当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma.

Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma.

Abstract：

:Glioblastoma (GBM) is a highly aggressive brain tumor for which novel therapeutic approaches, such as immunotherapy, are urgently needed. Zoledronate (ZOL), an inhibitor of osteoclastic activity, is known to stimulate peripheral blood-derived γδT cells and sensitize tumors to γδT cell-mediated killing. To investigate the feasibility of γδT cell-based immunotherapy for patients with GBM, we focused on the killing of GBM cell lines by γδT cells and the molecular mechanisms involved in these cell-cell interactions. Peripheral blood mononuclear cells were expanded in ZOL and interleukin (IL)-2 for 14 days, and γδT cells were enriched in the expanded cells by the immunomagnetic depletion of αβT cells. Gliomas are resistant to NK cells but susceptible to lymphokine-activated killer cells and some cytotoxic T lymphocytes. When the γδT cell-mediated killing of three GBM cell lines (U87MG, U138MG and A172 cells) and an NK-sensitive leukemia cell line (K562 cells) were tested, 32% U87MG, 15% U138MG, 1% A172, and 50% K562 cells were killed at an effector:target ratio of 5:1. The γδT cell-mediated killing of all three GBM cell lines was significantly enhanced by ZOL and this ZOL-enhanced killing was blocked by an anti-T cell receptor (TcR) antibody. These results indicated that TcR γδ is crucial for the recognition of ZOL-treated GBM cells by γδT cells. Since the low level killing of GBM cells by the γδT cells was enhanced by ZOL, γδT cell-targeting therapy in combination with ZOL treatment could be effective for patients with GBM.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Nakazawa T,Nakamura M,Park YS,Motoyama Y,Hironaka Y,Nishimura F,Nakagawa I,Yamada S,Matsuda R,Tamura K,Sugimoto T,Takeshima Y,Marutani A,Tsujimura T,Ouji N,Ouji Y,Yoshikawa M,Nakase H

doi

10.1007/s11060-013-1258-4

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

31-9

issue

1

eissn

0167-594X

issn

1573-7373

journal_volume

116

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Neonatal medulloblastoma.

    abstract：:A 9-day-old female presented with a large infra- and supratentorial medulloblastoma was treated by surgery, irradiation and chemotherapy. The infant suffered from vomit a few days after birth. She was hospitalized shortly thereafter, when head enlargement was noted. A CT scan taken on admission disclosed a large mass ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01053936

    authors： Kayama T,Yoshimoto T,Shimizu H,Sakurai Y

    更新日期：1993-02-01 00:00:00

  • Adeno-associated viral vector gene transfer into leptomeningeal xenografts.

    abstract：:Leptomeningeal carcinomatosis is a painful and debilitating complication of cancer. Indwelling reservoirs provide continuous assess to the subarachnoid space, making leptomeningeal cancer potentially amenable to gene therapy. Adeno-associated virus (AAV) is a defective virus not associated with any human disease. We u...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005702228721

    authors： Rosenfeld MR,Bergman I,Schramm L,Griffin JA,Kaplitt MG,Meneses PI

    更新日期：1997-09-01 00:00:00

  • Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells.

    abstract：:We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. Identification of in vitro PDGFR-targeting pharmacologic agents that are suitable for preclinical testing in medulloblastoma models in vivo will be critical for effici...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0259-9

    authors： Abouantoun TJ,Castellino RC,MacDonald TJ

    更新日期：2011-01-01 00:00:00

  • Development of the pediatric quality of life inventory neurofibromatosis type 1 module items for children, adolescents and young adults: qualitative methods.

    abstract：:Health-related quality of life (HRQOL) is arguably one of the most important measures in evaluating effectiveness of clinical treatments. At present, there is no disease-specific outcome measure to assess the HRQOL of children, adolescents and young adults with Neurofibromatosis Type 1 (NF1). This study aimed to devel...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2351-2

    authors： Nutakki K,Varni JW,Steinbrenner S,Draucker CB,Swigonski NL

    更新日期：2017-03-01 00:00:00

  • Surgery, tamoxifen, carboplatin, and radiotherapy in the treatment of newly diagnosed glioblastoma patients.

