Bone marrow transplantation for severe aplastic anemia secondary to temozolomide.

Abstract:

:Radiotherapy (RT) and concomitant/adjuvant therapy with temozolomide (Temodar) is a common treatment regimen for children and adults with glioma. Although temozolomide is generally well tolerated with temporary myelosuppression as the primary dose-limiting toxicity, irreversible bone-marrow aplasia after treatment with temozolomide has been reported. We report the case of an adolescent patient with a high-grade glioma who, after >2 years of event-free survival, underwent successful bone marrow transplantation for treatment of temozolomide-induced severe aplastic anemia (SAA).

journal_name

J Neurooncol

authors

Morris EB,Kasow K,Reiss U,Ellison D,Broniscer A

doi

10.1007/s11060-008-9704-4

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

237-9

issue

2

eissn

0167-594X

issn

1573-7373

journal_volume

91

pub_type

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