Abstract:
BACKGROUND AND PURPOSE:We aimed to compare three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for the treatment of glioblastoma. MATERIALS AND METHODS:Retrospective study of 220 patients with glioblastoma, treated with 3D-CRT or IMRT, with or without surgery. Dosimetric parameters as well as clinical and survival data for the two techniques were analyzed and compared. RESULTS:The median conformity index was 1.53 (range 0-2.69) for 3D-CRT and 1.25 (range 0.97-2.01) for IMRT, p < 10-4. The median homogeneity index was 0.10 (range 0.03-0.32) for 3D-CRT and 0.07 (range 0.03-0.18) for IMRT, p < 10-4. There were significantly fewer acute grade 1 and 2 neurological toxicities in the IMRT group especially for edema (1.3 versus 12.4%, p = 0.017), concentration disorders (6.6 versus 19.9%, p = 0.003) and consciousness disorders (2.6 versus 13.2%, p = 0.002) although IMRT patients had a significantly worse pre-treatment neurological status than 3D-CRT patients. Median survival was 16.0 months (range 11.9-17.8) for IMRT and 13.4 months (range 11.7-15.7) for 3D-CRT patients (p = 0.542). CONCLUSION:IMRT improved target conformity and reduced neurological toxicities for patients with glioblastomas.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Thibouw D,Truc G,Bertaut A,Chevalier C,Aubignac L,Mirjolet Cdoi
10.1007/s11060-017-2735-ysubject
Has Abstractpub_date
2018-04-01 00:00:00pages
429-438issue
2eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-017-2735-yjournal_volume
137pub_type
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更新日期:2004-08-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of neuro-oncology
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pub_type: 杂志文章,随机对照试验
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