    abstract：:A historically controlled phase II study was undertaken to investigate the efficacy and toxicity of a postoperative treatment consisting of high-dose continuous tamoxifen, carboplatin and radiotherapy in patients with newly diagnosed glioblastoma. Between 1995 and 1998, 50 patients with newly diagnosed glioblastomas u...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1026533016912

    authors： Puchner MJ,Herrmann HD,Berger J,Cristante L

    更新日期：2000-09-01 00:00:00

  • Paucity of retinoic acid receptor alpha (RAR alpha) nuclear immunostaining in gliomas and inability of retinoic acid to influence neural cell adhesion molecule (NCAM) expression.

    abstract：:Neural cell adhesion molecule (NCAM) is down-regulated during periods of embryological cell migration and may be important in local tumor migration or metastases. Conflicting information exists in the literature about NCAM expression in human glial tumors and little is known about its expression in human brain metasta...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006162211296

    authors： Kleinschmidt-DeMasters BK,Orr EA,Savelieva E,Owens GC,Kruse CA

    更新日期：1999-01-01 00:00:00

  • Cisplatin induced neuropathy: central, peripheral and autonomic nerve involvement.

    abstract：:A prospective study was performed in patients treated with cisplatin to evaluate the occurrence and degree of central, peripheral and autonomic neuropathy and to determine the most accurate method to study this neuropathy. Twelve patients were examined before, during and after treatment. Evaluation included neurologic...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF02341156

    authors： Boogerd W,ten Bokkel Huinink WW,Dalesio O,Hoppenbrouwers WJ,van der Sande JJ

    更新日期：1990-12-01 00:00:00

  • Signal transduction molecules in gliomas of all grades.

    abstract：PURPOSE:To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV g...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9683-5

    authors： Ermoian RP,Kaprealian T,Lamborn KR,Yang X,Jelluma N,Arvold ND,Zeidman R,Berger MS,Stokoe D,Haas-Kogan DA

    更新日期：2009-01-01 00:00:00

  • Bone marrow transplantation for severe aplastic anemia secondary to temozolomide.

    abstract：:Radiotherapy (RT) and concomitant/adjuvant therapy with temozolomide (Temodar) is a common treatment regimen for children and adults with glioma. Although temozolomide is generally well tolerated with temporary myelosuppression as the primary dose-limiting toxicity, irreversible bone-marrow aplasia after treatment wit...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9704-4

    authors： Morris EB,Kasow K,Reiss U,Ellison D,Broniscer A

    更新日期：2009-01-01 00:00:00

  • Opportunities for clinical research in meningioma.

    abstract：:Meningiomas, when benign, are commonly treated with surgical resection alone. However, the optimal treatment for patients with subtotally resected or recurrent World Health Organization (WHO) grade I tumors, or WHO grade II and III tumors, regardless of the extent of resection, is not well defined, with both a paucity...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-010-0375-6

    authors： Vogelbaum MA,Leland Rogers C,Linskey MA,Mehta MP

    更新日期：2010-09-01 00:00:00

  • Type beta transforming growth factor and epidermal growth factor suppress the plasminogen activator activity in a human glioblastoma cell line.

    abstract：:In the human glioblastoma cell line, T-MG1, plasminogen activator activity (PA-activity) was demonstrated by using the chromogenic substrate S-2251. Using monoclonal antibodies against human urokinase type PA (u-PA) and human tissue type PA (t-PA), only u-PA activity was found in T-MG1 cell extracts. The u-PA activity...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00163713

    authors： Helseth E,Dalen A,Unsgaard G,Vik R

    更新日期：1988-11-01 00:00:00

  • Primary intracranial myxoma of the parietal region. Illustrated case report.

    abstract：:An extremely rare case of primary intracranial myxoma mimicking an intraaxial parenchymal tumour is reported. A 25 year old male presented with complaints of headache and right sided hemiparesis. A gross total resection of the tumour was achieved. Histology confirmed that the tumour was a myxoma. Investigations did no...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9555-z

    authors： Menon RK,Goel A,Shah A,Goel N,Rajashekharan P

    更新日期：2008-06-01 00:00:00

  • Phase I study of bendamustine with concurrent whole brain radiation therapy in patients with brain metastases from solid tumors.

