Abstract：
:BCNU is increasingly used in low ethanol (ETOH) concentrations, 5% dextrose-water (D5W), or normal saline (NS) solutions, especially for intra-arterial and prolonged (e.g., 3 day) intravenous (IV) infusions. Little work, however, has been done to evaluate BCNU decomposition rates in concentrations, diluents, and temperatures similar to those employed clinically. This study examined BCNU solutions in ETOH, NS, and D5W to evaluate, conclusively, initial recovery and decomposition rates in these three diluents. Initial BCNU recovery rates were: 95.6 +/- 0.3% (100% D5W), 89.6 +/- 0.5% (15% ETOH), and 85.2 +/- 0.5% (NS) (P less than 0.001). Study of all solutions revealed no measurable BCNU decomposition over 24 hrs (0 degrees C) and no significant difference in decomposition rates between any of the diluents (19.5 degrees C). At 37 degrees C, the solutions showed different half-lives: 14.3 +/- 0.19 hrs (15% ETOH), 10.6 +/- 0.02 hrs (10% ETOH), 8.2 +/- 0.21 hrs (5% ETOH), 7.3 +/- 0.06 hrs (NS), and 6.8 +/- 0.07 hrs (D5W) (P less than 0.001). Decomposition rates between all three temperatures (19.5 degrees C, 37 degrees C, and 50 degrees C) were significantly different (P less than 0.01) for each diluent. Dissolving BCNU powder into either D5W or NS required only 5 min when hand-shaken at body temperature. This study of initial recovery and decomposition rates suggests that, although BCNU decomposition rates were significantly increased at body temperature (37 degrees C), it was quite low and essentially unaffected by different diluents at room temperature (i.e., 19.5 degrees C).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Tepe P,Hassenbusch SJ,Benoit R,Anderson JHdoi
10.1007/BF00146872subject
Has Abstractpub_date
1991-04-01 00:00:00pages
121-7issue
2eissn
0167-594Xissn
1573-7373journal_volume
10pub_type
杂志文章abstract：:A better understanding of the relationship between glioblastomas molecular subtypes and radio-chemotherapy is needed for the development of individualized strategies. In this study, we aimed to assess whether non-homologous end-joining (NHEJ) protein expression is associated and could predict responses to treatment of...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2367-7
更新日期：2017-04-01 00:00:00
abstract：:Gemistocytic astrocytoma still continues to be enigmatic; both in terms of definition and prognostic implications. The major issue of contention has been the clinical relevance of this pathological entity. The currently accepted definition of gemistocytic astrocytoma requires 20% or more gemistocytes, and considers th...
journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-005-4897-2
更新日期：2006-01-01 00:00:00
abstract：:Recently, many studies have found that the miR-106b ~25 cluster plays an oncogenic role in tumor progression. However, the precise role of each microRNAs (miRNAs) in the cluster is not yet clear. In the present study, we examined the expression of miR-106b in glioma samples and a tissue microarray by real-time PCR and...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1061-2
更新日期：2013-04-01 00:00:00
abstract：:To determine the impact of delay between surgery and radiotherapy on overall survival (OS) in temozolomide treatmented patients with the incorporation of O6-methylguanine-DNA methyltransferase (MGMT). From 2000 to 2012, 345 consecutive glioblastoma patients were treated with surgery, radiotherapy, and temozolomide at ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1302-4
更新日期：2014-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
abstract：:Glioblastoma (GBM) is the most malignant primary brain tumor and contains tumorigenic cancer stem cells (CSCs), which support the progression of tumor growth. The selection of CSCs and facilitation of the brain tumor niches may assist the development of novel therapeutics for GBM. Herein, hydrogel materials composed o...
journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-018-2763-2
更新日期：2018-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00165378
更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11060-012-0974-5
更新日期：2012-12-01 00:00:00
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2251-5
更新日期：2016-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/b:neon.0000024215.79178.27
更新日期：2004-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005714320865
更新日期：1997-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005771717409
更新日期：1997-03-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9756-5
更新日期：2009-04-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2822-8
更新日期：2018-07-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00165174
更新日期：1985-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1019987116596
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Despite aspirations to achieve equality in healthcare we know that socioeconomic differences exist and may affect treatment and patient outcome, also in serious diseases such as cancer. We investigated disparities in neurosurgical care and outcome for patients with low-grade glioma (LGG). METHODS:In this na...
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of neuro-oncology
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更新日期：2011-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
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更新日期：2009-07-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type：
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更新日期：2005-05-01 00:00:00
abstract：:Glioblastoma multiforme (GBM) remains refractory to conventional therapy. CD133+ GBM cells have been recently isolated and characterized as chemo-/radio-resistant tumor-initiating cells and are hypothesized to be responsible for post-treatment recurrence. In order to explore the molecular properties of tumorigenic CD1...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
abstract：:Bevacizumab has been reported to cause diffusion restriction in the tumor bed of patients with malignant gliomas. This study evaluated prolonged diffusion restriction, in the corpus callosum (CC), of patients with malignant brain tumors treated with bevacizumab. We retrospectively reviewed our database of patients tre...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1409-2
更新日期：2014-05-01 00:00:00
abstract：:Pilocytic astrocytomas are rare intracranial gliomas that are typically treated with surgical extirpation. Our aim was to report the radiologic and clinical outcomes of patients treated with stereotactic radiosurgery (SRS) for pilocytic astrocytoma in the primary and salvage setting. Patients with pilocytic astrocytom...
journal_title：Journal of neuro-oncology
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更新日期：2017-09-01 00:00:00
