Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor.

abstract：:We describe two patients with fatal vascular malformations of the thalamus whom we thought had gliomas. They had progressive neurological impairment with subacute onset as adults. Computed tomography showed lesions of increased density with slight post-contrast enhancement; cerebral angiography was normal. Without bio...

journal_title：Journal of neuro-oncology

authors： Norcross K,Ciric IS,Mikhael MA,Vick NA

更新日期：1985-01-01 00:00:00

abstract：:Pituitary adenomas produce the chemokine stromal cell-derived factor (SDF-1α/CXCL12) and its receptor, CXCR4. A recent study indicated that CXCL12 and CXCR4 are concomitantly up-regulated in hypoxia. The objective of this study was to analyze the molecular mechanism of hypoxia-mediated CXCR4 up-regulation and assess t...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Koketshu K,Nomura R,Teramoto A

更新日期：2010-10-01 00:00:00

abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...

journal_title：Journal of neuro-oncology

authors： Benke T,Wagner M,Pallua AK,Muigg A,Stockhammer G

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS). Unique involvement of the CNS has been reported rarely. We report our experience with LYG confined to the brain and...

journal_title：Journal of neuro-oncology

authors： Lucantoni C,De Bonis P,Doglietto F,Esposito G,Larocca LM,Mangiola A,Martini M,Papacci F,Teofili L,Pompucci A

更新日期：2009-09-01 00:00:00

abstract：:Aberrant expression of stem cell-related genes in tumors may confer more primitive and aggressive traits affecting clinical outcome. Here, we investigated expression and prognostic value of the neural stem cell marker CD133, as well as of the pluripotency genes LIN28 and OCT4 in 37 samples of pediatric medulloblastoma...

journal_title：Journal of neuro-oncology

authors： Rodini CO,Suzuki DE,Saba-Silva N,Cappellano A,de Souza JE,Cavalheiro S,Toledo SR,Okamoto OK

更新日期：2012-01-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline ph...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Conway DR,Franklin WA,Lillehei KO,Kruse CA

更新日期：1995-01-01 00:00:00

abstract：:The purpose of this study is to identify the needs of brain tumor patients and their caregivers to provide improved health services to these populations. Two different questionnaires were designed for patients and caregivers. Both questionnaires contained questions pertaining to three realms: disease symptoms/treatmen...

journal_title：Journal of neuro-oncology

authors： Parvataneni R,Polley MY,Freeman T,Lamborn K,Prados M,Butowski N,Liu R,Clarke J,Page M,Rabbitt J,Fedoroff A,Clow E,Hsieh E,Kivett V,Deboer R,Chang S

更新日期：2011-09-01 00:00:00

abstract：:Glioblastoma (GBM) is a highly aggressive brain tumor for which novel therapeutic approaches, such as immunotherapy, are urgently needed. Zoledronate (ZOL), an inhibitor of osteoclastic activity, is known to stimulate peripheral blood-derived γδT cells and sensitize tumors to γδT cell-mediated killing. To investigate ...

journal_title：Journal of neuro-oncology

authors： Nakazawa T,Nakamura M,Park YS,Motoyama Y,Hironaka Y,Nishimura F,Nakagawa I,Yamada S,Matsuda R,Tamura K,Sugimoto T,Takeshima Y,Marutani A,Tsujimura T,Ouji N,Ouji Y,Yoshikawa M,Nakase H

更新日期：2014-01-01 00:00:00

abstract：:Intracranial metastatic prostate carcinoma is rare. We sought to determine the clinical outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) for patients with intracranial prostate carcinoma metastases. We studied data from 10 patients who underwent radiosurgery for 15 intracranial metastases (9 dural-based an...

journal_title：Journal of neuro-oncology

authors： Flannery T,Kano H,Niranjan A,Monaco EA 3rd,Flickinger JC,Lunsford LD,Kondziolka D

更新日期：2010-02-01 00:00:00

abstract：:Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant (CD44v) isoforms. Based on clear differences in the expression of these CD44v isoforms between normal and malignant tissues, we believe that eluci...

journal_title：Journal of neuro-oncology

authors： Asman DC,Dirks JF,Ge L,Resnick NM,Salvucci LA,Gau JT,Becich MJ,Cooper DL,Dougherty GJ

更新日期：1995-12-01 00:00:00

abstract：:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI...

journal_title：Journal of neuro-oncology

authors： Korshunov A,Savostikova M,Ozerov S

更新日期：2002-07-01 00:00:00

abstract：:Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data fro...

journal_title：Journal of neuro-oncology

authors： Shabihkhani M,Telesca D,Movassaghi M,Naeini YB,Naeini KM,Hojat SA,Gupta D,Lucey GM,Ontiveros M,Wang MW,Hanna LS,Sanchez DE,Mareninov S,Khanlou N,Vinters HV,Bergsneider M,Nghiemphu PL,Lai A,Liau LM,Cloughesy TF,Yon

更新日期：2017-04-01 00:00:00

abstract：:Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. Here we aim to determine whether PLX4720, a specific BRAF V600E inhibitor, enhances the activi...

journal_title：Journal of neuro-oncology

authors： Dasgupta T,Olow AK,Yang X,Hashizume R,Nicolaides TP,Tom M,Aoki Y,Berger MS,Weiss WA,Stalpers LJ,Prados M,James CD,Mueller S,Haas-Kogan DA

更新日期：2016-02-01 00:00:00

abstract：:Neuron-specific enolase (NSE) is one of the iso-forms of enolase, a glycolytic enzyme found in the neuroendocrine system. NSE is one of the most widely used tumor markers in small-cell lung carcinoma (SCLC). To assess the value of NSE in discriminating between the sites of metastases in SCLC-patients with and without ...

