新日期：2006-06-01 00:00:00

abstract：:While surgery is proned in low-grade glioma (LGG), the invasion of functional areas frequently prevents a complete resection. We report the first case of a patient operated on for a left frontal LGG, diagnosed because of seizures, with partial resection due to an invasion of the controlateral hemisphere. Chemotherapy ...

journal_title：Journal of neuro-oncology

authors： Duffau H,Taillandier L,Capelle L

更新日期：2006-11-01 00:00:00

abstract：:Patients with metastatic disease are living longer and may be confronted with locally or regionally recurrent brain metastases (BM) after prior stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT). This study analyzes outcomes in patients without prior whole brain radiotherapy (WBRT) who we...

journal_title：Journal of neuro-oncology

authors： Kim DH,Schultheiss TE,Radany EH,Badie B,Pezner RD

更新日期：2013-10-01 00:00:00

abstract：:The Notch signal regulates both cell viability and apoptosis, and maintains stemness of various cancers including glioblastoma (GBM). Although Notch signal inhibition may be an effective strategy in treating GBM initiating cells (GICs), its applicability to the different subtypes of GBM remains unclear. Here, we analy...

journal_title：Journal of neuro-oncology

authors： Tanaka S,Nakada M,Yamada D,Nakano I,Todo T,Ino Y,Hoshii T,Tadokoro Y,Ohta K,Ali MA,Hayashi Y,Hamada J,Hirao A

更新日期：2015-01-01 00:00:00

abstract：:Thermal stability signatures of complex molecule interaction in biological fluids can be measured using a new approach called differential scanning calorimetry (DSC). The thermal stability of plasma proteome has been described previously as a method of producing a disease-specific "signature," termed thermogram, in se...

journal_title：Journal of neuro-oncology

authors： Chagovetz AA,Jensen RL,Recht L,Glantz M,Chagovetz AM

更新日期：2011-12-01 00:00:00

abstract：:Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates f...

journal_title：Journal of neuro-oncology

authors： Gittleman H,Kromer C,Ostrom QT,Blanda R,Russell J,Kruchko C,Barnholtz-Sloan JS

更新日期：2017-06-01 00:00:00

abstract：:Cancer metastasis can affect any part of the nervous system. When the peripheral nervous system is involved, the usual targets are cranial nerves, nerve roots and plexi. However, peripheral nerves and muscles can also be affected by compression or infiltration of neoplastic cells. This review focuses in the diagnosis ...

journal_title：Journal of neuro-oncology

authors： Ramchandren S,Dalmau J

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

journal_title：Journal of neuro-oncology

authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population. METHODS:We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed fo...

journal_title：Journal of neuro-oncology

authors： Wong J,Goddard K,Laperriere N,Dang J,Bouffet E,Bartels U,Hodgson D,Tyldesley S,Hukin J,Cheng S,Bedard PL,Lo AC

更新日期：2020-09-01 00:00:00

abstract：:Two patients with metastasis from lung carcinoma of the midbrain are presented. The computerized tomographic (CT) findings mimicked a primary pineal tumor, but autopsy confirmed a metastatic nodule in the midbrain in both cases. The rational approach to posterior third ventricular tumors seen on CT in adulthood is dis...

journal_title：Journal of neuro-oncology

authors： Tomita T,Wetzel N

更新日期：1984-01-01 00:00:00

abstract：:Intramedullary spinal cord metastases of solid neoplasms are associated with poor long-term survival. As the characteristics of secondary intramedullary spinal cord non-Hodgkin's lymphoma (NHL) are not well understood, we sought to describe its clinical features and outcome. We retrospectively reviewed the Mayo Clinic...

journal_title：Journal of neuro-oncology

authors： Flanagan EP,O'Neill BP,Habermann TM,Porter AB,Keegan BM

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:The uptake of the boron compound Na2B12H10-SH (BSH) in tumor and normal tissues was investigated in the frame of the EORTC phase I trial 'Postoperative treatment of glioblastoma with BNCT at the Petten Irradiation Facility' (protocol 11961). METHODS AND MATERIALS:The boron concentration in blood, tumor, normal...