    abstract：:A phase I study was conducted to evaluate the dose-limiting toxicities (DLTs) and to determine the maximum tolerated dose (MTD)/recommended phase II dose of bendamustine with concurrent whole brain radiation (WBR) in patients with brain metastases (BM) from solid tumors. Four doses of intravenous weekly bendamustine w...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1510-6

    authors： Pan E,Yu D,Zhao X,Neuger A,Smith P,Chinnaiyan P,Yu HH

    更新日期：2014-09-01 00:00:00

  • Intracranial pseudolymphoma.

    abstract：:Intracranial pseudolymphoma is a rare tumor of the central nervous system. A 35-year-old woman presented with a frontal subcutaneous tumor. Magnetic resonance imaging revealed a left frontal meningeal tumor involving subcutaneous tissue without bone involvement. The mass was completely removed and the histological asp...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006414717891

    authors： Donnet A,Horschowski N,Dufour H,Figarella-Branger D,Bryon PA,Berger F,Harle JR,Grisoli F

    更新日期：2000-04-01 00:00:00

  • Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.

    abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-0090-3

    authors： Cobert J,Hochberg E,Woldenberg N,Hochberg F

    更新日期：2010-07-01 00:00:00

  • Differential DNA methylome profiling of nonfunctioning pituitary adenomas suggesting tumour invasion is correlated with cell adhesion.

    abstract：:Global and gene-specific changes to the epigenome are hallmarks of most tumours including those of pituitary origin, and this fact might offer important clues about diagnostic and therapeutic applications. We performed global DNA methylation screening with 6 invasive and 6 noninvasive nonfunctioning pituitary adenomas...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2139-4

    authors： Gu Y,Zhou X,Hu F,Yu Y,Xie T,Huang Y,Zhao X,Zhang X

    更新日期：2016-08-01 00:00:00

  • Malignant intracranial epithelioid hemangioendothelioma presumably originating from the lung: case report.

    abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/b:neon.0000024215.79178.27

    authors： Endo T,Su CC,Numagami Y,Shirane R

    更新日期：2004-05-01 00:00:00

  • Case report: a patient with primary CNS lymphoma treated with temozolomide to complete response.

    abstract：:We report the case of a 72-year-old woman with primary CNS lymphoma of the mid-brain and pons who had a complete response to oral temozolomide chemotherapy. She initially presented in early 2001 with several weeks of progressive memory loss and unresponsiveness. Because of her age and impaired renal function, she was ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1019682400415

    authors： Lerro KA,Lacy J

    更新日期：2002-09-01 00:00:00

  • Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature.

    abstract：:Von Hippel-Lindau Disease, a multisystem familial cancer syndrome, is inherited as an autosomal-dominant trait. Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym. We re...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-5179-0

    authors： Ertas G,Altundag MB,Ucer AR,Cankal F,Altundag K

    更新日期：2005-07-01 00:00:00

  • BCNU stability as a function of ethanol concentration and temperature.

    abstract：:BCNU is increasingly used in low ethanol (ETOH) concentrations, 5% dextrose-water (D5W), or normal saline (NS) solutions, especially for intra-arterial and prolonged (e.g., 3 day) intravenous (IV) infusions. Little work, however, has been done to evaluate BCNU decomposition rates in concentrations, diluents, and tempe...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00146872

    authors： Tepe P,Hassenbusch SJ,Benoit R,Anderson JH

    更新日期：1991-04-01 00:00:00

  • STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma.

    abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1843-9

    authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

    更新日期：2015-09-01 00:00:00

  • Anti-differentiation non-coding RNA, ANCR, is differentially expressed in different types of brain tumors.

    abstract：:Long non-coding RNAs (lncRNAs) are important modulators of various cellular and molecular events, including cancer-associated pathways. The Anti-differentiation ncRNA (ANCR) is a key regulator of keratinocyte differentiation, where its expression is necessary to maintain epidermal progenitor's cells. Herein, we invest...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2809-5

    authors： Malakootian M,Mirzadeh Azad F,Fouani Y,Taheri Bajgan E,Saberi H,Mowla SJ

    更新日期：2018-06-01 00:00:00

  • Determination of proliferative activities in human brain tumor specimens: a comparison of three methods.