journal_title：Journal of neuro-oncology

authors： van de Pol M,Twijnstra A,ten Velde GP,Menheere PP

更新日期：1994-01-01 00:00:00

abstract：:The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic cleavage. ETs exert their biological effects through the activation of two receptors sub...

journal_title：Journal of neuro-oncology

authors： Paolillo M,Barbieri A,Zanassi P,Schinelli S

更新日期：2006-08-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of p...

journal_title：Journal of neuro-oncology

authors： Tichy J,Spechtmeyer S,Mittelbronn M,Hattingen E,Rieger J,Senft C,Foerch C

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Erlotinib and Gefitinib (EGFRi) are small molecules specifically inhibiting epidermal growth factor receptor (EGFR). We present here data of an exploratory study evaluating EGFRi monotherapy in patients with recurrent or progressive malignant glioma. PATIENTS:21 patients with recurrent or progressive mali...

journal_title：Journal of neuro-oncology

authors： Preusser M,Gelpi E,Rottenfusser A,Dieckmann K,Widhalm G,Dietrich W,Bertalanffy A,Prayer D,Hainfellner JA,Marosi C

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions. METHODS:A total of 75 pediatric patients with spinal tumor...

journal_title：Journal of neuro-oncology

authors： Chou SC,Kuo MF,Lai DM,Chen CM,Xiao F,Tsuang FY,Yang SH

更新日期：2020-02-01 00:00:00

abstract：:Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes, as the yolk sac circulation. Angiogenesis is responsible for the rem...

journal_title：Journal of neuro-oncology

authors： Patan S

更新日期：2000-10-01 00:00:00

abstract：:Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glio...

journal_title：Journal of neuro-oncology

authors： Qi ZX,Cai JJ,Chen LC,Yue Q,Gong Y,Yao Y,Mao Y

更新日期：2016-01-01 00:00:00

abstract：:Following surgical resection for brain metastases, fractionated stereotactic radiotherapy (FSRT) has been used as an alternative to single dose treatment for large cavities and to reduce risks of late toxicity. The purpose of this study was to evaluate the outcomes of patients treated with FSRT to the post-operative b...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Freilich JM,Abuodeh Y,Figura N,Patel N,Sarangkasiri S,Chinnaiyan P,Yu HH,Etame AB,Rao NG

更新日期：2014-05-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:In a cohort of 25 patients with supratentorial low grade glioma, the timing of radiotherapy made no significance difference for 10 year survival. Patients who received early radiotherapy had a 55% 10 year survival and those receiving delayed radiotherapy had a 53% 10 year survival. Radiotherapy was delayed a median of...

journal_title：Journal of neuro-oncology

authors： Knisely JP,Haffty BG,Christopher SR

更新日期：1997-08-01 00:00:00

abstract：:The aim of the present study is to evaluate the impact of extent of resection at initial and repeat craniotomy on overall survival of patients with recurrent glioblastoma. The authors retrospectively reviewed the records of all adults patients who underwent repeat resection of recurrent glioblastoma following radiatio...

journal_title：Journal of neuro-oncology

authors： Perrini P,Gambacciani C,Weiss A,Pasqualetti F,Delishaj D,Paiar F,Morganti R,Vannozzi R,Lutzemberger L

更新日期：2017-02-01 00:00:00

abstract：:Cell differentiation agent-2 (CDA-2) is an extraction from healthy human urine consisting of primary organic acids and peptides, and it has been demonstrated to inhibit growth and induce differentiation in glioma and other cell lines. But the mechanism of CDA-2 remains unclear. In this study, we demonstrated that CDA-...

journal_title：Journal of neuro-oncology

authors： Xie YK,Huo SF,Zhang G,Zhang F,Lian ZP,Tang XL,Jin C

更新日期：2012-11-01 00:00:00

abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

journal_title：Journal of neuro-oncology

authors： Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To assess the neurocognitive function and neurological toxicity of frameless linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) in patients with 10 or more brain metastases (BM). PATIENTS AND METHODS:Forty consecutive adult patients who received SRS for ten or more 10 BM < 3 cm in maximum size we...

journal_title：Journal of neuro-oncology

authors： Minniti G,Capone L,Nardiello B,El Gawhary R,Raza G,Scaringi C,Bianciardi F,Gentile P,Paolini S

更新日期：2020-05-01 00:00:00

abstract：:The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral a...

journal_title：Journal of neuro-oncology

authors： Clavo B,Robaina F,Valcarcel B,Catala L,Perez JL,Cabezon A,Jorge IJ,Fiuza D,Hernandez MA,Jover R,Carreras JL

更新日期：2012-01-01 00:00:00

abstract：:Health-related quality of life (HRQOL) is arguably one of the most important measures in evaluating effectiveness of clinical treatments. At present, there is no disease-specific outcome measure to assess the HRQOL of children, adolescents and young adults with Neurofibromatosis Type 1 (NF1). This study aimed to devel...

journal_title：Journal of neuro-oncology

authors： Nutakki K,Varni JW,Steinbrenner S,Draucker CB,Swigonski NL

更新日期：2017-03-01 00:00:00

abstract：:The treatment of visual pathway gliomas is controversial. The many retrospective studies reporting outcome data for patients with chiasmatic/hypothalamic gliomas are difficult to interpret for several reasons. First the natural history of these tumors is erratic with some reports suggesting that most visual pathway gl...

journal_title：Journal of neuro-oncology

authors： Garvey M,Packer RJ

更新日期：1996-05-01 00:00:00