journal_title：Journal of neuro-oncology

authors： Hideghéty K,Sauerwein W,Wittig A,Götz C,Paquis P,Grochulla F,Haselsberger K,Wolbers J,Moss R,Huiskamp R,Fankhauser H,de Vries M,Gabel D

更新日期：2003-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and ...

journal_title：Journal of neuro-oncology

authors： Sjöström S,Wibom C,Andersson U,Brännström T,Broholm H,Johansen C,Collatz-Laier H,Liu Y,Bondy M,Henriksson R,Melin B

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Glioblastoma (GBM) is the most common primary brain cancer. The average survival time for the majority of patients is approximately 15 months after diagnosis. A major feature of GBM that contributes to its poor prognosis is its high invasiveness. Caveolae are plasma membrane subdomains that participate in ...

journal_title：Journal of neuro-oncology

authors： Pu W,Nassar ZD,Khabbazi S,Xie N,McMahon KA,Parton RG,Riggins GJ,Harris JM,Parat MO

更新日期：2019-06-01 00:00:00

abstract：:Anti-PD-1/PD-L1 therapies have demonstrated activity in patients with advanced stage non-small cell lung cancer (NSCLC). However, little is known about the safety and feasibility of patients receiving anti-PD-1/PD-L1 therapy and stereotactic radiation for the treatment of brain metastases. Data were analyzed retrospec...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Kim S,Arrington J,Naghavi AO,Dilling TJ,Creelan BC,Antonia SJ,Caudell JJ,Harrison LB,Sahebjam S,Gray JE,Etame AB,Johnstone PA,Yu M,Perez BA

更新日期：2017-06-01 00:00:00

abstract：:Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults. Vestibular schwannomas are the most common, followed by meningiomas. Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors. We describe a pilocyti...

journal_title：Journal of neuro-oncology

authors： Francesco F,Maurizio I,Stefano C,Marina S,Ugo S,Massimo S

更新日期：2010-04-01 00:00:00

abstract：:Alkaline phosphatase (ALPase) and Mg2+-activated ATPase (Mg2+-ATPase) activities were demonstrated in human brain tumors by light and electron microscopy. Four cases of glioma, i.e., two cases of astrocytoma, grade II, and two cases of glioblastoma, were used as materials. At the light microscopic level, Mg2+-ATPase a...

journal_title：Journal of neuro-oncology

authors： Maeda T,Nishiyama F,Ogashiwa M,Takeuchi K,Hirano H

更新日期：1985-01-01 00:00:00

abstract：:Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

journal_title：Journal of neuro-oncology

authors： Nahreini P,Andreatta C,Hanson A,Prasad KN

更新日期：2003-05-01 00:00:00

abstract：:Soon after the initial description of acromegaly in the late 19th century, neurosurgeons performed the first operative procedures for the disease. Transcranial procedures eventually yielded to the transsphenoidal approach. Reasonably effective medical therapy was introduced in the 1970s and pharmacological progress co...

journal_title：Journal of neuro-oncology

authors： Jane JA Jr,Thapar K,Laws ER Jr

更新日期：2001-09-01 00:00:00

abstract：:Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial r...

journal_title：Journal of neuro-oncology

authors： Kadota RP,Stewart CF,Horn M,Kuttesch JF Jr,Burger PC,Kepner JL,Kun LE,Friedman HS,Heideman RL

更新日期：1999-05-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are important modulators of various cellular and molecular events, including cancer-associated pathways. The Anti-differentiation ncRNA (ANCR) is a key regulator of keratinocyte differentiation, where its expression is necessary to maintain epidermal progenitor's cells. Herein, we invest...

journal_title：Journal of neuro-oncology

authors： Malakootian M,Mirzadeh Azad F,Fouani Y,Taheri Bajgan E,Saberi H,Mowla SJ