    abstract：:Proliferative activities were determined in 72 human brain tumors, including 20 metastatic carcinomas, 41 gliomas, 8 meningiomas and 3 hematological tumors. Immunocytochemical techniques included labeling with monoclonal antibody (mAb) to bromodeoxyuridine (BrdU) which identifies S phase cells after previous in vitro ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00151242

    authors： Morimura T,Kitz K,Stein H,Budka H

    更新日期：1991-02-01 00:00:00

  • Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement.

    abstract：INTRODUCTION:There is growing evidence that the subventricular zone (SVZ) plays a key role in glioblastoma (GBM) tumorigenesis. However, little is known regarding how the SVZ, which is a harbor for adult neural stem cells, may be influenced by chemoradiation. The current diffusion-weighted imaging (DWI) study explored ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03460-5

    authors： Cho N,Wang C,Raymond C,Kaprealian T,Ji M,Salamon N,Pope WB,Nghiemphu PL,Lai A,Cloughesy TF,Ellingson BM

    更新日期：2020-05-01 00:00:00

  • Clinical and dosimetric study of radiotherapy for glioblastoma: three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy.

    abstract：BACKGROUND AND PURPOSE:We aimed to compare three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for the treatment of glioblastoma. MATERIALS AND METHODS:Retrospective study of 220 patients with glioblastoma, treated with 3D-CRT or IMRT, with or without surgery. Dosimetric para...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2735-y

    authors： Thibouw D,Truc G,Bertaut A,Chevalier C,Aubignac L,Mirjolet C

    更新日期：2018-04-01 00:00:00

  • Glioblastoma stem cells and stem cell-targeting immunotherapies.

    abstract：:Advancements in immunotherapeutics promise new possibilities for the creation of glioblastoma (GBM) treatment options. Ongoing work in cancer stem cell biology has progressively elucidated the role of this tumor sub-population in oncogenesis and has distinguished them as prime therapeutic targets. Current clinical tri...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-015-1729-x

    authors： Esparza R,Azad TD,Feroze AH,Mitra SS,Cheshier SH

    更新日期：2015-07-01 00:00:00

  • Bevacizumab for radiation necrosis following treatment of high grade glioma: a systematic review of the literature.

    abstract：:This review identifies the current literature on the use of bevacizumab for cerebral radiation necrosis in patients with high-grade gliomas, summarizes the clinical course and complications following bevacizumab, and discusses the relative costs and benefits of this therapeutic option. A Medline search was conducted o...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-013-1233-0

    authors： Lubelski D,Abdullah KG,Weil RJ,Marko NF

    更新日期：2013-12-01 00:00:00

  • Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: long term results of RTOG BR0131.

    abstract：:We report on the long-term results of a phase II study of pre-irradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (AO) and mixed anaplastic oligoastrocytoma. Pre-RT temozolomide was given for up to 6 cycles. RT with concurrent...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11060-015-1845-7

    authors： Vogelbaum MA,Hu C,Peereboom DM,Macdonald DR,Giannini C,Suh JH,Jenkins RB,Laack NN,Brachman DG,Shrieve DC,Souhami L,Mehta MP

    更新日期：2015-09-01 00:00:00

  • EMPACT syndrome: limited evidence despite a high-risk cohort.

    abstract：:Serious dermatologic adverse events such as erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have been reported in patients receiving antiepileptic drugs (AEDs) and cranial radiotherapy (RT). Given the frequency of AED-associated rashes and the infrequency of serious dermatolo...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1457-7

    authors： Bishop AJ,Chang M,Lacouture ME,Barker CA

    更新日期：2014-08-01 00:00:00

  • Metronomic chemotherapy with daily low-dose temozolomide and celecoxib in elderly patients with newly diagnosed glioblastoma multiforme: a retrospective analysis.

    abstract：:Chemotherapy is often omitted in elderly patients with glioblastoma multiforme due to a fear of side effects. We applied metronomic chemotherapy with low-dose temozolomide and celecoxib (LD-TEM/CEL) during and after external beam radiotherapy (EBRT) and here report on how this regimen compares to standard temozolomide...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1834-x

    authors： Welzel G,Gehweiler J,Brehmer S,Appelt JU,von Deimling A,Seiz-Rosenhagen M,Schmiedek P,Wenz F,Giordano FA

    更新日期：2015-09-01 00:00:00