更新日期：2018-06-01 00:00:00

abstract：:The treatment of visual pathway gliomas is controversial. The many retrospective studies reporting outcome data for patients with chiasmatic/hypothalamic gliomas are difficult to interpret for several reasons. First the natural history of these tumors is erratic with some reports suggesting that most visual pathway gl...

journal_title：Journal of neuro-oncology

authors： Garvey M,Packer RJ

更新日期：1996-05-01 00:00:00

abstract：:Patients with unresectable glioblastoma or anaplastic astrocytoma have a dismal prognosis. The role of neoadjuvant chemotherapy prior to irradiation in these patients has been studied primarily in non-randomized studies. We have compared the effect of neoadjuvant chemotherapy plus radiotherapy versus concomitant radio...

journal_title：Journal of neuro-oncology

authors： Capdevila L,Cros S,Ramirez JL,Sanz C,Carrato C,Romeo M,Etxaniz O,Hostalot C,Massuet A,Cuadra JL,Villà S,Balañà C

更新日期：2014-03-01 00:00:00

abstract：:A major toxic effect of the chemotherapeutic agents paclitaxel and cisplatin is peripheral neuropathy. We report the use of a rat model of cytotoxic neuropathy to evaluate the role of glutamate as a possible neuroprotectant for these two drugs. Neuropathy was manifest as gait disturbance in 100% of paclitaxel treated ...

journal_title：Journal of neuro-oncology

authors： Boyle FM,Wheeler HR,Shenfield GM

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS). Unique involvement of the CNS has been reported rarely. We report our experience with LYG confined to the brain and...

journal_title：Journal of neuro-oncology

authors： Lucantoni C,De Bonis P,Doglietto F,Esposito G,Larocca LM,Mangiola A,Martini M,Papacci F,Teofili L,Pompucci A

更新日期：2009-09-01 00:00:00

abstract：:To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution fr...

journal_title：Journal of neuro-oncology

authors： Kim JM,Miller JA,Kotecha R,Xiao R,Juloori A,Ward MC,Ahluwalia MS,Mohammadi AM,Peereboom DM,Murphy ES,Suh JH,Barnett GH,Vogelbaum MA,Angelov L,Stevens GH,Chao ST

更新日期：2017-06-01 00:00:00

abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...

journal_title：Journal of neuro-oncology

authors： Benke T,Wagner M,Pallua AK,Muigg A,Stockhammer G

更新日期：2004-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents a class of malignant gliomas which rapidly proliferate, invade and destroy surrounding brain tissues. This study examined micro-RNA (miRNA) speciation and miRNA effects on gene expression in six ATCC glioma and GBM cell lines and in 14 glioma and GBM samples obtained from human...

journal_title：Journal of neuro-oncology

authors： Lukiw WJ,Cui JG,Li YY,Culicchia F

更新日期：2009-01-01 00:00:00

abstract：:HDGF is overexpressed in gliomas as compared to normal brain. We therefore analyzed the molecular mechanisms of HDGF action in gliomas. HDGF was downregulated in normal brain tissue as compared to glioma specimens at both the mRNA and the protein levels. In glioma samples, increased HDGF expression was associated with...

journal_title：Journal of neuro-oncology

authors： Song Y,Hu Z,Long H,Peng Y,Zhang X,Que T,Zheng S,Li Z,Wang G,Yi L,Liu Z,Fang W,Qi S

更新日期：2014-09-01 00:00:00

abstract：:Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of D...

journal_title：Journal of neuro-oncology

authors： Baugh J,Bartels U,Leach J,Jones B,Chaney B,Warren KE,Kirkendall J,Doughman R,Hawkins C,Miles L,Fuller C,Hassall T,Bouffet E,Lane A,Hargrave D,Grill J,Hoffman LM,Jones C,Towbin A,Savage SA,Monje M,Li XN,Ziegler

更新日期：2017-04-01 00:00:00